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Results for "

adp-

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Arf Family GTPase (2) PARP (63) Poly(ADP-ribose) Glycohydrolase (PARG) (23) 5-HT Receptor (1) Adenosine Receptor (2) Adenylate Cyclase (3) Adrenergic Receptor (7) AMPK (2) Antifolate (1) Apoptosis (27) Arp2/3 Complex (1) ATP Citrate Lyase (1) ATP Synthase (3) Aurora Kinase (1) Autophagy (6) Bacterial (16) Bcl-2 Family (4) Biochemical Assay Reagents (12) c-Fms (2) c-Kit (2) Calcium Channel (10) Caspase (11) Cathepsin (1) CD38 (1) CDK (2) CFTR (2) Chloride Channel (2) CMV (3) Creatine Kinase (2) Cytochrome P450 (3) DNA/RNA Synthesis (14) Drug Derivative (8) Drug Intermediate (1) Drug Isomer (1) Drug Metabolite (5) Endogenous Metabolite (57) Enterovirus (2) Environmental Pollutants (2) ERK (2) Fatty Acid Synthase (FASN) (2) Fluorescent Dye (3) Fungal (3) Glucokinase (2) Glutamate Dehydrogenase (GLDH) (3) Glycosidase (2) Glycosyltransferase (1) GSK-3 (1) Guanylate Cyclase (1) HCV (1) Histamine Receptor (2) HMG-CoA Reductase (HMGCR) (3) HSP (4) HSV (3) Insecticide (4) Integrin (6) Interleukin Related (2) Isotope-Labeled Compounds (15) JAK (1) JNK (1) Keap1-Nrf2 (1) Kinesin (1) LDLR (2) LRRK2 (1) MEK (1) Methionine Adenosyltransferase (MAT) (1) Microtubule/Tubulin (1) Mitochondrial Metabolism (5) MMP (1) MOFs (1) mTOR (2) Myosin (1) NADH Dehydrogenase (1) NAMPT (1) NF-κB (5) NO Synthase (1) NOD-like Receptor (NLR) (3) NTPDase (2) Nucleoside Antimetabolite/Analog (21) P-glycoprotein (1) P2X Receptor (1) P2Y Receptor (50) p38 MAPK (2) p97 (1) PANoptosis (1) PDGFR (2) PERK (1) PGC-1α (1) Phosphodiesterase (PDE) (4) Phosphoglycerate Kinase (PGK) (1) Phosphoramidites (2) Phosphorylase (1) PKA (5) Platelet-activating Factor Receptor (PAFR) (4) PPAR (2) Prostaglandin Receptor (7) PROTACs (1) Protease Activated Receptor (PAR) (4) Pyruvate Kinase (2) Ras (1) Reactive Oxygen Species (ROS) (9) Reference Standards (29) RIP kinase (3) ROCK (1) SARS-CoV (7) Ser/Thr Protease (1) Small Interfering RNA (siRNA) (2) Src (2) STAT (1) Succinate Receptor 1 (1) Syk (1) Thrombin (2) Thymidylate Synthase (1) Toll-like Receptor (TLR) (1) TRP Channel (8) ULK (1) Virus Protease (1) Wee1 (1) Wnt (1) Xanthine Oxidase (7) β-catenin (1)
By Research Areas:	Cancer (127) Cardiovascular Disease (85) Endocrinology (11) Infection (32) Inflammation/Immunology (43) Metabolic Disease (50) Neurological Disease (41)
Click Chemistry:	Azide (1)
Oligonucleotides:	Nucleoside Analogs (5) Nucleotide Analogs (9) Hypoxanthine (2) Inosine (3) Mouse Pre-designed siRNA Sets (1) Human Pre-designed siRNA Sets (1) Phosphoramidites (2) Antisense Oligonucleotides (2) Adenine Nucleotide (8) siRNAs (2)

381

Inhibitors & Agonists

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Biochemical Assay Reagents

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MCE Kits

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Isotope-Labeled Compounds

Antibodies

Click Chemistry

Oligonucleotides

GMP Molecules

Targets Recommended: PARP Poly(ADP-ribose) Glycohydrolase (PARG) Arf Family GTPase

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-W010918

Adenosine 5'-diphosphate Maximum Cited Publications 9 Publications Verification Adenosine diphosphate; adp	Endogenous Metabolite	Others
Adenosine 5'-diphosphate (Adenosine diphosphate) is a nucleoside diphosphate. Adenosine 5'-diphosphate is the product of ATP dephosphorylation by ATPases. Adenosine 5'-diphosphate induces human platelet aggregation and inhibits stimulated adenylate cyclase by an action at P_2T-purinoceptors.

HY-F0001

NADH disodium salt 5+ Cited Publications Disodium NADH	Endogenous Metabolite	Metabolic Disease
NADH disodium salt (Disodium NADH) is an orally active reduced coenzyme. NADH disodium salt is a donor of ADP-ribose units in ADP-ribosylaton reactions and a precursor of cyclic ADP-ribose. NADH disodium salt plays a role as a regenerative electron donor in cellular energy metabolism, including glycolysis, β-oxidation and the tricarboxylic acid (TCA) cycle .

HY-108360

PDD 00017273 20+ Cited Publications	Poly(ADP-ribose) Glycohydrolase (PARG)	Cancer
PDD 00017273 is a potent inhibitor of Poly(ADP-ribose) Glycohydrolase (PARG), with an IC₅₀ of 26 nM, and a K_D of 1.45 nM .

HY-100973A

Adenosine 5′-diphosphoribose sodium 5+ Cited Publications adp ribose sodium	TRP Channel Autophagy	Metabolic Disease Endocrinology Cancer
Adenosine 5′-diphosphoribose sodium (ADP ribose sodium) is a nicotinamide adenine nucleotide (NAD ⁺) metabolite. Adenosine 5′-diphosphoribose sodium is the most potent and primary intracellular Ca ²⁺-permeable cation TRPM2 channel activator. Adenosine 5′-diphosphoribose sodium also can enhance autophagy .

HY-D0199

Adenosine 5'-diphosphate disodium Maximum Cited Publications 9 Publications Verification Adenosine diphosphate disodium; adp disodium	Endogenous Metabolite	Cardiovascular Disease
Adenosine 5'-diphosphate disodium is a nucleoside diphosphate. Adenosine 5'-diphosphate disodium is the product of ATP dephosphorylation by ATPases. Adenosine 5'-diphosphate disodium is a platelet aggregation agent for hemostasis and the development and extension of arterial thrombosis .

HY-N2522

Carboxyatractyloside dipotassium 2 Publications Verification Gummiferin dipotassium	Mitochondrial Metabolism Calcium Channel Reactive Oxygen Species (ROS)	Neurological Disease
Carboxyatractyloside dipotassium is a diterpenoid. Carboxyatractyloside dipotassium can be isolated from plants of the genus Xanthium. Carboxyatractyloside dipotassium is an *ADP/ATP* carrier inhibitor, inhibiting mitochondrial ADP/ATP transport. Carboxyatractyloside dipotassium promotes ROS production, induces Ca ²⁺ release, and leads to mitochondrial dysfunction. Carboxyatractyloside dipotassium induces lethargy, weakness, and epileptic seizures in rats .

HY-N1502

Carboxyatractyloside tripotassium 2 Publications Verification Gummiferin tripotassium	Mitochondrial Metabolism Reactive Oxygen Species (ROS) Calcium Channel	Neurological Disease
Carboxyatractyloside tripotassium is a diterpenoid. Carboxyatractyloside tripotassium can be isolated from plants of the genus Xanthium. Carboxyatractyloside tripotassium is an *ADP/ATP* carrier inhibitor, inhibiting mitochondrial ADP/ATP transport. Carboxyatractyloside tripotassium promotes ROS production, induces Ca ²⁺ release, and leads to mitochondrial dysfunction. Carboxyatractyloside tripotassium induces lethargy, weakness, and epileptic seizures in rats .

HY-100973

Adenosine 5′-diphosphoribose 5+ Cited Publications adp ribose	TRP Channel Autophagy	Neurological Disease Metabolic Disease Cancer
Adenosine 5′-diphosphoribose (ADP ribose) is a nicotinamide adenine nucleotide (NAD ⁺) metabolite. Adenosine 5′-diphosphoribose is the most potent and primary intracellular Ca ²⁺-permeable cation TRPM2 channel activator. Adenosine 5′-diphosphoribose also can enhance autophagy .

HY-158799

*Poly(ADP-ribose) Polymer/pADPr*	Poly(ADP-ribose) Glycohydrolase (PARG)	Others
Poly(ADP-ribose) Polymer/pADPr is a complex polymer of repeating ADP-ribose units, which is synthesized using poly(ADP-ribose) polymerase (PARP) in the presence of NAD ⁺, cleaved from PARP, and subsequently purified .

HY-N7395

*Cyclic ADP-ribose* 1 Publications Verification cadpR	Calcium Channel TRP Channel Endogenous Metabolite	Infection Cardiovascular Disease Neurological Disease Inflammation/Immunology Endocrinology
Cyclic ADP-ribose (cADPR) is a potent second messenger for calcium mobilization that is synthesized from NAD ⁺ by an ADP-ribosyl cyclase. Cyclic ADP-ribose increases cytosolic calcium mainly by Ryanodine receptor-mediated release from endoplasmic reticulum and also by extracellular influx through the opening of TRPM2 channels .

