1. Membrane Transporter/Ion Channel
  2. SGLT

Ertugliflozin L-pyroglutamic acid (Synonyms: PF-04971729 L-pyroglutamic acid)

Cat. No.: HY-15461A Purity: 99.98%
Handling Instructions

Ertugliflozin (PF-04971729) L-pyroglutamic acid is a potent, selective and orally active inhibitor of the sodium-dependent glucose cotransporter 2 (SGLT2), with an IC50 of 0.877 nM for h-SGLT2. A drug for the treatment of type 2 diabetes mellitus.

For research use only. We do not sell to patients.

Ertugliflozin L-pyroglutamic acid Chemical Structure

Ertugliflozin L-pyroglutamic acid Chemical Structure

CAS No. : 1210344-83-4

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 247 In-stock
Estimated Time of Arrival: December 31
5 mg USD 198 In-stock
Estimated Time of Arrival: December 31
10 mg USD 264 In-stock
Estimated Time of Arrival: December 31
50 mg USD 792 In-stock
Estimated Time of Arrival: December 31
100 mg   Get quote  
200 mg   Get quote  

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Other Forms of Ertugliflozin L-pyroglutamic acid:

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Description

Ertugliflozin (PF-04971729) L-pyroglutamic acid is a potent, selective and orally active inhibitor of the sodium-dependent glucose cotransporter 2 (SGLT2), with an IC50 of 0.877 nM for h-SGLT2[1]. A drug for the treatment of type 2 diabetes mellitus[2].

IC50 & Target

IC50: 0.877 nM (h-SGLT2)[1].

In Vitro

Ertugliflozin (PF-04971729) demonstrates >2000-fold selectivity for SGLT2 inhibition (relative to SGLT1) in vitro[3].

In Vivo

Ertugliflozin (PF-04971729) reveals a concentration-dependent glucosuria after oral administration to rats[3].

Solvent & Solubility
In Vitro: 

DMSO : ≥ 125 mg/mL (220.85 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.7668 mL 8.8339 mL 17.6678 mL
5 mM 0.3534 mL 1.7668 mL 3.5336 mL
10 mM 0.1767 mL 0.8834 mL 1.7668 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.08 mg/mL (3.67 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.08 mg/mL (3.67 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.08 mg/mL (3.67 mM); Clear solution

References
Molecular Weight

566.00

Formula

C₂₇H₃₂ClNO₁₀

CAS No.

1210344-83-4

SMILES

ClC1=CC=C([[email protected]]23O[[email protected]@](CO)(CO3)[[email protected]@H](O)[[email protected]](O)[[email protected]]2O)C=C1CC4=CC=C(OCC)C=C4.O=C5CC[[email protected]@H](C(O)=O)N5

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Shipping

Room temperature in continental US; may vary elsewhere

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Product Name:
Ertugliflozin L-pyroglutamic acid
Cat. No.:
HY-15461A
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Ertugliflozin L-pyroglutamic acid

Cat. No.: HY-15461A