1. Cell Cycle/DNA Damage
  2. Poly(ADP-ribose) Glycohydrolase (PARG)
  3. JA2131

JA2131 

Cat. No.: HY-137924
Handling Instructions

JA2131 is a small molecular inhibitor of Poly(ADP-ribose) Glycohydrolase (PARG) (IC50=0.4 μM). JA2131 regulate DNA damage responses, causes replication fork stalling and cancer cell death.

For research use only. We do not sell to patients.

JA2131 Chemical Structure

JA2131 Chemical Structure

CAS No. : 6505-99-3

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Description

JA2131 is a small molecular inhibitor of Poly(ADP-ribose) Glycohydrolase (PARG) (IC50=0.4 μM). JA2131 regulate DNA damage responses, causes replication fork stalling and cancer cell death[1][2].

In Vitro

JA2131 (10 mM; 1-2 h) induces hyperPARylation of PARP1 in PC3 cells[1].
JA2131 (10 μM; 2 wk) inhibits colony formation of MCF-7, PC3, and MDA-MB-231 cells, and (0.1 μM-1 mM; 72 h) shows cytotoxicity to inhibit MRC-50 cells with an IC50 value of 132 μM[1].
JA2131 (5 μM; 72 h) inhibits PC3, and A172 glioblastoma cells viability[1].
JA2131 (10 μM; 2 h) could be acting at the replication fork in HeLa cells[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay[1]

Cell Line: PC3, and A172 glioblastoma cells
Concentration: 0.1 μM-10 mM
Incubation Time: 72 hours
Result: Inhibited cell viability with IC50s of 33.05 μM (PC3 cells) and 55.34 μM (A172 cells), respectively.
Molecular Weight

341.45

Formula

C13H19N5O2S2

CAS No.
SMILES

O=C(N1C)N(C)C2=C(N=C(SCCN3CCOCC3)N2)C1=S

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Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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JA2131
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HY-137924
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