1. Membrane Transporter/Ion Channel
  2. SGLT
  3. Ertugliflozin

Ertugliflozin (Synonyms: PF-04971729)

Cat. No.: HY-15461 Purity: 99.64%
Handling Instructions

Ertugliflozin (PF-04971729) is a potent, selective and orally active inhibitor of the sodium-dependent glucose cotransporter 2 (SGLT2), with an IC50 of 0.877 nM for h-SGLT2. Has the potential for the treatment of type 2 diabetes mellitus.

For research use only. We do not sell to patients.

Ertugliflozin Chemical Structure

Ertugliflozin Chemical Structure

CAS No. : 1210344-57-2

Size Price Stock Quantity
Free Sample (0.5-1 mg)   Apply Now  
Solution
10 mM * 1 mL in DMSO USD 61 In-stock
Estimated Time of Arrival: December 31
Solid + Solvent
10 mM * 1 mL
ready for reconstitution
USD 61 In-stock
Estimated Time of Arrival: December 31
Solid
5 mg USD 55 In-stock
Estimated Time of Arrival: December 31
10 mg USD 77 In-stock
Estimated Time of Arrival: December 31
50 mg USD 132 In-stock
Estimated Time of Arrival: December 31
100 mg   Get quote  
200 mg   Get quote  

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Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of Ertugliflozin:

Top Publications Citing Use of Products

1 Publications Citing Use of MCE Ertugliflozin

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Ertugliflozin (PF-04971729) is a potent, selective and orally active inhibitor of the sodium-dependent glucose cotransporter 2 (SGLT2), with an IC50 of 0.877 nM for h-SGLT2[1]. Has the potential for the treatment of type 2 diabetes mellitus[2].

IC50 & Target

IC50: 0.877 nM (h-SGLT2)[1].

In Vitro

Ertugliflozin (PF-04971729) demonstrates >2000-fold selectivity for SGLT2 inhibition (relative to SGLT1) in vitro[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Ertugliflozin (PF-04971729) reveals a concentration-dependent glucosuria after oral administration to rats[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Clinical Trial
Molecular Weight

436.88

Formula

C22H25ClO7

CAS No.
SMILES

ClC1=CC=C([[email protected]]23O[[email protected]@](CO)(CO3)[[email protected]@H](O)[[email protected]](O)[[email protected]]2O)C=C1CC4=CC=C(OCC)C=C4

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 250 mg/mL (572.24 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.2890 mL 11.4448 mL 22.8896 mL
5 mM 0.4578 mL 2.2890 mL 4.5779 mL
10 mM 0.2289 mL 1.1445 mL 2.2890 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.08 mg/mL (4.76 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.08 mg/mL (4.76 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.08 mg/mL (4.76 mM); Clear solution

*All of the co-solvents are available by MCE.
Purity & Documentation

Purity: 99.64%

References
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Product Name:
Ertugliflozin
Cat. No.:
HY-15461
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