Molecular, functional, and pathological aspects of the mitochondrial ADP/ATP carrier

  • Physiology (Bethesda). 2006 Aug;21:242-9. doi: 10.1152/physiol.00005.2006.
C Dahout-Gonzalez  1 ,  H Nury ,  V Trézéguet ,  G J-M Lauquin ,  E Pebay-Peyroula ,  G Brandolin
Affiliations
  • 1. Département de Réponse et Dynamique Cellulaires, CEA-Grenoble, Laboratoire de Biochimie et Biophysique des Systèmes Intégrés, UMR 5092 CEA-CNRS-Université Joseph Fourier, Grenoble, France.
PMID: 16868313 DOI: 10.1152/physiol.00005.2006
Abstract

In providing the cell with ATP generated by Oxidative Phosphorylation, the mitochondrial ADP/ATP carrier plays a central role in aerobic eukaryotic cells. Combining biochemical, genetic, and structural approaches contributes to understanding the molecular mechanism of this essential transport system, the dysfunction of which is implicated in neuromuscular diseases.

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