Anticonvulsant agent 11
Anticonvulsant agent 11 (Compound 8b) is an anticonvulsant agent. Anticonvulsant agent 11 exerts neuroprotective effects by enhancing cell viability and reducing ROS levels. Anticonvulsant agent 11 induces the expression of GABAA α1, resulting in neuronal hyperpolarization. Anticonvulsant agent 11 increases the number of neurite-bearing cells and the length of neurites. Anticonvulsant agent 11 exhibits dose-dependent anticonvulsant effects in mice. Anticonvulsant agent 11 can be used for the research of epilepsy.
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- Formule: C25H15Cl4N5
- Masse moléculaire:527.23
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
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Help & FAQs
Activité biologique
Anticonvulsant agent 11 (1-40 μM; 24 h) exerts no significant neurotoxicity on SHSY-5Y cells at concentrations up to 20 μM, but causes a decrease in cell viability at 40 μM[1].
Anticonvulsant agent 11 (1-50 μM; 24 h) does not induce significant neurotoxicity in Neuro2a cells at concentrations not exceeding 10 μM, but causes a decrease in cell viability at 50 μM[1].
Anticonvulsant agent 11 (5-10 μM; 24 h) increases the proportion of neurite-bearing cells and the length of neurites in Neuro2a cells, with the effects at the concentration of 10 μM being significant compared with NGF treatment[1].
Anticonvulsant agent 11 (1-10 μM; 24 h) protects SHSY-5Y cells against PTZ-induced neurotoxicity by enhancing cell viability[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:SHSY-5Y
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Concentration:1-10 μM
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Incubation Time:24 h
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Result:Substantially increased cell viability in PTZ-exposed cells compared with PTZ alone-treated cells at 1, 5, and 10 μM.
Induced better cell viability (86.69%) compared to diazepam (75.79%).
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Swiss albino mice (either sex, 20-40 g, acute seizures induced by pentylenetetrazole)[1]
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Dosage:1 mg/kg; 2 mg/kg; 4 mg/kg
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Administration:i.p.; single dose (30 minutes prior to seizure induction)
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Result:Significantly delayed the latency of myoclonic and clonic seizures, reduced the duration of myoclonic and clonic seizures, reduced the number of jerks, and reduced seizure severity score compared to the PTZ-only group (1 mg/kg).
Significantly delayed the latency of myoclonic and clonic seizures, reduced the duration of myoclonic and clonic seizures, reduced the number of jerks, and reduced seizure severity score compared to the PTZ-only group (2 mg/kg).
Significantly delayed the latency of myoclonic and clonic seizures, reduced the duration of myoclonic and clonic seizures, reduced the number of jerks, and reduced seizure severity score compared to the PTZ-only group; efficacy was comparable to diazepam (4 mg/kg).
Chemical Information
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Masse moléculaire 527.23
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Formule C25H15Cl4N5
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SMILES
ClC1=CC(Cl)=C(/C=N/C2=C(C#N)N=C3N2CC(C=CC=C4)=C4NC3C5=C(Cl)C=C(Cl)C=C5)C=C1
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Anticonvulsant agent 11 Related Classifications
HY-182023 Related Classifications
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- Anticonvulsant agent 11
- Anticonvulsant agent11
- Anticonvulsant agent-11
- Reactive Oxygen Species (ROS)
- GABA Receptor
- PTZ-induced acute seizure mouse model
- neuronal excitability
- GABAA α1 receptor
- GABAA receptor α1/γ2 interface
- epilepsy
- SHSY-5Y cells
- Neuro2a cells
- neuronal cell lines
- chloride ion
- reactive oxygen species
- Inhibitor
- inhibitor
- inhibit