Nicotinamide 1,N6-ethenoadenine dinucleotide (solution)
Nicotinamide 1,N6-ethenoadenine dinucleotide (solution) (ε-NAD (solution)) is a fluorescent analog of NAD. Nicotinamide 1,N6-ethenoadenine dinucleotide can be cleaved by phosphodiesterase I (from C. adamanteus venom) and binds to bovine liver glutamate dehydrogenase. Nicotinamide 1,N6-ethenoadenine dinucleotide can serve as a substrate for G-ADP ribosylation of G proteins catalyzed by bacterial toxins. Nicotinamide 1,N6-ethenoadenine dinucleotide can be used as a fluorescent substrate for the study of ADP ribosylation reactions.
Solvent and concentration: ddH2O: 20 mM
For research use only. We do not sell to patients.
- CAS No.: 38806-38-1
- Formula: C23H27N7O14P2
- Molecular Weight:687.45
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Solvent and concentration: ddH2O: 20 mM
Nicotinamide 1,N6-ethenoadenine dinucleotide serves as a substrate for the bacterial toxin-catalyzed epsilon-ADP ribosylation of signal-transducing G-proteins[1].
Nicotinamide 1,N6-ethenoadenine dinucleotide can be cleaved into 5'-ε-AMP and nicotinamide mononucleotide by phosphodiesterase I (from C. adamanteus venom)[1].
Nicotinamide 1,N6-ethenoadenine dinucleotide binds to bovine liver glutamate dehydrogenase[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 38806-38-1
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Molecular Weight 687.45
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Formula C23H27N7O14P2
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SMILES
O[C@H]1[C@@H](O[C@@H]([C@H]1O)COP(OP(OC[C@H]2O[C@@H]([N+]3=CC=CC(C(N)=O)=C3)[C@@H]([C@@H]2O)O)([O-])=O)(O)=O)N4C5=C(N=C4)C6=NC=CN6C=N5
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Synonyms
ε-NAD (solution)
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Hingorani VN, et al. Fluorescent labeling of signal-transducing G-proteins. Pertussis toxin-catalyzed etheno-ADP ribosylation of transducin. J Biol Chem. 1988 Dec 25;263(36):19804-8. [Content Brief]
[2]. Favilla R, Mazzini A. The binding of 1,N6-etheno-NAD to bovine liver glutamate dehydrogenase. Biochim Biophys Acta. 1984 Jul 17;788(1):48-57. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Nicotinamide 1,N6-ethenoadenine dinucleotide (solution) Related Classifications
HY-DY1108 Related Classifications
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