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Sodium Chloride Cotransporter (NCC)

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Apical Sodium-Dependent Bile Acid Transporter (1) Chloride Channel (22) Na+/K+ ATPase (3) NKCC (12) SGLT (58) Sodium Channel (132) Sodium Chloride Cotransporter (NCC) (1) Sodium Phosphate Cotransporter (1) 5 alpha Reductase (1) 5-HT Receptor (2) Adrenergic Receptor (2) Akt (4) Amino Acid Derivatives (2) AMPK (3) Amyloid-β (1) Angiotensin Receptor (1) Angiotensin-converting Enzyme (ACE) (1) Antibiotic (2) Apolipoprotein (1) Apoptosis (13) ATP Synthase (1) Autophagy (6) Bacterial (10) Bcl-2 Family (1) Biochemical Assay Reagents (40) Calcium Channel (19) Carbonic Anhydrase (3) Carboxypeptidase (1) Casein Kinase (1) Caspase (6) Cdc42-binding kinase (1) CFTR (2) Cholinesterase (ChE) (1) Complement System (1) COX (2) Creatine Kinase (1) Cytochrome P450 (1) Dengue Virus (1) DNA Alkylator/Crosslinker (2) DNA/RNA Synthesis (3) Dopamine Receptor (4) Drug Derivative (2) Drug Intermediate (7) Drug Metabolite (3) Elastase (1) Endogenous Metabolite (12) Enterovirus (1) Environmental Pollutants (14) ERK (1) Ferroptosis (1) Filovirus (1) Flavivirus (1) Fluorescent Dye (7) Fungal (1) G protein-coupled Bile Acid Receptor 1 (1) GABA Receptor (17) Galectin (1) Glucocorticoid Receptor (1) Glucokinase (1) GLUT (5) Glutathione Peroxidase (1) Glycolate Oxidase (1) Glycosidase (1) GlyT (1) GPR68 (1) Guanylate Cyclase (1) HBV (1) HCV (1) HDAC (1) HIV (1) HMG-CoA Reductase (HMGCR) (1) IFNAR (1) iGluR (2) Insecticide (10) Interleukin Related (6) Isotope-Labeled Compounds (11) JAK (3) JNK (1) Keap1-Nrf2 (2) Lipoxygenase (1) LPL Receptor (1) MicroRNA (1) Mineralocorticoid Receptor (1) Mitophagy (1) MMP (2) MOFs (1) Monoamine Transporter (3) mTOR (6) nAChR (1) Neurokinin Receptor (2) NF-κB (5) NOD-like Receptor (NLR) (3) Opioid Receptor (2) Orphan GPCR (1) p38 MAPK (1) Parasite (8) PDHK (1) PDK-1 (1) Phosphatase (1) Phosphodiesterase (PDE) (2) Phospholipase (1) PI3K (4) PINK1/Parkin (1) PKC (1) Potassium Channel (20) PPAR (1) Prostaglandin Receptor (1) PROTAC Linkers (1) Proton Pump (1) Reactive Oxygen Species (ROS) (10) Reference Standards (36) RSV (1) SARS-CoV (4) Small Interfering RNA (siRNA) (3) STAT (3) STING (1) TGF-beta/Smad (2) TNF Receptor (2) Toll-like Receptor (TLR) (1) Trace Amine-associated Receptor (TAAR) (1) Transmembrane Glycoprotein (1) Transthyretin (TTR) (2) TRP Channel (5) TSH Receptor (1) Tyrosinase (1) VEGFR (1) γ-Glutamyl Transferase (GGT) (1)
By Research Areas:	Cancer (56) Cardiovascular Disease (59) Endocrinology (10) Infection (33) Inflammation/Immunology (38) Metabolic Disease (107) Neurological Disease (143)
Oligonucleotides:	saRNAs (1) Nucleotide Analogs (1) Aptamers (2) siRNA drugs (3) Antisense Oligonucleotides (4) Adenine Nucleotide (1) siRNAs (3)

391

Inhibitors & Agonists

Fluorescent Dyes

Biochemical Assay Reagents

Peptides

Inhibitory Antibodies

Natural
Products

Recombinant Proteins

Isotope-Labeled Compounds

Antibodies

Oligonucleotides

Targets Recommended: Sodium Chloride Cotransporter (NCC) Sodium Phosphate Cotransporter Chloride Channel Oligopeptide Cotransporter NKCC Na+/HCO3- Cotransporter Sodium Channel Na+/H+ Exchanger (NHE) SGLT Na+/K+ ATPase Apical Sodium-Dependent Bile Acid Transporter

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-15409

Empagliflozin Maximum Cited Publications 89 Publications Verification BI 10773	SGLT	Infection Metabolic Disease Cancer
Empagliflozin (BI 107730 is a selective sodium glucose cotransporter-2 (SGLT-2) inhibitor with an IC₅₀ of 3.1 nM for human SGLT-2 .

HY-10450

Dapagliflozin 65+ Cited Publications BMS-512148	SGLT	Metabolic Disease Cancer
Dapagliflozin (BMS-512148), a new type of agent used to treat diabetes mellitus (DM), is a competitive sodium/glucose cotransporter 2 (SGLT2) inhibitor, which results in excretion of glucose into the urine . Dapagliflozin induces HIF1 expression and attenuates renal IR injury .

HY-17468

Bumetanide 15+ Cited Publications Ro 10-6338; PF 1593	NKCC	Cardiovascular Disease Metabolic Disease
Bumetanide (Ro 10-6338; PF 1593), a highly potent loop diuretic, is a *Na ⁺-K ⁺-Cl ⁺ cotransporter* (NKCC) blocker. Bumetanide is a selective NKCC1 inhibitor, but also inhibits NKCC2, with IC₅₀**s of 0.68 μM and 4.0 μM for hNKCC1A and hNKCC2A, respectively .

HY-132609

Patisiran sodium 1 Publications Verification	Small Interfering RNA (siRNA) Transthyretin (TTR)	Neurological Disease
Patisiran sodium is a double-stranded small interfering RNA that targets a sequence within the transthyretin (TTR) messenger RNA. Patisiran sodium specifically inhibits hepatic synthesis of mutant and wild-type TTR. Patisiran sodium can be used for the research of hereditary TTR amyloidosis .

HY-108764

Mipomersen sodium 2 Publications Verification ISIS 301012	Apolipoprotein HCV	Metabolic Disease
Mipomersen sodium (ISIS 301012) is an antisense oligonucleotide inhibitor of apolipoprotein B (apoB). Mipomersen has anti-HCV effect and reduces the infectivity of the HCV. Mipomersen sodium can be used for the research of homozygous familial hypercholesterolemia (HoFH) .

HY-103023

CLP290 2 Publications Verification	Potassium Channel	Neurological Disease
CLP290 is an orally available activator of the neuron-specific K ⁺-Cl ^- cotransporter KCC2, displays potential for treatment of a wide range of neurological and psychiatric indications. CLP290 can significantly lower blood arginine-vasopressin (AVP) and glucose levels in STZ (HY-13753) rats .

HY-147080

Avacincaptad pegol sodium ARC1905	Complement System	Others
Avacincaptad pegol (ARC1905) sodium is a 40KDa PEG-conjugated aptamer. Avacincaptad pegol sodium targets complement factor 5 (C5), inhibits the cleavage of C5 into C5a and C5b, limits inflammatory stimulation and complement membrane attack complex (MAC), and is used to study age-related macular degeneration (AMD). Avacincaptad pegol sodium limits irregular cell apoptosis by targeting downstream factors in the complement cascade while preserving the early steps of the complement system .

HY-N1462

Atractyloside potassium salt 4 Publications Verification	Chloride Channel Autophagy mTOR AMPK	Cardiovascular Disease Metabolic Disease Cancer
Atractyloside potassium salt is a powerful and specific inhibitor of mitochondrial ADP/ATP transport. Atractyloside potassium salt inhibits chloride channels from mitochondrial membranes of rat heart. Atractyloside potassium salt activates autophagy, inhibits ANT2, mTOR and promotes the activation of p-AMPK. Atractyloside potassium salt has anti-cancer effects on non-small cell lung cancer and can inhibit liver steatosis. Atractylodesin potassium salt has nephrotoxicity .

HY-15461

Ertugliflozin 5 Publications Verification PF-04971729	SGLT	Metabolic Disease
Ertugliflozin (PF-04971729) is a potent, selective and orally active inhibitor of the sodium-dependent glucose cotransporter 2 (SGLT2), with an IC₅₀ of 0.877 nM for h-SGLT2 . Has the potential for the treatment of type 2 diabetes mellitus .

HY-10449

Luseogliflozin TS 071	SGLT	Metabolic Disease
Luseogliflozin (TS 071) is a potent, selective, orally active *sodium-dependent glucose cotransporter* (SGLT) 2 inhibitor, with an IC₅₀ of 2.26 nM, about 1765-fold selectivity over SGLT1 (IC₅₀**, 3990 nM). Luseogliflozin has the protential for researching type 2 diabetes .

HY-B0493

Niflumic acid 4 Publications Verification	Chloride Channel COX	Inflammation/Immunology Cancer
Niflumic acid is a calcium-activated chloride channel blocker and COX-2 inhibitor with the IC₅₀ value of 100 nM. Niflumic acid induces apoptosis through caspase-8/Bid/Bax pathway in lung cancer cells. Niflumic acide exhibits anti-tumor activity by affecting the expression of ERK1/2 and the activity of MMP2 and MMP9. Niflumic acid has orally bioactivity. Niflumic acid acts on rheumatoid arthritis .

HY-123011

Henagliflozin SHR3824	SGLT	Metabolic Disease
Henagliflozin (SHR3824) is a potent selective sodium-glucose co-transporter 2 (SGLT2) inhibitor with the IC₅₀ values of 2.38 and 4324 nM for human SGLT2 and SGLT1, respectively. Henagliflozin can be used in diabetes research .

HY-109144

Enavogliflozin DWP-16001	SGLT	Metabolic Disease
Enavogliflozin (DWP-16001), an antidiabetic agent, is an orally active, best-in-class and selective sodium-glucose cotransporter-2 (SGLT-2) inhibitor .

HY-14945

Remogliflozin etabonate GSK189075	SGLT	Metabolic Disease
Remogliflozin etabonate (GSK189075) is an orally active, selective and low-affinity *sodium glucose cotransporter* (SGLT2) inhibitor with K_i** values of 1.95 μM, 2.14 μM, 43.1 μM, 8.57 μM for hSGLT2, rSGLT2, hSGLT1, rSGLT1, respectively. Remogliflozin etabonate is a proagent based on benzylpyrazole glucoside and is metabolized to its active form, Remogliflozin, in the body. Remogliflozin etabonate exhibits antidiabetic efficacy in rodent models .

HY-132608

Inotersen sodium ISIS-420915 Sodium	Transthyretin (TTR)	Neurological Disease
Inotersen (ISIS-420915) sodium is a 2′-O-methoxyethyl-modified antisense oligonucleotide. Inotersen sodium inhibits the production of transthyretin (TTR) protein by targeting the TTR RNA transcript and reduces the levels of the TTR transcript. Inotersen sodium can be used for the research of hereditary TTR amyloidosis polyneuropathy .

HY-15461A

Ertugliflozin L-pyroglutamic acid 5 Publications Verification PF-04971729 L-pyroglutamic acid	SGLT	Metabolic Disease
Ertugliflozin L-pyroglutamic acid (PF-04971729 L-pyroglutamic acid) is a potent, selective and orally active inhibitor of the sodium-dependent glucose cotransporter 2 (SGLT2), with an IC₅₀ of 0.877 nM for h-SGLT2 . Has the potential for the treatment of type 2 diabetes mellitus .

HY-15409R

Empagliflozin (Standard) BI 10773 (Standard)	Reference Standards SGLT	Metabolic Disease
Empagliflozin (Standard) is the analytical standard of Empagliflozin. This product is intended for research and analytical applications. Empagliflozin (BI 107730 is a selective sodium glucose cotransporter-2 (SGLT-2) inhibitor with an IC₅₀ of 3.1 nM for human SGLT-2 .

HY-132613

Lumasiran sodium	Small Interfering RNA (siRNA) Glycolate Oxidase	Metabolic Disease
Lumasiran sodium, an investigational RNA interference (RNAi) therapeutic agent, reduces hepatic oxalate production by targeting glycolate oxidase. Lumasiran sodium reduces urinary oxalate excretion, the cause of progressive kidney failure in primary hyperoxaluria type 1 (PH1) .

HY-117348

NCC-149	HDAC	Neurological Disease
NCC-149 is a selective HDAC8 inhibitor and can be used for neural differentiation research .

HY-W134328

Blue dextran (MW 2000000) Dextran blue (MW 2000000)	Biochemical Assay Reagents	Others
Blue dextran (Dextran blue) (MW 2000000) is a high-molecular-weight long-chain polymer of D-glucose. Blue dextran (MW 2000000) serves as an important model macromolecular drug and molecular weight estimation marker, and can be used as a standard for gel permeation chromatography. The release of Blue dextran (MW 2000000) from alginate microspheres is regulated by preparation conditions; its release rate in a pH 6.8 environment is significantly faster than that in pH 1.2, and it exhibits release characteristics close to zero-order kinetics under this condition .

HY-169929

KCC2 potentiators-1	NKCC	Neurological Disease
KCC2 potentiators-1 (Compound 2) is a Potassium chloride cotransporter-2 (KCC2) potentiator. KCC2 potentiators-1 is promising for research of neurological disorder .

