8-MA-NAD+ sodium
8-MA-NAD+ (sodium) (8-Methylamino-NAD+ (sodium)) is a derivative of the signaling molecule and enzyme cofactor NAD+ (HY-B0445). 8-MA-NAD+ (sodium) can be used in the screening of analog-sensitive poly (ADP-ribose) polymerase 1 (PARP1) gatekeeper mutations. 8-MA-NAD+ (sodium) can be used in the synthesis of cyclic ADP-ribose (cADPR) derivatives.
For research use only. We do not sell to patients.
- Formula: C22H29N8NaO14P2
- Molecular Weight:714.45
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Biological Activity
Chemical Information
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Molecular Weight 714.45
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Formula C22H29N8NaO14P2
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SMILES
[O-]P(OP(OC[C@H]1O[C@@H](N2C(NC)=NC3=C(N=CN=C32)N)[C@H](O)[C@@H]1O)(O[Na])=O)(OC[C@@H]4[C@@H](O)[C@@H](O)[C@H]([N+]5=CC=CC(C(N)=O)=C5)O4)=O
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Synonyms
8-Methylamino-NAD+ sodium
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Gibson BA, et al. Chemical genetic discovery of PARP targets reveals a role for PARP-1 in transcription elongation. Science. 2016 Jul 1;353(6294):45-50. [Content Brief]
[2]. Moreau C, et al. Synthesis of cyclic adenosine 5'-diphosphate ribose analogues: a C2'endo/syn "southern" ribose conformation underlies activity at the sea urchin cADPR receptor. Org Biomol Chem. 2011 Jan 7;9(1):278-90. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
8-MA-NAD+ sodium Related Classifications
HY-134305A Related Classifications
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