2. Metabolic Enzyme/Protease Immunology/Inflammation
  3. Endogenous Metabolite NO Synthase
  4. MAHMA NONOate

MAHMA NONOate is a NO donor. MAHMA NONOate effectively inhibits platelet aggregation induced by either collagen or ADP.

For research use only. We do not sell to patients.

MAHMA NONOate Chemical Structure

MAHMA NONOate Chemical Structure

CAS No. : 146724-86-9

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5 mg USD 60 In-stock
10 mg USD 100 In-stock
25 mg USD 205 In-stock
50 mg USD 330 In-stock
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Based on 1 publication(s) in Google Scholar

MAHMA NONOate Related Antibodies

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Description

MAHMA NONOate is a NO donor. MAHMA NONOate effectively inhibits platelet aggregation induced by either collagen or ADP[1].

In Vitro

MAHMA NONOate (0.1 nM-100 μM) dose-dependently inhibits platelet aggregation induced by either collagen or ADP[1].
MAHMA NONOate shows inhibitory effects to pulmonary artery and platelet aggregation with log IC50 values of 7.18 and 6.16, respectively[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

MAHMA NONOate Related Antibodies
In Vivo

MAHMA NONOate (0.3-10 nmol/kg/min; i.v. once) shows both platelet inhibitory and vasodepressor effects in vivo[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male Wistar rats anaesthetised with pentobarbitone[2]
Dosage: 0.3-10 nmol/kg/min
Administration: Intravenous injection; 0.3-10 nmol/kg/min once
Result: Dose-dependently decreased in mean systemic artery pressure and showd a more potent effect than GSNO. Caused dose-dependent inhibition of the response to 0.3 μM/kg ADP.
Molecular Weight

204.27

Formula

C8H20N4O2
CAS No.
Appearance

Solid

Color

Off-white to light yellow

SMILES

CNCCCCCCN(C)N(O)N=O
Structure Classification
Initial Source
Shipping

Shipping with dry ice.
Storage

-80°C

*The compound is unstable in solutions, freshly prepared is recommended.

Solvent & Solubility
In Vitro: 

H2O : 62.5 mg/mL (305.97 mM; adjust pH to 10 with NaOH)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 4.8955 mL 24.4774 mL 48.9548 mL
5 mM 0.9791 mL 4.8955 mL 9.7910 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. The compound is unstable in solutions, freshly prepared is recommended.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation

COA (240 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. The compound is unstable in solutions, freshly prepared is recommended.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 4.8955 mL 24.4774 mL 48.9548 mL 122.3870 mL
5 mM 0.9791 mL 4.8955 mL 9.7910 mL 24.4774 mL
10 mM 0.4895 mL 2.4477 mL 4.8955 mL 12.2387 mL
15 mM 0.3264 mL 1.6318 mL 3.2637 mL 8.1591 mL
20 mM 0.2448 mL 1.2239 mL 2.4477 mL 6.1194 mL
25 mM 0.1958 mL 0.9791 mL 1.9582 mL 4.8955 mL
30 mM 0.1632 mL 0.8159 mL 1.6318 mL 4.0796 mL
40 mM 0.1224 mL 0.6119 mL 1.2239 mL 3.0597 mL
50 mM 0.0979 mL 0.4895 mL 0.9791 mL 2.4477 mL
60 mM 0.0816 mL 0.4080 mL 0.8159 mL 2.0398 mL
80 mM 0.0612 mL 0.3060 mL 0.6119 mL 1.5298 mL
100 mM 0.0490 mL 0.2448 mL 0.4895 mL 1.2239 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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MAHMA NONOate Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

MAHMA NONOate146724-86-9Endogenous MetaboliteNO SynthaseNitric oxide synthasesNOSGSNOnitric oxideplatelet aggregationcollagenADPpentobarbitonepulmonary arteryInhibitorinhibitorinhibit

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