HY-112065

PF-06869206 2 Publications Verification	Sodium Channel	Metabolic Disease
PF-06869206 is an orally bioavailable selective inhibitor of the sodium-phosphate cotransporter NaPi2a (SLC34A1) with an IC₅₀ of 380 nM .

HY-124738

BI 01383298 1 Publications Verification	Sodium Channel	Metabolic Disease
BI 01383298, a chemical probe, is a potent inhibitor of the *sodium-citrate co-transporter* (SLC13A5)** that is highly expressed in the liver .

HY-B1477

Clopamide 1 Publications Verification	Sodium Chloride Cotransporter (NCC)	Cardiovascular Disease Metabolic Disease
Clopamide is an orally active thiazide-like diuretic agent that inhibits the sodium-coupled chloride cotransporter SLC12A3. Clopamide has the potential for hypertension and cardiac failure research .

HY-109561

Pegaptanib sodium EYE001; NX1838	VEGFR	Metabolic Disease Inflammation/Immunology
Pegaptanib sodium is an RNA aptamer with polyethylene glycol modifications, which is directed against vascular endothelial growth factor (VEGF)-165. Pegaptanib could be used for the study of neovascular age-related macular degeneration (AMD) .

HY-76562

Methyl 6-bromopicolinate	Biochemical Assay Reagents	Others
Methyl 6-bromopicolinate is a synthetic intermediate used in the preparation of γ-secretase inhibitor library scaffolds .

HY-69359

Nipecotic acid 1 Publications Verification (±)-β-Homoproline; Hexahydronicotinic acid; 3-Carboxypiperidine	GABA Receptor	Neurological Disease
Nipecotic acid ((±)-β-Homoproline) is a potent inhibitor of neuronal and glial-aminobutyric acid (GABA) uptake in vitro. Nipecotic acid can also directly activate GABA_A-like chloride channels, with an EC₅₀ of approximately 300 μM .

HY-Z6449

Phenylephrone hydrochloride	Adrenergic Receptor	Neurological Disease
Phenylephrine hydrochlorid is an α1-adrenergic receptor agonist. As a sympathomimetic agent, Phenylephrine hydrochlorid exerts similar effects to epinephrine and ephedrine. Phenylephrine hydrochlorid induces vasoconstriction and increases perfusion pressure .

HY-15409S

Empagliflozin-d4 BI 10773-d₄	SGLT	Metabolic Disease
Empagliflozin-d₄ is deuterium labeled Empagliflozin. Empagliflozin (BI 107730 is a selective sodium glucose cotransporter-2 (SGLT-2) inhibitor with an IC₅₀ of 3.1 nM for human SGLT-2 .

HY-10450S

Dapagliflozin-d5 BMS-512148-d₅	Isotope-Labeled Compounds SGLT	Metabolic Disease Cancer
Dapagliflozin-d₅ is a deuterium labeled Dapagliflozin (HY-10450). Dapagliflozin is a competitive SGLT2 inhibitor .

HY-N0143A

Phlorizin dihydrate Maximum Cited Publications 15 Publications Verification Floridzin dihydrate	SGLT PI3K Akt GLUT NF-κB JAK STAT Caspase Apoptosis DNA/RNA Synthesis mTOR Bacterial	Infection Neurological Disease Metabolic Disease Cancer
Phlorizin (Floridzin) dihydrate is an orally active non-selective sodium-glucose cotransporter (SGLT) inhibitor, with an IC₅₀ of 0.04 μM and a K_i of 39 nM against hSGLT2, and an IC₅₀ of 0.17 μM and a K_i of 0.31 μM against hSGLT1. Phlorizin dihydrate promotes GLUT4 translocation, inhibits gluconeogenesis and promotes glycogen synthesis by activating the PI3K/Akt/mTOR pathway. Phlorizin dihydrate reduces DNA damage and apoptosis (apoptosis) by inhibiting the NF-κB inflammatory pathway. Phlorizin dihydrate induces apoptosis via activating the Caspase pathway by antagonizing the JAK/STAT3 and PCK pathways. Phlorizin dihydrate also exhibits antibacterial, anti-inflammatory and neuroprotective activities .

HY-59243

4,7-Dichloroquinoline 1 Publications Verification	Drug Intermediate	Others
4,7-Dichloroquinoline is a dichloro-substituted quinoline that can be used for the synthesis of other active compounds .

HY-Y0532

N-Chlorosuccinimide 1 Publications Verification Succinchlorimide	Environmental Pollutants Bacterial	Infection
N-Chlorosuccinimide is a five-membered N-containing heterocyclic molecule. N-Chlorosuccinimide is a versatile reagent and can be used for different types of reactions, such as aliphatic and aromatic chlorination. N-Chlorosuccinimide can enhance the antimicrobial effect of Benzalkonium chloride (HY-B2232) on biofilm Pseudomonas aeruginosa .

HY-B1243

Propoxycaine hydrochloride 1 Publications Verification	Sodium Channel	Neurological Disease
Propoxycaine hydrochloride inhibits voltage-gated sodium channels, and thereby inhibits the ionic flux required for the initiation and conduction of impulses. Propoxycaine hydrochloride application can lead to a loss of sensation.

HY-109018

Velagliflozin 1 Publications Verification	SGLT	Metabolic Disease
Velagliflozin is an orally available sodium-glucose cotransporter 2 (SGLT2) inhibitor, with anti-diabetic activity.

HY-18172

KCC2 blocker 1	Potassium Channel	Neurological Disease
KCC2 blocker 1 is an orally active and selective K ⁺-Cl ^- cotransporter KCC2 blocker with an IC₅₀ of 1 μM. KCC2 blocker 1 is a benzyl prolinate .

HY-14902

Tofogliflozin 4 Publications Verification CSG452	SGLT	Metabolic Disease
Tofogliflozin(CSG-452) is a potent and highly specific sodium/glucose cotransporter 2(SGLT2) inhibitor with Ki values of 2.9, 14.9, and 6.4 nM for human, rat, and mouse SGLT2.

HY-128677

NCC007	Casein Kinase	Neurological Disease
NCC007 is a dual casein kinase Iα (CKIα) and δ (CKIδ) inhibitor with IC₅₀s of 1.8 and 3.6 μM, respectively. NCC007 can be used in research of modulating mammalian circadian rhythms .

HY-W687022A

Chloroethene (polymer) Polyvinyl Chloride	Environmental Pollutants Biochemical Assay Reagents	Endocrinology
Chloroethene polymer (Polyvinyl chloride) is an orally active vinyl chloride polymer. Chloroethene polymer is cytotoxic, reproductively toxic, and an endocrine disruptor. Chloroethene polymer can be used in the research of packaging inner surfaces, food wrapping paper, agricultural crop coverings, and plastic bottles .

HY-106158

T-1095	SGLT	Metabolic Disease
T-1095 is a selective and orally active *Na ⁺-glucose cotransporter* (SGLT) inhibitor with IC₅₀**s of 22.8 µM and 2.3 µM for human SGLT1 and SGLT2, respectively. T-1095 can be used for diabetes research .

HY-Y0344H

Sodium chloride, United States Pharmacopeia (USP) Reference Standard Halite (Pharmaceutical primary standard, USP)	Biochemical Assay Reagents Na+/K+ ATPase Interleukin Related	Inflammation/Immunology Cancer
Sodium chloride, United States Pharmacopeia (USP) Reference Standard is an orally active salt. Sodium chloride, United States Pharmacopeia (USP) Reference Standard induces the expression of ATP1A1. Sodium chloride, for cell culture induces the pro-inflammatory cytokines IL-2, TNFα, IL-9 and several chemokines. Sodium chloride, United States Pharmacopeia (USP) Reference Standard enhances the anti-tumor activities of Digoxin (HY-B1049) against small cell lung cancer. Sodium chloride, United States Pharmacopeia (USP) Reference Standard drives autoimmune disease by the induction of pathogenic Th17 cells .

HY-10449A

Luseogliflozin hydrate TS 071 hydrate	SGLT	Metabolic Disease
Luseogliflozin (TS 071) hydrate is a selective potent and orally active second-generation sodium-glucose co-transporter 2 (SGLT2) inhibitor with an IC₅₀ of 2.26 nM. Luseogliflozin hydrate can be used for the research of type 2 diabetes mellitus (T2DM) .

HY-117494

Flumethiazide NSC 44626	Sodium Channel Chloride Channel	Cardiovascular Disease
Flumethiazide (NSC 44626) is an orally active diuretic agent. Flumethiazide has marked diuretic and natruretic effects with significant effects on Sodium, Chloride and water but not on potassium excretion. Flumethiazide can be used for cardiac diseases like essential hypertension research .

HY-109542

Cyclopenthiazide	Biochemical Assay Reagents	Metabolic Disease
Cyclopenthiazide is a benzothiadiazine diuretic with antihypertensive properties. Cyclopenthiazide exerts a diuretic effect by inhibiting the reabsorption of sodium chloride and water at the distal renal tubules. Cyclopenthiazide increases the excretory capacity of the rat kidney .

HY-109092

Licogliflozin 1 Publications Verification LIK066	SGLT	Metabolic Disease Inflammation/Immunology
Licogliflozin is a sodium glucose cotransporter (SGLT1 and SGLT2) inhibitor.

HY-122369

Histargin	Carboxypeptidase	Metabolic Disease
Histargin is a selective carboxypeptidase B inhibitor with an IC₅₀ of 17 μg/mL and a K_i of 30 μM. Histargin exerts competitive inhibition with substrate, with inhibitory activity abolished by metal cations. Histargin shows no significant inhibitory activity against carboxypeptidase A, aminopeptidase A, or aminopeptidase B .

HY-13414

Remogliflozin Remogliflozin A	SGLT	Metabolic Disease
Remogliflozin is a potent and selective inhibitor of SGLT2 (sodium-glucose cotransporter 2) with K_is of 12.4 and 26 nM for human and rat SGLT2, respectively. Remogliflozin is the active form of Remogliflozin etabonate(HY-14945) .

HY-Y0537J

Potassium chloride, meets analytical specification of Ph. Eur., BP, USP, FCC, E508, ≤0.0001% Al	Biochemical Assay Reagents	Others
Potassium chloride, meets analytical specification of Ph. Eur., BP, USP, FCC, E508, ≤0.0001% Al is a neutral potassium salt that can be used for buffer preparation, and can be used in biochemical research .

HY-B0493R

Niflumic acid (Standard)	Reference Standards Chloride Channel COX	Inflammation/Immunology
Niflumic acid (Standard) is the analytical standard of Niflumic acid. This product is intended for research and analytical applications. Niflumic acid is a calcium-activated chloride channel blocker and COX-2 inhibitor with the IC₅₀ value of 100 nM. Niflumic acid induces apoptosis through caspase-8/Bid/Bax pathway in lung cancer cells. Niflumic acide exhibits anti-tumor activity by affecting the expression of ERK1/2 and the activity of MMP2 and MMP9. Niflumic acid has orally bioactivity. Niflumic acid acts on rheumatoid arthritis .

HY-15461R

Ertugliflozin (Standard) PF-04971729 (Standard)	Reference Standards SGLT	Metabolic Disease
Ertugliflozin (Standard) is the analytical standard of Ertugliflozin. This product is intended for research and analytical applications. Ertugliflozin (PF-04971729) is a potent, selective and orally active inhibitor of the sodium-dependent glucose cotransporter 2 (SGLT2), with an IC₅₀ of 0.877 nM for h-SGLT2 . Has the potential for the treatment of type 2 diabetes mellitus .

Cat. No.	Product Name	Type

HY-103311

Ruthenium red 10+ Cited Publications Ammoniated ruthenium oxyChloride	Fluorescent Dyes
Ruthenium red (Ammoniated ruthenium oxychloride) is a polycationic dye widely used for electron microscopy (EM) of cells, tissues and vegetative bacteria. Ruthenium red strongly reacts with phospholipids and fatty acids and binds to acidic mucopolysaccharides. Ruthenium red is a L-type calcium current (I_Ca) blocker .

HY-D2481

Asante potassium green-2 TMA APG-2 TMA	Fluorescent Dyes
Asante potassium green-2 TMA (APG-2 (TMA)) is a cell-impermeable K ⁺ fluorescent indicator that produces a fluorescent response to changes in extracellular potassium ion concentration (Ex/Em = 525/545 nm) .

HY-D2482

Asante potassium green-1 AM APG-1 AM	Fluorescent Dyes
Asante potassium green-1 AM (APG-1 AM) is a cell-permeable K ⁺-sensitive fluorescent indicator and potassium ion indicator that exhibits minimal interference from Na ⁺ and pH at physiologically relevant intracellular levels. Asante potassium green-1 AM enables non-invasive monitoring and quantitative analysis of intracellular potassium ion concentrations (Ex/Em = 522/547 nm) .

HY-D1442

SBFI tetraammonium	Fluorescent Dyes
SBFI (tetraammonium), the tetraammonium salt of SBFI, is a cell-impermeant sodium fluorescence indicator. SBFI (tetraammonium) is sodium-sensitive dye. The excitation wavelength is set 333 nm, and the emission wavelength is 539 nm for SBFI .

HY-D3205

Bis(picolinoyl)fluorescein	Fluorescent Dyes
Bis (picolinoyl) fluorescein is a Cu ²⁺ esterase activity probe with both fluorogenic and chromogenic properties. Bis (picolinoyl) fluorescein enables quantitative analysis of free Cu ²⁺, as well as detection of esterolytic activity of Cu bound to organic ligands or biomolecules .

