Dealanylascamycin
Dealanylascamycin (AT-265) (Compound 2) is a nucleoside antibiotic. AT 265 is a carbonic anhydrase (CA) inhibitor, with Ki values of 167, 65.2, 234, and 143 nM for hCA I, hCA II, hCA IV, and hCA IX respectively. Dealanylascamycin is the active form of Ascamycin (HY-121071). Dealanylascamycin exhibits broad-spectrum antibacterial activity and is effective against pathogenic bacteria such as Xanthomonas citri (MIC = 0.4 μg/mL). Dealanylascamycin has high cytotoxicity.
연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.
- CAS No.: 66522-52-9
- 화학식: C10H13ClN6O6S
- 분자량:380.76
-
보관:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
- 순도&문서
- References
-
Help & FAQs
All Antibiotic Isoforms
More
Biological Activity
제품 설명
IC50 & Target
[1]|
hCA I 167 nM (Ki) |
hCA II 65.2 nM (Ki) |
hCA IX 143 nM (Ki) |
Cellular Effect
|
Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| HEK293 | CC50 |
<0.15 μM
Compound: 2
|
Cytotoxicity against HEK293 cells
Cytotoxicity against HEK293 cells
|
[PMID: 29685656] |
Chemical Information
-
CAS No. 66522-52-9
-
분자량 380.76
-
화학식 C10H13ClN6O6S
-
SMILES
O[C@H]1[C@@H](O)[C@H](N2C3=NC(Cl)=NC(N)=C3N=C2)O[C@@H]1COS(N)(=O)=O
-
Synonyms
AT-265
-
선적
Room temperature in continental US; may vary elsewhere.
-
보관
Please store the product under the recommended conditions in the Certificate of Analysis.
순도&문서
References
[1]. Mujumdar P, et al. Synthesis, structure and bioactivity of primary sulfamate-containing natural products. Bioorg Med Chem Lett. 2018 Sep 15;28(17):3009-3013. [Content Brief]
[2]. Isono K, et al. Ascamycin and dealanylascamycin, nucleoside antibiotics from Streptomyces sp. J Antibiot (Tokyo). 1984 Jun;37(6):670-2. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Dealanylascamycin Related Classifications
HY-101136 Related Classifications
Powered by Bioz