HY-134353B

ADP-β-S trilithium Adenosine 5'-β-thiodiphosphate trilithium	P2Y Receptor NF-κB Interleukin Related Caspase	Neurological Disease Inflammation/Immunology Cancer
ADP-β-S (Adenosine 5'-(β-thiodiphosphate)) trilithium is a non-hydrolyzable ADP analog and a P2Y12 receptor agonist. ADP-β-S trilithium activates the P2Y12 receptor in microglia, thereby triggering downstream inflammatory signaling pathways. ADP-β-S trilithium activates P2Y purinergic receptors in rat pancreatic β cells and enhances glucose-induced insulin secretion. ADP-β-S trilithium can be used in the research of diseases such as inflammation and diabetes .

HY-108648

*2-MeS-ADP* trisodium** 2-Methylthioadenosine diphosphate trisodium; 2-Methylthio-adp trisodium	P2Y Receptor	Neurological Disease
2-Methylthioadenosine diphosphate trisodium is a potent purinergic P2Y receptors agonist, with EC₅₀s of 19, 6.2, and 5 nM for human P2Y13, mouse P2Y13 and human P2Y12, respectively. 2-Methylthioadenosine diphosphate trisodium has pEC₅₀s of 8.29 and 5.75 for human P2Y1 and rat P2Y6, respectively. 2-Methylthioadenosine diphosphate trisodium induces platelet aggregation and shape change, and inhibits cyclic AMP accumulation in platelets exposed to prostaglandin E1 .

HY-P2806

Pyruvate Kinase, Microorganism PK; Fluorokinase	Endogenous Metabolite	Metabolic Disease Cancer
Pyruvate Kinase, Microorganism (PK) is a glycolytic enzyme that catalyzes the conversion of phosphoenolpyruvate and ADP to pyruvate and ATP .

HY-101020

Picolinamide 2-Picolinamide	PARP	Metabolic Disease
Picolinamide (2-Picolinamide) is an inhibitor of *Poly(ADP-ribose) synthetase* of nuclei from rat pancreatic islet cells .

HY-P2799

Creatine phosphokinase, Rabbit muscle 1 Publications Verification CPK	Endogenous Metabolite	Metabolic Disease Cancer
Creatine phosphokinase, Rabbit muscle (CPK) catalyzes the reversible reaction of creatine and ATP to form phosphocreatine and ADP. Creatine phosphokinase is a key enzyme for maintaining a constant ATP/ADP ratio during rapid energy turnover .

HY-F0001R

NADH disodium salt (Standard) 1 Publications Verification Disodium NADH (Standard)	Reference Standards Endogenous Metabolite	Metabolic Disease
NADH (disodium salt) (Standard) is the analytical standard of NADH (disodium salt). This product is intended for research and analytical applications. NADH disodium salt (Disodium NADH) is an orally active reduced coenzyme. NADH disodium salt is a donor of ADP-ribose units in ADP-ribosylaton reactions and a precursor of cyclic ADP-ribose. NADH disodium salt plays a role as a regenerative electron donor in cellular energy metabolism, including glycolysis, β-oxidation and the tricarboxylic acid (TCA) cycle .

HY-107867

(±)-Clopidogrel bisulfate	P2Y Receptor	Cardiovascular Disease Inflammation/Immunology
(±)-Clopidogrel bisulfate is a platelet P2Y12 receptor inhibitor and an *adenosine diphosphate (ADP) receptor* antagonist. (±)-Clopidogrel bisulfate inhibits the binding of ADP to its receptors on the membranes of platelet cells, and blocks ADP-mediated activation of the glycoprotein GPIIb/IIIa complex. (±)-Clopidogrel bisulfate reduces vascular inflammation and angiotensin II induced-abdominal aortic aneurysm progression. (±)-Clopidogrel bisulfate has anti-inflammatory effects .

HY-108648A

2-MeSADP 2-Methylthioadenosine diphosphate; 2-Methylthio-adp	P2Y Receptor	Neurological Disease
2-MeSADP is a P2Y receptor agonist, with an EC₅₀ of 5 nM for human P2Y12, EC₅₀ values of 19 nM and 13 nM for human P2Y13, and an EC₅₀ of 6.2 nM for mouse P2Y13. It shows slightly higher selectivity for P2Y12 over human P2Y13. 2-MeSADP triggers increases in intracellular calcium levels, Gi-mediated cAMP inhibition, adenylate cyclase inhibition and downstream signal transduction. 2-MeSADP can be used in research related to glaucoma .

HY-134216

MAHMA NONOate 1 Publications Verification	Endogenous Metabolite NO Synthase	Cardiovascular Disease
MAHMA NONOate is a NO donor. MAHMA NONOate effectively inhibits platelet aggregation induced by either collagen or ADP .

HY-136830

ADP-Glucose disodium Adenosine-5'-diphosphoglucose disodium	Biochemical Assay Reagents	Others
ADP-Glucose disodiumIs an immediate precursor for the biosynthesis of storage polysaccharides in plants, green algae and cyanobacteria, and structural polysaccharides in some bacteria, by the addition of glucose. It is used to produce amylose, amylopectin, starch and other polysaccharides by amylose synthase or starch synthase in plastids. ADPGUsually produced in plastids, although it can be biosynthesized in the cytoplasm of some grasses and imported into plastids by membrane-bound transporters .

HY-134279

8-Br-NAD+ sodium	Calcium Channel	Others
8-Br-NAD+ sodium is an NAD+ derivative that acts as a substrate for transfer to diversely modified ADP-ribosylated molecules .

HY-G0023

Niraparib metabolite M1 Niraparib carboxylic acid metabolite M1; M1 metabolite of niraparib	Drug Metabolite	Others
Niraparib metabolite M1 is a metabolite of niraparib, and the latter one acts as a novel poly(ADP-Ribose) polymerase (PARP) inhibitor.

HY-178208

MDOLL-0286	Poly(ADP-ribose) Glycohydrolase (PARG)	Cancer
MDOLL-0286 is a selective *Poly(ADP-ribose) Glycohydrolase (PARG)* (ARH3) inhibitor with an IC₅₀ of 2.3μM. MDOLL-0286 can inhibit ARH3’s poly-ADP-ribose hydrolytic activity on cellular substrates. MDOLL-0286 can inhibit DNA damage response. MDOLL-0286 can be used for the research of cancer .

HY-131009

Fluorescein-NAD+	PARP	Others
Fluorescein-NAD+ is an alternative to radiolabeled NAD and a substrate for ADP-ribosylation. Fluorescein-NAD+ can be used in PARP assays by fluorescence microscopy. Extinction Coefficient: 262 nm.

HY-W010918S2

Adenosine 5'-diphosphate-15N5 dilithium Adenosine diphosphate-15N5 dilithium; adp-15N5 dilithium	Isotope-Labeled Compounds Endogenous Metabolite	Cardiovascular Disease
Adenosine 5'-diphosphate- ¹⁵N₅ (Adenosine diphosphate- ¹⁵N₅ dilithium) dilithium is ¹⁵N labeled Adenosine 5'-diphosphate (HY-W010918). Adenosine 5'-diphosphate (Adenosine diphosphate) is a nucleoside diphosphate. Adenosine 5'-diphosphate is the product of ATP dephosphorylation by ATPases. Adenosine 5'-diphosphate induces human platelet aggregation and inhibits stimulated adenylate cyclase by an action at P_2T-purinoceptors.

HY-135782

*iso-ADP* ribose**	Poly(ADP-ribose) Glycohydrolase (PARG)	Cancer
iso-ADP ribose is the small-molecule ligand for protein nucleic acid modification, comprising parts of two consecutive ADP-ribosyl units within the PAR chain. iso-ADP ribose specifically binds WWE, FHA and OB-fold domains, enabling PAR-dependent functional responses like ubiquitylation and supporting DNA damage signaling and repair. iso-ADP ribose can be used for cancer research .

HY-N7395A

*Cyclic ADP-ribose ammonium* 1 Publications Verification cadpR ammonium	Calcium Channel TRP Channel Endogenous Metabolite	Infection Cardiovascular Disease Neurological Disease Inflammation/Immunology Endocrinology
Cyclic ADP-ribose ammonium (cADPR ammonium) is a potent second messenger for calcium mobilization that is synthesized from NAD ⁺ by an ADP-ribosyl cyclase. Cyclic ADP-ribose ammonium increases cytosolic calcium mainly by Ryanodine receptor-mediated release from endoplasmic reticulum and also by extracellular influx through the opening of TRPM2 channels .

HY-134354A

pNP-ADPr disodium adp-ribose-pNP disodium	Poly(ADP-ribose) Glycohydrolase (PARG)	Others
pNP-ADPr disodium is a colorimetric substrate that used for the first continuous Poly(ADP-ribose) glycohydrolase (PARG) and ADP-ribosyl hydrolase 3 (ARH3) activity assays. pNP-ADPr disodium can be used for the research of poly(ADP-ribose)polymerase (PARP) enzymes .

