Ascr#10  (Synonyms: Asc-C9)

Ascr#10 (Asc-C9) is an orally active thermogenesis inducer and insecticide that can be obtained from Monochamus alternatus. Ascr#10 binds to the insect adipokinetic hormone (AKH) receptor (K_a=272 µM) and stimulates mitochondrial biogenesis via the PGC1α-UCP4 axis. Consequently, Ascr#10 induces UCP4-mediated uncoupled respiration, reduces the ATP/ADP ratio and accelerates lipid mobilization, thereby driving the thermogenesis process. Ascr#10 delays pupation and exerts specific chemotaxis toward dispersive fourth-stage pinewood nematode LIV larvae. Ascr#10 promotes cold acclimation of Monochamus alternatus larvae through metabolic inhibition and cryoprotectant accumulation, enhancing their survival rate under cold stress. Ascr#10 also induces browning of white adipose tissue and activates brown adipose tissue in mice, thereby helping the body resist cold and tumor growth. Ascr#10 can be widely applied to research related to pine wilt disease, lung tumors and cold stress^[1][2][3].

Ascr#10 (300 nM) activates AKHR in transfected Drosophila S2 cells, triggering a greater than 60% maximum increase in intracellular Ca²⁺ fluorescence intensity^[2].
Ascr#10 (3 aM-3 µM; 72 h) increases fecundity of native Bursaphelenchus xylophilus isolate US1 at concentrations of 3 aM, 3 fM, and 3 pM after 72 h incubation^[4].
Ascr#10 (0.1 nM; 10 days) drives gene expression changes linked to metabolic depression and accumulation of cryoprotectants like glycerol, trehalose, and sorbitol in last-instar larval Monochamus alternatus^[5].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Ascr#10 (1 µM; oral feeding; continuous; 2 days) improves cold stress tolerance in wild-type Drosophila melanogaster via AKHR-dependent upregulation of UCP4a and thermogenesis^[2].
Ascr#10 (10 mg/kg; i.p. injection; every 2 days; 4 weeks) activates BAT and induces subcutaneous WAT browning in mice to enhance thermogenesis and cold tolerance, while also inhibiting lung tumor growth^[2].
Ascr#10 (0.1 nM; mixed into artificial diet; continuous feeding; 10 days) enhances cold hardiness in 5th instar Monochamus alternatus larvae, reducing LT₅₀ by 3.2 °C via metabolic depression and upregulation of cryoprotectant synthesis genes^[5].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

304.38

C₁₅H₂₈O₆

1355681-08-1

O([C@@H](CCCCCCC(O)=O)C)[C@H]1[C@H](O)C[C@@H](O)[C@H](C)O1

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Zhao L, et al. Ascarosides coordinate the dispersal of a plant-parasitic nematode with the metamorphosis of its vector beetle. Nat Commun. 2016;7:12341. Published 2016 Aug 1.

  [2]. Zhao L, et al. A chemical signal that promotes insect survival via thermogenesis[J]. Research Square, 2023: rs. 3. rs-2756320.

  [3]. Zhou J, et al. A Cold Stress-Activated Endocrine Sentinel Chemical Hormone Promotes Insect Survival via Mitochondrial Adaptations Through the Adipokinetic Hormone Receptor. Adv Sci (Weinh). 2026;13(10):e09822.

  [4]. Zhao M, et al. Major ascaroside pheromone component asc-C5 influences reproductive plasticity among isolates of the invasive species pinewood nematode. Integr Zool. 2021;16(6):893-907.

  [5]. Zhang B, et al. miR-31-5p regulates cold acclimation of the wood-boring beetle Monochamus alternatus via ascaroside signaling[J]. BMC biology, 2020, 18(1): 184.