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  4. ART3 Protein, Human (HEK293, His)

ART3 Protein, Human (HEK293, His)

Cat. No.: HY-P74409
Handling Instructions

ART3 is a member of the mono-ADP-ribosyltransferase family genes which is involved in cell division, DNA-repair and the regulation of the inflammatory response. The temporary and restricted expression of ART3 in spermatocytes might be linked to cell division processes underlying the formation of spermatocytes and the regulation of spermatogenesis. Moreover, it induces TNBC cell growth and invasion by activating Akt and ERK. ART3 Protein, Human (HEK293, His) is the recombinant human-derived ART3 protein, expressed by HEK293 , with C-His labeled tag. The total length of ART3 Protein, Human (HEK293, His) is 362 a.a., with molecular weight of ~49 kDa.

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Description

ART3 is a member of the mono-ADP-ribosyltransferase family genes which is involved in cell division, DNA-repair and the regulation of the inflammatory response. The temporary and restricted expression of ART3 in spermatocytes might be linked to cell division processes underlying the formation of spermatocytes and the regulation of spermatogenesis. Moreover, it induces TNBC cell growth and invasion by activating Akt and ERK. ART3 Protein, Human (HEK293, His) is the recombinant human-derived ART3 protein, expressed by HEK293 , with C-His labeled tag. The total length of ART3 Protein, Human (HEK293, His) is 362 a.a., with molecular weight of ~49 kDa.

Background

ART3 is a member of the mono-ADP-ribosyltransferase family genes which is involved in cell division, DNA-repair and the regulation of the inflammatory response. ART3 mRNA can be detected in unstimulated monocytes, alveolar epithelial cells, spermatocytes in testes, macrophages, T lymphocytes and other cell types. The expression of ART3 is associated with physiological and pathological functions, including spermatogenesis and damage to the number of cardiomyocytes. The temporary and restricted expression of ART3 in spermatocytes might be linked to cell division processes underlying the formation of spermatocytes and the regulation of spermatogenesis. And ART3 protein is significantly overexpressed in human TNBC tumors tissue and cell lines through. Overexpression of ART3 in MDA-MB-231 breast cancer cells increased cell proliferation, invasion, and survival in vitro and growth of xenograft tumors by activating Akt and ERK. Moreover, ART3 may play important roles in central nervous system (CNS) pathophysiology after traumatic brain injury (TBI)[1][2].

Species

Human

Source

HEK293

Tag

C-His

Accession

AAH08397 (M1-S362)

Gene ID

419  [NCBI]

Molecular Construction
N-term
ART3 (M1-S362)
Accession # AAH08397
His
C-term
Synonyms
Ecto-ADP-ribosyltransferase 3; ARTC3; ART3; TMART
Molecular Weight

Approximately 49 kDa

Purity

Greater than 90% as determined by reducing SDS-PAGE.

Endotoxin Level

<1 EU/μg, determined by LAL method.

Documentation

ART3 Protein, Human (HEK293, His) Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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ART3 Protein, Human (HEK293, His)
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HY-P74409
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