HY-D3170

C-HBrO-GGT

Fluorescent Dyes

C-HBrO-GGT is a sequence-activated two-photon fluorescent probe. C-HBrO-GGT exhibits sequential fluorescence activation properties: it generates fluorescence in response to hypobromous acid only after being hydrolytically activated by γ-glutamyl transpeptidase. C-HBrO-GGT enables verification of the voltage-gated chloride channel (CLC-1)-HBrO-catalase (CAT)-GGT signaling pathway at the cellular level. C-HBrO-GGT can serve as a tool to indicate the precise location of mature atherosclerotic plaques and provide early warning of plaque formation. C-HBrO-GGT is applicable to relevant research on atherosclerosis .

HY-172754

ICAAc

Fluorescent Dyes

ICAAc is a solvatochromic fluorophore with reduced basicity. ICAAc demonstrates significant solvatochromic behavior across solvents of varying polarity, with a large dipole moment difference and low quantum yield in water, making it a tunable solvatochromic fluorophore. ICAAc enables pH sensing via UV-vis/fluorescence detection and in microenvironments including sodium lauryl sulfate micelle Stern layers. ICAAc acts as a supravital cell stain for epifluorescence imaging of live cancer cells .

HY-W699451

MTSET chloride

Fluorescent Dyes

MTSET chloride is a membrane-impermeable, thiol-specific reagent that primarily acts as an inhibitor of the Nav1.5 sodium channel. MTSET chloride reduces the peak sodium current amplitude of most mutant Nav1.5 channels, induces a hyperpolarizing shift in steady-state inactivation, and slows the recovery process, but shows no activity against wild-type and non-inactivating Nav1.5 channel mutants. MTSET chloride reacts covalently with T336C mutant P2X2 receptors, partially reversibly blocks ATP-induced cation currents, and exerts no effect on wild-type P2X2 receptors .

Cat. No.	Product Name	Type

HY-Y0537E

Potassium chloride, for cell culture

1 Publications Verification

Biochemical Assay Reagents

Potassium chloride, for cell culture is potassium chloride that can be used for cell culture. Potassium chloride, for cell culture increases extracellular potassium ion concentration to induce cellular depolarization, thereby activating voltage-gated calcium channels and regulating intracellular calcium signaling. Potassium chloride, for cell culture upregulates Brn-5. Potassium chloride, for cell culture inhibits the proliferation of neurons and some plant cells .

HY-B1610N

Sodium Citrate Buffer, 0.1M, pH 4.0 5+ Cited Publications	Biochemical Assay Reagents
Sodium Citrate Buffer, 0.1M, pH 4.0 is an acidic, aqueous buffer solution. Sodium Citrate Buffer, 0.1M, pH 4.0 resists pH fluctuations, chelates metal ions, and regulates the redox potential of the system. Sodium Citrate Buffer, 0.1M, pH 4.0 is widely used in molecular biology, immunohistochemistry (IHC), and biochemistry .

HY-Y1325H

Sodium acetate trihydrate, meets analytical specification of Ph. Eur. BP USP FCC E262, ≤0.00002% Al

4 Publications Verification

Biochemical Assay Reagents

Sodium acetate trihydrate is a carboxylic acid and short-chain fatty acid (SCFAs). Sodium acetate trihydrate activates AMPK, increases ROS, cleaved caspase 9, PPARα, downregulates SREBP-1c, ChREBP expression. Sodium acetate trihydrate exhibits antifungal activity against Saccharomyces cerevisiae W303-1A. Sodium acetate trihydrate regulates energy metabolism. Sodium acetate trihydrate has anticancer activity against gastric cancer. Sodium acetate trihydrate induces writhing reaction and ulcerative colitis. Sodium acetate trihydrate can be used in the researches for gastric cancer, ulcerative colitis, hepatic steatosis, and pain .

HY-B2243B

Anhydrous sodium dihydrogen phosphate, for molecular biology 1 Publications Verification Sodium phosphate monobasic for molecular biology; MonoSodium dihydrogen orthophosphate for molecular biology; MonoSodium phosphate for molecular biology	Biochemical Assay Reagents
Anhydrous sodium dihydrogen phosphate, for molecular biology is an inorganic salt compound that can be used as a buffer and nutritional supplement. Anhydrous sodium dihydrogen phosphate, for molecular biology can be used in molecular biology experiments .

HY-141582

Ceramide 3

N-Stearoyl phytosphingosine

Biochemical Assay Reagents

Ceramide 3 (N-Stearoyl phytosphingosine) is an orally active major component of intercellular lipids in the stratum corneum of the skin, and belongs to the ceramide family. Ceramide 3 inhibits c-jun and NF-κB activation induced by Histamine (HY-B1204), and suppresses the expression of IL-4 and TNF-α. Ceramide 3 inhibits scratching behavior and vascular permeability in mice, and exhibits antihistamine effects in guinea pig ileum. Ceramide 3 improves skin barrier function, reduces transepidermal water loss, erythema and the number of circulating epidermal cells, and accelerates barrier repair of irritated or dysfunctional skin .

HY-B1610J

Sodium Citrate Buffer, 0.5M, pH 5.0 1 Publications Verification	Biochemical Assay Reagents
Sodium Citrate Buffer, 0.5M, pH 5.0 is a commonly used buffer composed of citric acid and sodium citrate. Sodium Citrate Buffer, 0.5M, pH 5.0 is widely used in molecular biology, immunohistochemistry (IHC), and biochemistry .

HY-Y0308H

Sodium phosphate dibasic, for molecular biology DiSodium hydrogen phosphate, for molecular biology	Biochemical Assay Reagents
Sodium phosphate dibasic (Disodium hydrogen phosphate), for molecular biology, is a type of phosphate salt that can be used in molecular biology research to prepare stable buffers free of RNase/DNase/protease .

HY-B1610M

Sodium Citrate Buffer, 0.5M, pH 6.5	Biochemical Assay Reagents
Sodium Citrate Buffer, 0.5M, pH 6.5 is a commonly used buffer composed of citric acid and sodium citrate. Sodium Citrate Buffer, 0.5M, pH 6.5 is widely used in molecular biology, immunohistochemistry (IHC), and biochemistry .

HY-160113

Sodium phosphate buffer 0.02 M, pH 6.9

Biochemical Assay Reagents

Sodium phosphate buffer 0.02 M, pH 6.9 is a commonly used aqueous biological buffer that maintains a stable pH value. Sodium phosphate buffer 0.02 M, pH 6.9 is often used in enzyme activity assays, such as α-amylase assays. Sodium phosphate buffer 0.02 M, pH 6.9 is prepared by mixing disodium hydrogen phosphate (Na₂HPO₄) (HY-B2243) and sodium dihydrogen phosphate (NaH₂PO₄) (HY-Y0308) to a total concentration of 0.02 M .

HY-B2243D

Anhydrous sodium dihydrogen phosphate, for cell culture 1 Publications Verification Sodium phosphate monobasic, for cell culture; MonoSodium dihydrogen orthophosphate, for cell culture; MonoSodium phosphate, for cell culture	Biochemical Assay Reagents
Anhydrous sodium dihydrogen phosphate, for cell culture is an inorganic salt compound that can be used as a buffer and nutritional supplement. Anhydrous sodium dihydrogen phosphate, for cell culture can be used in cell culture .

HY-W250727

TNS sodium

1 Publications Verification

6-(p-Tolylamino)naphthalene-2-sulfonate Sodium

Biochemical Assay Reagents

TNS (6-(p-Tolylamino) naphthalene-2-sulfonate) sodium is a fluorescent probe used to detect the conformational state of proteins. TNS sodium binds to the central hydrophobic calyx of β-lactoglobulin (β-LG) to form a 1:1 complex, which stabilizes the folded conformation of β-LG. TNS sodium shows weak fluorescent signals in aqueous solution, but its fluorescence intensity increases significantly upon binding to the hydrophobic domains of proteins, with the maximum excitation wavelength and maximum emission wavelength located at 321 nm and 446 nm, respectively .

HY-W134328

Blue dextran (MW 2000000)

Dextran blue (MW 2000000)

Biochemical Assay Reagents

Blue dextran (Dextran blue) (MW 2000000) is a high-molecular-weight long-chain polymer of D-glucose. Blue dextran (MW 2000000) serves as an important model macromolecular drug and molecular weight estimation marker, and can be used as a standard for gel permeation chromatography. The release of Blue dextran (MW 2000000) from alginate microspheres is regulated by preparation conditions; its release rate in a pH 6.8 environment is significantly faster than that in pH 1.2, and it exhibits release characteristics close to zero-order kinetics under this condition .

HY-W034344

Sodium methanesulfonate

Biochemical Assay Reagents

Sodium methanesulfonate is a hygroscopic atmospheric aerosol, which typically forms from the reaction of methanesulfonic acid with sodium chloride or sea salt particles. Sodium methanesulfonate can serve as a substrate for oxidation reactions, undergoing heterogeneous oxidation by hydroxyl radicals at the air-aerosol interface, thereby initiating subsequent aerosol-phase chain reactions. Sodium methanesulfonate exhibits significant temperature-dependent deliquescence and efflorescence properties; particularly at lower temperatures relevant to the troposphere, its deliquescence and efflorescence relative humidity increase accordingly .

HY-B1610L

Sodium Citrate Buffer, 0.5M, pH 6.0 1 Publications Verification	Biochemical Assay Reagents
Sodium citrate buffer, 0.5M, pH 6.0, is a commonly used buffer with main components are citric acid and sodium hydrogen phosphate. Sodium citrate buffer, 0.5M, pH 6.0 is used for RNA isolation and antigens detection in fixed tissue .

HY-126437I

Poly-L-lysine hydrobromide (MW 1000-5000)	Biochemical Assay Reagents
Poly-L-lysine hydrobromide (MW 1000-5000) is a homopolymer of L-lysine and a polycationic non-viral gene delivery vector. Poly-L-lysine hydrobromide (MW 1000-5000) forms complexes with plasmid DNA. Poly-L-lysine hydrobromide (MW 1000-5000) is applicable to relevant research on lung cancer .

HY-W019885A

Sodium tripolyphosphate (STPP), 98% Sodium triphosphate pentabasic, 98%	Biochemical Assay Reagents
Sodium tripolyphosphate (STPP), 98% is an inorganic, non-toxic polyphosphate crosslinker, inducer and enhancer. Sodium tripolyphosphate (STPP), 98% induces the formation of unique needle-like microcrystals in sodium alginate-chitosan composite films. Sodium tripolyphosphate (STPP), 98% enhances the DPPH free radical scavenging activity of sodium alginate-chitosan composite films .

HY-W096983

DTAC,for IPC,≥99% Dodecyltrimethylammonium Chloride,for IPC,≥99%	Biochemical Assay Reagents
DTAC (Dodecyltrimethylammonium chloride), for IPC, ≥99% is a quaternary ammonium cationic surfactant. DTAC, for IPC, ≥99% can form micelles in aqueous media, which interact with and encapsulate Diclofenac sodium (HY-15037) molecules; the micellization process is entropy-driven at lower temperatures and enthalpy-driven at higher temperatures .

HY-76562

Methyl 6-bromopicolinate	Biochemical Assay Reagents
Methyl 6-bromopicolinate is a synthetic intermediate used in the preparation of γ-secretase inhibitor library scaffolds .

HY-N0143A

Phlorizin dihydrate

Maximum Cited Publications

15 Publications Verification

Floridzin dihydrate

Biochemical Assay Reagents

Phlorizin (Floridzin) dihydrate is an orally active non-selective sodium-glucose cotransporter (SGLT) inhibitor, with an IC₅₀ of 0.04 μM and a K_i of 39 nM against hSGLT2, and an IC₅₀ of 0.17 μM and a K_i of 0.31 μM against hSGLT1. Phlorizin dihydrate promotes GLUT4 translocation, inhibits gluconeogenesis and promotes glycogen synthesis by activating the PI3K/Akt/mTOR pathway. Phlorizin dihydrate reduces DNA damage and apoptosis (apoptosis) by inhibiting the NF-κB inflammatory pathway. Phlorizin dihydrate induces apoptosis via activating the Caspase pathway by antagonizing the JAK/STAT3 and PCK pathways. Phlorizin dihydrate also exhibits antibacterial, anti-inflammatory and neuroprotective activities .

HY-59243

4,7-Dichloroquinoline 1 Publications Verification	Biochemical Assay Reagents
4,7-Dichloroquinoline is a dichloro-substituted quinoline that can be used for the synthesis of other active compounds .

HY-W014841

Sodium hippurate, 98%

1 Publications Verification

N-Benzoylglycine Sodium, 98%

Biochemical Assay Reagents

Sodium hippurate, 98% is an orally active metabolite. Sodium hippurate, 98% can be produced by intestinal microorganisms from the metabolism of polyphenols, benzoic acid. Sodium hippurate, 98% decreases NRF2, MMP9 and leads to ROS accumulation. Sodium hippurate, 98% activates TGFβ/SMAD signaling. Sodium hippurate, 98% improves hyperuricemia and colitis. Sodium hippurate, 98% can also be used in cardiovascular disease research . .

HY-D0876

POPSO	Biochemical Assay Reagents
POPSO is a zwitterionic buffer, increases osmolality and shows marked inhibition of anion uniport. POPSO inhibits chloride uniport with an IC₅₀ value of 24 mM. POPSO enhances copper uptake and toxicity in alga, impairs mitochondrial inner membrane. The working pH range of POPSO sesquisodium salt is 7.2-8.5 .

