SLC1542 Protein, Human (HEK293, GFP-Strep-His)
The SLC15A2 protein is a proton-coupled amino acid transporter that prefers dipeptides and transports oligopeptides containing 2 to 4 amino acids. The stoichiometric ratio of protons to peptides is 2:1 or 3:1, which helps the kidneys absorb dipeptides and tripeptides. SLC1542 Protein, Human (HEK293, GFP-Strep-His) is the recombinant human-derived SLC15A2 protein, expressed by HEK293 , with C-GFP-Strep-His tag.
- Species: Human
- Source: HEK293
-
Storage:Stored at -80°C for 1 year from date of receipt. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Technical Parameters
-
Product Properties
- Documentation
- Help & FAQs
Biological Activity
Description
The SLC15A2 protein is a proton-coupled amino acid transporter that prefers dipeptides and transports oligopeptides containing 2 to 4 amino acids. The stoichiometric ratio of protons to peptides is 2:1 or 3:1, which helps the kidneys absorb dipeptides and tripeptides. SLC1542 Protein, Human (HEK293, GFP-Strep-His) is the recombinant human-derived SLC15A2 protein, expressed by HEK293 , with C-GFP-Strep-His tag.
Background
SLC15A2 protein, a proton-coupled amino-acid transporter, demonstrates a preference for transporting oligopeptides containing 2 to 4 amino acids, with a notable affinity for dipeptides. Its transport activity involves a proton to peptide stoichiometry of 2:1 or 3:1, facilitating the absorption of circulating di- and tripeptides from the glomerular filtrate within the kidney. Beyond its role in peptide transport, SLC15A2 exhibits versatility by transporting various substances, including beta-lactam antibiotics like cefadroxil, other antiviral and anticancer drugs, the dipeptide-like aminopeptidase inhibitor bestatin, and carnosine. Notably, its involvement in innate immunity extends to promoting the detection of microbial pathogens by NOD-like receptors (NLRs), and it mediates the transport of bacterial peptidoglycans across cellular membranes, such as muramyl dipeptide (MDP), a ligand for NOD2, particularly in macrophages.
Technical Parameters
-
Species Human
-
Source HEK293
-
Tag C-His;C-Strep;C-GFP
-
Accession
Q16348 (N2-L729)
-
Gene ID6565
-
Molecular Construction
-
N-term
-
SLC15A2 (N2-L729)
Accession # Q16348 -
GFP-Strep-His
-
C-term
-
-
Protein Length
Full Length
-
Synonyms
SLC15A2; Solute Carrier Family 15 (Oligopeptide Transporter), Member 2; Solute Carrier Family 15 Member 2; Solute Carrier Family 15 (H+/Peptide Transporter), Member 2; PEPT2; Oligopeptide Transporter, Kidney Isoform; Kidney H(+)/Peptide Cotransporter; SLC
-
AA Sequence
NPFQKNESKETLFSPVSIEEVPPRPPSPPKKPSPTICGSNYPLSIAFIVVNEFCERFSYYGMKAVLILYFLYFLHWNEDTSTSIYHAFSSLCYFTPILGAAIADSWLGKFKTIIYLSLVYVLGHVIKSLGALPILGGQVVHTVLSLIGLSLIALGTGGIKPCVAAFGGDQFEEKHAEERTRYFSVFYLSINAGSLISTFITPMLRGDVQCFGEDCYALAFGVPGLLMVIALVVFAMGSKIYNKPPPEGNIVAQVFKCIWFAISNRFKNRSGDIPKRQHWLDWAAEKYPKQLIMDVKALTRVLFLYIPLPMFWALLDQQGSRWTLQAIRMNRNLGFFVLQPDQMQVLNPLLVLIFIPLFDFVIYRLVSKCGINFSSLRKMAVGMILACLAFAVAAAVEIKINEMAPAQPGPQEVFLQVLNLADDEVKVTVVGNENNSLLIESIKSFQKTPHYSKLHLKTKSQDFHFHLKYHNLSLYTEHSVQEKNWYSLVIREDGNSISSMMVKDTESRTTNGMTTVRFVNTLHKDVNISLSTDTSLNVGEDYGVSAYRTVQRGEYPAVHCRTEDKNFSLNLGLLDFGAAYLFVITNNTNQGLQAWKIEDIPANKMSIAWQLPQYALVTAGEVMFSVTGLEFSYSQAPSSMKSVLQAAWLLTIAVGNIIVLVVAQFSGLVQWAEFILFSCLLLVICLIFSIMGYYYVPVKTEDMRGPADKHIPHIQGNMIKLETKKTKL
-
Predicted Molecular Mass
112.6 KDa
-
Purity
≥ 90%, as determined by reducing SDS-PAGE.
Product Properties
Solution
<1 EU/μg, determined by LAL method.
Please use rapid thawing with running water to thaw the protein.
Stored at -80°C for 1 year from date of receipt. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.
Shipping with dry ice
Documentation
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Powered by Bioz