HY-W010918R

Adenosine 5'-diphosphate (Standard) Adenosine diphosphate (Standard); adp (Standard)	Reference Standards Endogenous Metabolite	Others
Adenosine 5'-diphosphate (Standard) is the analytical standard of Adenosine 5'-diphosphate. This product is intended for research and analytical applications. Adenosine 5'-diphosphate (Adenosine diphosphate) is a nucleoside diphosphate. Adenosine 5'-diphosphate is the product of ATP dephosphorylation by ATPases. Adenosine 5'-diphosphate induces human platelet aggregation and inhibits stimulated adenylate cyclase by an action at P_2T-purinoceptors. In Vitro: Adenosine 5'-diphosphate consists of the pyrophosphate group, the pentose sugar ribose, and the nucleobase adenine. Adenosine 5'-diphosphate is the product of ATP dephosphorylation by ATPases. ADP is converted back to ATP by ATP synthases. ATP is an important energy transfer molecule in cells. Adenosine 5'-diphosphate is utilized in a wide number of cellular processes, including respiration, biosynthetic reactions, motility, and cell division.

HY-135846

PDD00031705 1 Publications Verification	Poly(ADP-ribose) Glycohydrolase (PARG)	Cancer
PDD00031705 is a benzimidazolone core cell-inactive inhibitor of *Poly (ADP-ribose) glycohydrolase (PARG)* .

HY-D0199R

Adenosine 5'-diphosphate disodium (Standard) Adenosine diphosphate disodium (Standard); adp disodium (Standard)	Endogenous Metabolite Reference Standards	Cardiovascular Disease
Adenosine 5'-diphosphate (disodium) (Standard) is the analytical standard of Adenosine 5'-diphosphate (disodium). This product is intended for research and analytical applications. Adenosine 5'-diphosphate disodium is a nucleoside diphosphate. Adenosine 5'-diphosphate disodium is the product of ATP dephosphorylation by ATPases. Adenosine 5'-diphosphate disodium is a platelet aggregation agent for hemostasis and the development and extension of arterial thrombosis .

HY-W010918S3

Adenosine 5'-diphosphate-13C5 Adenosine diphosphate-¹³C₅; adp-¹³C₅	Isotope-Labeled Compounds Endogenous Metabolite	Others
Adenosine 5'-diphosphate- ¹³C₅ (Adenosine diphosphate- ¹³C₅) is the ¹³C-labeled Adenosine 5'-diphosphate (HY-W010918). Adenosine 5'-diphosphate (Adenosine diphosphate) is a nucleoside diphosphate. Adenosine 5'-diphosphate is the product of ATP dephosphorylation by ATPases. Adenosine 5'-diphosphate induces human platelet aggregation and inhibits stimulated adenylate cyclase by an action at P2T-purinoceptors.

HY-117804

8-Br-cADPR 8-Bromo-Cyclic adp-Ribose	TRP Channel	Neurological Disease Metabolic Disease
8-Br-cADPR (8-Bromo-Cyclic ADP-Ribose), a *cyclic adenosine diphosphate (ADP)-ribose (cADPR)* antagonist, is a TRPM2 ion channel antagonist. 8-Br-cADPR reduces renal damage and the expression of caspase-3 and TRPM2 .

HY-100973AR

Adenosine 5′-diphosphoribose sodium (Standard) adp ribose sodium (Standard)	Reference Standards TRP Channel Autophagy	Metabolic Disease Endocrinology Cancer
Adenosine 5′-diphosphoribose (sodium) (Standard) is the analytical standard of Adenosine 5′-diphosphoribose (sodium). This product is intended for research and analytical applications. Adenosine 5′-diphosphoribose sodium (ADP ribose sodium) is a nicotinamide adenine nucleotide (NAD+) metabolite. Adenosine 5′-diphosphoribose sodium is the most potent and primary intracellular Ca2+-permeable cation TRPM2 channel activator. Adenosine 5′-diphosphoribose sodium also can enhance autophagy .

HY-P990037

Erzotabart GEN3014	CD38	Inflammation/Immunology Cancer
Erzotabart is an IgG1-kappa, anti-CD38 (ADP-ribosyl cyclase 1, cyclic ADP-ribose hydrolase 1, cADPr hydrolase 1, cADPR1) Homo sapiens monoclonal antibody. Erzotabart shows antineoplastic activity .

HY-158359

5′-XDP sodium Xanthosine 5′-diphosphate sodium	Endogenous Metabolite	Others
5’-XDP sodium (Xanthosine 5' -diphosphate sodium) is an ADP analog involved in the synthesis of ribosomes .

HY-Z0283S

Benzamide-15N Benzenecarboxamide-¹⁵N; Phenylamide-¹⁵N	Endogenous Metabolite PARP	Others
Benzamide- ¹⁵N is a ¹⁵N-labeled Benzamide. Benzamide inhibits poly(ADP-ribose) polymerase (PARP) .

HY-E70122

Uridylate kinase	Others	Others
Uridylate kinase is a member of the nucleoside mono-phosphate (NMP) kinase family and catalyzes the reaction ATP+NMP ADP+NDP with moderate specificity for UMP .

HY-D1107

NCT-TFP	PARP	Others
NCT-TFP is PARP probe used to identifying Poly(ADP-ribose) polymerases (PARP) inhibitors (extracted from patent US20190331688A1) .

HY-135782A

*iso-ADP* ribose TEA**	Poly(ADP-ribose) Glycohydrolase (PARG)	Cancer
iso-ADP ribose TEA is the small-molecule ligand for protein nucleic acid modification, comprising parts of two consecutive ADP-ribosyl units within the PAR chain. iso-ADP ribose TEA specifically binds WWE, FHA and OB-fold domains, enabling PAR-dependent functional responses like ubiquitylation and supporting DNA damage signaling and repair. iso-ADP ribose TEA can be used for cancer research .

HY-134354

pNP-ADPr adp-ribose-pNP	Poly(ADP-ribose) Glycohydrolase (PARG)	Others
pNP-ADPr is a colorimetric substrate that used for the first continuous Poly(ADP-ribose) glycohydrolase (PARG) and ADP-ribosyl hydrolase 3 (ARH3) activity assays. pNP-ADPr can be used for the research of poly(ADP-ribose)polymerase (PARP) enzymes .

HY-W250154

β-Nicotinamide adenine dinucleotide reduced dipotassium	Endogenous Metabolite	Metabolic Disease
β-Nicotinamide adenine dinucleotide reduced dipotassium is an orally active reduced coenzyme. β-Nicotinamide adenine dinucleotide reduced dipotassium is a donor of ADP-ribose units in ADP-ribosylaton reactions and a precursor of cyclic ADP-ribose. β-Nicotinamide adenine dinucleotide reduced dipotassium plays a role as a regenerative electron donor in cellular energy metabolism, including glycolysis, β-oxidation and the tricarboxylic acid (TCA) cycle .

HY-136501

MRS2395	P2Y Receptor	Cardiovascular Disease
MRS2395, an dipivaloyl derivative, is a potent P2Y12 receptor antagonist. MRS2395 inhibits ADP-induced platelet activation with a K_i of 3.6 μM. MRS2395 inhibits cAMP induced by ADP in rat platelets in the presence of PGE1 with an IC₅₀ of 7 µM. MRS2395 enhances platelet dense granule release in response to TRAP-6 .

HY-E70556

ADP-ribose pyrophosphatase	Biochemical Assay Reagents	Metabolic Disease
ADP-ribose pyrophosphatase is an ADP-ribose pyrophosphatase that catalyzes the hydrolysis of ADP-ribose to AMP and ribose 5-phosphate .

HY-131831A

*6-Bn-ADP* sodium** N6-benzyl adp sodium	ATP Synthase	Cancer
6-Bn-ADP (N6-benzyl ADP) sodium is a derivative of Adenosine 5'-diphosphate (ADP) (HY-W010918) that inhibits ATP hydrolysis. 6-Bn-ADP sodium inhibits the ATPase activities of Mortalin, Hsc70, and Hsp70 protein with K_is of 86.51 μM, 294.5 μM, and 1612 μM, respectively .

HY-134353A

ADP-β-S trisodium Adenosine 5'-(β-thiodiphosphate) trisodium	Interleukin Related P2Y Receptor NF-κB Caspase	Neurological Disease Inflammation/Immunology Cancer
ADP-β-S (Adenosine 5'-(β-thiodiphosphate)) trilithium is a non-hydrolyzable ADP analog and a P2Y12 receptor agonist. ADP-β-S trilithium activates the P2Y12 receptor in microglia, thereby triggering downstream inflammatory signaling pathways. ADP-β-S trilithium activates P2Y purinergic receptors in rat pancreatic β cells and enhances glucose-induced insulin secretion. ADP-β-S trilithium can be used in the research of diseases such as inflammation and diabetes .

