CD38 inhibitor 1

Name: CD38 inhibitor 1
Brand: MedChemExpress
SKU: HY-123999
Rating: 5.0 (12 reviews)

Cat. No.: HY-123999 Purity: 99.64%: Data Sheet
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CD38 inhibitor 1 (compound 78c) is a potent CD38 inhibitor with IC₅₀s of 7.3 nM and 1.9 nM for hCD38 and mouse CD38.

For research use only. We do not sell to patients.

CAS No. : 1700637-55-3

Size	Stock	Quantity

Free Sample (0.1 - 0.2 mg)	Apply Now
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	In-stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	In-stock	Estimated Time of Arrival: December 31
Solid
5 mg	In-stock	Estimated Time of Arrival: December 31
10 mg	In-stock	Estimated Time of Arrival: December 31
25 mg	In-stock	Estimated Time of Arrival: December 31
50 mg	In-stock	Estimated Time of Arrival: December 31
100 mg	In-stock	Estimated Time of Arrival: December 31
250 mg	In-stock	Estimated Time of Arrival: December 31
500 mg	In-stock	Estimated Time of Arrival: December 31
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Customer Review

Based on 12 publication(s) in Google Scholar

12 Publications Citing Use of MCE CD38 inhibitor 1

RT-PCR

In Vivo Efficacy Study

: CD38 inhibitor 1 purchased from MedChemExpress. Usage Cited in: Aging Cell. 2025 Sep;24(9):e70162.; Western blotting analyses and quantification of TBK1 and phosphorylated TBK1 in the liver. C57BL/6 mice, CD38 inhibitor 1 (78c) was administered to mice by intraperitoneal injection (10 mg/kg/dose) twice daily for 2 months. Control mice received vehicle (5% DMSO, 15% PEG400, 80% of 15% hydroxypropyl‐g‐cyclodextrin (in citrate buffer pH 6.0)) injections.

: CD38 inhibitor 1 purchased from MedChemExpress. Usage Cited in: Brain Behav Immun. 2024 Jan:115:64-79. [Abstract]; (A) Schematic illustrations of the experiment and timeline. (B) Representative tracks of the OFT. (C) Total distances and percentage of time spent in the center of OFT. (D) FST immobility time. (E) TST immobility time. (F) Scores of SPT. Wild-type C57BL/6 mice, after a week of intraperitoneal injection with the CD38 inhibitor 1 (compound 78c) at a dose of 15 mg/kg every 2 days, a single intraperitoneal (i.p.) injection of LPS was administered 24 h after the last dose.

: CD38 inhibitor 1 purchased from MedChemExpress. Usage Cited in: Brain Behav Immun. 2024 Jan:115:64-79. [Abstract]; Representative immunofluorescent images of CD38 expression in CA3 and DG of hippocampus and cortex. Wild-type C57BL/6 mice, After a week of intraperitoneal injection with the CD38 inhibitor 1 (compound 78c) at a dose of 15 mg/kg every 2 days, a single intraperitoneal (i.p.) injection of LPS was administered 24 h after the last dose.

: CD38 inhibitor 1 purchased from MedChemExpress. Usage Cited in: Brain Behav Immun. 2024 Jan:115:64-79. [Abstract]; Representative immunohistochemistry Sholl images of Iba1+ microglia in hippocampus. Wild-type C57BL/6 mice, After a week of intraperitoneal injection with the CD38 inhibitor 1 (compound 78c) at a dose of 15 mg/kg every 2 days, a single intraperitoneal (i.p.) injection of LPS was administered 24 h after the last dose.

: CD38 inhibitor 1 purchased from MedChemExpress. Usage Cited in: Brain Behav Immun. 2024 Jan:115:64-79. [Abstract]; Protein bands of SNAP25 and Syn in hippocampus and cortex. Wild-type C57BL/6 mice, After a week of intraperitoneal injection with the CD38 inhibitor 1 (compound 78c) at a dose of 15 mg/kg every 2 days, a single intraperitoneal (i.p.) injection of LPS was administered 24 h after the last dose.

: CD38 inhibitor 1 purchased from MedChemExpress. Usage Cited in: Cell Death Dis. 2020 Jan 6;11(1):15. [Abstract]; qPCR showing IFNγ, TNFα, IL-2 and IL-12 levels in activated CD4+ T cells or LPS-stimulated HOKs, following CD38 inhibitor 1 (CD38 inhibitor) treatment. Real-time PCR analysis of IFNγ, TNFα, IL-2 and IL-12 levels in HOKs during miR-26a. 12-h PKCδ/CD38 inhibitors (CD38 inhibitor 1, 20 nM) pre-treatment, HOKs were stimulated with LPS or activated CD4+ T cells production for 24 h.

