ART1 Protein, Cynomolgus (HEK293, His)

ART1 Protein is an arginine-specific ADP-ribosyltransferase. ART1 is involved in the regulation of a diverse array of pathophysiological processes, including proliferation, invasion, apoptosis, autophagy and angiogenesis of colorectal cancer (CRC) cells. ART1 plays a crucial role in the elevation of glucose consumption in CT26 cells and may regulate GLUT1-dependent glycolysis in CRC via the PI3K/AKT/HIF1α pathway. ART1 Protein, Cynomolgus (HEK293, His) is the recombinant cynomolgus-derived ART1 protein, expressed by HEK293 , with C-His labeled tag. The total length of ART1 Protein, Cynomolgus (HEK293, His) is 272 a.a., with molecular weight of ~31.7 KDa.

NAD(P)(+)--arginine ADP-ribosyltransferase (ART1), an arginine-specific ADP-ribosyltransferase, catalyzes the transfer of ADP-ribose moiety to arginine residues on an acceptor protein using nicotinamide adenine dinucleotide (NAD+) as a substrate, thus eliciting changes in the activities and functions of the acceptor proteins. ART1 is involved in the regulation of a diverse array of pathophysiological processes, including proliferation, invasion, apoptosis, autophagy and angiogenesis of colorectal cancer (CRC) cells. ART1 plays a crucial role in the elevation of glucose consumption in CT26 cells and may regulate GLUT1-dependent glycolysis in CRC via the PI3K/AKT/HIF1α pathway. In addition, ART1 plays a role in glycolysis and energy metabolism under high glucose conditions and promotes angiogenesis in colorectal cancer cells through the PI3K/AKT pathway^[1].

Cynomolgus

HEK293

C-His

XP_005579037 (Q23-N294)

102142531  [NCBI]

Approximately 31.7 kDa.

Greater than 95% as determined by reducing SDS-PAGE.

<1 EU/μg, determined by LAL method.