HY-Y0344H

Sodium chloride, United States Pharmacopeia (USP) Reference Standard

Halite (Pharmaceutical primary standard, USP)

Biochemical Assay Reagents

Sodium chloride, United States Pharmacopeia (USP) Reference Standard is an orally active salt. Sodium chloride, United States Pharmacopeia (USP) Reference Standard induces the expression of ATP1A1. Sodium chloride, for cell culture induces the pro-inflammatory cytokines IL-2, TNFα, IL-9 and several chemokines. Sodium chloride, United States Pharmacopeia (USP) Reference Standard enhances the anti-tumor activities of Digoxin (HY-B1049) against small cell lung cancer. Sodium chloride, United States Pharmacopeia (USP) Reference Standard drives autoimmune disease by the induction of pathogenic Th17 cells .

HY-Y0537J

Potassium chloride, meets analytical specification of Ph. Eur., BP, USP, FCC, E508, ≤0.0001% Al	Biochemical Assay Reagents
Potassium chloride, meets analytical specification of Ph. Eur., BP, USP, FCC, E508, ≤0.0001% Al is a neutral potassium salt that can be used for buffer preparation, and can be used in biochemical research .

HY-W133954

Sodium metaborate tetrahydrate, 99%	Biochemical Assay Reagents
Sodium metaborate tetrahydrate, 99% is a derivative of the borax compound. Sodium metaborate tetrahydrate, 99% can be used as a source of boron in the production of sodium borohydride (NaBH4) .

HY-Y0332H

Sodium dihydrogen phosphate dihydrate, for molecular biology

Sodium phosphate monobasic dihydrate, for molecular biology

Biochemical Assay Reagents

Sodium dihydrogen phosphate dihydrate (Sodium phosphate monobasic dihydrate), for molecular biology is a phosphate compound and nucleating agent. At a content of 1.2%, Sodium dihydrogen phosphate dihydrate, for molecular biology eliminates the supercooling degree of sodium acetate trihydrate to 0°C while maintaining or slightly enhancing its latent heat storage capacity. Sodium dihydrogen phosphate dihydrate, for molecular biology can serve as a starting material for the synthesis of degradable sodium phosphate glasses, which are applied in craniomaxillofacial bone repair. Sodium dihydrogen phosphate dihydrate, for molecular biology is widely used in research on craniomaxillofacial bone repair and related fields .

HY-W008585

Benzo-15-crown-5-ether B15C5	Biochemical Assay Reagents
Benzo-15-crown-5-ether can be used as a chelating agent for sodium and potassium .

HY-W094708D

Sodium phosphate dibasic dihydrate, meets analytical specification of Ph. Eur. BP DiSodium hydrogen phosphate dihydrate, meets analytical specification of Ph. Eur. BP	Biochemical Assay Reagents
Sodium phosphate dibasic dihydrate, meets analytical specification of Ph. Eur. BP is an inorganic salt that can be used for life science related research .

HY-Y1325E

Sodium acetate trihydrate, United States Pharmacopeia (USP) Reference Standard Sodium acetate trihydrate (Pharmaceutical primary standard, USP)	Biochemical Assay Reagents
Sodium acetate trihydrate, United States Pharmacopeia (USP) Reference Standard is an inorganic salt that can be used for life science related research .

HY-W009022

Diantipyrylmethane	Biochemical Assay Reagents
Diantipyrylmethane is a chromogenic reagent commonly used for the determination of the contents of metals such as Au (III), Ti (IV), Ir, Fe (III), molybdenum, neodymium, U (IV), iridium, platinum and rhenium via spectrophotometry and extraction photometry. Diantipyrylmethane can also form a fluorescent complex with Er (III) ions, which is applied to the determination of erbium .

HY-111157

Dezinamide AHR11748; AN051; ADD94057	Biochemical Assay Reagents
Dezinamide (ADD94057) is an antiepileptic agent. Dezinamide binds to the voltage-sensitive sodium channel .

Cat. No.	Product Name	Target	Research Area

HY-A0248B

Polymyxin B2	Antibiotic Bacterial	Infection Inflammation/Immunology
Polymyxin B2 is a polypeptide antibiotic with particularly potent antibacterial activity against Gram-negative bacteria. Polymyxin B2 kills bacteria by binding to lipopolysaccharide molecules on the bacterial cell membrane, disrupting membrane integrity and causing leakage of intracellular contents. Polymyxin B2 is used in studies related to Pseudomonas aeruginosa infection and acute enteritis .

HY-P1604

ATX-II 1 Publications Verification	Sodium Channel	Cardiovascular Disease Inflammation/Immunology
ATX-II is a selective sodium channel modulator toxin. ATX-II enhances late sodium current, prevents full sodium channel inactivation, and generates persistent current fractions. ATX-II has pro-arrhythmic effect. ATX-II slows intrinsic heart rate, prolongs QT interval and sinus node recovery time, and causes sinus pauses and arrests. ATX-II can be used for the research of atrial fibrillation, long QT syndrome, and long QT3 syndrome .

HY-P1604A

ATX-II TFA 1 Publications Verification	Sodium Channel	Cardiovascular Disease Inflammation/Immunology
ATX-II TFA is a selective sodium channel modulator toxin. ATX-II TFA enhances late sodium current, prevents full sodium channel inactivation, and generates persistent current fractions. ATX-II TFA has pro-arrhythmic effect. ATX-II TFA slows intrinsic heart rate, prolongs QT interval and sinus node recovery time, and causes sinus pauses and arrests. ATX-II TFA can be used for the research of atrial fibrillation, long QT syndrome, and long QT3 syndrome .

HY-P1218B

Phrixotoxin 3-NH2 TFA	Sodium Channel	Neurological Disease
Phrixotoxin 3-NH2 TFA is a derivative of Phrixotoxin 3 TFA (HY-P1218A). Phrixotoxin 3 TFA is a potent blocker of voltage-gated sodium channels, with IC₅₀s of 0.6, 42, 72, 288, 610 nM for NaV1.2, NaV1.3, NaV1.4, NaV1.1 and NaV1.5, respectively. Phrixotoxin 3 TFA modulates voltage-gated sodium channels with properties similar to those of typical gating-modifier toxins, both by causing a depolarizing shift in gating kinetics and by blocking the inward component of the sodium current .

HY-P1220A

Huwentoxin-IV TFA	Sodium Channel	Neurological Disease
Huwentoxin-IV TFA is a potent and selective sodium channel blocker, inhibits neuronal Nav1.7, Nav1.2, Nav1.3 and Nav1.4 with IC₅₀s of 26, 150, 338 and 400 nM, respectively. Huwentoxin-IV TFA preferentially blocks peripheral nerve subtype Nav1.7 by binding neurotoxin receptor site 4. Huwentoxin-IV TFA has analgesic effects on animal models of inflammatory and neuropathic pain .

HY-P5152

Scorpion toxin Tf2	Sodium Channel	Neurological Disease
Scorpion toxin Tf2 is a selective human voltage-gated sodium channel Nav1.3 (hNav1.3) activator. Scorpion toxin Tf2 selectively shifts the channel's activation voltage to more negative values, enabling channel opening at resting membrane potentials. Scorpion toxin Tf2 can be used for the research of epilepsy, nociception (after spinal cord injury) .

HY-P10236

Ac-WEHD-pNA	Caspase	Others
Ac-WEHD-pNA is a colorimetric substrate for caspase 1, 4, 5 and 14, which is utilized to measure the caspase activity .

HY-P5807

Cn2 toxin β-Mammal toxin Cn2	Sodium Channel	Neurological Disease
Cn2 toxin is aβ- toxoins. Cn2 toxin can bind to the voltage sensing domain of voltage gated sodium channels (Na_v) .

HY-P1218

Phrixotoxin 3	Sodium Channel	Neurological Disease
Phrixotoxin 3 is a potent blocker of voltage-gated sodium channels, with IC₅₀s of 0.6, 42, 72, 288, 610 nM for NaV1.2, NaV1.3, NaV1.4, NaV1.1 and NaV1.5, respectively. Phrixotoxin 3 modulates voltage-gated sodium channels with properties similar to those of typical gating-modifier toxins, both by causing a depolarizing shift in gating kinetics and by blocking the inward component of the sodium current .

HY-P11363

(Des-Asp1,Ile8)-Angiotensin II	Angiotensin Receptor	Cardiovascular Disease
(Des-Asp1,Ile8)-Angiotensin II is a peptide related to angiotensin II. (Des-Asp1,Ile8)-Angiotensin II can be used for studying the interaction between angiotensin II and its receptors .

HY-P1219

Jingzhaotoxin-III β-TRTX-Cj1α	Sodium Channel	Neurological Disease
Jingzhaotoxin-III is a potent and selective blocker of Nav1.5 channels, with an IC₅₀ of 348 nM, and shows no effect on other sodium channel isoforms. Jingzhaotoxin-III can selectively inhibit the activation of cardiac sodium channel but not neuronal subtypes, and hopefully represents an important ligand for discriminating cardiac VGSC subtype .

HY-P1220

Huwentoxin-IV	Sodium Channel	Neurological Disease
Huwentoxin-IV is a potent and selective sodium channel blocker, inhibits neuronal Nav1.7, Nav1.2, Nav1.3 and Nav1.4 with IC₅₀s of 26, 150, 338 and 400 nM, respectively. Huwentoxin-IV preferentially blocks peripheral nerve subtype Nav1.7 by binding neurotoxin receptor site 4. Huwentoxin-IV has analgesic effects on animal models of inflammatory and neuropathic pain .

HY-P5772

Jingzhaotoxin-II	Sodium Channel	Neurological Disease
Jingzhaotoxin-II, a 32 amino acid residues including two acidic and two basic residues, is a neurotoxin. Jingzhaotoxin-II inhibits voltage-gated sodium channels (VGSC) that significantly slows rapid inactivation of TTX-resistant (TTX-R) VGSC on cardiac myocytes with the IC₅₀ of 0.26 μM .

HY-P5943

Pterinotoxin-1	Sodium Channel	Neurological Disease
Pterinotoxin-1 is a sodium channel inhibitor peptide toxin .

HY-P5942

Pterinotoxin-2	Sodium Channel	Inflammation/Immunology
Pterinotoxin-2 is a sodium channel inhibitor peptide toxin .

HY-P5180

Hainantoxin-III	Sodium Channel	Neurological Disease
Jingzhaotoxin-V is a peptide that inhibits potassium currents in Xenopus laevis oocytes with an IC₅₀ value of 604.2 nM. Jingzhaotoxin-V also inhibits tetrodotoxin-resistant and tetrodotoxin-sensitive sodium currents in rat dorsal root ganglion neurons with IC₅₀ values of 27.6 and 30.2 nM, respectively .

HY-P5773

Jingzhaotoxin-34	Sodium Channel	Neurological Disease
Jingzhaotoxin-34, a 35-residue polypeptide, is a neurotoxin. Jingzhaotoxin-34 inhibits tetrodotoxin-sensitive (TTX-S) sodium currents (IC₅₀ of ~85 nM) while having no significant effects on tetrodotoxin-resistant (TTX-R) sodium currents on rat dorsal root ganglion neurons .

HY-P5177

GsAF-II	Sodium Channel Potassium Channel	Neurological Disease
GsAF-II is a peptide toxin that blocks hERG1 subtype potassium channels in a voltage-dependent manner. GsAF-II blocks Nav1.x subtype sodium channels .

HY-P5179

Huwentoxin I HWTX-I	Calcium Channel Sodium Channel	Neurological Disease
Huwentoxin I (HWTX-I) is a peptide toxin that inhibits voltage-gated sodium channels and N-type calcium channels. Huwentoxin I inhibits sodium channels in rat hippocampus and cockroach dorsal unpaired median (DUM) neurons with IC₅₀ values of 66.1 and 4.80 nM, respectively .

HY-P5770

Jingzhaotoxin-V	Sodium Channel	Neurological Disease
Jingzhaotoxin-V, a 29-residue polypeptide, is derived from the venom of the spider Chilobrachys jingzhao. Jingzhaotoxin-V inhibits tetrodotoxin-resistant and tetrodotoxin-sensitive sodium currents in rat dorsal root ganglion neurons with IC₅₀ values of 27.6 nM and 30.2 nM, respectively. Jingzhaotoxin-V also inhibits Kv4.2 potassium currents expressed in Xenpus Laevis oocytes (IC₅₀ of 604.2 nM) .

HY-P5771

Jingzhaotoxin-IX	Sodium Channel	Neurological Disease
Jingzhaotoxin-IX, a C-terminally amidated peptide composed of 35 amino acid residues, is a neurotoxin. Jingzhaotoxin-IX inhibits voltage-gated sodium channels (both tetrodotoxin-resistant and tetrodotoxin-sensitive isoforms) and Kv2.1 channel. Jingzhaotoxin-IX has no effect on delayed rectifier potassium channel Kv1.1, 1.2 and 1.3 .

HY-P5868

mHuwentoxin-IV	Sodium Channel	Neurological Disease
mHuwentoxin-IV is a naturally modified Huwentoxin-IV (HY-P1220). mHuwentoxin-IV inhibits tetrodotoxin-sensitive (TTX-S) voltage-gated sodium channels of dorsal root ganglion neurons with an IC₅₀ of 54.16 nM. mHuwentoxin-IV inhibition of tetrodotoxin-sensitive sodium channels is not reversed by strong depolarization voltages .

HY-P5184

Hainantoxin-IV HNTX-IV	Sodium Channel	Neurological Disease
Hainantoxin-IV is a specific antagonist of Sodium Channel, targeting to tetrodotoxin-sensitive (TTX-S) voltage-gated sodium channels. His28 and Lys32 are the key resiudes of Hainantoxin-IV for binding with target, while Hainantoxin-IV adopts an inhibitor cystine knot motif .

