1. Membrane Transporter/Ion Channel
  2. Potassium Channel
  3. KCC2 blocker 1

KCC2 blocker 1 

Cat. No.: HY-18172
Handling Instructions

KCC2 blocker 1 is an orally active and selective K+-Cl- cotransporter KCC2 blocker with an IC50 of 1 μM. KCC2 blocker 1 is a benzyl prolinate and has antiepileptic effect.

For research use only. We do not sell to patients.

KCC2 blocker 1 Chemical Structure

KCC2 blocker 1 Chemical Structure

CAS No. : 1228439-36-8

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Description

KCC2 blocker 1 is an orally active and selective K+-Cl- cotransporter KCC2 blocker with an IC50 of 1 μM. KCC2 blocker 1 is a benzyl prolinate and has antiepileptic effect[1].

IC50 & Target

IC50: 1 μM (KCC2)[1]

In Vitro

KCC2 blocker 1 (compound 13; 100 μM) inhibits NKCC1 with 35%.

In Vivo

KCC2 blocker 1 (compound 13; 1 mg/kg iv and 6 mg/kg po) has a t1/2 of 0.3 hours, a CL of 26 mL/min/kg, a C max of 457 ng/mL and a AUC of 726 ng•h/mL for male Wistar rats[1].

Animal Model: Male Wistar rats[1]
Dosage: 1 mg/kg or 6 mg/kg (Pharmacokinetic Analysis)
Administration: IV (1 mg/kg) and PO (6 mg/kg)
Result: Had a t1/2 of 0.3 hours, a CL of 26 mL/min/kg, a C max of 457 ng/mL and a AUC of 726 ng•h/mL.
Molecular Weight

415.50

Formula

C₂₂H₂₅NO₅S

CAS No.

1228439-36-8

SMILES

O=C(OCC1=CC=CC=C1)C2(CC3=CC=C(S(=O)(C)=O)C=C3)N(C(C)=O)CCC2

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

KCC2 blocker 1Potassium ChannelKcsAbenzylprolinateKCC2versusNKCC1ADMEantiepilepticInhibitorinhibitorinhibit

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KCC2 blocker 1
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HY-18172
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