54490-26-5
54490-26-5
Chemical Structure
NSC745887
- CAS No.: 54490-26-5
- Formula:C16H8N2O2
- Molecular Weight:260.25
IUPAC Name: naphtho[2,3-f]quinoxaline-7,12-dione
InChIKey: DGLSEJAACVWJNU-UHFFFAOYSA-N
SMILES: O=C(C1=CC=C2N=CC=NC2=C1C3=O)C4=C3C=CC=C4
Biological Activity: NSC745887 (compound 25) is an inhibitor that targets DNA topoisomerase cleavage, activates the caspase-8/9-caspase-3-poly (ADP-ribose) polymerase cascade, and induces apoptosis in cancer cells. NSC745887 enhances γH2AX expression and causes DNA fragmentation leading to DNA damage[1][2].
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NSC745887 | NSC745887 (compound 25) is an inhibitor that targets DNA topoisomerase cleavage, activates the caspase-8/9-caspase-3-poly (ADP-ribose) polymerase cascade, and induces apoptosis in cancer cells. NSC745887 enhances γH2AX expression and causes DNA fragmentation leading to DNA damage. | |||||||||||||||||||||
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References
- [1]. Fann LY, et al. Identification and preclinical evaluation of the small molecule, NSC745887, for treating glioblastomas via suppressing DcR3-associated signaling pathways. Oncotarget. 2017 Dec 27;9(15):11922-11937. [Content Brief]
- [2]. Huang HS, et al. Synthesis, cytotoxicity and human telomerase inhibition activities of a series of 1,2-heteroannelated anthraquinones and anthra[1,2-d]imidazole-6,11-dione homologues. Bioorg Med Chem. 2009;17(21):7418-7428. [Content Brief]