HY-P3777

β-Bag cell peptide	Potassium Channel	Neurological Disease
β-Bag cell peptide is a neuroactive peptide. β-Bag cell peptide elevates cyclic AMP levels in the bag cell neurons. β-Bag cell peptide decreases the amplitudes of the voltage-dependent potassium currents .

HY-P1218A

Phrixotoxin 3 TFA	Sodium Channel	Neurological Disease
Phrixotoxin 3 TFA is a potent blocker of voltage-gated sodium channels, with IC₅₀s of 0.6, 42, 72, 288, 610 nM for NaV1.2, NaV1.3, NaV1.4, NaV1.1 and NaV1.5, respectively. Phrixotoxin 3 TFA modulates voltage-gated sodium channels with properties similar to those of typical gating-modifier toxins, both by causing a depolarizing shift in gating kinetics and by blocking the inward component of the sodium current .

HY-P5164

GrTx1	Sodium Channel	Neurological Disease
GrTx1 is a peptide toxin originally isolated from the venom of the spider Grammostola rosea. GrTx1 blocks sodium channel, with IC₅₀s of 0.63 μM, 0.23 μM, 0.77 μM, 1.29 μM, 0.63 μM and 0.37 μM for Nav1.1, Nav1.2, Nav1.3, Nav1.4, Nav1.6 and Nav1.7, repectively . GrTx1 can be used for neurological disease research .

Cat. No.	Product Name	Target	Research Area	Image

HY-P990163

Anti-Mouse Siglec-H Antibody (440c)	Transmembrane Glycoprotein	Inflammation/Immunology
Anti-Mouse Siglec-H Antibody (440c) is a rat-derived IgG2b type antibody inhibitor, targeting to mouse Siglec-H. Anti-Mouse Siglec-H Antibody (440c) recognizes sialic acid-binding immunoglobulin (Ig)-like lectin family (Siglec-H) selectively expressing on plasmacytoid DCs and interferon–producing cells. Anti-Mouse Siglec-H Antibody (440c) can be used for the researches of inflammation and immunology, such as colitis .

HY-P992040

HAIL-12 16G2	Interleukin Related	Others
HAIL-12 (16G2) is anan anti-human Interleukin-12 (IL-12p70) monoclonal antibody. HAIL-12 inhibits IL-12-mediated proliferation of T cells from human peripheral blood mononuclear cells .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N0142

Phloretin Maximum Cited Publications 24 Publications Verification NSC 407292; RJC 02792	Classification of Application Fields Rosaceae Plants Dihydrochalcones Endogenous metabolite Human Gut Microbiota Metabolites Flavonoids Microorganisms Malus pumila Mill. Phenols Polyphenols Disease Research Fields Source Classification Cancer	SGLT Endogenous Metabolite GLUT
Phloretin (NSC 407292; RJC 02792) is a flavonoid extracted from Malus pumila Mill.，has anti-inflammatory activities. Phloridzin is a specific，competitive and orally active inhibitor of sodium/glucose cotransporters in the intestine (SGLT1) and kidney (SGLT2). Phloretin inhibits Yeast-made GLUT1 as well as Human erythrocyte GLUT1 with IC₅₀values of 49 μM and 61 μM，respectively .Phloretin has the potential for the treatment of rheumatoid arthritis (RA) and allergic airway inflammation .

HY-N6691

Veratridine 4 Publications Verification 3-Veratroylveracevine	Alkaloids Veratrum nigrum Linn. Liliaceae Plants Isoquinoline Alkaloids Source Classification	Sodium Channel
Veratridine (3-Veratroylveracevine) is a plant neurotoxin, a voltage-gated sodium channels (VGSCs) agonist. Veratridine inhibits the peak current of Nav1.7, with an IC₅₀ of 18.39 µM. Veratridine regulates sodium ion channels mainly by activating sodium ion channels, preventing channel inactivation and increasing sodium ion flow .

HY-W016562

Hippuric acid 1 Publications Verification Benzoylglycine	Microorganisms Classification of Application Fields Ketones, Aldehydes, Acids Disease markers Endocrine diseases Metabolic Disease Nervous System Disorder Endogenous metabolite Disease Research Fields Source Classification	Endogenous Metabolite Keap1-Nrf2 MMP Reactive Oxygen Species (ROS) TGF-beta/Smad
Hippuric Acid is an orally active metabolite. Hippuric Acid can be produced by intestinal microorganisms from the metabolism of polyphenols, benzoic acid. Hippuric Acid decreases NRF2, MMP9 and leads to ROS accumulation. Hippuric Acid activates TGFβ/SMAD signaling. Hippuric Acid improves hyperuricemia and colitis. Hippuric Acid can also be used in cardiovascular disease research . .

HY-N0143

Phlorizin 10+ Cited Publications Floridzin	Structural Classification Flavonoids Classification of Application Fields Malus pumila Mill. Rosaceae Phenols Polyphenols Metabolic Disease Plants Dihydrochalcones Disease Research Fields Source Classification	Caspase JAK GLUT STAT Apoptosis Bacterial SGLT mTOR Akt NF-κB PI3K DNA/RNA Synthesis
Phlorizin (Floridzin) is an orally active non-selective sodium-glucose cotransporter (SGLT) inhibitor, with an IC₅₀ of 0.04 μM and a K_i of 39 nM against hSGLT2, and an IC₅₀ of 0.17 μM and a K_i of 0.31 μM against hSGLT1. Phlorizin promotes GLUT4 translocation, inhibits gluconeogenesis and promotes glycogen synthesis by activating the PI3K/Akt/mTOR pathway. Phlorizin reduces DNA damage and apoptosis (apoptosis) by inhibiting the NF-κB inflammatory pathway. Phlorizin induces apoptosis via activating the Caspase pathway by antagonizing the JAK/STAT3 and PCK pathways. Phlorizin also exhibits antibacterial, anti-inflammatory and neuroprotective activities .

HY-B1494

Picrotoxinin 4 Publications Verification	Structural Classification other families Terpenoids Sesquiterpenes Plants Source Classification	Chloride Channel GABA Receptor
Picrotoxinin, a potent convulsant, is a chloride channel blocker. Picrotoxinin is a noncompetitive GABA_A receptor antagonist, which negatively modulates the action of GABA on GABA_A receptors. Picrotoxinin inhibits α₁β₂γ_2L GABA_A receptor with an IC₅₀ of 1.15 μM .

HY-N1462

Atractyloside potassium salt 4 Publications Verification	Cardiovascular Disease Classification of Application Fields Terpenoids Pterocarpus soyauxii Taub. Diterpenoids Plants Compositae Disease Research Fields Source Classification	Chloride Channel Autophagy mTOR AMPK
Atractyloside potassium salt is a powerful and specific inhibitor of mitochondrial ADP/ATP transport. Atractyloside potassium salt inhibits chloride channels from mitochondrial membranes of rat heart. Atractyloside potassium salt activates autophagy, inhibits ANT2, mTOR and promotes the activation of p-AMPK. Atractyloside potassium salt has anti-cancer effects on non-small cell lung cancer and can inhibit liver steatosis. Atractylodesin potassium salt has nephrotoxicity .

HY-12546

Brevetoxin B Brevetoxin-2; PbTx-2	Structural Classification Natural Products Microorganisms Animals Source Classification	Sodium Channel Apoptosis Calcium Channel Potassium Channel Caspase
Brevetoxin B (Brevetoxin-2) is a red tide toxin. Brevetoxin B affects sodium, potassium and calcium currents in nerve terminals. Brevetoxin B also modulates the metabolic activity of Jurkat cells, reduces cell viability and induces apoptosis. Brevetoxin B can be used in research on synaptic transmission and tumors .

HY-N1881

4',5-Dihydroxyflavone 3 Publications Verification	Structural Classification Flavonoids Classification of Application Fields Flavones Leguminosae Glycine max (L.) merr Other Diseases Phenols Polyphenols Plants Disease Research Fields Source Classification	Lipoxygenase Glycosidase
4',5-Dihydroxyflavone (Compound 2c; Compound B3) is a type of flavonoid compound. 4',5-Dihydroxyflavone can inhibit various oxidases and its IC₅₀ values for collagenase A (ColA) and α-glucosidase are less than 1 μM and 66 μM respectively; for soybean lipoxygenase-1 (LOX-1), its K_i value is 102.6 μM. 4',5-Dihydroxyflavone can be used in studies on anti-toxicity and anti-diabetes .

HY-N2877

Annonacin 1 Publications Verification	Natural Products Neurological Disease Classification of Application Fields Annona muricata Linn. Plants Annonaceae Disease Research Fields Source Classification	Potassium Channel Sodium Channel Na+/K+ ATPase Calcium Channel Apoptosis
Annonacin is an acetylgenin that is toxic by inhibiting the pathway of the mitochondrial complex. Annonacin increases tau phosphorylation in R406W ^+/+ mice. Annonacin acts as an inhibitor of the sodium/potassium and sarcoplasmic reticulum (SERCA) ATPase pumps. Annonacin has significant killing effect on ovarian cancer cell, cervical cancer cell, breast cancer cell, bladder cancer cell and skin cancer cell. Annonacin induces apoptosis through Bax and Caspase-3-related pathways .

HY-113404

DL-Dopa	Structural Classification Classification of Application Fields Ketones, Aldehydes, Acids Other Diseases Phenols Polyphenols Endogenous metabolite Disease Research Fields Source Classification	Tyrosinase Dopamine Receptor
DL-Dopa is a dopamine precursor. It serves as a substrate for Mushroom Tyrosinase, which oxidizes it to dopaquinone, an intermediate in the DOPA-melanin polymerization process, and this reaction can be detected at 475 nm. DL-Dopa also forms synergistic hydrophobic and π-π stacking interactions with cationic surfactants. Its binding to cetylpyridinium chloride (HY-B1464) is stronger and exhibits better thermodynamic stability than its binding to benzalkonium chloride (HY-B2232). DL-Dopa can compensate for dopamine depletion in the brain and is applicable to research related to Parkinson's disease .

HY-N3651

Curzerenone 1 Publications Verification	Infection Structural Classification Classification of Application Fields Terpenoids Sesquiterpenes Curcuma phaeocaulis Valeton Plants Disease Research Fields Source Classification Zingiberaceae	Bacterial Reactive Oxygen Species (ROS) Apoptosis PI3K Akt mTOR
Curzerenone is an orally active sesquiterpene compound and Antibacterial agent. Curzerenone can be isolated from Curcuma zedoaria and Curcuma aeruginosa plants. Curzerenone increases ROS levels, activates Apoptotic signaling pathways, and attenuates the PI3K/AKT/mTOR signaling pathway. Curzerenone exhibits anticancer activity against liver cancer and cervical cancer. Curzerenone has antioxidant effects. Curzerenone shows weak antibacterial activity against Escherichia coli. Curzerenone can be used in research related to hepatocellular carcinoma, cervical cancer, and Escherichia coli infection .

HY-N2511

Trimyristin	Structural Classification Classification of Application Fields Metabolic Disease Myristicaceae Plants Myristica fragrans Houtt. Endogenous metabolite Disease Research Fields Lipid Source Classification	Cholinesterase (ChE) Phosphatase
Trimyristin is an orally active compound. Trimyristin can be isolated from the seeds of nutmeg (Myristica fragrans). Trimyristin inhibits the activities of acetylcholinesterase (AChE), ACP and ALP, with IC₅₀ values of 0.11, 0.16 and 0.18 mM, respectively. Trimyristin exerts competitive-noncompetitive inhibition on acetylcholinesterase, uncompetitive inhibition on ACP, and competitive/noncompetitive inhibition on ALP. Trimyristin restores the downregulated acetylcholinesterase concentration in the cerebral cortex of rats exposed to sodium arsenite. Trimyristin can be used in studies related to fascioliasis and neurotoxicity .

HY-N3990

Hardwickiic acid 1 Publications Verification (-)-Hardwickiic acid; (-)-Hardwikiic acid	Pueraria tuberosa (Roxb. ex Willd.) DC. Neurological Disease Classification of Application Fields Plants Compositae Infection other families Terpenoids Croton tiglium Linn. Diterpenoids Euphorbiaceae Disease Research Fields Source Classification	Sodium Channel Parasite
Hardwickiic acid ((-)-Hardwickiic acid) is a diterpenoid compound. Hardwickiic acid can block tetrodotoxin-sensitive voltage-dependent sodium channels and possesses multiple activities such as insecticidal, antinociceptive, and neurotransmitter release-regulating effects. Hardwickiic acid can be used in the study of neurological diseases .

HY-122439

Lovastatin acid Mevinolinic acid; MSD803	Human Gut Microbiota Metabolites Endogenous metabolite Source Classification	HMG-CoA Reductase (HMGCR) Drug Metabolite
Lovastatin acid (Mevinolinic acid; MSD803), an active metabolite of Lovastatin (HY-N0504), is a potent competitive HMG-CoA reductase inhibitor with a K_i of 0.6 nM. Lovastatin acid acts as a competitive inhibitor with respect to substrate HMG-CoA, interfering cholesterol synthesis. Lovastatin acid can be used for the research of hypercholesterolemia .

HY-34409

3-Methyl-2-butenal 3-Methylbut-2-en-1-al	Structural Classification Natural Products Humulus lupulus L. Plants Moraceae Source Classification	Drug Intermediate
3-Methyl-2-butenal (3-Methylbut-2-en-1-al) is an enone aldehyde that occurs in hops (Humulus lupulus L.) .

