1. Metabolic Enzyme/Protease
  2. ATP Citrate Lyase
  3. NDI-091143

NDI-091143 

Cat. No.: HY-127111 Purity: 99.72%
Handling Instructions

NDI-091143 is a potent and high-affinity human ATP-citrate lyase (ACLY) inhibitor with an IC50 of 2.1 nM (ADP-Glo assay), a Ki of 7.0 nM and a Kd of 2.2 nM. NDI-091143 inhibits ACLY catalysis allosterically, by stabilizing large conformational changes in the citrate domain that indirectly block the binding and recognition of citrate.

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NDI-091143 Chemical Structure

NDI-091143 Chemical Structure

CAS No. : 2375840-87-0

Size Price Stock Quantity
10 mM * 1  mL in DMSO USD 350 In-stock
Estimated Time of Arrival: December 31
5 mg USD 350 In-stock
Estimated Time of Arrival: December 31
10 mg USD 550 In-stock
Estimated Time of Arrival: December 31
50 mg   Get quote  
100 mg   Get quote  

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Customer Review

Based on 1 publication(s) in Google Scholar

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Description

NDI-091143 is a potent and high-affinity human ATP-citrate lyase (ACLY) inhibitor with an IC50 of 2.1 nM (ADP-Glo assay), a Ki of 7.0 nM and a Kd of 2.2 nM. NDI-091143 inhibits ACLY catalysis allosterically, by stabilizing large conformational changes in the citrate domain that indirectly block the binding and recognition of citrate[1].

IC50 & Target

IC50: 2.1 nM (human ATP-citrate lyase); Ki: 7.0 nM (human ATP-citrate lyase); Kd: 2.2 nM (human ATP-citrate lyase)[1]

In Vitro

Thermal shift assays shows that NDI-091143 gives rise to considerable stabilization of both full-length ACLY and the N-terminal segment. The thermal shift data are consistent with limited proteolysis experiments using full-length ACLY, in which NDI-091143 together with Mg-ATP provided the greatest protection against digestion by chymotrypsin[1].

Molecular Weight

453.84

Formula

C₂₀H₁₄ClF₂NO₅S

CAS No.

2375840-87-0

SMILES

O=C(OC)C1=CC(S(=O)(NC2=CC(C3=CC=CC=C3)=C(F)C=C2F)=O)=C(O)C(Cl)=C1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (275.43 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.2034 mL 11.0171 mL 22.0342 mL
5 mM 0.4407 mL 2.2034 mL 4.4068 mL
10 mM 0.2203 mL 1.1017 mL 2.2034 mL
*Please refer to the solubility information to select the appropriate solvent.
References

Purity: 99.72%

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Keywords:

NDI-091143NDI091143NDI 091143ATP Citrate LyaseACLYInhibitorinhibitorinhibit

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NDI-091143
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HY-127111
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