1. Membrane Transporter/Ion Channel
  2. SGLT
  3. Velagliflozin

Velagliflozin is an orally available sodium-glucose cotransporter 2 (SGLT2) inhibitor, with anti-diabetic activity.

For research use only. We do not sell to patients.

Velagliflozin Chemical Structure

Velagliflozin Chemical Structure

CAS No. : 946525-65-1

Size Price Stock Quantity
1 mg USD 450 In-stock
5 mg USD 1450 In-stock
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Based on 1 publication(s) in Google Scholar

Other Forms of Velagliflozin:

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1 Publications Citing Use of MCE Velagliflozin

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Description

Velagliflozin is an orally available sodium-glucose cotransporter 2 (SGLT2) inhibitor, with anti-diabetic activity.

IC50 & Target

SGLT2

 

In Vitro

Velagliflozin is an oral sodium-glucose cotransporter 2 (SGLT2) inhibitor with antidiabetic activity. Velagliflozin reduces renal glucose reabsorption and stimulates glycosuria, which lowers blood sugar and insulin concentrations[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Velagliflozin (1 mg/kg; p.o.; single dose) increases cholesterol, albumin, beta-hydroxybutyrate (BHB), nonesterified fatty acids (NEFA), and urinary glucose excretion, and decreases respiratory exchange ratio in cats[1].
Velagliflozin (0.3 mg/kg; p.o.; once daily for 18 d) is well tolerated and can improve insulin disorders and prevent laminitis in ponies by reducing the high insulin response of dietary non-structural carbohydrates (NSC)[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

395.45

Formula

C23H25NO5

CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O[C@H]1[C@H](C2=CC(CC3=CC=C(C4CC4)C=C3)=C(C#N)C=C2)O[C@H](CO)[C@@H](O)[C@@H]1O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 200 mg/mL (505.75 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.5288 mL 12.6438 mL 25.2876 mL
5 mM 0.5058 mL 2.5288 mL 5.0575 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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g

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.5288 mL 12.6438 mL 25.2876 mL 63.2191 mL
5 mM 0.5058 mL 2.5288 mL 5.0575 mL 12.6438 mL
10 mM 0.2529 mL 1.2644 mL 2.5288 mL 6.3219 mL
15 mM 0.1686 mL 0.8429 mL 1.6858 mL 4.2146 mL
20 mM 0.1264 mL 0.6322 mL 1.2644 mL 3.1610 mL
25 mM 0.1012 mL 0.5058 mL 1.0115 mL 2.5288 mL
30 mM 0.0843 mL 0.4215 mL 0.8429 mL 2.1073 mL
40 mM 0.0632 mL 0.3161 mL 0.6322 mL 1.5805 mL
50 mM 0.0506 mL 0.2529 mL 0.5058 mL 1.2644 mL
60 mM 0.0421 mL 0.2107 mL 0.4215 mL 1.0537 mL
80 mM 0.0316 mL 0.1580 mL 0.3161 mL 0.7902 mL
100 mM 0.0253 mL 0.1264 mL 0.2529 mL 0.6322 mL
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Velagliflozin Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Velagliflozin
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HY-109018
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