2. Immunology/Inflammation NF-κB Metabolic Enzyme/Protease Membrane Transporter/Ion Channel Neuronal Signaling
  3. Reactive Oxygen Species (ROS) GABA Receptor
  4. Anticonvulsant agent 11

Anticonvulsant agent 11 (Compound 8b) is an anticonvulsant agent. Anticonvulsant agent 11 exerts neuroprotective effects by enhancing cell viability and reducing ROS levels. Anticonvulsant agent 11 induces the expression of GABAA α1, resulting in neuronal hyperpolarization. Anticonvulsant agent 11 increases the number of neurite-bearing cells and the length of neurites. Anticonvulsant agent 11 exhibits dose-dependent anticonvulsant effects in mice. Anticonvulsant agent 11 can be used for the research of epilepsy.

For research use only. We do not sell to patients.

Anticonvulsant agent 11

Anticonvulsant agent 11 Chemical Structure

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Anticonvulsant agent 11 Related Antibodies

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Description

Anticonvulsant agent 11 (Compound 8b) is an anticonvulsant agent. Anticonvulsant agent 11 exerts neuroprotective effects by enhancing cell viability and reducing ROS levels. Anticonvulsant agent 11 induces the expression of GABAA α1, resulting in neuronal hyperpolarization. Anticonvulsant agent 11 increases the number of neurite-bearing cells and the length of neurites. Anticonvulsant agent 11 exhibits dose-dependent anticonvulsant effects in mice. Anticonvulsant agent 11 can be used for the research of epilepsy[1].

In Vitro

Anticonvulsant agent 11 (1-40 μM; 24 h) exerts no significant neurotoxicity on SHSY-5Y cells at concentrations up to 20 μM, but causes a decrease in cell viability at 40 μM[1].
Anticonvulsant agent 11 (1-50 μM; 24 h) does not induce significant neurotoxicity in Neuro2a cells at concentrations not exceeding 10 μM, but causes a decrease in cell viability at 50 μM[1].
Anticonvulsant agent 11 (5-10 μM; 24 h) increases the proportion of neurite-bearing cells and the length of neurites in Neuro2a cells, with the effects at the concentration of 10 μM being significant compared with NGF treatment[1].
Anticonvulsant agent 11 (1-10 μM; 24 h) protects SHSY-5Y cells against PTZ-induced neurotoxicity by enhancing cell viability[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Anticonvulsant agent 11 Related Antibodies

Cell Viability Assay[1]

Cell Line: SHSY-5Y
Concentration: 1-10 μM
Incubation Time: 24 h
Result: Substantially increased cell viability in PTZ-exposed cells compared with PTZ alone-treated cells at 1, 5, and 10 μM.
Induced better cell viability (86.69%) compared to diazepam (75.79%).
In Vivo

Compound 8b (1-4 mg/kg; i.p.; single dose) exhibits a dose-dependent anticonvulsant effect in the PTZ-induced acute seizure mouse model, significantly delaying seizure onset, reducing seizure duration, frequency, and severity[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Swiss albino mice (either sex, 20-40 g, acute seizures induced by pentylenetetrazole)[1]
Dosage: 1 mg/kg; 2 mg/kg; 4 mg/kg
Administration: i.p.; single dose (30 minutes prior to seizure induction)
Result: Significantly delayed the latency of myoclonic and clonic seizures, reduced the duration of myoclonic and clonic seizures, reduced the number of jerks, and reduced seizure severity score compared to the PTZ-only group (1 mg/kg).
Significantly delayed the latency of myoclonic and clonic seizures, reduced the duration of myoclonic and clonic seizures, reduced the number of jerks, and reduced seizure severity score compared to the PTZ-only group (2 mg/kg).
Significantly delayed the latency of myoclonic and clonic seizures, reduced the duration of myoclonic and clonic seizures, reduced the number of jerks, and reduced seizure severity score compared to the PTZ-only group; efficacy was comparable to diazepam (4 mg/kg).
Molecular Weight

527.23

Formula

C25H15Cl4N5
SMILES

ClC1=CC(Cl)=C(/C=N/C2=C(C#N)N=C3N2CC(C=CC=C4)=C4NC3C5=C(Cl)C=C(Cl)C=C5)C=C1
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Anticonvulsant agent 11 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Anticonvulsant agent 11Anticonvulsant agent11Anticonvulsant agent-11Reactive Oxygen Species (ROS)GABA ReceptorGamma-aminobutyric acid Receptorγ-Aminobutyric acid ReceptorPTZ-induced acute seizure mouse modelneuronal excitabilityGABAA α1 receptorGABAA receptor α1/γ2 interfaceepilepsySHSY-5Y cellsNeuro2a cellsneuronal cell lineschloride ionreactive oxygen speciesInhibitorinhibitorinhibit

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