152595-59-0
Chemical Structure
WAY-123783
- CAS No.: 152595-59-0
- Formula:C12H11F3N2OS
- Molecular Weight:288.29
IUPAC Name: 4-(4-(methylthio)benzyl)-5-(trifluoromethyl)-1,2-dihydro-3H-pyrazol-3-one
InChIKey: OSDLDYCKEYCPPZ-UHFFFAOYSA-N
SMILES: O=C1NNC(C(F)(F)F)=C1CC2=CC=C(C=C2)SC
Biological Activity: WAY-123783 is a potent, selective and orally active sodium-dependent glucose cotransporter 2 (SGLT2) inhibitor producing activity after metabolism. WAY-123783 can increase the excretion of sugar in urine and at the same time lower the blood sugar level in db/db mice (ED50 = 9.85 mg/kg). WAY-123783 can be used for the research of metabolic disease, such as diabetes[1][2].
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WAY-123783 | WAY-123783 is a potent, selective and orally active sodium-dependent glucose cotransporter 2 (SGLT2) inhibitor producing activity after metabolism. WAY-123783 can increase the excretion of sugar in urine and at the same time lower the blood sugar level in db/db mice (ED50 = 9.85 mg/kg). WAY-123783 can be used for the research of metabolic disease, such as diabetes. | |||||||||||||||||||||
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- [1]. Ohsumi K, Matsueda H, Hatanaka T, Hirama R, Umemura T, Oonuki A, Ishida N, Kageyama Y, Maezono K, Kondo N. Pyrazole-O-glucosides as novel Na(+)-glucose cotransporter (SGLT) inhibitors. Bioorg Med Chem Lett. 2003 Jul 21;13(14):2269-72. [Content Brief]
- [2]. Kees KL, et al. New potent antihyperglycemic agents in db/db mice: synthesis and structure-activity relationship studies of (4-substituted benzyl) (trifluoromethyl)pyrazoles and -pyrazolones. J Med Chem. 1996 Sep 27;39(20):3920-8. [Content Brief]
Keywords