HY-N16021

4A-MPLA ammonium	Structural Classification Lipid	Toll-like Receptor (TLR) Cdc42-binding kinase Galectin
4A-MPLA ammonium is an orally active TLR4 agonist. 4A-MPLA ammonium induces TLR4 endocytosis dependent on Cdc42 and galectin-3, triggering TRIF-mediated signaling and sustained IFN-β production. 4A-MPLA ammonium promotes lipid droplet formation, upregulates interferon-stimulated genes and type I IFN signaling genes, downregulates lysosome/phagosome function genes, and modulates tolerogenic dendritic cell function. 4A-MPLA ammonium can be used for the research of colitis .

HY-122369

Histargin	Structural Classification Microorganisms Ketones, Aldehydes, Acids Source Classification	Carboxypeptidase
Histargin is a selective carboxypeptidase B inhibitor with an IC₅₀ of 17 μg/mL and a K_i of 30 μM. Histargin exerts competitive inhibition with substrate, with inhibitory activity abolished by metal cations. Histargin shows no significant inhibitory activity against carboxypeptidase A, aminopeptidase A, or aminopeptidase B .

HY-135000

Decarbamoylsaxitoxin DcSTX; DecarbamoylSTX	Structural Classification Natural Products Microorganisms Source Classification	Endogenous Metabolite Drug Metabolite
Decarbamoylsaxitoxin is a sodium channel inhibitor that blocks the influx of sodium ions through the membranes of excitable nerves and skeletal muscle cells, thereby preventing the formation of action potentials. Decarbamoylsaxitoxin is an acidic hydrolysis product of saxitoxin, and its toxic effects on mice are identical to those of saxitoxin. Decarbamoylsaxitoxin inhibits veratridine- and ouabain-induced swelling and lysis of mouse neuroblastoma cells by blocking Na ⁺ channels. Decarbamoylsaxitoxin can be used in studies related to paralytic shellfish poisoning .

HY-N0142R

Phloretin (Standard) Maximum Cited Publications 24 Publications Verification NSC 407292 (Standard); RJC 02792 (Standard)	Structural Classification Human Gut Microbiota Metabolites Flavonoids Classification of Application Fields Malus pumila Mill. Rosaceae Phenols Plants Endogenous metabolite Disease Research Fields Source Classification Cancer	Reference Standards SGLT Endogenous Metabolite GLUT
Phloretin (Standard) is the analytical standard of Phloretin. This product is intended for research and analytical applications. Phloretin (NSC 407292; RJC 02792) is a flavonoid extracted from Malus pumila Mill., has anti-inflammatory activities. Phloridzin is a specific, competitive and orally active inhibitor of sodium/glucose cotransporters in the intestine (SGLT1) and kidney (SGLT2). Phloretin inhibits Yeast-made GLUT1 as well as Human erythrocyte GLUT1 with IC₅₀values of 49 μM and 61 μM, respectively .Phloretin has the potential for the treatment of rheumatoid arthritis (RA) and allergic airway inflammation .

HY-129140

Delphinidin-3-O-arabinoside chloride 1 Publications Verification	Anthocyans Flavonoids Rhododendron simsii Planch. Plants Ericaceae Source Classification	Others
Delphinidin-3-O-arabinoside chloride is an anthocyanin chloride compound. It is formed by combining Delphinidin (an anthocyanin with a natural purple color) with the 3-O-arabinoside group. Delphinidin-3-O-arabinoside can be isolated from Rhododendron and is in the form of furanose .

HY-N16421

Leporin A	Structural Classification Natural Products Microorganisms Source Classification	Insecticide GABA Receptor Sodium Channel
Leporin A is an insecticide. Leporin A binds to GABA receptors or sodium channels to disrupt neurotransmission .

HY-N6691R

Veratridine (Standard) 3-Veratroylveracevine (Standard)	Alkaloids Structural Classification Veratrum nigrum Linn. Liliaceae Plants Isoquinoline Alkaloids Source Classification	Reference Standards Sodium Channel
Veratridine (Standard) is the analytical standard of Veratridine. This product is intended for research and analytical applications. Veratridine (3-Veratroylveracevine) is a plant neurotoxin, a voltage-gated sodium channels (VGSCs) agonist. Veratridine inhibits the peak current of Nav1.7, with an IC₅₀ of 18.39?μM. Veratridine regulates sodium ion channels mainly by activating sodium ion channels, preventing channel inactivation and increasing sodium ion flow .

HY-N1462R

Atractyloside potassium salt (Standard)	Structural Classification Terpenoids Pterocarpus soyauxii Taub. Diterpenoids Plants Compositae Source Classification	Reference Standards Chloride Channel Autophagy mTOR AMPK
Atractyloside (potassium salt) (Standard) is the analytical standard of Atractyloside (potassium salt). This product is intended for use in research and analytical applications. Atractyloside potassium salt is a powerful and specific inhibitor of mitochondrial ADP/ATP transport. Atractyloside potassium salt inhibits chloride channels from mitochondrial membranes of rat heart. Atractyloside potassium salt activates autophagy, inhibits ANT2, mTOR and promotes the activation of p-AMPK. Atractyloside potassium salt has anti-cancer effects on non-small cell lung cancer and can inhibit liver steatosis. Atractylodesin potassium salt has nephrotoxicity .

HY-B1494R

Picrotoxinin (Standard)	Structural Classification Natural Products other families Plants Source Classification	Reference Standards Chloride Channel GABA Receptor
Picrotoxinin (Standard) is the analytical standard of Picrotoxinin. This product is intended for research and analytical applications. Picrotoxinin, a potent convulsant, is a chloride channel blocker. Picrotoxinin is a noncompetitive GABAA receptor antagonist, which negatively modulates the action of GABA on GABAA receptors. Picrotoxinin inhibits α1β2γ2L GABAA receptor with an IC₅₀ of 1.15 μM .

HY-W740651

Jasmolin II	Structural Classification Natural Products Plants Compositae Phaseolus lunatus Billb. ex Beurl. Source Classification	Insecticide Sodium Channel
Jasmolin II is an insecticide targeting voltage-gated sodium channels in insects. Jasmolin II leads to neuronal hyperexcitation and insect paralysis. Jasmolin II is promising for research of agricultural pests .

HY-N0143R

Phlorizin (Standard) Floridzin (Standard)	Structural Classification Flavonoids Malus pumila Mill. Rosaceae Phenols Polyphenols Plants Dihydrochalcones Source Classification	Reference Standards Caspase JAK GLUT STAT Apoptosis Bacterial SGLT mTOR Akt NF-κB PI3K DNA/RNA Synthesis
Phlorizin (Floridzin) (Standard) is the analytical standard of Phlorizin. This product is intended for research and analytical applications. Phlorizin is an orally active non-selective sodium-glucose cotransporter (SGLT) inhibitor, with an IC₅₀ of 0.04 μM and a K_i of 39 nM against hSGLT2, and an IC₅₀ of 0.17 μM and a K_i of 0.31 μM against hSGLT1. Phlorizin promotes GLUT4 translocation, inhibits gluconeogenesis and promotes glycogen synthesis by activating the PI3K/Akt/mTOR pathway. Phlorizin reduces DNA damage and apoptosis (apoptosis) by inhibiting the NF-κB inflammatory pathway. Phlorizin induces apoptosis via activating the Caspase pathway by antagonizing the JAK/STAT3 and PCK pathways. Phlorizin also exhibits antibacterial, anti-inflammatory and neuroprotective activities .

HY-W783593

Avermectin A1a	Structural Classification Microorganisms Antibiotics Source Classification	Parasite
Avermectin A1a is a potent and broad-spectrum antiparasitic agent. Avermectin A1a targets nematodes and arthropods by binding to their glutamate-gated chloride channels to block nerve signal transmission and induce paralysis. Avermectin A1a can be used for the study of parasitic infection .

HY-N17355

Des-N-methylnoracronycine	Structural Classification Alkaloids Glycosmis arborea (Retz.) Corrêa Other Alkaloids Rutaceae Plants Source Classification	Biochemical Assay Reagents
Des-N-methylnoracronycine is an acridone alkaloid found in the root bark of Glycosmis pentaphylla (Retz.) Correa. Des-N-methylnoracronycine has antitumor and platelet aggregation inhibitory activities .

HY-136897

Avermectin A2b	Structural Classification Microorganisms Macrolide Antibiotics Antibiotics Source Classification	Endogenous Metabolite Insecticide Parasite
Avermectin A2b is an avermectin. Avermectins are produced during the fermentation of the actinomycete Streptomyces avermitilis. Avermectins possess anthelmintic and insecticidal properties, and are commonly used as insecticides for the control of pests and parasitic worms .

HY-N18023

Kaempferol-3-O-β-D-Glucose-7-O- β-D-Gentianoside	Structural Classification Phenols Polyphenols Lepidium apetalumWilld. Plants Brassicaceae Source Classification	Others
Kaempferol-3-O-β-D-Glucose-7-O-β-D-Gentianoside is a kaempferol glycoside found in the seeds of Lepidium apetalum Willd. Kaempferol-3-O-β-D-Glucose-7-O-β-D-Gentianoside shows no obvious inhibitory effect on Sodium oleate (HY-N1446B)-induced triglyceride overloading in liver cells .

HY-N19425

Pulsatilloside A	Structural Classification Ketones, Aldehydes, Acids Ranunculaceae Plants Pulsatilla chinensis (Bunge) Regel Source Classification	Apoptosis
Pulsatilloside A is an anti-Apoptotic agent. Pulsatilloside A can be isolated from the roots of P. chinensis. Pulsatilloside A exerts a protective effect against apoptosis induced by sodium cyanide and glucose deprivation .

HY-N17493

Spinosic acid A	Triterpenes Structural Classification Terpenoids Rubiaceae Catunaregam spinosa (Thunb.) Tirveng. Plants Source Classification	Others
Spinosic acid A is a triterpene sapogenin. Spinosic acid A is found in Randia spinosa(Thunb.) Poir. .

Species:	Human (12) Rat (1)
Tag:	GFP (2) His (11) Tag Free (1) Strep (3) MBP (3) Fc (2) Flag (4)
Source:	HEK293 (8) Sf9 insect cells (1) E. coli (4)

Cat. No.	Compare	Product Name	Species	Source	Image

HY-P702027

	SLC17A3 Protein, Human (sf9, His, MBP, FLAG) SLC17A3; Sodium-dependent phosphate transport protein 4; Na(+)/PI Cotransporter 4; Sodium/phosphate Cotransporter 4; Solute carrier family 17 member 3	Human	Sf9 insect cells
	SLC17A3 is a voltage-driven organic anion transporter that plays a critical role in the renal proximal tubule. It actively promotes urate secretion and is essential for the elimination of the end products of purine metabolism. SLC17A3 Protein, Human (sf9, His, MBP, FLAG) is the recombinant human-derived SLC17A3 protein, expressed by sf9 insect cells , with N-MBP, C-Flag, N-8*His labeled tag.

HY-P703215

	SLC12A3 Protein, Human (HEK293, His, MBP, Flag) NCC; TSC	Human	HEK293
	SLC12A3 Protein, Human (HEK293, His, MBP, Flag) is the recombinant human-derived SLC12A3, expressed by HEK293 , with His, MBP, Flag labeled tag. ,

HY-P704117

	SLC34A2 Protein, Human (HEK293, His, mFc) Sodium-dependent phosphate transport protein 2B; Sodium-phosphate transport protein 2B; Na(+)-dependent phosphate Cotransporter 2B; Na(+)-dependent phosphate Cotransporter 2B; NaPi3b; Sodium/phosphate Cotransporter 2B (Na(+)/Pi Cotransporter 2B; NaPi-2b); Solute carrier family 34 member 2; SLC34A2	Human	HEK293
	SLC34A2 Protein, Human (HEK293, His, mFc) is the recombinant human-derived SLC34A2 protein, expressed by HEK293, with N-10*His & C-mFc tag.

HY-P7840A

	CLIC1 Protein, Human (N-His) Chloride Intracellular Channel Protein 1; Chloride Channel ABP; Nuclear Chloride Ion Channel 27; NCC27; Regulatory Nuclear Chloride Ion Channel Protein; hRNCC; CLIC1; G6; NCC27	Human	E. coli
	The CLIC1 protein exhibits specific lysophospholipase activity and plays a critical role in mediating cellular responses to oxidative stress. As a member of the chloride intracellular channel family, CLIC1 is involved in a variety of physiological processes, including cell volume regulation, membrane potential regulation, and regulation of cell cycle progression. CLIC1 Protein, Human (N-His) is the recombinant human-derived CLIC1 protein, expressed by E. coli , with N-6*His labeled tag.

HY-P705442

	SLC34A2 Protein, Rat (His) Sodium-dependent phosphate transport protein 2B; Slc34a2; Sodium-phosphate transport protein 2B; Na(+)-dependent phosphate Cotransporter 2B; Sodium/phosphate Cotransporter 2B (Na(+)/Pi Cotransporter 2B; NaPi-2b); Solute carrier family 34 member 2 (rNaPi IIb)	Rat	E. coli

HY-P705441

	SLC34A2 Protein, Human (HEK293, Fc) Sodium-dependent phosphate transport protein 2B; SLC34A2; Sodium-phosphate transport protein 2B; Na(+)-dependent phosphate Cotransporter 2B; NaPi3b; Sodium/phosphate Cotransporter 2B (Na(+)/Pi Cotransporter 2B; NaPi-2b); Solute carrier family 34 member 2	Human	HEK293

HY-P702022

	SLC12A2 Protein, Human (HEK293, His, StrepII, FLAG) SLC12A2; Solute carrier family 12 member 2; Basolateral Na-K-Cl symporter; Bumetanide-sensitive Sodium-(potassium)-Chloride Cotransporter 2	Human	HEK293
	SLC12A2 Protein mediates electroneutral transport of chloride, potassium, and/or sodium ions across the membrane, crucial for regulating ionic balance and cell volume. SLC12A2 Protein, Human (HEK293, His, Strep, FLAG) is the recombinant human-derived SLC12A2 protein, expressed by HEK293 insect cells , with N-Strep, C-Flag, N-8*His labeled tag.

