P2Y1 Protein, Human (sf9, FLAG, His)
The P2Y1 protein acts as a receptor for extracellular adenine nucleotides, specifically ADP. In platelets, ADP binding activates phospholipase C, leading to intracellular calcium mobilization, platelet shape changes, and aggregation. P2Y1 Protein, Human (sf9, FLAG, His) is the recombinant human-derived P2Y1 protein, expressed by sf9 insect cells , with C-10*His, N-Flag labeled tag.
- Species: Human
- Source: Sf9 insect cells
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Storage:Stored at -80°C for 1 year from date of receipt. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.
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Biological Activity
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Technical Parameters
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Product Properties
- Documentation
- Help & FAQs
Biological Activity
Description
The P2Y1 protein acts as a receptor for extracellular adenine nucleotides, specifically ADP. In platelets, ADP binding activates phospholipase C, leading to intracellular calcium mobilization, platelet shape changes, and aggregation. P2Y1 Protein, Human (sf9, FLAG, His) is the recombinant human-derived P2Y1 protein, expressed by sf9 insect cells , with C-10*His, N-Flag labeled tag.
Background
The P2Y1 receptor serves as a receptor for extracellular adenine nucleotides, particularly ADP. Upon binding to ADP, this receptor, found notably in platelets, triggers the mobilization of intracellular calcium ions through the activation of phospholipase C. Consequently, this activation induces changes in platelet shape and, ultimately, platelet aggregation. ATP acts as an antagonist, inhibiting the ADP-induced mobilization of calcium ions. Specific antagonists of the P2Y1 receptor, such as A3P5PS, A3P5P, and A2P5P, have been identified and shown to impede downstream signaling events mediated by the mobilization of calcium ions from intracellular stores, as well as platelet shape changes in response to extracellular ADP.
Technical Parameters
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Species Human
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Source Sf9 insect cells
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Tag C-10*His;N-Flag
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Accession
P47900 (P2Y1 (T2-P7)-BRIL-P2Y1 (A8-K247)-rubredoxin-P2Y1 (P253-L373), D320N)
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Gene ID5028
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Protein Length
Partial
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Synonyms
P2RY1; P2Y Purinoceptor 1; Purinergic Receptor P2Y1; ADP Receptor; P2Y1; P2 Purinoceptor Subtype Y1; SARCC; Platelet ADP Receptor; Suppressing Androgen Receptor In Renal Cell Carcinoma; Purinergic Receptor; Purinergic Receptor P2Y, G-Protein Coupled, 1; A
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Purity
≥ 90%, as determined by reducing SDS-PAGE.
Product Properties
Solution.
<1 EU/μg, determined by LAL method.
Please use rapid thawing with running water to thaw the protein.
Stored at -80°C for 1 year from date of receipt. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.
Shipping with dry ice.
Documentation
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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