2. Membrane Transporter/Ion Channel
  3. SGLT
  4. Licogliflozin

Licogliflozin  (Synonyms: LIK066)

Cat. No.: HY-109092 Purity: ≥98.0%
COA Handling Instructions

Licogliflozin is a sodium glucose cotransporter (SGLT1 and SGLT2) inhibitor.

For research use only. We do not sell to patients.

Licogliflozin Chemical Structure

Licogliflozin Chemical Structure

CAS No. : 1291094-73-9

Size Price Stock Quantity
Free Sample (0.1 - 0.5 mg)   Apply Now  
Solution
10 mM * 1 mL in DMSO USD 275 In-stock
Solid + Solvent
10 mM * 1 mL
ready for reconstitution
 USD 275 In-stock
Solid
5 mg USD 250 In-stock
10 mg USD 450 In-stock
25 mg USD 900 In-stock
50 mg USD 1350 In-stock
100 mg USD 2250 In-stock
200 mg   Get quote  
500 mg   Get quote  

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This product is a controlled substance and not for sale in your territory.

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Based on 1 publication(s) in Google Scholar

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Description

Licogliflozin is a sodium glucose cotransporter (SGLT1 and SGLT2) inhibitor.

IC50 & Target

SGLT1, SGLT2[1]
In Vitro

Licogliflozin (LIK066) is a non-anti-fibrotic treatment agent for non-alcoholic steatohepatitis (NASH).

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Clinical Trial
Molecular Weight

416.46

Appearance

Solid

Formula

C23H28O7
CAS No.
SMILES

O[[email protected]]1[[email protected]](C2=CC(CC3=CC=C4C(OCCO4)=C3)=C(CC)C=C2)O[[email protected]](CO)[[email protected]@H](O)[[email protected]@H]1O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (240.12 mM; Need ultrasonic)

H2O : 2 mg/mL (4.80 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.4012 mL 12.0060 mL 24.0119 mL
5 mM 0.4802 mL 2.4012 mL 4.8024 mL
10 mM 0.2401 mL 1.2006 mL 2.4012 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  PBS

    Solubility: 10 mg/mL (24.01 mM); Clear solution; Need ultrasonic and warming and heat to 60°C

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (6.00 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (6.00 mM); Clear solution

*All of the co-solvents are available by MCE.
Purity & Documentation
References
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

Licogliflozin1291094-73-9LIK066LIK 066LIK-066SGLTSodium-dependent glucose cotransportersInhibitorinhibitorinhibit

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