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Biological Activity
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Description

CD38 inhibitor 1 (compound 78c) is a potent CD38 inhibitor with IC₅₀s of 7.3 nM and 1.9 nM for hCD38 and mouse CD38^[1].

IC₅₀ & Target

IC50: 7.3 nM (hCD38), 1.9 nM (mouse CD38)^[1]
Ki: 0.3 nM (WT hCD38)^[1]

In Vivo

CD38 inhibitor (30 mg/kg; oral administration; 2 and 6 hours) significantly elevates NAD levels in liver and muscle^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Diet induced obese (DIO) C57Bl6 mice^[1]
Dosage:	30 mg/kg
Administration:	Orally once
Result:	NAD levels were significantly increased at both the 2 and 6 h time points in liver and muscle.

Molecular Weight

413.53

Formula

C₂₂H₂₇N₃O₃S

CAS No.

1700637-55-3

Appearance

Solid

Color

Light yellow to brown

SMILES

O=C1N(C)C2=C(C=C(C3=CN=CS3)C=C2)C(N[C@H]4CC[C@H](OCCOC)CC4)=C1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	2 years
	-20°C	1 year

Solvent & Solubility

In Vitro:

DMSO : 25 mg/mL (60.46 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.4182 mL	12.0910 mL	24.1820 mL
5 mM	0.4836 mL	2.4182 mL	4.8364 mL
10 mM	0.2418 mL	1.2091 mL	2.4182 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.5 mg/mL (6.05 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: 2.5 mg/mL (6.05 mM); Suspended solution; Need ultrasonic

This protocol yields a suspended solution of 2.5 mg/mL. Suspended solution can be used for oral and intraperitoneal injection.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Protocol 3

Add each solvent one by one: 10% DMSO 90% Corn Oil
Solubility: ≥ 2.5 mg/mL (6.05 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL Corn oil, and mix evenly.

For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: Corn Oil
Solubility: 10 mg/mL (24.18 mM); Suspended solution; Need ultrasonic
Protocol 2

Add each solvent one by one: 50% PEG300 50% Saline
Solubility: 10 mg/mL (24.18 mM); Suspended solution; Need ultrasonic

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

DMSO +

Tween-80 +

Saline

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Calculation results:

Working solution concentration: mg/mL

Method for preparing stock solution: mg drug dissolved in μL DMSO (Stock solution concentration: mg/mL).

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).

Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.

If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.

Purity & Documentation

Purity: 99.83%

Select Batch:

Data Sheet (278 KB) SDS (393 KB)

COA (252 KB) HNMR (304 KB) LCMS (168 KB) Elemental Analysis Report (111 KB)

Handling Instructions (2659 KB)

References

[1]. Haffner CD, et al. Discovery, Synthesis, and Biological Evaluation of Thiazoloquin(az)olin(on)es as Potent CD38 Inhibitors. J Med Chem. 2015 Apr 23;58(8):3548-71. [Content Brief]

[2]. Tarragó MG, Chini CCS, Kanamori KS, et al. A Potent and Specific CD38 Inhibitor Ameliorates Age-Related Metabolic Dysfunction by Reversing Tissue NAD+ Decline. Cell Metab. 2018;27(5):1081-1095.e10. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.4182 mL	12.0910 mL	24.1820 mL	60.4551 mL
	5 mM	0.4836 mL	2.4182 mL	4.8364 mL	12.0910 mL
	10 mM	0.2418 mL	1.2091 mL	2.4182 mL	6.0455 mL
	15 mM	0.1612 mL	0.8061 mL	1.6121 mL	4.0303 mL
	20 mM	0.1209 mL	0.6046 mL	1.2091 mL	3.0228 mL
	25 mM	0.0967 mL	0.4836 mL	0.9673 mL	2.4182 mL
	30 mM	0.0806 mL	0.4030 mL	0.8061 mL	2.0152 mL
	40 mM	0.0605 mL	0.3023 mL	0.6046 mL	1.5114 mL
	50 mM	0.0484 mL	0.2418 mL	0.4836 mL	1.2091 mL
	60 mM	0.0403 mL	0.2015 mL	0.4030 mL	1.0076 mL

CD38 inhibitor 1 Related Classifications

Metabolic Disease

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CD38 inhibitor 11700637-55-3CD38Inhibitorinhibitorinhibit

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CD38 inhibitor 1

Customer Review

CD38 inhibitor 1 Related Antibodies

12 Publications Citing Use of MCE CD38 inhibitor 1

Featured Recommendations

•Related Screening Libraries:

•Related Small Molecules:

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Biological Activity

Purity & Documentation

References

Customer Review

Molarity Calculator

Dilution Calculator

Complete Stock Solution Preparation Table

CD38 inhibitor 1 Related Classifications

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