1. Anti-infection
  2. Enterovirus
  3. Golgicide A

Golgicide A 

Cat. No.: HY-100540 Purity: 99.17%
Handling Instructions

Golgicide A is a potent, highly specific, and reversible inhibitor of the cis-Golgi ADP-ribosylation factor guanine nucleotide exchange factors (ArfGEF), GBF1. Golgicide A drastically reduced replication of coxsackievirus B3 (CVB3) and other human enterovirus species.

For research use only. We do not sell to patients.

Golgicide A Chemical Structure

Golgicide A Chemical Structure

CAS No. : 1139889-93-2

Size Price Stock Quantity
10 mM * 1  mL in DMSO USD 71 In-stock
Estimated Time of Arrival: December 31
5 mg USD 65 In-stock
Estimated Time of Arrival: December 31
10 mg USD 115 In-stock
Estimated Time of Arrival: December 31
50 mg USD 450 In-stock
Estimated Time of Arrival: December 31
100 mg USD 780 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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Customer Review

Based on 1 publication(s) in Google Scholar

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  • Biological Activity

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Description

Golgicide A is a potent, highly specific, and reversible inhibitor of the cis-Golgi ADP-ribosylation factor guanine nucleotide exchange factors (ArfGEF), GBF1[1]. Golgicide A drastically reduced replication of coxsackievirus B3 (CVB3) and other human enterovirus species[2].

IC50 & Target

GBF1[1]

In Vitro

Golgicide A (GCA) is a potent and highly effective inhibitor of shiga toxin activity. Golgicide A (GCA) inhibits the effect of shiga toxin on protein synthesis with an IC50 of 3.3 μM[1].

Molecular Weight

284.30

Formula

C₁₇H₁₄F₂N₂

CAS No.

1139889-93-2

SMILES

FC1=CC2=C(NC(C3=CC=CN=C3)[[email protected]@]4([H])[[email protected]]2([H])C=CC4)C(F)=C1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (439.68 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.5174 mL 17.5871 mL 35.1741 mL
5 mM 0.7035 mL 3.5174 mL 7.0348 mL
10 mM 0.3517 mL 1.7587 mL 3.5174 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 12.5 mg/mL (43.97 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 12.5 mg/mL (43.97 mM); Clear solution

*All of the co-solvents are provided by MCE.
References

Purity: 99.17%

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Keywords:

Golgicide AEnterovirusRhinovirusHRVHRVsHEVHEVsInhibitorinhibitorinhibit

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Product Name:
Golgicide A
Cat. No.:
HY-100540
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