NOD1-IN-1
NOD1/-IN-1 (Compound 2) is a potent RIPK2 inhibitor with an IC50 value of 0.65 nM determined by ADP-Glo assays. NOD1/-IN-1 selectively inhibits the NOD1 pathway (with an IC50 of 33 nM for NOD1), blocking the production of pro-inflammatory cytokines and thereby reducing inflammation. NOD1/-IN-1 is applicable for research in the field of colitis.
For research use only. We do not sell to patients.
- CAS No.: 687627-78-7
- Formula: C16H14ClN3O3
- Molecular Weight:331.75
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
Biological Activity
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NOD1 33 nM (IC50) |
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| BaF3 | IC50 |
110 nM
Compound: 21
|
Inhibition of KDR (unknown origin) expressed in mouse BA/F3 cells assessed as reduction in cell viability after 48 hrs by Cell titre glo-based luminescence assay
Inhibition of KDR (unknown origin) expressed in mouse BA/F3 cells assessed as reduction in cell viability after 48 hrs by Cell titre glo-based luminescence assay
|
[PMID: 26874741] |
| BaF3 | IC50 |
940 nM
Compound: 21
|
Inhibition of KIF5B/RET (unknown origin) expressed in mouse BA/F3 cells assessed as reduction in cell viability after 48 hrs by Cell titre glo-based luminescence assay
Inhibition of KIF5B/RET (unknown origin) expressed in mouse BA/F3 cells assessed as reduction in cell viability after 48 hrs by Cell titre glo-based luminescence assay
|
[PMID: 26874741] |
| Sf21 | IC50 |
58 nM
Compound: 21
|
Inhibition of recombinant His-tagged human KDR expressed in insect Sf21 cells preincubated for 15 mins followed by substrate addition measured after 20 mins by HTRF assay
Inhibition of recombinant His-tagged human KDR expressed in insect Sf21 cells preincubated for 15 mins followed by substrate addition measured after 20 mins by HTRF assay
|
[PMID: 26874741] |
Chemical Information
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CAS No. 687627-78-7
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Molecular Weight 331.75
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Formula C16H14ClN3O3
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SMILES
ClC1=CC=C(C=C1O)NC2=NC=NC3=CC(OC)=C(OC)C=C23
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)