CLIC1 - chloride intracellular channel 1 Gene

Also Known as G6; CL1C1; NCC27; CLCNL1

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 1192

About CLIC1

Cytogenetic location: 6p21.33 Genomic coordinates (GRCh38): 6:31,730,581-31,737,318 (from NCBI)

This gene has 5 transcripts (splice variants), 1 gene allele, 249 orthologues and 14 paralogues. Ubiquitous expression in placenta (RPKM 110.8), bone marrow (RPKM 106.5) and 25 other tissues.

Summary

Chloride channels are a diverse group of proteins that regulate fundamental cellular processes including stabilization of cell membrane potential, transepithelial transport, maintenance of intracellular pH, and regulation of cell volume. Chloride intracellular channel 1 is a member of the p64 family; the protein localizes principally to the cell nucleus and exhibits both nuclear and plasma membrane chloride ion channel activity. [provided by RefSeq, Jul 2008]

CLIC1 Products (3)

mRNA Protein Name
NM_001287593.1 NP_001274522.1 chloride intracellular channel protein 1
NM_001287594.3 NP_001274523.1 chloride intracellular channel protein 1
NM_001288.6 NP_001279.2 chloride intracellular channel protein 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables chloride channel activity IDA
IDA: Inferred from direct assay
9139710 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
12163479 GOA
Biological Process GO Annotation Evidence References Source
acts upstream of or within chloride transport IDA
IDA: Inferred from direct assay
9139710 GOA
Cellular Component GO Annotation Evidence References Source
located in cytoplasm IDA
IDA: Inferred from direct assay
10793131 GOA
located in extracellular exosome IDA
IDA: Inferred from direct assay
15326289 GOA
located in nuclear envelope IDA
IDA: Inferred from direct assay
9139710 GOA
located in perinuclear region of cytoplasm IDA
IDA: Inferred from direct assay
12681486 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CLIC1 Protein Structure

GST_N_3

GST_N_3: Glutathione S-transferase, N-terminal domain (24 - 86)

GST_C_2

GST_C_2: Glutathione S-transferase, C-terminal domain (127 - 210)

  • 0
  • 100
  • 200
  • 241 a.a.
Protein Preferred Names Protein Names

chloride intracellular channel protein 1

  • RNCC protein

CLIC1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
CLIC1 O00299 TPRN Homo sapiens Q4KMQ1-2
Anti Tag CoIP
28514442
Intra
CLIC1 O00299 TPRN Homo sapiens Q4KMQ1-2
Validated Y2H
32296183
Intra
CLIC1 O00299 TPRN Homo sapiens Q4KMQ1-2
Y2H Array
32296183
Intra
CLIC1 O00299 TPRN Homo sapiens Q4KMQ1-2
Y2H Prey Pooling
32296183
Intra
CLIC1 O00299 MEOX2 Homo sapiens Q6FHY5
Validated Y2H
32296183
Intra
CLIC1 O00299 MEOX2 Homo sapiens Q6FHY5
Y2H Array
32296183
Intra
CLIC1 O00299 MEOX2 Homo sapiens Q6FHY5
Y2H Prey Pooling
32296183
Intra
CLIC1 O00299 NHSL2 Homo sapiens Q5HYW2
Validated Y2H
32296183
Intra
CLIC1 O00299 LSM1 Homo sapiens O15116
Validated Y2H
32296183
Intra
CLIC1 O00299 LSM1 Homo sapiens O15116
Y2H Array
32296183
Intra
CLIC1 O00299 LSM1 Homo sapiens O15116
Y2H
14667819
Intra
CLIC1 O00299 LSM1 Homo sapiens O15116
Y2H Prey Pooling
32296183
Intra
CLIC1 O00299 PSMD10 Homo sapiens O75832
Anti Tag CoIP
24338975
Intra
CLIC1 O00299 PSMD10 Homo sapiens O75832
Pull Down
24338975
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant CLIC1 Proteins

Cat. No. Product Name Accession Purity
HY-P7840A CLIC1 Protein, Human (N-His) O00299 (A2-K241) ≥ 90%, as determined by reducing SDS-PAGE.

CLIC1 Antibodies

Cat. No. Product Name Application Reactivity
HY-P83062 CLIC1 Antibody (YA2807) WB, ICC/IF, FC, IP Human, Mouse, Rat
HY-P83062A CLIC1 Antibody (YA2807)(PBS only) WB, ICC/IF, FC, IP Human, Mouse, Rat

Related Diseases

Diseases Alias
Intrahepatic Gall Duct Cancer

  • Malignant Neoplasm Of Intrahepatic Bile Ducts

  • Malignant Neoplasm Of Intrahepatic Gall Duct

  • Ca Intrahepatic Bile Ducts

  • Malignant Neoplasm Of Intrahepatic Biliary Passages

  • Intrahepatic Bile Duct Carcinoma
Colorectal Cancer

  • Colon Cancer

  • Colorectal Carcinoma

  • Colon Carcinoma

  • Colorectal Cancer, Susceptibility To

  • Carcinoma Of Colon

  • CRC

  • Colorectal Cancer With Chromosomal Instability, Somatic

  • Colon Cancer, Somatic

  • Colon Cancer, Susceptibility To

  • Colonic Neoplasms

  • Colorectal Neoplasms

  • Colorectal Cancer, Somatic

  • Colon Cancer, Advanced, Somatic

  • Colonic Carcinoma

  • Colorectal Carcinomas

  • Colon Cancers

  • Colorectal Cancers

  • Cancer, Colorectal, Somatic

  • Cancer, Colon

  • Cancer, Colorectal, Susceptibility To

  • Colorectal Neoplasm

  • Colonic Neoplasm

  • Malignant Tumor Of Colon
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-12693A (Rac)-Methylindazone Inhibitor / Unkown
HY-RS02803 CLIC1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19667 Clic1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26160 Clic1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus CLIC1 MGD MGI:2148924
Rattus norvegicus CLIC1 RGD RGD:1303043
Bos taurus CLIC1 VGNC VGNC:27439
Felis catus CLIC1 VGNC VGNC:60959
Others CLIC1 NCBI