HY-175081

8-Br-cADPR sodium salt 8-Bromo-Cyclic adp-Ribose sodium salt	TRP Channel	Metabolic Disease
8-Br-cADPR (8-Bromo-Cyclic ADP-Ribose) sodium salt, a *cyclic adenosine diphosphate (ADP)-ribose (cADPR)* antagonist, is a TRPM2 ion channel antagonist. 8-Br-cADPR sodium salt reduces renal damage and the expression of caspase-3 and TRPM2 .

HY-137749A

MANT-dADP trisodium 2'-Deoxy-3'-MANT-adp trisodium	Biochemical Assay Reagents	Others
MANT-dADP (trisodium) (2'-Deoxy-3'-MANT-ADP (trisodium)) is a fluorescent nucleotide derivative, with an emission maximum of 453 nm upon excitation at 350 nm. MANT-dADP (trisodium) can decrease inositol phoshate formation in CHO-K1 cells that express human purinergic P2Y₁₂ receptor. MANT-dADP (trisodium) can be studied in research on the interaction between cardiac troponin I and myofibrils .

HY-176089

Adenosine-5'-O-diphosphoribose phosphate sodium adp-ribose phosphate sodium; P-adp-Rib sodium	HMG-CoA Reductase (HMGCR)	Others
Adenosine-5'-O-diphosphoribose phosphate sodium is a structural analog of NADPH (HY-113324). Adenosine-5'-O-diphosphoribose phosphate sodium is an HMG-CoA reductase inhibitor. Adenosine-5'-O-diphosphoribose phosphate sodium inhibits microsomal HMG-CoA reductase with an apparent K_i value of 550 μM at low thiol concentrations .

HY-P2984

Adenosine triphosphatase	Endogenous Metabolite	Metabolic Disease
Adenosine triphosphatase is an enzyme that catalyzes the decomposition of ATP into ADP and a free phosphate ion (Pi) .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-W010918

Adenosine 5'-diphosphate Maximum Cited Publications 9 Publications Verification Adenosine diphosphate; adp	Structural Classification Ketones, Aldehydes, Acids Endogenous metabolite Source Classification	Endogenous Metabolite
Adenosine 5'-diphosphate (Adenosine diphosphate) is a nucleoside diphosphate. Adenosine 5'-diphosphate is the product of ATP dephosphorylation by ATPases. Adenosine 5'-diphosphate induces human platelet aggregation and inhibits stimulated adenylate cyclase by an action at P_2T-purinoceptors.

HY-F0001

NADH disodium salt 5+ Cited Publications Disodium NADH	Natural Products Classification of Application Fields Other Diseases Endogenous metabolite Disease Research Fields Source Classification	Endogenous Metabolite
NADH disodium salt (Disodium NADH) is an orally active reduced coenzyme. NADH disodium salt is a donor of ADP-ribose units in ADP-ribosylaton reactions and a precursor of cyclic ADP-ribose. NADH disodium salt plays a role as a regenerative electron donor in cellular energy metabolism, including glycolysis, β-oxidation and the tricarboxylic acid (TCA) cycle .

HY-111557

YM-254890 Maximum Cited Publications 17 Publications Verification	Cardiovascular Disease Natural Products Microorganisms Classification of Application Fields Disease Research Fields Source Classification	P2Y Receptor
YM-254890 is a selective G_αq/11 protein inhibitor isolated from Chromobacterium sp. YM-254890 shows no inhibition of other G protein subtypes. YM-254890 inhibits platelet aggregation induced by ADP by blocking the P2Y₁ signal transduction pathway, with an IC₅₀ value below 0.6 μM .

HY-16929

Latrunculin A 10+ Cited Publications LAT-A	Macrolide Antibiotics Animals Classification of Application Fields Antibiotics Marine natural products Other Diseases Sponge Disease Research Anticancer Disease Research Fields Source Classification	Arp2/3 Complex
Latrunculin A (LAT-A), found in the red sea sponge Latrunculia magnifica, is a G-actin polymerization inhibitor. Latrunculin A binds to actin monomers and inhibits polymerization of actin with K_ds of 0.1, 0.4, 4.7 μM and 0.19 μM for ATP-actin, ADP-Pi-actin, ADP-actin and G-actin, respectively. Latrunculin A has effective anti-metastatic properties for cancer research. Latrunculin A blocks cell migration .

HY-N1462

Atractyloside potassium salt 4 Publications Verification	Cardiovascular Disease Classification of Application Fields Terpenoids Pterocarpus soyauxii Taub. Diterpenoids Plants Compositae Disease Research Fields Source Classification	Chloride Channel Autophagy mTOR AMPK
Atractyloside potassium salt is a powerful and specific inhibitor of mitochondrial ADP/ATP transport. Atractyloside potassium salt inhibits chloride channels from mitochondrial membranes of rat heart. Atractyloside potassium salt activates autophagy, inhibits ANT2, mTOR and promotes the activation of p-AMPK. Atractyloside potassium salt has anti-cancer effects on non-small cell lung cancer and can inhibit liver steatosis. Atractylodesin potassium salt has nephrotoxicity .

HY-113432

Nudifloramide 2PY	Alkaloids Structural Classification Other disease Classification of Application Fields Disease markers Pyridine Alkaloids Metabolic Disease Endogenous metabolite Disease Research Fields Source Classification	Endogenous Metabolite PARP
Nudifloramide (2PY) is one of the end products of nicotinamide-adenine dinucleotide (NAD) degradation. Nudifloramide significantly inhibits *poly(ADP-ribose) polymerase (PARP-1)* activity in vitro .

HY-D0199

Adenosine 5'-diphosphate disodium Maximum Cited Publications 9 Publications Verification Adenosine diphosphate disodium; adp disodium	Structural Classification Ketones, Aldehydes, Acids Endogenous metabolite Source Classification	Endogenous Metabolite
Adenosine 5'-diphosphate disodium is a nucleoside diphosphate. Adenosine 5'-diphosphate disodium is the product of ATP dephosphorylation by ATPases. Adenosine 5'-diphosphate disodium is a platelet aggregation agent for hemostasis and the development and extension of arterial thrombosis .

HY-N2522

Carboxyatractyloside dipotassium 2 Publications Verification Gummiferin dipotassium	other families Classification of Application Fields Terpenoids Other Diseases Diterpenoids Plants Disease Research Fields Source Classification	Mitochondrial Metabolism Calcium Channel Reactive Oxygen Species (ROS)
Carboxyatractyloside dipotassium is a diterpenoid. Carboxyatractyloside dipotassium can be isolated from plants of the genus Xanthium. Carboxyatractyloside dipotassium is an *ADP/ATP* carrier inhibitor, inhibiting mitochondrial ADP/ATP transport. Carboxyatractyloside dipotassium promotes ROS production, induces Ca ²⁺ release, and leads to mitochondrial dysfunction. Carboxyatractyloside dipotassium induces lethargy, weakness, and epileptic seizures in rats .

HY-N1502

Carboxyatractyloside tripotassium 2 Publications Verification Gummiferin tripotassium	other families Classification of Application Fields Terpenoids Diterpenoids Plants Disease Research Fields Source Classification Cancer	Mitochondrial Metabolism Reactive Oxygen Species (ROS) Calcium Channel
Carboxyatractyloside tripotassium is a diterpenoid. Carboxyatractyloside tripotassium can be isolated from plants of the genus Xanthium. Carboxyatractyloside tripotassium is an *ADP/ATP* carrier inhibitor, inhibiting mitochondrial ADP/ATP transport. Carboxyatractyloside tripotassium promotes ROS production, induces Ca ²⁺ release, and leads to mitochondrial dysfunction. Carboxyatractyloside tripotassium induces lethargy, weakness, and epileptic seizures in rats .

HY-N7765

Oenothein B	Infection other families Classification of Application Fields Phenols Polyphenols Plants Inflammation/Immunology Disease Research Fields Source Classification	HCV Bacterial Apoptosis Fungal
Oenothein B is a dimeric macrocyclic ellagitannin and has widely pharmacological activities, including antioxidant, anti-inflammatory, antifungal, anti-HCV, and antitumor properties. Oenothein B is a potent and specific inhibitor of *poly(ADP-ribose) glycohydrolase* .

HY-N0466

Rebaudioside A	Structural Classification Classification of Application Fields Plants Compositae Endogenous metabolite Sweeteners Food Research Trifolium hybridum L. Terpenoids Other Diseases Diterpenoids Disease Research Fields Source Classification	Glycosidase HMG-CoA Reductase (HMGCR) Fatty Acid Synthase (FASN) LDLR
Rebaudioside A is an orally effective steviol glycoside with high sweetness. Rebaudioside A acts as an inhibitor of α-glucosidase with an IC₅₀ value of 35.01 μg/mL. Rebaudioside A increases the ATP/ADP ratio in β cells in a glucose-dependent manner, thereby inhibiting KATP channels, leading to membrane depolarization, calcium influx, and ultimately stimulating insulin secretion. Rebaudioside A activates the SREBP signaling pathway by inhibiting HMGCR, the rate-limiting enzyme in cholesterol synthesis, resulting in increased expression of LDLR on the cell surface, thus promoting the uptake of LDL-C in the blood. Rebaudioside A can be used for studies on blood glucose and lipid regulation as well as anti-obesity .