HY-P703077

	SLC12A2 Protein, Human (HEK293, His, StrepⅡ, GFP) SLC12A2; Solute carrier family 12 member 2; Basolateral Na-K-Cl symporter; Bumetanide-sensitive Sodium-(potassium)-Chloride Cotransporter 2	Human	HEK293
	SLC12A2 Protein mediates electroneutral transport of chloride, potassium, and/or sodium ions across the membrane, crucial for regulating ionic balance and cell volume. SLC12A2 Protein, Human (HEK293, His, Strep, GFP) is the recombinant human-derived SLC12A2 protein, expressed by HEK293 , with N-Strep, N-EGF, N-His labeled tag.

HY-P7763

	HCC-1/CCL14 Protein, Human (HEK293, His) 1 Publications Verification rHuCCL14, His; C-C Motif Chemokine 14; Chemokine CC-1/CC-3; HCC-1/HCC-3; HCC-1(1-74); NCC-2; Small-Inducible Cytokine A14; CCL14; NCC2; SCYA14	Human	HEK293
	HCC-1/CCL14 Protein, Human (HEK293, His) is a CC chemokine with weak activity against human monocytes, promotes monocyte, eosinophil and T-lymphocyte chemotaxis, and mediates allergic airway inflammation and cancer. HCC-1/CCL14 Protein, Human (HEK293, His) is a recombinant human HCC-1/CCL14(T20-N93) expressed by HEK293 with a his tag.

HY-P703316

	SLC17A5 Protein, Human (HEK293, His, MBP, Flag) Sialin; H(+)/nitrate Cotransporter; H(+)/sialic acid Cotransporter; AST; Membrane glycoprotein HP59; Solute carrier family 17 member 5; Vesicular excitatory amino acid transporter; VEAT; SLC17A5; Homo sapiens; Human; AST	Human	HEK293
	SLC17A5 Protein, Human (HEK293, His, MBP, Flag) is the recombinant human-derived SLC17A5, expressed by HEK293 , with His, MBP, Flag labeled tag. ,

HY-P7266

	MIP-5/CCL15 Protein, Human rHuMIP-5/CCL15; C-C motif chemokine 15; HCC-2; SCYA15; NCC3	Human	E. coli
	MIP-5/CCL15 Protein, Human is a CC chemokine with strong chemotactic properties towards myeloid cells such as dendritic cells, monocytes, neutrophils and some T-lymphocytes. MIP-5/CCL15 Protein, Human binds to chemokine receptors CCR1 and CCR3 and plays a key role in leukocyte recruitment and inflammatory disease development. development. MIP-5/CCL15 Protein, Human is a recombinant human MIP-5/CCL15 (Q22-I113) expressed by E. coli.

HY-P73812

	MIP-5/CCL15 Protein, Human (68a.a, His) MIP-5; CCL15; C-C motif chemokine 15; HCC-2; SCYA15; NCC3	Human	E. coli
	MIP-5/CCL15 Protein, Human (68a.a, His) is a CC chemokine with strong chemotactic properties towards myeloid cells such as dendritic cells, monocytes, neutrophils and some T-lymphocytes. MIP-5/CCL15 Protein, Human (68a.a, His) binds to chemokine receptors CCR1 and CCR3 and plays a key role in leukocyte recruitment and inflammatory disease development. development. MIP-5/CCL15 Protein, Human (68a.a, His) is a recombinant human MIP-5/CCL15 (S46–I113) expressed by E. coli with a his tag at the C end.

HY-P705643

	SLC1542 Protein, Human (HEK293, GFP-Strep-His) SLC15A2; Solute carrier family 15 member 2; Kidney H(+)/peptide Cotransporter; Oligopeptide transporter; kidney isoform; Peptide transporter 2	Human	HEK293
	The SLC15A2 protein is a proton-coupled amino acid transporter that prefers dipeptides and transports oligopeptides containing 2 to 4 amino acids. The stoichiometric ratio of protons to peptides is 2:1 or 3:1, which helps the kidneys absorb dipeptides and tripeptides. SLC1542 Protein, Human (HEK293, GFP-Strep-His) is the recombinant human-derived SLC15A2 protein, expressed by HEK293 , with C-GFP-Strep-His tag.

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Cat. No.	Product Name	Chemical Structure

HY-15409S

Empagliflozin-d4
Empagliflozin-d₄ is deuterium labeled Empagliflozin. Empagliflozin (BI 107730 is a selective sodium glucose cotransporter-2 (SGLT-2) inhibitor with an IC₅₀ of 3.1 nM for human SGLT-2 .

HY-10450S

Dapagliflozin-d5
Dapagliflozin-d₅ is a deuterium labeled Dapagliflozin (HY-10450). Dapagliflozin is a competitive SGLT2 inhibitor .

HY-B0135S

Furosemide-d5

Furosemide-d₅ is the deuterium labeled Furosemide. Furosemide is a potent and orally active inhibitor of Na+/K+/2Cl-?(NKCC) cotransporter, NKCC1 and NKCC2 .?Furosemide is also a GABAA?receptors antagonist and displays 100-fold selectivity for?α6-containing receptors than?α1-containing receptors. Furosemide acts as a loop diuretic and used for the study of congestive heart failure, hypertension and edema .

HY-15409S1

Empagliflozin-13C6
Empagliflozin- ¹³C₆ (BI 10773- ¹³C₆) is ¹³C labeled Empagliflozin. Empagliflozin (BI 107730 is a selective sodium glucose cotransporter-2 (SGLT-2) inhibitor with an IC₅₀ of 3.1 nM for human SGLT-2 .

HY-15409S2

Empagliflozin-d6
Empagliflozin-d₆ (BI 10773-d₆) is deuterium labeled Empagliflozin. Empagliflozin (BI 107730 is a selective sodium glucose cotransporter-2 (SGLT-2) inhibitor with an IC₅₀ of 3.1 nM for human SGLT-2 .

HY-15461S

Ertugliflozin-d5
Ertugliflozin-d₅ is the deuterium labeled Ertugliflozin . Ertugliflozin (PF-04971729) is a potent, selective and orally active inhibitor of the sodium-dependent glucose cotransporter 2 (SGLT2), with an IC₅₀ of 0.877 nM for h-SGLT2 . Has the potential for the treatment of type 2 diabetes mellitus .

HY-15461S1

Ertugliflozin-d9
Ertugliflozin-d₉ is deuterated labeled Ertugliflozin (HY-15461). Ertugliflozin (PF-04971729) is a potent, selective and orally active inhibitor of the sodium-dependent glucose cotransporter 2 (SGLT2), with an IC₅₀ of 0.877 nM for h-SGLT2 . Has the potential for the treatment of type 2 diabetes mellitus .

HY-111095S3A

D-(-)-Lactic acid-13C-2 sodium
D-(-)-Lactic acid- ¹³C-2 (sodium) is a ¹³C-labeled D-(-)-Lactic acid (HY-111095). D-(-)-Lactic acid can be used for a variety of biochemical studies.

HY-10450S5

Dapagliflozin-13C6-1
Dapagliflozin- ¹³C₆-1 is ¹³C labeled Dapagliflozin. Dapagliflozin (BMS-512148), a new type of agent used to treat diabetes mellitus (DM), is a competitive sodium/glucose cotransporter 2 (SGLT2) inhibitor, which results in excretion of glucose into the urine . Dapagliflozin induces HIF1 expression and attenuates renal IR injury .

HY-10450S3

Dapagliflozin-13C6
Dapagliflozin- ¹³C₆ (BMS-512148- ¹³C₆) is ¹³C labeled Dapagliflozin. Dapagliflozin (BMS-512148), a new type of agent used to treat diabetes mellitus (DM), is a competitive sodium/glucose cotransporter 2 (SGLT2) inhibitor, which results in excretion of glucose into the urine . Dapagliflozin induces HIF1 expression and attenuates renal IR injury .

HY-10450S2

Dapagliflozin-d4
Dapagliflozin-d₄ (BMS-512148-d₄) is deuterium labeled Dapagliflozin. Dapagliflozin (BMS-512148), a new type of agent used to treat diabetes mellitus (DM), is a competitive sodium/glucose cotransporter 2 (SGLT2) inhibitor, which results in excretion of glucose into the urine . Dapagliflozin induces HIF1 expression and attenuates renal IR injury .

HY-113202S1

Stearoyl-L-carnitine-d9 chloride

Stearoyl-L-carnitine-d9 chloride is the deuterium labeled Stearoyl-L-carnitine chloride. Stearoyl-L-carnitine chloride, a fatty ester lipid molecule, is an endogenous metabolite. Stearoyl-L-carnitine chloride can be used as PKC inhibitor. Stearoyl-L-carnitine chloride accumulates in β cells, leading to arrest of insulin synthesis and energy deficiency in type 2 diabetes mouse. Stearoyl-L-carnitine chloride inhibits lecithin cholesterol acyltransferase (LCAT) in rat and rabbits plasma. Stearoyl-L-carnitine chloride acts as a metabolomics biomarker for Parkinson’s disease. Stearoyl-L-carnitine chloride is a less potent inhibitor of GlyT2 .

HY-166652S

Empagliflozin-d8
Empagliflozin-d₈ is the deuterium labeled Empagliflozin. Empagliflozin (BI 107730 is a selective sodium glucose cotransporter-2 (SGLT-2) inhibitor with an IC₅₀ of 3.1 nM for human SGLT-2 .

HY-166548S

Remogliflozin etabonate-d7

Remogliflozin etabonate-d₇ (GSK189075-d₇) is the deuterium labeled Remogliflozin etabonate. Remogliflozin etabonate (GSK189075) is an orally active, selective and low-affinity sodium glucose cotransporter (SGLT2) inhibitor with K_i values of 1.95 μM, 2.14 μM, 43.1 μM, 8.57 μM for hSGLT2, rSGLT2, hSGLT1, rSGLT1, respectively. Remogliflozin etabonate is a proagent based on benzylpyrazole glucoside and is metabolized to its active form, Remogliflozin, in the body. Remogliflozin etabonate exhibits antidiabetic efficacy in rodent models .

Host:	Rat (1) Mouse (8) Rabbit (6)
Reactivity:	Human (6) mouse (2) rat (2) Rat (7) Mouse (7) human (5)
Application:	IHC-P (9) ICC/IF (7) IF-Tissue (4) IP (7) WB (13) IHC-F (3) FC (2) ELISA (6)
Isotype:	IgG (6) IgG1 (7) IgG2a (1)
Conjugation:	Non-conjugated (15)
Clonality:	Monoclonal (8) Recombinant (7)
Modification:	Unmodified (13)

Cat. No.	Compare	Product Name	Application	Reactivity	Image

HY-P87092

	Slc12a5/KCC2 Antibody (YA6785) Electroneutral potassium Chloride Cotransporter 2 antibody; Electroneutral potassium-Chloride Cotransporter 2 antibody; Erythroid K Cl Cotransporter 2 antibody; Furosemide sensitive K Cl Cotransporter antibody; hKCC2 antibody; K-Cl Cotransporter 2 antibody; KCC 2 antibody; KCC2 antibody; KIAA1176 antibody; Neuronal K Cl Cotransporter antibody; Electroneutral potassium Chloride Cotransporter 2 antibody; Electroneutral potassium-Chloride Cotransporter 2 antibody; Erythroid K Cl Cotransporter 2 antibody; Furosemide sensitive K Cl Cotransporter antibody; hKCC2 antibody; K-Cl Cotransporter 2 antibody; KCC 2 antibody; KCC2 antibody; KIAA1176 antibody; Neuronal K Cl Cotransporter antibody; Neuronal K-Cl Cotransporter antibody; Potassium Chloride Cotransporter antibody; Potassium Chloride transporter 5 antibody; rKCC2 antibody; S12A5 antibody; S12A5_HUMAN antibody; SLC12A5 antibody; Solute carrier family 12 (potassium Chloride transporter) member 5 antibody; Solute carrier family 12 member 5 antibody;	IHC-F, WB	Mouse, Rat
	Slc12a5/KCC2 Antibody (YA6785) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to Slc12a5/KCC2.

HY-P85302

	NPT1 Antibody (YA4994) SLC17A1; NPT1; Sodium-dependent phosphate transport protein 1; Na; +; /PI Cotransporter 1; Na/Pi-4; Renal Na; +; -dependent phosphate Cotransporter 1; Renal Sodium-dependent phosphate transport protein 1; Renal Sodium-phosphate transport protei	WB, ELISA	Human
	NPT1 Antibody (YA4994) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to NPT1.

