Art. -Nr.: HY-12611

Sergliflozin etabonate

(Synonyms: GW-869682X)

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Sergliflozin etabonate (GW-869682X) is a potent and orally active sodium glucose cotransporter (SGLT2) inhibitor. Sergliflozin etabonate shows antidiabetic and antihyperglycemic effects. Sergliflozin etabonate significantly reduces non-fasting blood glucose levels in diabetic mice. Sergliflozin etabonate has the potential for the research of diabetes.

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Reinheit: 99.64%
CAS. Nr.: 408504-26-7
Formel: C₂₃H₂₈O₉
Molecular Weight:448.46

Speicherung:

4°C, protect from light

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Sergliflozin etabonate Chemical Structure

CAS. Nr.: 408504-26-7

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Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- Cellular Effect
- In Vivo
Chemical Information
Lösungsmittel & Löslichkeit
- In Vitro
- In Vivo
Reinheit & Dokumentation
Verweise
Help & FAQs
Classifications
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Biologische Aktivität

Beschreibung

IC₅₀ & Target^[1]

SGLT2

Alle SGLT Isoform-spezifische Produkte anzeigen :

SGLT1
SGLT2

Cellular Effect

Cell Line	Type	Value	Description	References
CHO	IC₅₀	260 nM Compound: 3	Inhibition of human SGLT2 expressed in CHO cells assessed as [14C]AMG uptake after 45 mins Inhibition of human SGLT2 expressed in CHO cells assessed as [14C]AMG uptake after 45 mins	[PMID: 21873071]
CHO	IC₅₀	22 μM Compound: 3	Inhibition of human SGLT1 expressed in CHO cells assessed as [14C]AMG uptake after 45 mins Inhibition of human SGLT1 expressed in CHO cells assessed as [14C]AMG uptake after 45 mins	[PMID: 21873071]
CHO-K1	IC₅₀	260 nM Compound: 2	Inhibition of human SGLT2 expressed in CHO-K1 cells by [14C]AMG uptake assay Inhibition of human SGLT2 expressed in CHO-K1 cells by [14C]AMG uptake assay	[PMID: 22652255]
CHO-K1	IC₅₀	22 μM Compound: 2	Inhibition of human SGLT1 expressed in CHO-K1 cells by [14C]AMG uptake assay Inhibition of human SGLT1 expressed in CHO-K1 cells by [14C]AMG uptake assay	[PMID: 22652255]

In Vivo

Sergliflozin etabonate (1, 3, 10, 30 mg/kg; oral; once) significantly reduces non-fasting blood glucose levels in KK-Ay mice in a dose-dependent manner^[1].
Sergliflozin etabonate (1.7, 8.4, 45.7 mg/kg in the 0.001, 0.005, and 0.025% sergliflozin etabonate; fed; daily for 9 weeks) reduces non-fasting blood glucose level and decreases triglyceride content in the liver in a dose-dependent manner in KK-Ay mice^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

14 weeks, Female KK-Ay mice^[1]
Dosage:

1, 3, 10, 30 mg/kg
Administration:

Oral; once
Result:

Significantly reduced non-fasting blood glucose level with the reduction in blood glucose level at 2 h post dosing in the 1 mg/kg group, 3 mg/kg group, 10 mg/kg group, and 30 mg/kg group was 12, 15, 28, and 39%, respectively.

Animal Model:

4 weeks, Female KK-Ay mice^[1]
Dosage:

1.7, 8.4, 45.7 mg/kg in the 0.001, 0.005, and 0.025% sergliflozin etabonate
Administration:

Fed, daily for 9 weeks
Result:

Reduced non-fasting blood glucose level and decreased triglyceride content in the liver in a dose-dependent manner in diabetic control KK-Ay mice.

Chemical Information

CAS. Nr. 408504-26-7
Appearance Solid
Molecular Weight 448.46
Formel C₂₃H₂₈O₉
Color White to off-white
SMILES

COC(C=C1)=CC=C1CC(C=CC=C2)=C2O[C@@H]3O[C@@H]([C@H]([C@@H]([C@H]3O)O)O)COC(OCC)=O
Synonyms

GW-869682X
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

4°C, protect from light

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Lösungsmittel & Löslichkeit

In Vitro:

DMSO : ≥ 100 mg/mL (222.99 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

* "≥" means soluble, but saturation unknown.