HY-N7395

*Cyclic ADP-ribose* 1 Publications Verification cadpR	Cardiovascular Disease Structural Classification Natural Products Neurological Disease Classification of Application Fields Endogenous metabolite Inflammation/Immunology Disease Research Fields Endocrinology Source Classification	Calcium Channel TRP Channel Endogenous Metabolite
Cyclic ADP-ribose (cADPR) is a potent second messenger for calcium mobilization that is synthesized from NAD ⁺ by an ADP-ribosyl cyclase. Cyclic ADP-ribose increases cytosolic calcium mainly by Ryanodine receptor-mediated release from endoplasmic reticulum and also by extracellular influx through the opening of TRPM2 channels .

HY-113371

2-Methylcitric acid Methylcitric acid	Human Gut Microbiota Metabolites Microorganisms Classification of Application Fields Ketones, Aldehydes, Acids Disease markers Endocrine diseases Metabolic Disease Endogenous metabolite Disease Research Fields Source Classification	Endogenous Metabolite
2-Methylcitric acid (Methylcitric acid) is an endogenous metabolite in the 2-methylcitric acid cycle. 2-Methylcitric acid accumulates in methylmalonic and propionic acidemias and acts as a marker metabolite. 2-Methylcitric acid markedly inhibits ADP-stimulated and uncoupled respiration in mitochondria supported by glutamate .

HY-N6818

5,7,4'-Trimethoxyflavone 2 Publications Verification TMF	Structural Classification Flavonoids Classification of Application Fields Flavones Kaempferia parviflora Wall. ex Baker Plants Disease Research Fields Source Classification Zingiberaceae Cancer	Apoptosis Caspase PARP Endogenous Metabolite CFTR
5,7,4’-Trimethoxyflavone can be isolated from the medicinal plant Kaempferia parviflora (KP). 5,7,4’-Trimethoxyflavone is a CFTR activator and EC₅₀ is 64 μM. 5,7,4’-Trimethoxyflavone induces apoptosis, increases proteolytic activation of caspase-3, and degradation of ADP-ribose polymerase (PARP) protein. 5,7,4’-Trimethoxyflavone has antitumor activity. 5,7,4’-Trimethoxyflavone can be used to prevent skin aging and oxidative stress .

HY-Z0283

Benzamide 1 Publications Verification Benzenecarboxamide; Phenylamide	Alkaloids Human Gut Microbiota Metabolites Classification of Application Fields Other Alkaloids Other Diseases Endogenous metabolite Disease Research Fields Source Classification	Endogenous Metabolite PARP
Benzamide (Benzenecarboxamide) is a potent *poly(ADP-ribose) polymerase (PARP)* inhibitor. Benzamide has protective activity against both glutamate- and methamphetamine (METH)-induced neurotoxicity in vitro. Benzamide can attenuate the METH-induced dopamine depletions and exhibits neuroprotective activity in mice, also has no acute effect on striatal dopamine metabolism and does not reduce body temperature .

HY-F0001R

NADH disodium salt (Standard) 1 Publications Verification Disodium NADH (Standard)	Structural Classification Natural Products Endogenous metabolite Source Classification	Reference Standards Endogenous Metabolite
NADH (disodium salt) (Standard) is the analytical standard of NADH (disodium salt). This product is intended for research and analytical applications. NADH disodium salt (Disodium NADH) is an orally active reduced coenzyme. NADH disodium salt is a donor of ADP-ribose units in ADP-ribosylaton reactions and a precursor of cyclic ADP-ribose. NADH disodium salt plays a role as a regenerative electron donor in cellular energy metabolism, including glycolysis, β-oxidation and the tricarboxylic acid (TCA) cycle .

HY-134216

MAHMA NONOate 1 Publications Verification	Cardiovascular Disease Alkaloids Classification of Application Fields Other Alkaloids Endogenous metabolite Disease Research Fields Source Classification	Endogenous Metabolite NO Synthase
MAHMA NONOate is a NO donor. MAHMA NONOate effectively inhibits platelet aggregation induced by either collagen or ADP .

HY-N6801

Nivalenol	Infection Structural Classification Microorganisms Classification of Application Fields Terpenoids Sesquiterpenes Inflammation/Immunology Disease Research Fields Source Classification	Caspase Apoptosis Bcl-2 Family
Nivalenol, a trichothecene mycotoxin that can be produced by Fusarium graminearum, is a fungal metabolite present in agricultural product. Nivalenol modulates apoptotic pathway, cell cycle regulation, Bax, ERK, caspase-3, and poly-ADP-ribose synthase activity in macrophages. Nivalenol inhibits ribosomal peptidyltransferase site, protein synthesis, DNA synthesis, and cell proliferation. Nivalenol induces late-stage apoptotic morphological changes, reduces cellular metabolism, and decreases cell proliferation in erythroleukemia cells. Nivalenol induces lymphocyte apoptosis in murine thymus, spleen, and Peyer's patches. Nivalenol can be used for the research of erythroleukemia .

HY-N1910

4'-O-Methylbavachalcone 4 Publications Verification	Infection Structural Classification Chalcones Flavonoids Classification of Application Fields Leguminosae Phenols Polyphenols Psoralea corylifolia L. Plants Disease Research Fields Source Classification	SARS-CoV Virus Protease Succinate Receptor 1 ERK
4'-O-Methylbavachalcone is an orally active prenylated flavonoid that inhibits the activity of SARS-CoV papain-like protease (PLpro), with an IC₅₀ of 10.1 μM and a K_i of 4.6 μM. 4'-O-Methylbavachalcone inhibits poly (ADP-ribose) polymerase-mediated cell death (parthanatos), reduces cerebral infarct volume, binds to the orthosteric site of SUCNR1, blocks the interaction between succinate and SUCNR1, inhibits SUCNR1 activity, blocks the nuclear translocation of NFATc4, suppresses the activation of the ERK1/2 signaling pathway, inhibits cardiomyocyte hypertrophy and restores the expression of α-actinin. 4'-O-Methylbavachalcone can be used in studies related to ischemic stroke, SARS-CoV and cardiomyocyte hypertrophy .

HY-W051513

2-Methylquinazolin-4-ol 1 Publications Verification	Natural Products Microorganisms Classification of Application Fields Other Diseases Disease Research Fields Source Classification	PARP
2-Methylquinazolin-4-ol is a potent competitive *poly(ADP-ribose) synthetase* inhibitor, with a K_i of 1.1 μM. 2-Methylquinazolin-4-ol mammalian aspartate transcarbamylase (ATCase) inhibitor, with 0.20 mM .

HY-N5021

Anhydrosafflor yellow B AHSYB	Quinones Simple Phenylpropanols Carthamus tinctorius L. Phenols Polyphenols Benzene Quinones Phenylpropanoids Plants Compositae Source Classification	Others
Anhydrosafflor yellow B (AHSYB) is a quinochalcone C-glycoside isolated from Carthamus tinctorius. Anhydrosafflor yellow B inhibits ADP-induced platelet aggregation, exhibits significant anti-oxidative effects in vitro, and possesses certain activity against H₂O₂-induced cytotoxicity in cultured PC12 cells and primary neuronal cells .

HY-N7395A

*Cyclic ADP-ribose ammonium* 1 Publications Verification cadpR ammonium	Cardiovascular Disease Structural Classification Natural Products Neurological Disease Classification of Application Fields Endogenous metabolite Inflammation/Immunology Disease Research Fields Endocrinology Source Classification	Calcium Channel TRP Channel Endogenous Metabolite
Cyclic ADP-ribose ammonium (cADPR ammonium) is a potent second messenger for calcium mobilization that is synthesized from NAD ⁺ by an ADP-ribosyl cyclase. Cyclic ADP-ribose ammonium increases cytosolic calcium mainly by Ryanodine receptor-mediated release from endoplasmic reticulum and also by extracellular influx through the opening of TRPM2 channels .

HY-W010918R

Adenosine 5'-diphosphate (Standard) Adenosine diphosphate (Standard); adp (Standard)	Structural Classification Human Gut Microbiota Metabolites Microorganisms Ketones, Aldehydes, Acids Disease markers Nervous System Disorder Endogenous metabolite Cardiovascular System Disorder Source Classification	Reference Standards Endogenous Metabolite
Adenosine 5'-diphosphate (Standard) is the analytical standard of Adenosine 5'-diphosphate. This product is intended for research and analytical applications. Adenosine 5'-diphosphate (Adenosine diphosphate) is a nucleoside diphosphate. Adenosine 5'-diphosphate is the product of ATP dephosphorylation by ATPases. Adenosine 5'-diphosphate induces human platelet aggregation and inhibits stimulated adenylate cyclase by an action at P_2T-purinoceptors. In Vitro: Adenosine 5'-diphosphate consists of the pyrophosphate group, the pentose sugar ribose, and the nucleobase adenine. Adenosine 5'-diphosphate is the product of ATP dephosphorylation by ATPases. ADP is converted back to ATP by ATP synthases. ATP is an important energy transfer molecule in cells. Adenosine 5'-diphosphate is utilized in a wide number of cellular processes, including respiration, biosynthetic reactions, motility, and cell division.

