Dealanylascamycin
Dealanylascamycin (AT-265) (Compound 2) is a nucleoside antibiotic. AT 265 is a carbonic anhydrase (CA) inhibitor, with Ki values of 167, 65.2, 234, and 143 nM for hCA I, hCA II, hCA IV, and hCA IX respectively. Dealanylascamycin is the active form of Ascamycin (HY-121071). Dealanylascamycin exhibits broad-spectrum antibacterial activity and is effective against pathogenic bacteria such as Xanthomonas citri (MIC = 0.4 μg/mL). Dealanylascamycin has high cytotoxicity.
For research use only. We do not sell to patients.
- CAS No.: 66522-52-9
- Formula: C10H13ClN6O6S
- Molecular Weight:380.76
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
All Antibiotic Isoforms
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Biological Activity
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hCA I 167 nM (Ki) |
hCA II 65.2 nM (Ki) |
hCA IX 143 nM (Ki) |
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HEK293 | CC50 |
<0.15 μM
Compound: 2
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Cytotoxicity against HEK293 cells
Cytotoxicity against HEK293 cells
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[PMID: 29685656] |
Chemical Information
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CAS No. 66522-52-9
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Molecular Weight 380.76
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Formula C10H13ClN6O6S
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SMILES
O[C@H]1[C@@H](O)[C@H](N2C3=NC(Cl)=NC(N)=C3N=C2)O[C@@H]1COS(N)(=O)=O
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Synonyms
AT-265
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Mujumdar P, et al. Synthesis, structure and bioactivity of primary sulfamate-containing natural products. Bioorg Med Chem Lett. 2018 Sep 15;28(17):3009-3013. [Content Brief]
[2]. Isono K, et al. Ascamycin and dealanylascamycin, nucleoside antibiotics from Streptomyces sp. J Antibiot (Tokyo). 1984 Jun;37(6):670-2. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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