SLC17A3 Protein, Human (sf9, His, MBP, FLAG)
SLC17A3 is a voltage-driven organic anion transporter that plays a critical role in the renal proximal tubule. It actively promotes urate secretion and is essential for the elimination of the end products of purine metabolism. SLC17A3 Protein, Human (sf9, His, MBP, FLAG) is the recombinant human-derived SLC17A3 protein, expressed by sf9 insect cells , with N-MBP, C-Flag, N-8*His labeled tag.
- Species: Human
- Source: Sf9 insect cells
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Storage:Stored at -80°C for 1 year from date of receipt. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.
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Biological Activity
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Technical Parameters
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Product Properties
- Documentation
- Help & FAQs
Biological Activity
Description
SLC17A3 is a voltage-driven organic anion transporter that plays a critical role in the renal proximal tubule. It actively promotes urate secretion and is essential for the elimination of the end products of purine metabolism. SLC17A3 Protein, Human (sf9, His, MBP, FLAG) is the recombinant human-derived SLC17A3 protein, expressed by sf9 insect cells , with N-MBP, C-Flag, N-8*His labeled tag.
Background
SLC17A3 assumes a pivotal role as a voltage-driven, multispecific organic anion transporter, predominantly situated on the apical surface of renal proximal tubules. Notably, it actively contributes to the secretion of urate from the cell into the tubular lumen, playing a crucial role in the elimination of urate, the final product of purine metabolism. Beyond its involvement in urate handling, SLC17A3 may also exert influence on the metabolism and secretion of various compounds, including estrone sulfate, estradiol-17-beta-glucuronide, ochratoxin A, and certain drugs such as bumetanide. The multifaceted transport functions of SLC17A3 underscore its significance in renal physiology, particularly in the intricate processes of urate elimination and the handling of diverse organic anions.
Technical Parameters
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Species Human
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Source Sf9 insect cells
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Tag N-MBP;C-Flag;N-8*His
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Accession
O00476 (A2-L420)
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Gene ID10786
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Molecular Construction
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N-term
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8*His-MBP
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SLC17A3 (A2-L420)
Accession # O00476 -
Flag
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C-term
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Protein Length
Full Length
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Synonyms
SLC17A3; Sodium-Dependent Phosphate Transport Protein 4; Solute Carrier Family 17 Member 3; Sodium/Phosphate Cotransporter 4; NPT4; Na(+)/PI Cotransporter 4; Solute Carrier Family 17 (Organic Anion Transporter), Member 3; UAQTL4; Solute Carrier Family 17
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AA Sequence
ATKTELSPTARESKNAQDMQVDETLIPRKVPSLCSARYGIALVLHFCNFTTIAQNVIMNITMVAMVNSTSPQSQLNDSSEVLPVDSFGGLSKAPKSLPAKSSILGGQFAIWEKWGPPQERSRLCSIALSGMLLGCFTAILIGGFISETLGWPFVFYIFGGVGCVCCLLWFVVIYDDPVSYPWISTSEKEYIISSLKQQVGSSKQPLPIKAMLRSLPIWSICLGCFSHQWLVSTMVVYIPTYISSVYHVNIRDNGLLSALPFIVAWVIGMVGGYLADFLLTKKFRLITVRKIATILGSLPSSALIVSLPYLNSGYITATALLTLSCGLSTLCQSGIYINVLDIAPRYSSFLMGASRGFSSIAPVIVPTVSGFLLSQDPEFGWRNVFFLLFAVNLLGLLFYLIFGEADVQEWAKERKLTRL
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Purity
≥ 90%, as determined by reducing SDS-PAGE.
Product Properties
Solution.
<1 EU/μg, determined by LAL method.
Please use rapid thawing with running water to thaw the protein.
Stored at -80°C for 1 year from date of receipt. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.
Shipping with dry ice.
Documentation
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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