2. Others Metabolic Enzyme/Protease
  3. Fluorescent Dye Phosphodiesterase (PDE) Glutamate Dehydrogenase (GLDH)
  4. Nicotinamide 1,N6-ethenoadenine dinucleotide

Nicotinamide 1,N6-ethenoadenine dinucleotide  (Synonyms: ε-NAD)

Cat. No.: HY-137592 Purity: 99.05%
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SDS
Handling Instructions Technical Support

Nicotinamide 1,N6-ethenoadenine dinucleotide (ε-NAD) is a fluorescent analog of NAD. Nicotinamide 1,N6-ethenoadenine dinucleotide can be cleaved by phosphodiesterase I (from C. adamanteus venom) and binds to bovine liver glutamate dehydrogenase. Nicotinamide 1,N6-ethenoadenine dinucleotide can serve as a substrate for G-ADP ribosylation of G proteins catalyzed by bacterial toxins. Nicotinamide 1,N6-ethenoadenine dinucleotide can be used as a fluorescent substrate for the study of ADP ribosylation reactions.

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Nicotinamide 1,N6-ethenoadenine dinucleotide

Nicotinamide 1,N6-ethenoadenine dinucleotide 화학구조

CAS No. : 38806-38-1

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고객리뷰

Based on 1 publication(s) in Google Scholar

Other Forms of Nicotinamide 1,N6-ethenoadenine dinucleotide:

Nicotinamide 1,N6-ethenoadenine dinucleotide Related Antibodies

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제품 설명

Nicotinamide 1,N6-ethenoadenine dinucleotide (ε-NAD) is a fluorescent analog of NAD. Nicotinamide 1,N6-ethenoadenine dinucleotide can be cleaved by phosphodiesterase I (from C. adamanteus venom) and binds to bovine liver glutamate dehydrogenase. Nicotinamide 1,N6-ethenoadenine dinucleotide can serve as a substrate for G-ADP ribosylation of G proteins catalyzed by bacterial toxins. Nicotinamide 1,N6-ethenoadenine dinucleotide can be used as a fluorescent substrate for the study of ADP ribosylation reactions[1][2].

IC50 & Target[1]

PDEI

 

In Vitro

Nicotinamide 1,N6-ethenoadenine dinucleotide serves as a substrate for the bacterial toxin-catalyzed epsilon-ADP ribosylation of signal-transducing G-proteins[1].
Nicotinamide 1,N6-ethenoadenine dinucleotide can be cleaved into 5'-ε-AMP and nicotinamide mononucleotide by phosphodiesterase I (from C. adamanteus venom)[1].
Nicotinamide 1,N6-ethenoadenine dinucleotide binds to bovine liver glutamate dehydrogenase[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Nicotinamide 1,N6-ethenoadenine dinucleotide Related Antibodies
분자량

687.45

화학식

C23H27N7O14P2
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O[C@H]1[C@@H](O[C@@H]([C@H]1O)COP(OP(OC[C@H]2O[C@@H]([N+]3=CC=CC(C(N)=O)=C3)[C@@H]([C@@H]2O)O)([O-])=O)(O)=O)N4C5=C(N=C4)C6=NC=CN6C=N5
선적

Room temperature in continental US; may vary elsewhere.
보관

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

용액&용해도
In Vitro: 

H2O : 100 mg/mL (145.47 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.4547 mL 7.2733 mL 14.5465 mL
5 mM 0.2909 mL 1.4547 mL 2.9093 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
순도&문서

Purity: 99.05%

SDS (394 KB)

COA (249 KB) HNMR (229 KB) RP-HPLC (206 KB) LCMS (100 KB) Elemental Analysis Report (106 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 1.4547 mL 7.2733 mL 14.5465 mL 36.3663 mL
5 mM 0.2909 mL 1.4547 mL 2.9093 mL 7.2733 mL
10 mM 0.1455 mL 0.7273 mL 1.4547 mL 3.6366 mL
15 mM 0.0970 mL 0.4849 mL 0.9698 mL 2.4244 mL
20 mM 0.0727 mL 0.3637 mL 0.7273 mL 1.8183 mL
25 mM 0.0582 mL 0.2909 mL 0.5819 mL 1.4547 mL
30 mM 0.0485 mL 0.2424 mL 0.4849 mL 1.2122 mL
40 mM 0.0364 mL 0.1818 mL 0.3637 mL 0.9092 mL
50 mM 0.0291 mL 0.1455 mL 0.2909 mL 0.7273 mL
60 mM 0.0242 mL 0.1212 mL 0.2424 mL 0.6061 mL
80 mM 0.0182 mL 0.0909 mL 0.1818 mL 0.4546 mL
100 mM 0.0145 mL 0.0727 mL 0.1455 mL 0.3637 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Nicotinamide 1,N6-ethenoadenine dinucleotide Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Nicotinamide 1,N6-ethenoadenine dinucleotide38806-38-1ε-NADFluorescent DyePhosphodiesterase (PDE)Glutamate Dehydrogenase (GLDH)Glutamate Dehydrogenaseglutamate dehydrogenaseInhibitorinhibitorinhibit

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상품명:
Nicotinamide 1,N6-ethenoadenine dinucleotide
Cat. No.:
HY-137592
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