HY-D0199R

Adenosine 5'-diphosphate disodium (Standard) Adenosine diphosphate disodium (Standard); adp disodium (Standard)	Structural Classification Natural Products Endogenous metabolite Source Classification	Endogenous Metabolite Reference Standards
Adenosine 5'-diphosphate (disodium) (Standard) is the analytical standard of Adenosine 5'-diphosphate (disodium). This product is intended for research and analytical applications. Adenosine 5'-diphosphate disodium is a nucleoside diphosphate. Adenosine 5'-diphosphate disodium is the product of ATP dephosphorylation by ATPases. Adenosine 5'-diphosphate disodium is a platelet aggregation agent for hemostasis and the development and extension of arterial thrombosis .

HY-113432R

Nudifloramide (Standard) 2PY (Standard)	Structural Classification Natural Products Endogenous metabolite Source Classification	Reference Standards Endogenous Metabolite PARP
Nudifloramide (Standard) is the analytical standard of Nudifloramide. This product is intended for research and analytical applications. Nudifloramide (2PY) is one of the end products of nicotinamide-adenine dinucleotide (NAD) degradation. Nudifloramide significantly inhibits *poly(ADP-ribose) polymerase (PARP-1)* activity in vitro .

HY-113371A

2-Methylcitric acid trisodium Methylcitric acid trisodium	Classification of Application Fields Ketones, Aldehydes, Acids Metabolic Disease Endogenous metabolite Disease Research Fields Source Classification	Endogenous Metabolite
2-Methylcitric acid trisodium (Methylcitric acid trisodium) is an endogenous metabolite in the 2-methylcitric acid cycle. 2-Methylcitric acid trisodium accumulates in methylmalonic and propionic acidemias and acts as a marker metabolite. 2-Methylcitric acid trisodium markedly inhibits ADP-stimulated and uncoupled respiration in mitochondria supported by glutamate .

HY-W250154

β-Nicotinamide adenine dinucleotide reduced dipotassium	Natural Products Classification of Application Fields Metabolic Disease Endogenous metabolite Disease Research Fields Source Classification	Endogenous Metabolite
β-Nicotinamide adenine dinucleotide reduced dipotassium is an orally active reduced coenzyme. β-Nicotinamide adenine dinucleotide reduced dipotassium is a donor of ADP-ribose units in ADP-ribosylaton reactions and a precursor of cyclic ADP-ribose. β-Nicotinamide adenine dinucleotide reduced dipotassium plays a role as a regenerative electron donor in cellular energy metabolism, including glycolysis, β-oxidation and the tricarboxylic acid (TCA) cycle .

HY-N7614

Anemarrhenasaponin A2 1 Publications Verification Schidigerasaponin F2; Timosaponin AII	Cardiovascular Disease Liliaceae Classification of Application Fields Anemarrhena asphodeloides Bunge Plants Disease Research Fields Steroids Source Classification	Others
Anemarrhenasaponin A2 (Schidigerasaponin F2) is a steroidal saponin isolated from the rhizomes of Anemarrhena asphodeloides. Anemarrhenasaponin A2 inhibits ADP-induced platelet aggregation .

HY-N1717

2-Acetylbenzoic acid	Natural Products Ketones, Aldehydes, Acids Impatiens balsamina Linn. Balsaminaceae Plants Source Classification	Platelet-activating Factor Receptor (PAFR)
2-Acetylbenzoic acid, a Benzoic acid (HY-N0216) derivative, is a weak platelet aggregation inhibitor. 2-Acetylbenzoic acid inhibits Adenosine 5'-diphosphate (ADP, HY-W010918)-induced platelet aggregation .

HY-134556

2'-Hydroxyflavanone	Flavonoids Mimosa pudica Linn. Leguminosae Flavonones Plants Source Classification	Apoptosis
2'-Hydroxyflavanone is a flavanone that can inhibit cancer cell proliferation, induce apoptosis, and reduce inflammation. 2'-Hydroxyflavanone shows inhibitory effect on platelet aggregation caused by two inducers with IC₅₀s 47.8 μM arachidonic acid (AA) and 147.2 μM aenosine diphosphate (ADP) .

HY-N6801R

Nivalenol (Standard)	Structural Classification Microorganisms Terpenoids Sesquiterpenes Source Classification	Reference Standards Caspase Apoptosis Bcl-2 Family
Nivalenol (Standard) is the analytical standard of Nivalenol (HY-N6801). This product is intended for research and analytical applications. Nivalenol, a trichothecene mycotoxin that can be produced by Fusarium graminearum, is a fungal metabolite present in agricultural product. Nivalenol modulates apoptotic pathway, cell cycle regulation, Bax, ERK, caspase-3, and poly-ADP-ribose synthase activity in macrophages. Nivalenol inhibits ribosomal peptidyltransferase site, protein synthesis, DNA synthesis, and cell proliferation. Nivalenol induces late-stage apoptotic morphological changes, reduces cellular metabolism, and decreases cell proliferation in erythroleukemia cells. Nivalenol induces lymphocyte apoptosis in murine thymus, spleen, and Peyer's patches. Nivalenol can be used for the research of erythroleukemia.

HY-N0466R

Rebaudioside A (Standard)	Structural Classification Trifolium hybridum L. Terpenoids Diterpenoids Plants Compositae Endogenous metabolite Source Classification	Reference Standards Glycosidase HMG-CoA Reductase (HMGCR) Fatty Acid Synthase (FASN) LDLR
Rebaudioside A (Standard) is the analytical standard of Rebaudioside A. This product is intended for research and analytical applications. Rebaudioside A is an orally effective steviol glycoside with high sweetness. Rebaudioside A acts as an inhibitor of α-glucosidase with an IC₅₀ value of 35.01 μg/mL. Rebaudioside A increases the ATP/ADP ratio in β cells in a glucose-dependent manner, thereby inhibiting KATP channels, leading to membrane depolarization, calcium influx, and ultimately stimulating insulin secretion. Rebaudioside A activates the SREBP signaling pathway by inhibiting HMGCR, the rate-limiting enzyme in cholesterol synthesis, resulting in increased expression of LDLR on the cell surface, thus promoting the uptake of LDL-C in the blood. Rebaudioside A can be used for studies on blood glucose and lipid regulation as well as anti-obesity.

HY-100973R

Adenosine 5′-diphosphoribose (Standard) adp ribose (Standard)	Human Gut Microbiota Metabolites Microorganisms Endogenous metabolite Source Classification	Reference Standards Endogenous Metabolite
Cyanidin 3,5-diglucoside (chloride) (Standard) is the analytical standard of Cyanidin 3,5-diglucoside (chloride). This product is intended for research and analytical applications. Cyanidin 3,5-diglucoside chloride is a type of anthocyanin. Cyanidin 3,5-diglucoside chloride inhibits hyperbaric pressure-induced GLAST decrease. Cyanidin 3,5-diglucoside chloride has the potential for the research of glaucoma .

HY-120311

Benadrostin	Microorganisms Antibiotics Other Antibiotics Source Classification	PARP
Benadrostin is a *Poly(ADP-ribose) synthetase* inhibitor with an IC₅₀ of 35 μM .

HY-145520

(±)-2'-hydroxy Ceramide (d18:0/18:0) (±)-2'-hydroxy Cer(d18:0/18:0)	Structural Classification Neurological Disease Classification of Application Fields Endogenous metabolite Disease Research Fields Lipid Source Classification	Endogenous Metabolite
(±)-2'-hydroxy Ceramide (d18:0/18:0) is a sphingomyelin that can be isolated from mammalian platelets stimulation by ADP .

HY-N13135

Kadsutherin G	Kadsura heteroclita (Roxb.) Craib Lignans Phenylpropanoids Plants Schisandraceae Source Classification	Others
Kadsutherin G (compound 3) is a lignin isolated from Kadsura. Kadsutherin G inhibits adenosine diphosphate (ADP)-induced platelet aggregation by 33.1 % .

HY-N2522R

Carboxyatractyloside dipotassium (Standard) Gummiferin dipotassium (Standard)	other families Terpenoids Diterpenoids Plants Source Classification	Reference Standards Mitochondrial Metabolism Calcium Channel Reactive Oxygen Species (ROS)
Carboxyatractyloside (dipotassium) (Standard) is the analytical standard of Carboxyatractyloside dipotassium (HY-N2522). This product is intended for research and analytical applications. Carboxyatractyloside dipotassium is a diterpenoid. Carboxyatractyloside dipotassium can be isolated from plants of the genus Xanthium. Carboxyatractyloside dipotassium is an *ADP/ATP* carrier inhibitor, inhibiting mitochondrial ADP/ATP transport. Carboxyatractyloside dipotassium promotes ROS production, induces Ca ²⁺ release, and leads to mitochondrial dysfunction. Carboxyatractyloside dipotassium induces lethargy, weakness, and epileptic seizures in rats .

