2. Membrane Transporter/Ion Channel
  3. SGLT
  4. Ertugliflozin L-pyroglutamic acid

Ertugliflozin L-pyroglutamic acid  (Synonyms: PF-04971729 L-pyroglutamic acid)

Cat. No.: HY-15461A Purity: 99.77%
COA Handling Instructions

Ertugliflozin L-pyroglutamic acid (PF-04971729 L-pyroglutamic acid) is a potent, selective and orally active inhibitor of the sodium-dependent glucose cotransporter 2 (SGLT2), with an IC50 of 0.877 nM for h-SGLT2. Has the potential for the treatment of type 2 diabetes mellitus.

For research use only. We do not sell to patients.

Ertugliflozin L-pyroglutamic acid Chemical Structure

Ertugliflozin L-pyroglutamic acid Chemical Structure

CAS No. : 1210344-83-4

Size Price Stock Quantity
Solution
10 mM * 1 mL in DMSO USD 62 In-stock
Solid + Solvent
10 mM * 1 mL
ready for reconstitution
 USD 62 In-stock
Solid
5 mg USD 50 In-stock
10 mg USD 70 In-stock
50 mg USD 120 In-stock
100 mg   Get quote  
200 mg   Get quote  

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Based on 1 publication(s) in Google Scholar

Other Forms of Ertugliflozin L-pyroglutamic acid:

Top Publications Citing Use of Products

1 Publications Citing Use of MCE Ertugliflozin L-pyroglutamic acid

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Ertugliflozin L-pyroglutamic acid (PF-04971729 L-pyroglutamic acid) is a potent, selective and orally active inhibitor of the sodium-dependent glucose cotransporter 2 (SGLT2), with an IC50 of 0.877 nM for h-SGLT2[1]. Has the potential for the treatment of type 2 diabetes mellitus[2].

IC50 & Target

SGLT2

 

In Vitro

Ertugliflozin L-pyroglutamic acid (PF-04971729 L-pyroglutamic acid) demonstrates >2000-fold selectivity for SGLT2 inhibition (relative to SGLT1) in vitro[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo

Ertugliflozin L-pyroglutamic acid (PF-04971729 L-pyroglutamic acid) reveals a concentration-dependent glucosuria after oral administration to rats[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Clinical Trial
Molecular Weight

566.00

Appearance

Solid

Formula

C27H32ClNO10
CAS No.
SMILES

ClC1=CC=C([[email protected]]23O[[email protected]@](CO)(CO3)[[email protected]@H](O)[[email protected]](O)[[email protected]]2O)C=C1CC4=CC=C(OCC)C=C4.O=C5CC[[email protected]@H](C(O)=O)N5
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 125 mg/mL (220.85 mM)

H2O : 5 mg/mL (8.83 mM; ultrasonic and warming and heat to 60°C)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.7668 mL 8.8339 mL 17.6678 mL
5 mM 0.3534 mL 1.7668 mL 3.5336 mL
10 mM 0.1767 mL 0.8834 mL 1.7668 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.08 mg/mL (3.67 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.08 mg/mL (3.67 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.08 mg/mL (3.67 mM); Clear solution

*All of the co-solvents are available by MCE.
Purity & Documentation
References
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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  • Dilution Calculator

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The dilution calculator equation

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This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

Ertugliflozin L-pyroglutamic acid1210344-83-4PF-04971729 L-pyroglutamic acidSGLTSodium-dependent glucose cotransportersInhibitorinhibitorinhibit

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