Cat. No.: HY-123786

NSC745887

NSC745887 (compound 25) is an inhibitor that targets DNA topoisomerase cleavage, activates the caspase-8/9-caspase-3-poly (ADP-ribose) polymerase cascade, and induces apoptosis in cancer cells. NSC745887 enhances γH2AX expression and causes DNA fragmentation leading to DNA damage.

For research use only. We do not sell to patients.

CAS No.: 54490-26-5
Formula: C₁₆H₈N₂O₂
Molecular Weight:260.25

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (271 KB)

NSC745887 Chemical Structure

CAS No.: 54490-26-5

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
Chemical Information
Purity & Documentation
References
Calculators
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Classifications
Bioz

Biological Activity

Description

All Caspase Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
786-0	GI₅₀	8.87 μM Compound: 25, NSC-745887	Growth inhibition of human 786-0 cells Growth inhibition of human 786-0 cells	[PMID: 19804981]
A498	GI₅₀	9.31 μM Compound: 25, NSC-745887	Growth inhibition of human A498 cells Growth inhibition of human A498 cells	[PMID: 19804981]
A549	GI₅₀	4.53 μM Compound: 25, NSC-745887	Growth inhibition of human A549 cells Growth inhibition of human A549 cells	[PMID: 19804981]
ACHN	GI₅₀	3.85 μM Compound: 25, NSC-745887	Growth inhibition of human ACHN cells Growth inhibition of human ACHN cells	[PMID: 19804981]
BT-549	GI₅₀	12.2 μM Compound: 25, NSC-745887	Growth inhibition of human BT549 cells Growth inhibition of human BT549 cells	[PMID: 19804981]
CAKI-1	GI₅₀	5.83 μM Compound: 25, NSC-745887	Growth inhibition of human Caki1 cells Growth inhibition of human Caki1 cells	[PMID: 19804981]
CCRF-CEM	GI₅₀	2.46 μM Compound: 25, NSC-745887	Growth inhibition of human CCRF-CEM cells Growth inhibition of human CCRF-CEM cells	[PMID: 19804981]
COLO 205	GI₅₀	3.4 μM Compound: 25, NSC-745887	Growth inhibition of human COLO205 cells Growth inhibition of human COLO205 cells	[PMID: 19804981]
DU-145	GI₅₀	11.4 μM Compound: 25, NSC-745887	Growth inhibition of human DU145 cells Growth inhibition of human DU145 cells	[PMID: 19804981]
EKVX	GI₅₀	3.45 μM Compound: 25, NSC-745887	Growth inhibition of human EKVX cells Growth inhibition of human EKVX cells	[PMID: 19804981]
HCC 2998	GI₅₀	1.4 μM Compound: 25, NSC-745887	Growth inhibition of human HCC2998 cells Growth inhibition of human HCC2998 cells	[PMID: 19804981]
HCT-116	GI₅₀	12.3 μM Compound: 25, NSC-745887	Growth inhibition of human HCT116 cells Growth inhibition of human HCT116 cells	[PMID: 19804981]
HCT-15	GI₅₀	4.63 μM Compound: 25, NSC-745887	Growth inhibition of human HCT15 cells Growth inhibition of human HCT15 cells	[PMID: 19804981]
HL-60(TB)	GI₅₀	0.68 μM Compound: 25, NSC-745887	Growth inhibition of human HL-60(TB) cells Growth inhibition of human HL-60(TB) cells	[PMID: 19804981]
HOP-62	GI₅₀	5.64 μM Compound: 25, NSC-745887	Growth inhibition of human HOP62 cells Growth inhibition of human HOP62 cells	[PMID: 19804981]
HOP-92	GI₅₀	22.5 μM Compound: 25, NSC-745887	Growth inhibition of human HOP92 cells Growth inhibition of human HOP92 cells	[PMID: 19804981]
Hs-578T	GI₅₀	14.1 μM Compound: 25, NSC-745887	Growth inhibition of human Hs 578T cells Growth inhibition of human Hs 578T cells	[PMID: 19804981]
