1. Membrane Transporter/Ion Channel
  2. ATP Synthase
  3. Bongkrekic acid

Bongkrekic acid 

Cat. No.: HY-136406
Handling Instructions

Bongkrekic acid is a mitochondrial toxin secreted by the bacteria Pseudomonas cocovenenans. Bongkrekic acid specific ligand for mitochondrial adenine nucleotide translocase (ANT) rather than the electron transport chain. Bongkrekic acid has to cross the mitochondrial inner membrane to produce its inhibitory effect on ADP/ATP transport.

For research use only. We do not sell to patients.

Bongkrekic acid Chemical Structure

Bongkrekic acid Chemical Structure

CAS No. : 11076-19-0

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Description

Bongkrekic acid is a mitochondrial toxin secreted by the bacteria Pseudomonas cocovenenans[1]. Bongkrekic acid specific ligand for mitochondrial adenine nucleotide translocase (ANT) rather than the electron transport chain. Bongkrekic acid has to cross the mitochondrial inner membrane to produce its inhibitory effect on ADP/ATP transport[2].

In Vitro

Bongkrekic acid (0-50 μM; 48 hours) stimulated formazan formation in MDA-MB-231, MCF-7 and LTED cells with EC50 of 34.14 μM, >50 μM and 2.58 μM, respectively.
Bongkrekic acid (0.1-25 μM; 48 hours) decreases the living cell numbers in LTED cells and parent MCF-7 cells in a dose-dependent manner[1].

Molecular Weight

486.60

Formula

C₂₈H₃₈O₇

CAS No.

11076-19-0

SMILES

OC(CC(/C=C/[[email protected]@H](C)C/C=C/CC/C=C/C=C\C[[email protected]@H](OC)/C(C)=C\C=C(C)\C(O)=O)=C/C(O)=O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

Bongkrekic acidATP SynthaseMDA-MB-231MCF-7LTED cellsbreast cancerformazan formationMitochondrial ToxinInhibitorinhibitorinhibit

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