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

2.2299 mL

11.1493 mL

22.2985 mL

5 mM

0.4460 mL

2.2299 mL

4.4597 mL

10 mM

0.2230 mL

1.1149 mL

2.2299 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

Stock Solution Working Solution

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline

Solubility: ≥ 5 mg/mL (11.15 mM); Clear solution

This protocol yields a clear solution of ≥ 5 mg/mL (saturation unknown).

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (50.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)

Solubility: ≥ 5 mg/mL (11.15 mM); Clear solution

This protocol yields a clear solution of ≥ 5 mg/mL (saturation unknown).

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (50.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

Protocol 3

Add each solvent one by one: 10% DMSO 90% Corn Oil

Solubility: ≥ 5 mg/mL (11.15 mM); Clear solution

This protocol yields a clear solution of ≥ 5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (50.0 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage Dosage
mg/kg
Animal Weight (Per Animal) Animal Weight (Per Animal)
g
Dosing Volume (Per Animal) Dosing Volume (Per Animal)
μL
Number of Animals Number of Animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

%
DMSO +

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
%
+
+
%
Tween-80 + +
%
Saline +

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Working solution concentration: 0.22 mg/mL

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (276 KB)
SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Katsuno K, et al. Long-term treatment with sergliflozin etabonate improves disturbed glucose metabolism in KK-A(y) mice. Eur J Pharmacol. 2009 Sep 15;618(1-3):98-104. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	2.2299 mL	11.1493 mL	22.2985 mL	55.7463 mL
	5 mM	0.4460 mL	2.2299 mL	4.4597 mL	11.1493 mL
	10 mM	0.2230 mL	1.1149 mL	2.2299 mL	5.5746 mL
	15 mM	0.1487 mL	0.7433 mL	1.4866 mL	3.7164 mL
	20 mM	0.1115 mL	0.5575 mL	1.1149 mL	2.7873 mL
	25 mM	0.0892 mL	0.4460 mL	0.8919 mL	2.2299 mL
	30 mM	0.0743 mL	0.3716 mL	0.7433 mL	1.8582 mL
	40 mM	0.0557 mL	0.2787 mL	0.5575 mL	1.3937 mL
	50 mM	0.0446 mL	0.2230 mL	0.4460 mL	1.1149 mL
	60 mM	0.0372 mL	0.1858 mL	0.3716 mL	0.9291 mL
	80 mM	0.0279 mL	0.1394 mL	0.2787 mL	0.6968 mL
	100 mM	0.0223 mL	0.1115 mL	0.2230 mL	0.5575 mL

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Sergliflozin etabonate

Empagliflozin

Canagliflozin

Dapagliflozin

Sotagliflozin

Empagliflozin (Standard)

Ipragliflozin

Mizagliflozin

Ertugliflozin

Canagliflozin hemihydrate

Dapagliflozin ((2S)-1,2-propanediol, hydrate)

Tofogliflozin

Velagliflozin

Alle SGLT Isoform-spezifische Produkte anzeigen

Biologische Aktivität

Chemical Information

Lösungsmittel & Löslichkeit

Reinheit & Dokumentation

Verweise

Help & FAQs

Complete Stock Solution Preparation Table

Bioz

Sergliflozin etabonate

Empagliflozin

Canagliflozin

Dapagliflozin

Sotagliflozin

Empagliflozin (Standard)

Ipragliflozin

Mizagliflozin

Ertugliflozin

Canagliflozin hemihydrate

Dapagliflozin ((2S)-1,2-propanediol, hydrate)

Tofogliflozin

Velagliflozin

Alle SGLT Isoform-spezifische Produkte anzeigen

Biologische Aktivität

Chemical Information

Lösungsmittel & Löslichkeit

Reinheit & Dokumentation

Verweise

Help & FAQs

Complete Stock Solution Preparation Table

Sergliflozin etabonate Related Classifications

HY-12611 Related Classifications

Bioz