1. Membrane Transporter/Ion Channel
  2. SGLT
  3. Velagliflozin

Velagliflozin 

Cat. No.: HY-109018 Purity: 99.92%
COA Handling Instructions

Velagliflozin is an orally available sodium-glucose cotransporter 2 (SGLT2) inhibitor, with anti-diabetic activity.

For research use only. We do not sell to patients.

Velagliflozin Chemical Structure

Velagliflozin Chemical Structure

CAS No. : 946525-65-1

Size Price Stock Quantity
1 mg USD 450 In-stock
5 mg USD 1450 In-stock
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This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of Velagliflozin:

Top Publications Citing Use of Products

1 Publications Citing Use of MCE Velagliflozin

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Velagliflozin is an orally available sodium-glucose cotransporter 2 (SGLT2) inhibitor, with anti-diabetic activity.

IC50 & Target

SGLT2

 

In Vitro

Velagliflozin is an oral sodium-glucose cotransporter 2 (SGLT2) inhibitor with antidiabetic activity. Velagliflozin reduces renal glucose reabsorption and stimulates glycosuria, which lowers blood sugar and insulin concentrations[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Velagliflozin (1 mg/kg; p.o.; single dose) increases cholesterol, albumin, beta-hydroxybutyrate (BHB), nonesterified fatty acids (NEFA), and urinary glucose excretion, and decreases respiratory exchange ratio in cats[1].
Velagliflozin (0.3 mg/kg; p.o.; once daily for 18 d) is well tolerated and can improve insulin disorders and prevent laminitis in ponies by reducing the high insulin response of dietary non-structural carbohydrates (NSC)[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

395.45

Appearance

Oil

Formula

C23H25NO5

CAS No.
SMILES

O[[email protected]]1[[email protected]](C2=CC(CC3=CC=C(C4CC4)C=C3)=C(C#N)C=C2)O[[email protected]](CO)[[email protected]@H](O)[[email protected]@H]1O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Pure form -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 200 mg/mL (505.75 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.5288 mL 12.6438 mL 25.2876 mL
5 mM 0.5058 mL 2.5288 mL 5.0575 mL
10 mM 0.2529 mL 1.2644 mL 2.5288 mL
*Please refer to the solubility information to select the appropriate solvent.
Purity & Documentation
References
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Product Name:
Velagliflozin
Cat. No.:
HY-109018
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