HY-P83742

	SLC12A1 Antibody (YA3471) BSC1 antibody; Bumetanide sensitive Sodium 3 antibody; Bumetanide-sensitive Sodium-(potassium)-Chloride Cotransporter 2 antibody; Kidney specific Na K Cl symporter antibody; Kidney-specific Na-K-Cl symporter antibody; MGC48843 antibody; Na K 2Cl Cotransporter antibody; NKCC2 antibody; potassiumChloride Cotransporter 2 antibody; S12A1_HUMAN antibody; Slc12a1 antibody; Sodium potassium Chloride Cotransporter 2 antibody; solute carrier family 12 (Sodium/potassium/Chloride transporters) antibody; Solute carrier family 12 member 1 antibody	WB, IHC-P, ICC/IF	Human, Mouse, Rat
	SLC12A1 Antibody (YA3471) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to SLC12A1.

HY-P89587

	SLC4A4 Antibody (YA8931) NBC, NBC1, NBCE1, SLC4A4, Electrogenic Sodium bicarbonate Cotransporter 1, Sodium bicarbonate Cotransporter, Na(+)/HCO3(-) Cotransporter, Solute carrier family 4 member 4, kNBC1	WB, ICC/IF, IF-Tissue, IHC-P, IP, ELISA	human, mouse, rat
	SLC4A4 Antibody (YA8931) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to SLC4A4.

HY-P87139

	VGLUT2 Antibody (YA6832) Differentiation associated BNPI antibody; Differentiation associated Na dependent inorganic phosphate Cotransporter antibody; Differentiation associated Na(+) dependent inorganic phosphate Cotransporter antibody; Differentiation-associated BNPI antibody; Differentiation-associated Na(+)-dependent inorganic phosphate Cotransporter antibody; DNPI antibody; SLC17A6 antibody; Sodium dependent inorganic phosphate Cotransporter antibody; Solute carrier family 17 (Sodium dependent inorganic phosphate Cotransporter) member 6 antibody; Solute carrier family 17 member 6 antibody; Differentiation associated BNPI antibody; Differentiation associated Na dependent inorganic phosphate Cotransporter antibody; Differentiation associated Na(+) dependent inorganic phosphate Cotransporter antibody; Differentiation-associated BNPI antibody; Differentiation-associated Na(+)-dependent inorganic phosphate Cotransporter antibody; DNPI antibody; SLC17A6 antibody; Sodium dependent inorganic phosphate Cotransporter antibody; Solute carrier family 17 (Sodium dependent inorganic phosphate Cotransporter) member 6 antibody; Solute carrier family 17 member 6 antibody; Vesicular glutamate transporter 2 antibody; Vesicular glutamate transporter type 2 antibody; VGLU2_HUMAN antibody; VGLUT 2 antibody; VGluT2 antibody;	WB, IHC-F, IHC-P	Mouse, Rat
	VGLUT2 Antibody (YA6832) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to VGLUT2.

HY-P89551

	CCL14 Antibody (YA8895) NCC2, SCYA14, CCL14, C-C motif chemokine 14, Chemokine CC-1/CC-3, HCC-1(1-74), NCC-2, Small-inducible cytokine A14, HCC-1/HCC-3	WB, ICC/IF, IF-Tissue, IHC-P, IP, ELISA	human
	CCL14 Antibody (YA8895) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to CCL14.

HY-P87141

	VGluT1 Antibody (YA6834) BNPI antibody; Brain specific Na (+) dependent inorganic phosphate Cotransporter antibody; Brain specific Na dependent inorganic phosphate Cotransporter antibody; Brain-specific Na(+)-dependent inorganic phosphate Cotransporter antibody; Slc17a7 antibody; Solute carrier family 17 (Sodium-dependent inorganic phosphate Cotransporter), member 7 antibody; Solute carrier family 17 member 7 antibody; Vesicular glutamate transporter 1 antibody; VGLU1_HUMAN antibody; VGLUT 1 antibody; BNPI antibody; Brain specific Na (+) dependent inorganic phosphate Cotransporter antibody; Brain specific Na dependent inorganic phosphate Cotransporter antibody; Brain-specific Na(+)-dependent inorganic phosphate Cotransporter antibody; Slc17a7 antibody; Solute carrier family 17 (Sodium-dependent inorganic phosphate Cotransporter), member 7 antibody; Solute carrier family 17 member 7 antibody; Vesicular glutamate transporter 1 antibody; VGLU1_HUMAN antibody; VGLUT 1 antibody; VGluT1 antibody;	WB, IHC-P, IHC-F	Mouse, Rat
	VGluT1 Antibody (YA6834) is a Rat -derived and non-conjugated IgG1 monoclonal antibody, targeting to VGluT1.

HY-P87140

	VGluT1 Antibody (YA6833) BNPI antibody; Brain specific Na (+) dependent inorganic phosphate Cotransporter antibody; Brain specific Na dependent inorganic phosphate Cotransporter antibody; Brain-specific Na(+)-dependent inorganic phosphate Cotransporter antibody; Slc17a7 antibody; Solute carrier family 17 (Sodium-dependent inorganic phosphate Cotransporter), member 7 antibody; Solute carrier family 17 member 7 antibody; Vesicular glutamate transporter 1 antibody; VGLU1_HUMAN antibody; VGLUT 1 antibody; BNPI antibody; Brain specific Na (+) dependent inorganic phosphate Cotransporter antibody; Brain specific Na dependent inorganic phosphate Cotransporter antibody; Brain-specific Na(+)-dependent inorganic phosphate Cotransporter antibody; Slc17a7 antibody; Solute carrier family 17 (Sodium-dependent inorganic phosphate Cotransporter), member 7 antibody; Solute carrier family 17 member 7 antibody; Vesicular glutamate transporter 1 antibody; VGLU1_HUMAN antibody; VGLUT 1 antibody; VGluT1 antibody;	WB, IHC-P	Mouse, Rat
	VGluT1 Antibody (YA6833) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to VGluT1.

HY-P81437

	SLC34A2 Antibody (YA1182) SLC34A2; Sodium-dependent phosphate transport protein 2B; Sodium-phosphate transport protein 2B; Na(+)-dependent phosphate Cotransporter 2B; NaPi3b; Sodium/phosphate Cotransporter 2B (Na(+)/Pi Cotransporter 2B; NaPi-2b); Solute carrier family 34 member 2	IHC-P	Human
	SLC34A2 Antibody (YA1182) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to SLC34A2.

HY-P81437A

	SLC34A2 Antibody (YA1182)(PBS only) SLC34A2; Sodium-dependent phosphate transport protein 2B; Sodium-phosphate transport protein 2B; Na(+)-dependent phosphate Cotransporter 2B; NaPi3b; Sodium/phosphate Cotransporter 2B (Na(+)/Pi Cotransporter 2B; NaPi-2b); Solute carrier family 34 member 2	IHC-P	Human
	SLC34A2 Antibody (YA1182) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to SLC34A2.

HY-P810025

	SLC5A12 Antibody (YA9369) SMCT2, SLC5A12, Sodium-coupled monocarboxylate transporter 2, Electroneutral Sodium monocarboxylate Cotransporter, Low-affinity Sodium-lactate Cotransporter, Solute carrier family 5 member 12	WB, ICC/IF, IF-Tissue, IP, ELISA	human, mouse, rat
	SLC5A12 Antibody (YA9369) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to SLC5A12.

HY-P83062

	CLIC1 Antibody (YA2807) Chloride intracellular channel protein 1; Chloride channel ABP; Nuclear Chloride ion channel 27; NCC27; Regulatory nuclear Chloride ion channel protein; hRNCC	WB, ICC/IF, FC, IP	Human, Mouse, Rat
	CLIC1 Antibody (YA2807) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to CLIC1.

HY-P83062A

	CLIC1 Antibody (YA2807)(PBS only) Chloride intracellular channel protein 1; Chloride channel ABP; Nuclear Chloride ion channel 27; NCC27; Regulatory nuclear Chloride ion channel protein; hRNCC	WB, ICC/IF, FC, IP	Human, Mouse, Rat
	CLIC1 Antibody (YA2807) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to CLIC1.

HY-P810020

	SLC13A5 Antibody (YA9364) NACT, SLC13A5, Na(+)/citrate Cotransporter, NaCT, Sodium-coupled citrate transporter, Sodium-dependent citrate transporter, Solute carrier family 13 member 5	WB, ICC/IF, IF-Tissue, IHC-P, IP, ELISA	human
	SLC13A5 Antibody (YA9364) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to SLC13A5.

HY-P810033

	NaDC-3 Antibody (YA9377) NADC3, SDCT2, SLC13A3, Na(+)/dicarboxylate Cotransporter 3, NaDC-3, hNaDC3, Na(+)-coupled carboxylate transporter 3, Sodium-dependent high-affinity dicarboxylate transporter 2, Solute carrier family 13 member 3, NaC3	WB, IP, ELISA	human
	NaDC-3 Antibody (YA9377) is a Mouse-derived and non-conjugated IgG2a monoclonal antibody, targeting to NaDC-3.

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Cat. No.	Product Name		Classification

HY-132609

Patisiran sodium 1 Publications Verification		siRNAs siRNA drugs
Patisiran sodium is a double-stranded small interfering RNA that targets a sequence within the transthyretin (TTR) messenger RNA. Patisiran sodium specifically inhibits hepatic synthesis of mutant and wild-type TTR. Patisiran sodium can be used for the research of hereditary TTR amyloidosis .

HY-108764

Mipomersen sodium 2 Publications Verification ISIS 301012		Antisense Oligonucleotides
Mipomersen sodium (ISIS 301012) is an antisense oligonucleotide inhibitor of apolipoprotein B (apoB). Mipomersen has anti-HCV effect and reduces the infectivity of the HCV. Mipomersen sodium can be used for the research of homozygous familial hypercholesterolemia (HoFH) .

HY-147080

Avacincaptad pegol sodium ARC1905		Aptamers
Avacincaptad pegol (ARC1905) sodium is a 40KDa PEG-conjugated aptamer. Avacincaptad pegol sodium targets complement factor 5 (C5), inhibits the cleavage of C5 into C5a and C5b, limits inflammatory stimulation and complement membrane attack complex (MAC), and is used to study age-related macular degeneration (AMD). Avacincaptad pegol sodium limits irregular cell apoptosis by targeting downstream factors in the complement cascade while preserving the early steps of the complement system .

HY-132608

Inotersen sodium ISIS-420915 Sodium		Antisense Oligonucleotides
Inotersen (ISIS-420915) sodium is a 2′-O-methoxyethyl-modified antisense oligonucleotide. Inotersen sodium inhibits the production of transthyretin (TTR) protein by targeting the TTR RNA transcript and reduces the levels of the TTR transcript. Inotersen sodium can be used for the research of hereditary TTR amyloidosis polyneuropathy .

HY-B2243B

Anhydrous sodium dihydrogen phosphate, for molecular biology 1 Publications Verification Sodium phosphate monobasic for molecular biology; MonoSodium dihydrogen orthophosphate for molecular biology; MonoSodium phosphate for molecular biology		Others
Anhydrous sodium dihydrogen phosphate, for molecular biology is an inorganic salt compound that can be used as a buffer and nutritional supplement. Anhydrous sodium dihydrogen phosphate, for molecular biology can be used in molecular biology experiments .

HY-100973

Adenosine 5′-diphosphoribose Maximum Cited Publications 8 Publications Verification ADP ribose		Nucleotide Analogs Adenine Nucleotide
Adenosine 5′-diphosphoribose (ADP ribose) is a nicotinamide adenine nucleotide (NAD ⁺) metabolite. Adenosine 5′-diphosphoribose is the most potent and primary intracellular Ca ²⁺-permeable cation TRPM2 channel activator. Adenosine 5′-diphosphoribose also can enhance autophagy .

HY-132613

Lumasiran sodium		siRNAs siRNA drugs
Lumasiran sodium, an investigational RNA interference (RNAi) therapeutic agent, reduces hepatic oxalate production by targeting glycolate oxidase. Lumasiran sodium reduces urinary oxalate excretion, the cause of progressive kidney failure in primary hyperoxaluria type 1 (PH1) .

HY-145725

Baliforsen sodium IONIS 598769 Sodium; ISIS 598769 Sodium		Antisense Oligonucleotides
Baliforsen (sodium) is an antisense oligonucleotide (16 nucleotides) designed to target myotonic dystrophy protein kinase (DMPK) mRNA and research myotonic dystrophy.

HY-109561

Pegaptanib sodium EYE001; NX1838		Aptamers
Pegaptanib sodium is an RNA aptamer with polyethylene glycol modifications, which is directed against vascular endothelial growth factor (VEGF)-165. Pegaptanib could be used for the study of neovascular age-related macular degeneration (AMD) .

HY-132607A

MTL-CEBPA sodium CEBPA-51 Sodium		saRNAs
MTL-CEBPA (sodium) is the sodium form of MTL-CEBPA (HY-132607). MTL-CEBPA (sodium) is a small activating RNA targeting for upregulation of C/EBPα. MTL-CEBPA (sodium) has anti-inflammatory and anti-cancer activity .

HY-148410C

Zorevunensen negative control STK-001 negative control		Antisense Oligonucleotides
Zorevunensen (STK-001) negative control is the negative control form of Zorevunensen (HY-148410). Zorevunensen is an antisense oligonucleotide that is intended to increase the level of productive SCN1A mRNA and consequently increase the expression of the sodium channel Nav_1.1 protein. Zorevunersen is used for the study of Dravet syndrome .

HY-132606C

Scrambled Nedosiran sodium		siRNAs siRNA drugs
Scrambled Nedosiran sodium is a scrambled sequence of Nedosiran sodium (HY-132606A). Scrambled Nedosiran sodium has a random sequence of the amino acids that are the same as the active fragment Nedosiran sodium. Scrambled Nedosiran sodium is usually used as a negative control .

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Sodium Chloride Cotransporter (NCC)

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