WAY-123783
WAY-123783 is a potent, selective and orally active sodium-dependent glucose cotransporter 2 (SGLT2) inhibitor producing activity after metabolism. WAY-123783 can increase the excretion of sugar in urine and at the same time lower the blood sugar level in db/db mice (ED50 = 9.85 mg/kg). WAY-123783 can be used for the research of metabolic disease, such as diabetes.
For research use only. We do not sell to patients.
- CAS No.: 152595-59-0
- Formula: C12H11F3N2OS
- Molecular Weight:288.29
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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SGLT2 |
Chemical Information
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CAS No. 152595-59-0
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Molecular Weight 288.29
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Formula C12H11F3N2OS
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SMILES
O=C1NNC(C(F)(F)F)=C1CC2=CC=C(C=C2)SC
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Ohsumi K, Matsueda H, Hatanaka T, Hirama R, Umemura T, Oonuki A, Ishida N, Kageyama Y, Maezono K, Kondo N. Pyrazole-O-glucosides as novel Na(+)-glucose cotransporter (SGLT) inhibitors. Bioorg Med Chem Lett. 2003 Jul 21;13(14):2269-72. [Content Brief]
[2]. Kees KL, et al. New potent antihyperglycemic agents in db/db mice: synthesis and structure-activity relationship studies of (4-substituted benzyl) (trifluoromethyl)pyrazoles and -pyrazolones. J Med Chem. 1996 Sep 27;39(20):3920-8. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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