35988-42-2
Chemical Structure
Carboxyatractyloside
Synonym(s): CATR
- CAS No.: 35988-42-2
- Formula:C31H46O18S2
- Molecular Weight:770.82
InChIKey: AQFATIOBERWBDY-LIGJTEMZSA-N
SMILES: C[C@]12[C@@]3([H])[C@@]4(CC[C@]1([H])C(C(O)=O)(C[C@H](C2)O[C@@H]5[C@@H]([C@H]([C@@H]([C@H](O5)CO)OS(=O)(O)=O)OS(=O)(O)=O)OC(CC(C)C)=O)C(O)=O)C[C@@](C([C@@H]4O)=C)([H])CC3
Biological Activity: Carboxyatractyloside (CATR) is a tight-binding inhibitor of adenine nucleotide translocase, and represents the major toxic component of Xanthium sibiricum. Carboxyatractyloside competes with ADP for binding to the translocase, blocks the translocation of ADP/ATP across the inner mitochondrial membrane, and thereby inhibits ADP-stimulated respiration. In the presence of Cyclosporin A (HY-B0579), Carboxyatractyloside still induces permeability transition in liver mitochondria of aged rats, exhibiting significant hepatotoxicity and nephrotoxicity. Carboxyatractyloside is widely used in studies related to hepatotoxicity, nephrotoxicity and Alzheimer's disease[1][2][3].
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Carboxyatractyloside | Carboxyatractyloside (CATR) is a tight-binding inhibitor of adenine nucleotide translocase, and represents the major toxic component of Xanthium sibiricum. Carboxyatractyloside competes with ADP for binding to the translocase, blocks the translocation of ADP/ATP across the inner mitochondrial membrane, and thereby inhibits ADP-stimulated respiration. In the presence of Cyclosporin A (HY-B0579), Carboxyatractyloside still induces permeability transition in liver mitochondria of aged rats, exhibiting significant hepatotoxicity and nephrotoxicity. Carboxyatractyloside is widely used in studies related to hepatotoxicity, nephrotoxicity and Alzheimer's disease. | |||||||||||||||||||||
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- [1]. Pan H, et al. Simultaneous quantification of atractyloside and carboxyatractyloside in rat plasma by LC‐MS/MS: Application to a pharmacokinetic study after oral administration of Xanthii Fructus extract[J]. Journal of separation science, 2020, 43(3): 590-597.
- [2]. Lima M S, et al. The effect of atractyloside and carboxyatractyloside on adenine nucleotide translocation in mitochondria of Vigna sinensis (L.) Savi cv. serido[J]. Archives of Biochemistry and Biophysics, 1979, 193(2): 368-372.
- [3]. García N, et al. Cyclosporin A is unable to inhibit carboxyatractyloside-induced permeability transition in aged mitochondria. Comp Biochem Physiol C Toxicol Pharmacol. 2009;149(3):374-381. [Content Brief]
Keywords