HY-N13134

Kadsutherin F	Kadsura heteroclita (Roxb.) Craib Lignans Phenylpropanoids Plants Schisandraceae Source Classification	Others
Kadsutherin F (compound 2) is a lignin that can be isolated from Kadsura. Kadsutherin F has an inhibitory effect on adenosine diphosphate (ADP)-induced platelet aggregation with an inhibition rate of 49.47% .

HY-126643

Wedeloside	Microorganisms Terpenoids Diterpenoids Source Classification	Mitochondrial Metabolism
Wedeloside is a diterpenoid amino glycoside isolated from the plant Wedelia asperrima. Wedeloside is capable of inhibiting ADP-stimulated respiration in mitochondria and possesses potential anti-tumor activity. Wedeloside is applicable in drug development and toxicological research .

HY-N4266

Vinaginsenoside R8	Cardiovascular Disease Panax ginseng C. A. Meyer Triterpenes Classification of Application Fields Terpenoids Plants Disease Research Fields Araliaceae Source Classification	Others
Vinaginsenoside R8, a triterpenoid glycoside isolated from the rhizomes of Panacis majoris. Vinaginsenoside R8 displays activities against adenosine diphosphate (ADP)-induced platelet aggregation (IC₅₀=25.18 μM) .

HY-N10272

(±)-Avenaciolide	Infection Structural Classification Natural Products Microorganisms Classification of Application Fields Disease Research Fields Source Classification	Fungal Bacterial
Avenaciolide is an antifungal bis-γ-lactone found in Aspergillus avenaceus. Avenaciolide has also antibacterial action. Avenaciolide is a specific inhibitor of glutamate transport in rat liver mitochondria. Avenaciolide interferes with the ability of ADP to stimulate the rate of glutamate oxidation .

HY-N12070

11-O-β-D-glucopyranosyl thamnosmonin	Coumarins Phenylpropanoids Cynara scolymus L. Umbelliferae Plants Source Classification	Others
11-O-β-D-glucopyranosyl thamnosmonin, a coumarin glucosides, can be isolated from the roots of Angelica apaensis. 11-O-β-D-glucopyranosyl thamnosmonin has weak inhibitory activity on the aggregation of rabbit platelets induced by PAF, AA, and ADP .

HY-N14932

Aggreceride A	Natural Products Microorganisms Source Classification	Platelet-activating Factor Receptor (PAFR)
Aggreceride A is a platelet aggregation inhibitor. Aggreceride A shows an inhibitory activity against aggregation induced by Adenosine 5'-diphosphate (ADP) (HY-W010918), Arachidonic acid (HY-109590) and PAF (platelet activating factor), but was less active against aggregation induced by collagen .

HY-134313A

8-NH2-ATP tetrasodium 8-Aminoadenosine-5'-O-triphosphate tetrasodium	Natural Products Classification of Application Fields Metabolic Disease Endogenous metabolite Disease Research Fields Source Classification	DNA/RNA Synthesis Endogenous Metabolite
8-NH2-ATP tetrasodium, an inactive form of ATP, is produced by 8-NH2-Ado. 8-NH2-Ado tetrasodium induces apoptosis-related cleavage of poly (ADP-ribose) polymerase .

HY-N14933

Aggreceride B	Natural Products Microorganisms Source Classification	Platelet-activating Factor Receptor (PAFR)
Aggreceride B is a platelet aggregation inhibitor. Aggreceride B shows an inhibitory activity against aggregation induced by Adenosine 5'-diphosphate (ADP) (HY-W010918), Arachidonic acid (HY-109590) and PAF (platelet activating factor), but was less active against aggregation induced by collagen .

HY-N14934

Aggreceride C	Natural Products Microorganisms Source Classification	Platelet-activating Factor Receptor (PAFR)
Aggreceride C is a platelet aggregation inhibitor. Aggreceride C shows an inhibitory activity against aggregation induced by Adenosine 5'-diphosphate (ADP) (HY-W010918), Arachidonic acid (HY-109590) and PAF (platelet activating factor), but was less active against aggregation induced by collagen .

HY-134313

8-NH2-ATP 8-Aminoadenosine-5'-O-triphosphate	Natural Products Classification of Application Fields Metabolic Disease Endogenous metabolite Disease Research Fields Source Classification	DNA/RNA Synthesis Endogenous Metabolite
8-NH2-ATP, an inactive form of ATP, is produced by 8-NH2-Ado. 8-NH2-Ado is reported to be potent as shown by induction of apoptosis-related cleavage of poly (ADP-ribose) polymerase .

HY-B0887BR

(-)-trans-Permethrin (Standard) (-)-trans-NRDC-143 (Standard); (1S)-trans-Permethrin (Standard)	Microorganisms Source Classification	Insecticide Reference Standards
Atractyloside (potassium salt) (Standard) is the analytical standard of Atractyloside (potassium salt). This product is intended for research and analytical applications. Atractyloside potassium salt is a toxic diterpenoid glycoside that can be isolated from the fruits of Xanthium sibiricum. Atractyloside potassium salt is a powerful and specific inhibitor of mitochondrial ADP/ATP transport. Atractyloside potassium salt inhibits chloride channels from mitochondrial membranes of rat heart .

HY-112175R

N-Acetylhistamine (Standard) N-Omega-acetylhistamine (Standard)	Structural Classification Microorganisms Ketones, Aldehydes, Acids Endogenous metabolite Source Classification	Reference Standards Histamine Receptor Endogenous Metabolite
Ethacridine (lactate monohydrate) (Standard) is the analytical standard of Ethacridine (lactate monohydrate). This product is intended for research and analytical applications. Ethacridine lactate (Acrinol) monohydrate is a widely used antiseptic and abortifacient. Ethacridine lactate monohydrate is effective against Staphylococcus aureus and other gram-positive cocci. Ethacridine lactate monohydrate is also a poly(ADP-ribose) glycohydrolase (PARG) inhibitor .

HY-N2374R

Eupatorin (Standard)	Flavonoids Classification of Application Fields Cruciferae Phenols Isatis tinctoria L. Plants Disease Research Fields Source Classification Cancer	Reference Standards Apoptosis
Eupatorin (Standard) is the analytical standard of Eupatorin. This product is intended for research and analytical applications. Eupatorin, a naturally occurring flavone, arrests cells at the G2-M phase of the cell cycle and induces apoptotic cell death involving activation of multiple caspases, mitochondrial release of cytochrome c and poly(ADP-ribose) polymerase cleavage .

Cat. No.	Product Name	Chemical Structure

HY-W010918S2

Adenosine 5'-diphosphate-15N5 dilithium

Adenosine 5'-diphosphate- ¹⁵N₅ (Adenosine diphosphate- ¹⁵N₅ dilithium) dilithium is ¹⁵N labeled Adenosine 5'-diphosphate (HY-W010918). Adenosine 5'-diphosphate (Adenosine diphosphate) is a nucleoside diphosphate. Adenosine 5'-diphosphate is the product of ATP dephosphorylation by ATPases. Adenosine 5'-diphosphate induces human platelet aggregation and inhibits stimulated adenylate cyclase by an action at P_2T-purinoceptors.

HY-113432S

Nudifloramide-d3
Nudifloramide-d₃ (2PY-d₃) is the deuterium labeled Nudifloramide. Nudifloramide (2PY) is one of the end products of nicotinamide-adenine dinucleotide (NAD) degradation. Nudifloramide significantly inhibits poly(ADP-ribose) polymerase (PARP-1) activity in vitro .

HY-W010918S3

Adenosine 5'-diphosphate-13C5

Adenosine 5'-diphosphate- ¹³C₅ (Adenosine diphosphate- ¹³C₅) is the ¹³C-labeled Adenosine 5'-diphosphate (HY-W010918). Adenosine 5'-diphosphate (Adenosine diphosphate) is a nucleoside diphosphate. Adenosine 5'-diphosphate is the product of ATP dephosphorylation by ATPases. Adenosine 5'-diphosphate induces human platelet aggregation and inhibits stimulated adenylate cyclase by an action at P2T-purinoceptors.

HY-Z0283S

Benzamide-15N
Benzamide- ¹⁵N is a ¹⁵N-labeled Benzamide. Benzamide inhibits poly(ADP-ribose) polymerase (PARP) .

HY-15284S2

Prasugrel-d4
Prasugrel-d₄ is the deuterium labeled Prasugrel . Prasugrel (PCR 4099), a thienopyridine and proagent, inhibits platelet function. Prasugrel is an orally active and potent P2Y12 receptor antagonist, and inhibits ADP-induced platelet aggregation .

HY-113371S

2-Methylcitric acid-d3

2-Methylcitric acid-d₃ is the deuterium labeled 2-Methylcitric acid. 2-Methylcitric acid (Methylcitric acid) is an endogenous metabolite in the 2-methylcitric acid cycle. 2-Methylcitric acid accumulates in methylmalonic and propionic acidemias and acts as a marker metabolite. 2-Methylcitric acid markedly inhibits ADP-stimulated and uncoupled respiration in mitochondria supported by glutamate .

