CLIC1 Antibody (YA2807)
(Synonyms: Chloride intracellular channel protein 1; Chloride channel ABP; Nuclear chloride ion channel 27; NCC27; Regulatory nuclear chloride ion channel protein; hRNCC)
Based on 1 Customer Validation
CLIC1 Antibody (YA2807) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to CLIC1.
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Host:
Rabbit
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Isotype:
IgG
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Application:
WB, ICC/IF, FC, IP
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Reactivity :
Human, Mouse, Rat
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Formulation:
Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA
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Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
WB
WB: Western Blot
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ICC/IF
ICC/IF: Immunocytochemistry/
Immunofluorescence |
FC
FC: Flow Cytometry
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IP
IP: Immunoprecipitation
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|---|---|---|---|---|
| Dilution Ratio | 1:500-1:1000 | 1:100 | 1:200-1:500 | 1:20-1:50 |
Product Details
CLIC1 Antibody (YA2807) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to CLIC1.
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Host Rabbit
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Clonality Recombinant,Monoclonal
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Species ReactivityHuman, Mouse, Rat
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Observed Molecular WeightObserved band size: 27 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
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Calculated Molecular Weight Predicted band size: 27 kDa
Entrez Gene: 1192 Human ; 114584 Mouse ; 406864 Rat
SwissProt: O00299 Human ; Q9Z1Q5 Mouse ; Q6MG61 Rat
OMIM: 602872 Human
Recombinant protein of human CLIC1
Endogenous
Affinity Purified
Non-conjugated
Unmodified
IgG
Product Properties
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Appearance
Liquid
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Formulation
Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA
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Concentration
Batch-dependent, Please check the COA for the concentration of each lot. Check Lot Concentration
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
CLIC1 is an In the soluble state, catalyzes glutaredoxin-like thiol disulfide exchange reactions with reduced glutathione as electron donor. Reduces selenite and dehydroascorbate and may act as an antioxidant during oxidative stress response. Can insert into membranes and form voltage-dependent multi-ion conductive channels. Membrane insertion seems to be redox-regulated and may occur only under oxidizing conditions. Involved in regulation of the cell cycle[1][2].
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Subcellular Localization
Nucleus; Nucleus membrane; Single-pass membrane protein; Cytoplasm; Cell membrane; Single-pass membrane protein; Endoplasmic reticulum
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Expression
Tissue_specificity:Expression is prominent in heart, placenta, liver, kidney and pancreas -
Subunit
Monomer. Homodimer (in vitro). Interacts with TRAPPC2. Dimerization requires a conformation change that leads to the exposure of a large hydrophobic surface. In vivo, this may lead to membrane insertion. Interacts with AKAP9
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SwissProt ID
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Synonyms
Chloride intracellular channel protein 1; Chloride channel ABP; Nuclear chloride ion channel 27; NCC27; Regulatory nuclear chloride ion channel protein; hRNCC
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Research Field
Signal Transduction
Documentation
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