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Cat. No.: HY-135782

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iso-ADP ribose

iso-ADP ribose is the small-molecule ligand for protein nucleic acid modification, comprising parts of two consecutive ADP-ribosyl units within the PAR chain. iso-ADP ribose specifically binds WWE, FHA and OB-fold domains, enabling PAR-dependent functional responses like ubiquitylation and supporting DNA damage signaling and repair. iso-ADP ribose can be used for cancer research.

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CAS No.: 15720-01-1
Formule: C₁₅H₂₃N₅O₁₄P₂
Masse moléculaire:559.32

Stockage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (273 KB)

iso-ADP ribose Chemical Structure

CAS No.: 15720-01-1

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- In Vitro
Chemical Information
Pureté et documentation
Références
Calculators
Help & FAQs
Classifications
Bioz

Activité biologique

Description

In Vitro

iso-ADP ribose specifically binds WWE domains in specific human proteins with sub-micromolar affinity, enabling PAR-dependent functional responses like ubiquitylation^[1].
iso-ADP ribose specifically binds FHA domains of human APTX and PNKP to support DNA damage signaling and repair^[1].
iso-ADP ribose specifically binds OB-fold domains of human SSB1 and BRCA2 to mediate early recruitment to DNA break sites^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 15720-01-1
Masse moléculaire 559.32
Formule C₁₅H₂₃N₅O₁₄P₂
SMILES

NC1=NC=NC2=C1N=CN2[C@H]3[C@H](O[C@H]4[C@H](O)[C@H](O)[C@@H](COP(O)(O)=O)O4)[C@H](O)[C@@H](COP(O)(O)=O)O3
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (273 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Teloni F, et al. Readers of poly(ADP-ribose): designed to be fit for purpose. Nucleic Acids Res. 2016;44(3):993-1006. [Content Brief]

Calculators

Calculateur de molarité

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculateur de dilution

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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