HT-29	GI₅₀	7.01 μM Compound: 25, NSC-745887	Growth inhibition of human HT-29 cells Growth inhibition of human HT-29 cells	[PMID: 19804981]
IGROV-1	GI₅₀	2.55 μM Compound: 25, NSC-745887	Growth inhibition of human IGROV1 cells Growth inhibition of human IGROV1 cells	[PMID: 19804981]
K562	GI₅₀	0.07 μM Compound: 25, NSC-745887	Growth inhibition of human K562 cells Growth inhibition of human K562 cells	[PMID: 19804981]
KM12	GI₅₀	5.26 μM Compound: 25, NSC-745887	Growth inhibition of human KM12 cells Growth inhibition of human KM12 cells	[PMID: 19804981]
LOX IMVI	GI₅₀	4.2 μM Compound: 25, NSC-745887	Growth inhibition of human LOXIMVI cells Growth inhibition of human LOXIMVI cells	[PMID: 19804981]
M14	GI₅₀	5.14 μM Compound: 25, NSC-745887	Growth inhibition of human M14 cells Growth inhibition of human M14 cells	[PMID: 19804981]
Malme-3M	GI₅₀	4.48 μM Compound: 25, NSC-745887	Growth inhibition of human MALME-3M cells Growth inhibition of human MALME-3M cells	[PMID: 19804981]
MCF7	GI₅₀	0.72 μM Compound: 25, NSC-745887	Growth inhibition of human MCF7 cells Growth inhibition of human MCF7 cells	[PMID: 19804981]
MDA-MB-231	GI₅₀	19.1 μM Compound: 25, NSC-745887	Growth inhibition of human MDA-MB-231 cells Growth inhibition of human MDA-MB-231 cells	[PMID: 19804981]
MDA-MB-435	GI₅₀	11.1 μM Compound: 25, NSC-745887	Growth inhibition of human MDA-MB-435 cells Growth inhibition of human MDA-MB-435 cells	[PMID: 19804981]
MOLT-4	GI₅₀	3.65 μM Compound: 25, NSC-745887	Growth inhibition of human MOLT4 cells Growth inhibition of human MOLT4 cells	[PMID: 19804981]
NCI/ADR-RES	GI₅₀	5.68 μM Compound: 25, NSC-745887	Growth inhibition of human NCI/ADR-RES cells Growth inhibition of human NCI/ADR-RES cells	[PMID: 19804981]
NCI-H226	GI₅₀	16.6 μM Compound: 25, NSC-745887	Growth inhibition of human NCI-H226 cells Growth inhibition of human NCI-H226 cells	[PMID: 19804981]
NCI-H23	GI₅₀	12 μM Compound: 25, NSC-745887	Growth inhibition of human NCI-H23 cells Growth inhibition of human NCI-H23 cells	[PMID: 19804981]
NCI-H322M	GI₅₀	16.3 μM Compound: 25, NSC-745887	Growth inhibition of human NCI-H322M cells Growth inhibition of human NCI-H322M cells	[PMID: 19804981]
NCI-H460	GI₅₀	2.01 μM Compound: 25, NSC-745887	Growth inhibition of human NCI-H460 cells Growth inhibition of human NCI-H460 cells	[PMID: 19804981]
NCI-H522	GI₅₀	4.64 μM Compound: 25, NSC-745887	Growth inhibition of human NCI-H522 cells Growth inhibition of human NCI-H522 cells	[PMID: 19804981]
OVCAR-3	GI₅₀	2.34 μM Compound: 25, NSC-745887	Growth inhibition of human OVCAR-3 cells Growth inhibition of human OVCAR-3 cells	[PMID: 19804981]
OVCAR-4	GI₅₀	10.5 μM Compound: 25, NSC-745887	Growth inhibition of human OVCAR4 cells Growth inhibition of human OVCAR4 cells	[PMID: 19804981]
OVCAR-5	GI₅₀	29.3 μM Compound: 25, NSC-745887	Growth inhibition of human OVCAR5 cells Growth inhibition of human OVCAR5 cells	[PMID: 19804981]
OVCAR-8	GI₅₀	5.07 μM Compound: 25, NSC-745887	Growth inhibition of human OVCAR8 cells Growth inhibition of human OVCAR8 cells	[PMID: 19804981]
RXF 393	GI₅₀	6.43 μM Compound: 25, NSC-745887	Growth inhibition of human RXF393 cells Growth inhibition of human RXF393 cells	[PMID: 19804981]
