SLC4A4 Antibody (YA8931)
(Synonyms: NBC, NBC1, NBCE1, SLC4A4, Electrogenic sodium bicarbonate cotransporter 1, Sodium bicarbonate cotransporter, Na(+)/HCO3(-) cotransporter, Solute carrier family 4 member 4, kNBC1)
Based on 1 Customer Validation
SLC4A4 Antibody (YA8931) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to SLC4A4.
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Host:
Mouse
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Isotype:
IgG
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Application:
WB, ICC/IF, IF-Tissue, IHC-P, IP, ELISA
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Reactivity :
human, mouse, rat
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Formulation:
Supplied in PBS(pH7.4) containing 0.1% gelatin and < 0.1% sodium azide.
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Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
WB
WB: Western Blot
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ICC/IF
ICC/IF: Immunocytochemistry/
Immunofluorescence |
IF-Tissue
IF-Tissue: Immunofluorescence-Tissue
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IHC-P
IHC-P: Immunohistochemistry-Paraffin
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IP
IP: Immunoprecipitation
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ELISA
ELISA: Enzyme Linked Immunosorbent Assay
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|---|---|---|---|---|---|---|
| Dilution Ratio | 1:100-1000 | 1:50-500 | 1:50-500 | 1:100-500 | 1-2μg per 100-500μg Total protein | 1:30-3000 |
Product Details
SLC4A4 Antibody (YA8931) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to SLC4A4.
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Host Mouse
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Species Reactivityhuman, mouse, rat
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Calculated Molecular Weight Predicted band size: 116 kDa
OMIM: 604278
A synthesized peptide derived from human SLC4A4.
Endogenous
Affinity purified
Non-conjugated
Unmodified
IgG
Product Properties
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Appearance
Solution
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Formulation
Supplied in PBS(pH7.4) containing 0.1% gelatin and < 0.1% sodium azide.
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Concentration
Batch-dependent, Please check the COA for the concentration of each lot. Check Lot Concentration
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Storage & Stability
Stored at 2-8°C for 1 year, do not freeze.
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Shipping
Shipping with blue ice.
Background
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Function
SLC4A4 is an Electrogenic sodium/bicarbonate cotransporter with a Na(+):HCO3(-) stoichiometry varying from 1:2 to 1:3. May regulate bicarbonate influx/efflux at the basolateral membrane of cells and regulate intracellular pH
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Subcellular Localization
Basolateral cell membrane; Cell membrane
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Expression
Tissue_Specificity: Expressed in the corneal endothelium cells (at protein level). Expressed in pancreas and to a lower extent in heart, skeletal muscle, liver, parotid salivary glands, prostate, colon, stomach, thyroid, brain and spinal cord. -
Isoforms & Post-Translational Modification
SLC4A4 has 5 isoforms, Q9Y6R1-1: amino acid length is 1079, molecular weight is 121461 Da (predicted); Q9Y6R1-2: amino acid length is 1035, molecular weight is 116040 Da (predicted); Q9Y6R1-3: amino acid length is 646, molecular weight is 72049 Da (predicted); Q9Y6R1-4: amino acid length is 995, molecular weight is 112272 Da (predicted); Q9Y6R1-5: amino acid length is 1094, molecular weight is 123181 Da (predicted).
Phosphorylation of Ser-1026 by PKA increases the binding of CA2 and changes the Na(+):HCO3(-) stoichiometry of the transporter from 3:1 to 2:1. Phosphorylated in presence of STK39 and dephosphorylated in presence of PP1 phosphatase. -
Subunit
Homodimer.
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SwissProt ID
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Synonyms
NBC, NBC1, NBCE1, SLC4A4, Electrogenic sodium bicarbonate cotransporter 1, Sodium bicarbonate cotransporter, Na(+)/HCO3(-) cotransporter, Solute carrier family 4 member 4, kNBC1
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