iso-ADP ribose TEA 

iso-ADP ribose TEA is the small-molecule ligand for protein nucleic acid modification, comprising parts of two consecutive ADP-ribosyl units within the PAR chain. iso-ADP ribose TEA specifically binds WWE, FHA and OB-fold domains, enabling PAR-dependent functional responses like ubiquitylation and supporting DNA damage signaling and repair. iso-ADP ribose TEA can be used for cancer research^[1].

iso-ADP ribose TEA specifically binds WWE domains in specific human proteins with sub-micromolar affinity, enabling PAR-dependent functional responses like ubiquitylation^[1].
iso-ADP ribose TEA specifically binds FHA domains of human APTX and PNKP to support DNA damage signaling and repair^[1].
iso-ADP ribose TEA specifically binds OB-fold domains of human SSB1 and BRCA2 to mediate early recruitment to DNA break sites^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

761.70

C₂₇H₅₃N₇O₁₄P₂

Solid

White to off-white

CCN(CC)CC.CCN(CC)CC.NC1=NC=NC2=C1N=CN2[C@H]3[C@H](O[C@H]4[C@H](O)[C@H](O)[C@@H](COP(O)(O)=O)O4)[C@H](O)[C@@H](COP(O)(O)=O)O3

Room temperature in continental US; may vary elsewhere.

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

• [1]. Teloni F, et al. Readers of poly(ADP-ribose): designed to be fit for purpose. Nucleic Acids Res. 2016;44(3):993-1006.  [Content Brief]