1. Membrane Transporter/Ion Channel
  2. SGLT
  3. T-1095

T-1095 

Cat. No.: HY-106158
Handling Instructions

T-1095 is a selective and orally active Na+-glucose cotransporter (SGLT) inhibitor with IC50s of 22.8 µM and 2.3 µM for human SGLT1 and SGLT2, respectively. T-1095 can be used for diabetes research.

For research use only. We do not sell to patients.

T-1095 Chemical Structure

T-1095 Chemical Structure

CAS No. : 209746-59-8

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Description

T-1095 is a selective and orally active Na+-glucose cotransporter (SGLT) inhibitor with IC50s of 22.8 µM and 2.3 µM for human SGLT1 and SGLT2, respectively. T-1095 can be used for diabetes research[1].

IC50 & Target[1]

hSGLT1

22.8 μM (IC50)

hSGLT2

2.3 μM (IC50)

In Vivo

T-1095 is absorbed into the circulation via oral administration, is metabolized to the active form, T-1095A, and suppresses the activity of SGLTs in the kidney[1].
Orally administered T-1095 (3-30 mg/kg) increases urinary glucose excretion in diabetic animals, thereby decreasing blood glucose levels[1].
With long-term T-1095 (0.01% or 0.1% T-1095 mixed diet; for 28 days) treatment, both blood glucose and HbA1c levels were reduced in streptozotocin (STZ)-induced diabetic rats and yellow KK mice. In addition, there was amelioration of abnormal carbohydrate metabolism, i.e., hyperinsulinemia and hypertriglyceridemia, and of the development of microalbuminuria, in yellow KK mice[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

516.49

Formula

C26H28O11

CAS No.
SMILES

O=C(C(C(O)=C1)=C(C=C1C)O[[email protected]@H]([[email protected]@H]([[email protected]]2O)O)O[[email protected]@H]([[email protected]]2O)COC(OC)=O)CCC3=CC=C4C(C=CO4)=C3

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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T-1095
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