2. Membrane Transporter/Ion Channel
  3. SGLT
  4. Velagliflozin proline

Velagliflozin proline is an oral sodium-glucose cotransporter 2 (SGLT2) inhibitor with antidiabetic activity. Velagliflozin proline reduces renal glucose reabsorption and stimulates glycosuria, which lowers blood sugar and insulin concentrations.

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Velagliflozin proline Chemical Structure

Velagliflozin proline Chemical Structure

CAS No. : 1539295-26-5

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1 mg USD 450 In-stock
5 mg USD 1450 In-stock
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Based on 1 publication(s) in Google Scholar

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Velagliflozin proline Related Antibodies

Top Publications Citing Use of Products

1 Publications Citing Use of MCE Velagliflozin proline

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Description

Velagliflozin proline is an oral sodium-glucose cotransporter 2 (SGLT2) inhibitor with antidiabetic activity. Velagliflozin proline reduces renal glucose reabsorption and stimulates glycosuria, which lowers blood sugar and insulin concentrations[1].

In Vivo

Velagliflozin (1 mg/kg; p.o.; single dose) proline increases cholesterol, albumin, beta-hydroxybutyrate (BHB), nonesterified fatty acids (NEFA), and urinary glucose excretion, and decreases respiratory exchange ratio in cats[1].
Velagliflozin (0.3 mg/kg; p.o.; once daily for 18 d) proline is well tolerated and can improve insulin disorders and prevent laminitis in ponies by reducing the high insulin response of dietary non-structural carbohydrates (NSC)[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

510.58

Formula

C28H34N2O7
CAS No.
Appearance

Solid-Liquid Mixture

Color

White to off-white

SMILES

OC([C@@H]1CCCN1)=O.O[C@H]2[C@H](C3=CC(CC4=CC=C(C5CC5)C=C4)=C(C#N)C=C3)O[C@H](CO)[C@@H](O)[C@@H]2O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Pure form -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (195.86 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.9586 mL 9.7928 mL 19.5856 mL
5 mM 0.3917 mL 1.9586 mL 3.9171 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.9586 mL 9.7928 mL 19.5856 mL 48.9639 mL
5 mM 0.3917 mL 1.9586 mL 3.9171 mL 9.7928 mL
10 mM 0.1959 mL 0.9793 mL 1.9586 mL 4.8964 mL
15 mM 0.1306 mL 0.6529 mL 1.3057 mL 3.2643 mL
20 mM 0.0979 mL 0.4896 mL 0.9793 mL 2.4482 mL
25 mM 0.0783 mL 0.3917 mL 0.7834 mL 1.9586 mL
30 mM 0.0653 mL 0.3264 mL 0.6529 mL 1.6321 mL
40 mM 0.0490 mL 0.2448 mL 0.4896 mL 1.2241 mL
50 mM 0.0392 mL 0.1959 mL 0.3917 mL 0.9793 mL
60 mM 0.0326 mL 0.1632 mL 0.3264 mL 0.8161 mL
80 mM 0.0245 mL 0.1224 mL 0.2448 mL 0.6120 mL
100 mM 0.0196 mL 0.0979 mL 0.1959 mL 0.4896 mL
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Velagliflozin proline Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Velagliflozin proline1539295-26-5SGLTSodium-dependent glucose cotransportersSGLT2antidiabeticglucose reabsorptionglycosuriainsulinInhibitorinhibitorinhibit

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