1. Membrane Transporter/Ion Channel
  2. SGLT
  3. Ertugliflozin

Ertugliflozin (Synonyms: PF-04971729)

Cat. No.: HY-15461 Purity: 99.80%
Handling Instructions

Ertugliflozin (PF-04971729) is a potent, selective and orally active inhibitor of the sodium-dependent glucose cotransporter 2 (SGLT2), with an IC50 of 0.877 nM for h-SGLT2. A drug for the treatment of type 2 diabetes mellitus.

For research use only. We do not sell to patients.

Ertugliflozin Chemical Structure

Ertugliflozin Chemical Structure

CAS No. : 1210344-57-2

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10 mM * 1 mL in DMSO USD 55 In-stock
Estimated Time of Arrival: December 31
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Based on 1 publication(s) in Google Scholar

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Description

Ertugliflozin (PF-04971729) is a potent, selective and orally active inhibitor of the sodium-dependent glucose cotransporter 2 (SGLT2), with an IC50 of 0.877 nM for h-SGLT2[1]. A drug for the treatment of type 2 diabetes mellitus[2].

IC50 & Target

IC50: 0.877 nM (h-SGLT2)[1].

In Vitro

Ertugliflozin (PF-04971729) demonstrates >2000-fold selectivity for SGLT2 inhibition (relative to SGLT1) in vitro[3].

In Vivo

Ertugliflozin (PF-04971729) reveals a concentration-dependent glucosuria after oral administration to rats[3].

Clinical Trial
Molecular Weight

436.88

Formula

C₂₂H₂₅ClO₇

CAS No.

1210344-57-2

SMILES

ClC1=CC=C([[email protected]]23O[[email protected]@](CO)(CO3)[[email protected]@H](O)[[email protected]](O)[[email protected]]2O)C=C1CC4=CC=C(OCC)C=C4

Shipping

Room temperature in continental US; may vary elsewhere

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 46 mg/mL (105.29 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.2890 mL 11.4448 mL 22.8896 mL
5 mM 0.4578 mL 2.2890 mL 4.5779 mL
10 mM 0.2289 mL 1.1445 mL 2.2890 mL
*Please refer to the solubility information to select the appropriate solvent.
References

Purity: 99.80%

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Ertugliflozin
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