Carboxyatractyloside
Carboxyatractyloside (CATR) is a tight-binding inhibitor of adenine nucleotide translocase, and represents the major toxic component of Xanthium sibiricum. Carboxyatractyloside competes with ADP for binding to the translocase, blocks the translocation of ADP/ATP across the inner mitochondrial membrane, and thereby inhibits ADP-stimulated respiration. In the presence of Cyclosporin A (HY-B0579), Carboxyatractyloside still induces permeability transition in liver mitochondria of aged rats, exhibiting significant hepatotoxicity and nephrotoxicity. Carboxyatractyloside is widely used in studies related to hepatotoxicity, nephrotoxicity and Alzheimer's disease.
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- CAS No.: 35988-42-2
- Formula: C31H46O18S2
- Molecular Weight:770.82
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Carboxyatractyloside (CATR) (0.07-0.4 μM) potently inhibits ADP-stimulated respiration (a proxy for adenine nucleotide translocation) in Vigna sinensis hypocotyl mitochondria, with maximal inhibition at 0.4 μM, IC50 at 0.16 μM (ADP added first) or 0.21 μM (CATR added first), and an apparent competitive inhibition constant of 0.115 μM under specific concentration ranges[2].
Carboxyatractyloside (2 μM) induces fast Ca2+ efflux from freshly prepared rat liver mitochondria[3].
Carboxyatractyloside (0.5 μM) induces Ca2+ efflux from aged rat liver mitochondria even when they are pre-treated with CSA or BSA to stabilize Ca2+ retention[3].
Carboxyatractyloside (2 μM) does not induce Sr2+ efflux from aged rat liver mitochondria pre-loaded with Sr2+[3].
Carboxyatractyloside (0.5 μM) induces swelling in aged rat liver mitochondria even when they are pre-treated with CSA to reduce basal swelling[3].
Carboxyatractyloside (0.5 μM) induces fast collapse of transmembrane potential in aged rat liver mitochondria even when they are pre-treated with CSA to stabilize potential[3].
Carboxyatractyloside (2 μM) induces a slow collapse of transmembrane potential in aged rat liver mitochondria pre-loaded with Sr2+[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 35988-42-2
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Molecular Weight 770.82
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Formula C31H46O18S2
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SMILES
C[C@]12[C@@]3([H])[C@@]4(CC[C@]1([H])C(C(O)=O)(C[C@H](C2)O[C@@H]5[C@@H]([C@H]([C@@H]([C@H](O5)CO)OS(=O)(O)=O)OS(=O)(O)=O)OC(CC(C)C)=O)C(O)=O)C[C@@](C([C@@H]4O)=C)([H])CC3
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Synonyms
CATR
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Carboxyatractyloside Related Classifications
HY-182303 Related Classifications
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- Carboxyatractyloside
- 35988-42-2
- CATR
- Methionine Adenosyltransferase (MAT)
- plant mitochondria
- hepatotoxicity
- Xanthii Fructus
- alzheimer disease
- Vigna sinensis hypocotyl mitochondria
- nephrotoxicity
- adenine nucleotide translocator
- ADP/ATP transport
- rat liver mitochondria
- inner mitochondrial membrane
- Inhibitor
- inhibitor
- inhibit