Janagliflozin
Janagliflozin is orally active and highly selective sodium-glucose cotransporter 2 (SGLT2) inhibitor (IC50=0.0058 μM for SGLT2 and 4.802 μM for SGLT1). Janagliflozin inhibits SGLT2 in the proximal renal tubules, reducing glucose reabsorption and promoting urinary glucose excretion (UGE) to lower blood glucose levels. Janagliflozin is promising for research of type 2 diabetes mellitus.
For research use only. We do not sell to patients.
- CAS No.: 1800115-22-3
- Formula: C25H29ClO6
- Molecular Weight:460.95
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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SGLT1 4.802 μM (IC50) |
SGLT2 0.0058 μM (IC50) |
| NCT Number | Sponsor | Condition | Start Date |
Phase
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|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Chemical Information
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CAS No. 1800115-22-3
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Molecular Weight 460.95
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Formula C25H29ClO6
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SMILES
[H][C@](C1)(C2)[C@@]1([H])C[C@H]2OC3=CC=C(C=C3)CC4=CC([C@@H]5O[C@@H]([C@H]([C@@H]([C@H]5O)O)O)CO)=CC=C4Cl
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Song L, et al. A Model-Informed Approach to Accelerate the Clinical Development of Janagliflozin, an Innovative SGLT2 Inhibitor. Clin Pharmacokinet. 2023 Mar;62(3):505-518. [Content Brief]
[2]. Zhao H, et al. Prediction of janagliflozin pharmacokinetics in type 2 diabetes mellitus patients with liver cirrhosis or renal impairment using a physiologically based pharmacokinetic model. Eur J Pharm Sci. 2022 Dec 1;179:106298. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Janagliflozin Related Classifications
HY-178734 Related Classifications
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