iso-ADP ribose
iso-ADP ribose is the small-molecule ligand for protein nucleic acid modification, comprising parts of two consecutive ADP-ribosyl units within the PAR chain. iso-ADP ribose specifically binds WWE, FHA and OB-fold domains, enabling PAR-dependent functional responses like ubiquitylation and supporting DNA damage signaling and repair. iso-ADP ribose can be used for cancer research.
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研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 15720-01-1
- 分子式: C15H23N5O14P2
- 分子量:559.32
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
製品説明
体外実験
iso-ADP ribose specifically binds WWE domains in specific human proteins with sub-micromolar affinity, enabling PAR-dependent functional responses like ubiquitylation[1].
iso-ADP ribose specifically binds FHA domains of human APTX and PNKP to support DNA damage signaling and repair[1].
iso-ADP ribose specifically binds OB-fold domains of human SSB1 and BRCA2 to mediate early recruitment to DNA break sites[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
化学情報
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CAS 番号 15720-01-1
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分子量 559.32
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分子式 C15H23N5O14P2
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SMILES
NC1=NC=NC2=C1N=CN2[C@H]3[C@H](O[C@H]4[C@H](O)[C@H](O)[C@@H](COP(O)(O)=O)O4)[C@H](O)[C@@H](COP(O)(O)=O)O3
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
iso-ADP ribose 関連分類
HY-135782 関連分類
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