HY-N6801S

Nivalenol-13C15

Nivalenol- ¹³C₁₅ is the ¹³C labeled Nivalenol (HY-N6801) . Nivalenol, a trichothecene mycotoxin that can be produced by Fusarium graminearum, is a fungal metabolite present in agricultural product. Nivalenol modulates apoptotic pathway, cell cycle regulation, Bax, ERK, caspase-3, and poly-ADP-ribose synthase activity in macrophages. Nivalenol inhibits ribosomal peptidyltransferase site, protein synthesis, DNA synthesis, and cell proliferation. Nivalenol induces late-stage apoptotic morphological changes, reduces cellular metabolism, and decreases cell proliferation in erythroleukemia cells. Nivalenol induces lymphocyte apoptosis in murine thymus, spleen, and Peyer's patches. Nivalenol can be used for the research of erythroleukemia.

HY-136406S

Bongkrekic acid-13C28

1 Publications Verification

Bongkrekic acid- ¹³C₂₈ is the ¹³C labeled Bongkrekic acid (HY-136406). Bongkrekic acid is a mitochondrial toxin secreted by the bacteria Pseudomonas cocovenenans. Bongkrekic acid specific ligand for mitochondrial adenine nucleotide translocase (ANT) rather than the electron transport chain. Bongkrekic acid has to cross the mitochondrial inner membrane to produce its inhibitory effect on ADP/ATP transport .

HY-W711852

Benzamide-d5

Benzamide-d₅ (Benzenecarboxamide-d₅) is deuterium labeled Benzamide. Benzamide (Benzenecarboxamide) is a potent poly(ADP-ribose) polymerase (PARP) inhibitor. Benzamide has protective activity against both glutamate- and methamphetamine (METH)-induced neurotoxicity in vitro. Benzamide can attenuate the METH-induced dopamine depletions and exhibits neuroprotective activity in mice, also has no acute effect on striatal dopamine metabolism and does not reduce body temperature .

HY-W766548

Floxuridine-13C,15N2

Floxuridine- ¹³C, ¹⁵N₂ (5-Fluorouracil 2'-deoxyriboside- ¹³C, ¹⁵N₂) is the ¹³C- and ¹⁵N-labeled labeled Floxuridine (HY-B0097). Floxuridine (5-Fluorouracil 2'-deoxyriboside) is a pyrimidine analog and known as an oncology antimetabolite. Floxuridine inhibits Poly(ADP-Ribose) polymerase and induces DNA damage by activating the ATM and ATR checkpoint signaling pathways in vitro. Floxuridine is a extreamly potent inhibitor for S. aureus infection and induces cell apoptosis . Floxuridine has antiviral effects against HSV and CMV .

HY-107867S1

(Rac)-Clopidogrel hydrogen-d9 sulfate

(Rac)-Clopidogrel hydrogen-d₉ sulfate is the deuterium labeled (±)-Clopidogrel (bisulfate) (HY-107867). (±)-Clopidogrel bisulfate is a platelet P2Y12 receptor inhibitor and an adenosine diphosphate (ADP) receptor antagonist. (±)-Clopidogrel bisulfate inhibits the binding of ADP to its receptors on the membranes of platelet cells, and blocks ADP-mediated activation of the glycoprotein GPIIb/IIIa complex. (±)-Clopidogrel bisulfate reduces vascular inflammation and angiotensin II induced-abdominal aortic aneurysm progression. (±)-Clopidogrel bisulfate has anti-inflammatory effects .

HY-107867S2

Clopidogrel-13C,d3 sulfate

Clopidogrel- ¹³C,d₃ sulfate is the deuterium and ¹³C-labeled (±)-Clopidogrel (bisulfate) (HY-107867). (±)-Clopidogrel bisulfate is a platelet P2Y12 receptor inhibitor and an adenosine diphosphate (ADP) receptor antagonist. (±)-Clopidogrel bisulfate inhibits the binding of ADP to its receptors on the membranes of platelet cells, and blocks ADP-mediated activation of the glycoprotein GPIIb/IIIa complex. (±)-Clopidogrel bisulfate reduces vascular inflammation and angiotensin II induced-abdominal aortic aneurysm progression. (±)-Clopidogrel bisulfate has anti-inflammatory effects .

HY-15284S1

Prasugrel-d3
Prasugrel-d₃ is the deuterium labeled Prasugrel. Prasugrel (PCR 4099), a thienopyridine and proagent, inhibits platelet function. Prasugrel is an orally active and potent P2Y12 receptor antagonist, and inhibits ADP-induced platelet aggregation .

HY-15284S

Prasugrel-d5
Prasugrel-d₅ is deuterium labeled Prasugrel. Prasugrel (PCR 4099), a thienopyridine and prodrug, inhibits platelet function. Prasugrel is an orally active and potent P2Y12 receptor antagonist, and inhibits ADP-induced platelet aggregation .

HY-15284S3

Prasugrel-13C6
Prasugrel-13C6 is a deuterated labeled Prasugrel . Prasugrel (PCR 4099), a thienopyridine and proagent, inhibits platelet function. Prasugrel is an orally active and potent P2Y12 receptor antagonist, and inhibits ADP-induced platelet aggregation .

HY-167927S

Mycophenolic Acid-d3 Acyl-Beta-D-glucuronide
Mycophenolic Acid-d₃ Acyl-Beta-D-glucuronide is the deuterium labeled Mefuparib (HY-167927). Mefuparib (CVL218) is a poly ADP-ribose polymerase (PARP) inhibitor used in cancer research that exhibits potent brain penetration due to its high protein binding.

HY-113096S

Prostaglandin D1-d4
Prostaglandin D1-d₄ (PGD1-d₄) is deuterium labeled Prostaglandin D1. Prostaglandin D1 is a prostanoid which causes contractile and relaxant on isolated human pial arteries, it is also an inhibitor of ADP-induced platelet aggregation with an IC₅₀ value of 320 ng/ml. Prostaglandin D1 can be used for metabolic research .

HY-113113S

13,14-Dihydro PGE1-d4
13,14-Dihydro PGE1-d₄ (13,14-Dihydroprostaglandin E1-d₄) is deuterium labeled 13,14-Dihydro PGE1. 13,14-Dihydro PGE₁ is a metabolite of PGE₁ (Prostaglandin E1) which inhibits the ADP-induced platelet aggregation (ID₅₀ = 10.8 ng/mL platelet rich plasma) .

HY-17459S

Clopidogrel-d3 hydrogen sulfate

Clopidogrel-d₃ (hydrogen sulfate) is the deuterium labeled Clopidogrel hydrogen sulfate . Clopidogrel hydrogen sulfate is an antiplatelet agent to prevent blood clots. Clopidogrel hydrogen sulfate inhibits CYP2B6 and CYP2C19 with IC₅₀s of 18.2 nM and 524 nM, respectively. Clopidogrel hydrogen sulfate is a potent antithrombotic agent that inhibits ADP-induced platelet aggregation．Clopidogrel hydrogen sulfate also is an orally active P2Y(12) inhibitor .

HY-15283AS1

(±)-Clopidogrel-d4

(±)-Clopidogrel-d₄ ((±)-Clopidogrelum-d₄) is the deuterium labeled (±)-Clopidogrel (HY-107867). (±)-Clopidogrel is a platelet P2Y12 receptor inhibitor and an adenosine diphosphate (ADP) receptor antagonist. (±)-Clopidogrel inhibits the binding of ADP to its receptors on the membranes of platelet cells, and blocks ADP-mediated activation of the glycoprotein GPIIb/IIIa complex. (±)-Clopidogrel reduces vascular inflammation and angiotensin II induced-abdominal aortic aneurysm progression. (±)-Clopidogrel has anti-inflammatory effects .

HY-113432S2

Nudifloramide-13C,d3
Nudifloramide- ¹³C,d₃ (2PY- ¹³C,d₃) is the ¹³C- and deuterium labeled Nudifloramide (HY-113432). Nudifloramide (2PY) is one of the end products of nicotinamide-adenine dinucleotide (NAD) degradation. Nudifloramide significantly inhibits poly(ADP-ribose) polymerase (PARP-1) activity in vitro .

Targets Recommended: PARP Poly(ADP-ribose) Glycohydrolase (PARG) Arf Family GTPase

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-B0764G

Bucladesine sodium Dibutyryl cAMP sodium; DBcAMP sodium	PKA Reactive Oxygen Species (ROS) Apoptosis	Neurological Disease Inflammation/Immunology Cancer
Bucladesine (Dibutyryl cAMP; DBcAMP) sodium (GMP) is a Bucladesine sodium (HY-B0764) produced by using GMP guidelines. Bucladesine (Dibutyryl cAMP; DBcAMP) is a membrane-permeable 3′, 5′-cyclic adenosine monophosphate (cAMP) analog. Bucladesine selectively activates cAMP dependent protein kinase (PKA) by increasing the intracellular level of cAMP. Bucladesine significantly attenuates MDMA-induced increases in hippocampal mitochondrial ROS formation, mitochondrial outer membrane damage, cytochrome c release, and hippocampal ADP/ATP ratio, thereby improving spatial learning and memory impairments. Bucladesine exhibit anti-nociceptive and anti-inflammation effect. Bucladesine can inhibit cancer cells proliferation, induce apoptosis. Bucladesine can be used for the researches of neurological disease, cancer, inflammation .

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