SLC17A3 Protein, Human (sf9, His, MBP, FLAG)

SLC17A3 is a voltage-driven organic anion transporter that plays a critical role in the renal proximal tubule. It actively promotes urate secretion and is essential for the elimination of the end products of purine metabolism. SLC17A3 Protein, Human (sf9, His, MBP, FLAG) is the recombinant human-derived SLC17A3 protein, expressed by sf9 insect cells , with N-MBP, C-Flag, N-8*His labeled tag.

SLC17A3 assumes a pivotal role as a voltage-driven, multispecific organic anion transporter, predominantly situated on the apical surface of renal proximal tubules. Notably, it actively contributes to the secretion of urate from the cell into the tubular lumen, playing a crucial role in the elimination of urate, the final product of purine metabolism. Beyond its involvement in urate handling, SLC17A3 may also exert influence on the metabolism and secretion of various compounds, including estrone sulfate, estradiol-17-beta-glucuronide, ochratoxin A, and certain drugs such as bumetanide. The multifaceted transport functions of SLC17A3 underscore its significance in renal physiology, particularly in the intricate processes of urate elimination and the handling of diverse organic anions.

Human

Sf9 insect cells

N-MBP;C-Flag;N-8*His

O00476 (A2-L420)

10786

Full Length

ATKTELSPTARESKNAQDMQVDETLIPRKVPSLCSARYGIALVLHFCNFTTIAQNVIMNITMVAMVNSTSPQSQLNDSSEVLPVDSFGGLSKAPKSLPAKSSILGGQFAIWEKWGPPQERSRLCSIALSGMLLGCFTAILIGGFISETLGWPFVFYIFGGVGCVCCLLWFVVIYDDPVSYPWISTSEKEYIISSLKQQVGSSKQPLPIKAMLRSLPIWSICLGCFSHQWLVSTMVVYIPTYISSVYHVNIRDNGLLSALPFIVAWVIGMVGGYLADFLLTKKFRLITVRKIATILGSLPSSALIVSLPYLNSGYITATALLTLSCGLSTLCQSGIYINVLDIAPRYSSFLMGASRGFSSIAPVIVPTVSGFLLSQDPEFGWRNVFFLLFAVNLLGLLFYLIFGEADVQEWAKERKLTRL

≥ 90%, as determined by reducing SDS-PAGE.

<1 EU/μg, determined by LAL method.