MAHMA NONOate
Based on 1 publication(s) in Google Scholar
MAHMA NONOate is a NO donor. MAHMA NONOate effectively inhibits platelet aggregation induced by either collagen or ADP.
For research use only. We do not sell to patients.
- CAS No.: 146724-86-9
- Formula: C8H20N4O2
- Molecular Weight:204.27
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Storage:
-80°C
* The compound is unstable in solutions, freshly prepared is recommended.
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) MAHMA NONOate
MoreAll Endogenous Metabolite Isoforms
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Biological Activity
MAHMA NONOate (0.1 nM-100 μM) dose-dependently inhibits platelet aggregation induced by either collagen or ADP[1]. MAHMA NONOate shows inhibitory effects to pulmonary artery and platelet aggregation with log IC50 values of 7.18 and 6.16, respectively[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Male Wistar rats anaesthetised with pentobarbitone[2]
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Dosage:0.3-10 nmol/kg/min
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Administration:Intravenous injection; 0.3-10 nmol/kg/min once
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Result:Dose-dependently decreased in mean systemic artery pressure and showd a more potent effect than GSNO. Caused dose-dependent inhibition of the response to 0.3 μM/kg ADP.
Chemical Information
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CAS No. 146724-86-9
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Appearance Solid
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Molecular Weight 204.27
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Formula C8H20N4O2
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Color White to light yellow
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SMILES
CNCCCCCCN(C)N(O)N=O
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Structure Classification
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Initial Source
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Shipping
Shipping with dry ice.
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Storage
-80°C
* The compound is unstable in solutions, freshly prepared is recommended.
Publications (1)
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Journal Impact Factor
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Most Recent
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Biochem Biophys Res Commun
A novel genetically encoded indicator for deciphering cytosolic and mitochondrial nitric oxide in live cells. [Abstract]2025 Jan 19:749:151345. PMID: 39862720
Solvent & Solubility
H2O : 50 mg/mL (244.77 mM; ultrasonic and warming and heat to 60°C)
Please refer to the solubility information to select the appropriate solvent. The compound is unstable in solutions, freshly prepared is recommended.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. The compound is unstable in solutions, freshly prepared is recommended.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (269 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
[1]. Homer KL, Wanstall JC. Inhibition of rat platelet aggregation by the diazeniumdiolate nitric oxide donor MAHMA NONOate. Br J Pharmacol. 2002 Dec;137(7):1071-81. [Content Brief]
[2]. Homer KL, Wanstall JC. Platelet inhibitory effects of the nitric oxide donor drug MAHMA NONOate in vivo in rats. Eur J Pharmacol. 2003 Dec 15;482(1-3):265-70. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. The compound is unstable in solutions, freshly prepared is recommended.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O | 1 mM | 4.8955 mL | 24.4774 mL | 48.9548 mL | 122.3870 mL |
| 5 mM | 0.9791 mL | 4.8955 mL | 9.7910 mL | 24.4774 mL | |
| 10 mM | 0.4895 mL | 2.4477 mL | 4.8955 mL | 12.2387 mL | |
| 15 mM | 0.3264 mL | 1.6318 mL | 3.2637 mL | 8.1591 mL | |
| 20 mM | 0.2448 mL | 1.2239 mL | 2.4477 mL | 6.1194 mL | |
| 25 mM | 0.1958 mL | 0.9791 mL | 1.9582 mL | 4.8955 mL | |
| 30 mM | 0.1632 mL | 0.8159 mL | 1.6318 mL | 4.0796 mL | |
| 40 mM | 0.1224 mL | 0.6119 mL | 1.2239 mL | 3.0597 mL | |
| 50 mM | 0.0979 mL | 0.4895 mL | 0.9791 mL | 2.4477 mL | |
| 60 mM | 0.0816 mL | 0.4080 mL | 0.8159 mL | 2.0398 mL | |
| 80 mM | 0.0612 mL | 0.3060 mL | 0.6119 mL | 1.5298 mL | |
| 100 mM | 0.0490 mL | 0.2448 mL | 0.4895 mL | 1.2239 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
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