iso-ADP ribose
iso-ADP ribose is the small-molecule ligand for protein nucleic acid modification, comprising parts of two consecutive ADP-ribosyl units within the PAR chain. iso-ADP ribose specifically binds WWE, FHA and OB-fold domains, enabling PAR-dependent functional responses like ubiquitylation and supporting DNA damage signaling and repair. iso-ADP ribose can be used for cancer research.
For research use only. We do not sell to patients.
- CAS No.: 15720-01-1
- Formula: C15H23N5O14P2
- Molecular Weight:559.32
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
iso-ADP ribose specifically binds WWE domains in specific human proteins with sub-micromolar affinity, enabling PAR-dependent functional responses like ubiquitylation[1].
iso-ADP ribose specifically binds FHA domains of human APTX and PNKP to support DNA damage signaling and repair[1].
iso-ADP ribose specifically binds OB-fold domains of human SSB1 and BRCA2 to mediate early recruitment to DNA break sites[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 15720-01-1
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Molecular Weight 559.32
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Formula C15H23N5O14P2
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SMILES
NC1=NC=NC2=C1N=CN2[C@H]3[C@H](O[C@H]4[C@H](O)[C@H](O)[C@@H](COP(O)(O)=O)O4)[C@H](O)[C@@H](COP(O)(O)=O)O3
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
iso-ADP ribose Related Classifications
HY-135782 Related Classifications
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