SF-268	GI₅₀	4.98 μM Compound: 25, NSC-745887	Growth inhibition of human SF268 cells Growth inhibition of human SF268 cells	[PMID: 19804981]
SF-295	GI₅₀	4.35 μM Compound: 25, NSC-745887	Growth inhibition of human SF295 cells Growth inhibition of human SF295 cells	[PMID: 19804981]
SF-539	GI₅₀	2.18 μM Compound: 25, NSC-745887	Growth inhibition of human SF539 cells Growth inhibition of human SF539 cells	[PMID: 19804981]
SK-MEL-2	GI₅₀	12.7 μM Compound: 25, NSC-745887	Growth inhibition of human SK-MEL-2 cells Growth inhibition of human SK-MEL-2 cells	[PMID: 19804981]
SK-MEL-28	GI₅₀	21 μM Compound: 25, NSC-745887	Growth inhibition of human SK-MEL-28 cells Growth inhibition of human SK-MEL-28 cells	[PMID: 19804981]
SK-MEL-5	GI₅₀	3.93 μM Compound: 25, NSC-745887	Growth inhibition of human SK-MEL-5 cells Growth inhibition of human SK-MEL-5 cells	[PMID: 19804981]
SK-OV-3	GI₅₀	6.95 μM Compound: 25, NSC-745887	Growth inhibition of human SKOV3 cells Growth inhibition of human SKOV3 cells	[PMID: 19804981]
SN12C	GI₅₀	13.2 μM Compound: 25, NSC-745887	Growth inhibition of human SN12C cells Growth inhibition of human SN12C cells	[PMID: 19804981]
SNB-19	GI₅₀	13.4 μM Compound: 25, NSC-745887	Growth inhibition of human SNB19 cells Growth inhibition of human SNB19 cells	[PMID: 19804981]
SNB-75	GI₅₀	11.9 μM Compound: 25, NSC-745887	Growth inhibition of human SNB75 cells Growth inhibition of human SNB75 cells	[PMID: 19804981]
SW-620	GI₅₀	1.71 μM Compound: 25, NSC-745887	Growth inhibition of human SW620 cells Growth inhibition of human SW620 cells	[PMID: 19804981]
T47D	GI₅₀	12.6 μM Compound: 25, NSC-745887	Growth inhibition of human T47D cells Growth inhibition of human T47D cells	[PMID: 19804981]
TK-10	GI₅₀	5 μM Compound: 25, NSC-745887	Growth inhibition of human TK10 cells Growth inhibition of human TK10 cells	[PMID: 19804981]
U-251	GI₅₀	5.38 μM Compound: 25, NSC-745887	Growth inhibition of human U251 cells Growth inhibition of human U251 cells	[PMID: 19804981]
UACC-257	GI₅₀	13 μM Compound: 25, NSC-745887	Growth inhibition of human UACC257 cells Growth inhibition of human UACC257 cells	[PMID: 19804981]
UACC-62	GI₅₀	13.3 μM Compound: 25, NSC-745887	Growth inhibition of human UACC62 cells Growth inhibition of human UACC62 cells	[PMID: 19804981]
UO-31	GI₅₀	3.02 μM Compound: 25, NSC-745887	Growth inhibition of human UO31 cells Growth inhibition of human UO31 cells	[PMID: 19804981]

Chemical Information

CAS No. 54490-26-5
Molecular Weight 260.25
Formula C₁₆H₈N₂O₂
SMILES

O=C(C1=CC=C2N=CC=NC2=C1C3=O)C4=C3C=CC=C4
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (271 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Fann LY, et al. Identification and preclinical evaluation of the small molecule, NSC745887, for treating glioblastomas via suppressing DcR3-associated signaling pathways. Oncotarget. 2017 Dec 27;9(15):11922-11937. [Content Brief]

[2]. Huang HS, et al. Synthesis, cytotoxicity and human telomerase inhibition activities of a series of 1,2-heteroannelated anthraquinones and anthra[1,2-d]imidazole-6,11-dione homologues. Bioorg Med Chem. 2009;17(21):7418-7428. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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