Dapagliflozin keto impurity
Based on 1 Customer Validation
Dapagliflozin keto impurity (Oxo-dapagliflozin) is an oxo metabolite and related impurity of Dapagliflozin (HY-10450). Dapagliflozin keto impurity can be characterized by 1H NMR, 13C NMR and HRMS, and can be used in studies related to Dapagliflozin impurities and metabolites.
For research use only. We do not sell to patients.
- Purity : 98.19%
- CAS No.: 2169998-23-4
- Formula: C21H23ClO7
- Molecular Weight:422.86
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
In Vitro
Dapagliflozin keto impurity (Oxo-dapagliflozin) is an off-white amorphous solid, which is prepared via multi-step chemical synthesis using methoxyoxo-dapagliflozin as the starting material with a yield of 80%. Its structure is confirmed by NMR and HRMS[1].
Dapagliflozin keto impurity is obtained by hydrolyzing tetraacetyl oxo dapagliflozin with LiOH·H2O. The reaction proceeds at 20-30°C for 16 h, with a yield of 84%[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 2169998-23-4
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Appearance Solid
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Molecular Weight 422.86
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Formula C21H23ClO7
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Color White to off-white
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SMILES
ClC1=CC=C([C@H]2[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O2)C=C1C(C3=CC=C(OCC)C=C3)=O
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Synonyms
Oxo-dapagliflozin
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
In Vitro:
DMSO : 100 mg/mL (236.48 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (290 KB)
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SDS (394 KB)
- English - EN (394 KB)
- Français - FR (394 KB)
- Deutsch - DE (394 KB)
- Norwegian - NO (394 KB)
- Español - ES (394 KB)
- Swedish - SV (394 KB)
- Italian - IT (394 KB)
- Korean - KR (394 KB)
- Portuguese - PT (394 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.3648 mL | 11.8242 mL | 23.6485 mL | 59.1212 mL |
| 5 mM | 0.4730 mL | 2.3648 mL | 4.7297 mL | 11.8242 mL | |
| 10 mM | 0.2365 mL | 1.1824 mL | 2.3648 mL | 5.9121 mL | |
| 15 mM | 0.1577 mL | 0.7883 mL | 1.5766 mL | 3.9414 mL | |
| 20 mM | 0.1182 mL | 0.5912 mL | 1.1824 mL | 2.9561 mL | |
| 25 mM | 0.0946 mL | 0.4730 mL | 0.9459 mL | 2.3648 mL | |
| 30 mM | 0.0788 mL | 0.3941 mL | 0.7883 mL | 1.9707 mL | |
| 40 mM | 0.0591 mL | 0.2956 mL | 0.5912 mL | 1.4780 mL | |
| 50 mM | 0.0473 mL | 0.2365 mL | 0.4730 mL | 1.1824 mL | |
| 60 mM | 0.0394 mL | 0.1971 mL | 0.3941 mL | 0.9854 mL | |
| 80 mM | 0.0296 mL | 0.1478 mL | 0.2956 mL | 0.7390 mL | |
| 100 mM | 0.0236 mL | 0.1182 mL | 0.2365 mL | 0.5912 mL |
Dapagliflozin keto impurity Related Classifications
HY-I1198 Related Classifications
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