Cat. No.: HY-N1502

Carboxyatractyloside tripotassium

(Synonyms: Gummiferin tripotassium)

2 Cited Publications

Customer Review

Based on 2 publication(s) in Google Scholar

Carboxyatractyloside tripotassium is a diterpenoid. Carboxyatractyloside tripotassium can be isolated from plants of the genus Xanthium. Carboxyatractyloside tripotassium is an ADP/ATP carrier inhibitor, inhibiting mitochondrial ADP/ATP transport. Carboxyatractyloside tripotassium promotes ROS production, induces Ca²⁺ release, and leads to mitochondrial dysfunction. Carboxyatractyloside tripotassium induces lethargy, weakness, and epileptic seizures in rats.

For research use only. We do not sell to patients.

Purity: 99.97%
CAS No.: 77228-71-8
Formula: C₃₁H₄₃K₃O₁₈S₂
Molecular Weight:885.09

Storage:

-20°C, sealed storage, away from moisture and light

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Carboxyatractyloside tripotassium Chemical Structure

CAS No.: 77228-71-8

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Biological Activity
- Description
- In Vitro
- In Vivo
Chemical Information
Publications (2)
Solvent & Solubility
- In Vitro
Purity & Documentation
References
Help & FAQs
Classifications
Bioz

Biological Activity

Description

All Calcium Channel Isoforms :

In Vitro

Carboxyatractyloside (10-25 μM; 48 h) tripotassium promotes cell death in primary mouse lung endothelial cells and exacerbates mitochondrial dysfunction, including mitochondrial depolarization, increased ROS generation, and MPT pore opening^[2].
Carboxyatractyloside (2 μM) tripotassium induces Ca²⁺ release, mitochondrial swelling, and membrane potential collapse in aged rat liver mitochondria^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Carboxyatractyloside (13.5 mg/kg, i.p.) tripotassium causes symptoms such as lethargy, weakness, and seizures in rats, and cause histopathological damage to the liver and kidneys, including vacuolar degeneration and necrosis of hepatocytes and renal tubular necrosis^[5].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 77228-71-8
Appearance Solid
Molecular Weight 885.09
Formula C₃₁H₄₃K₃O₁₈S₂
Color White to off-white
SMILES

C=C([C@H](CC1)C2)[C@H](O)[C@@]32CC[C@]4([H])[C@@](C(O)=O)(C(O[K])=O)C[C@@H](O[C@@H]5[C@H]([C@@H]([C@H]([C@H](CO)O5)OS(=O)(O[K])=O)OS(=O)(O[K])=O)OC(CC(C)C)=O)C[C@@]4(C)[C@@]31[H]
Synonyms

Gummiferin tripotassium
Structure Classification
- Terpenoids
- Diterpenoids
Initial Source
- Plants
- other families
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, sealed storage, away from moisture and light

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Publications (2)

All IPCell Proliferation/Viability AssayFlow CytometryIHCIF

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Journal Impact Factor

Redox Biol

Redistribution of defective mitochondria-mediated dihydroorotate dehydrogenase imparts 5-fluorouracil resistance in colorectal cancer. [Abstract]

2024 Jul:73:103207. PMID: 38805974
EMBO Mol Med

Conformational change of adenine nucleotide translocase-1 mediates cisplatin resistance induced by EBV-LMP1. [Abstract]

2021 Dec 7;13(12):e14072. PMID: 34755470

Carboxyatractyloside tripotassium purchased from MedChemExpress. Usage Cited in: EMBO Mol Med. 2021 Dec 7;13(12):e14072. [Abstract]

Effect of inhibitors BKA and Carboxyatractyloside tripotassium (CATR) (5, 10, 20 nM) on ANT1‐VDAC1 binding in 293T cells.

Carboxyatractyloside tripotassium purchased from MedChemExpress. Usage Cited in: EMBO Mol Med. 2021 Dec 7;13(12):e14072. [Abstract]

CCK‐8 analysis of viability in HK1‐LMP1 cells treated for 24 h with Carboxyatractyloside tripotassium (CATR) (1 μM) alone, cisplatin (20 μM) alone, or cisplatin (20 μM) combined with CATR (1 μM).

Carboxyatractyloside tripotassium purchased from MedChemExpress. Usage Cited in: EMBO Mol Med. 2021 Dec 7;13(12):e14072. [Abstract]

Flow cytometry analysis of death of NPC cells treated for 24 h with CATR (1 μM) alone, Cisplatin (20 μM) alone, or Cisplatin (20 μM) combined with Carboxyatractyloside tripotassium (CATR) (1 μM).

Carboxyatractyloside tripotassium purchased from MedChemExpress. Usage Cited in: EMBO Mol Med. 2021 Dec 7;13(12):e14072. [Abstract]

Immunohistochemistry examination of the protein levels of Ki67 treated with Carboxyatractyloside tripotassium (CATR) (1 mg/kg, i.p.).

Carboxyatractyloside tripotassium purchased from MedChemExpress. Usage Cited in: EMBO Mol Med. 2021 Dec 7;13(12):e14072. [Abstract]

Apoptosis was analyzed by TUNEL assay treated with Carboxyatractyloside tripotassium (CATR) (1 μM).

Solvent & Solubility

In Vitro:

H₂O : ≥ 50 mg/mL (56.49 mM)

* "≥" means soluble, but saturation unknown.

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

1.1298 mL

5.6491 mL

11.2983 mL

5 mM

0.2260 mL

1.1298 mL

2.2597 mL

10 mM

0.1130 mL

0.5649 mL

1.1298 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Molarity Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Dilution Calculator

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Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (283 KB)
SDS (480 KB)
- English - EN (480 KB)
- Français - FR (480 KB)
- Deutsch - DE (480 KB)
- Norwegian - NO (480 KB)
- Español - ES (480 KB)
- Swedish - SV (480 KB)
- Italian - IT (480 KB)
- Korean - KR (480 KB)
- Portuguese - PT (480 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Ri M, et al. Identification of Toyocamycin, an agent cytotoxic for multiple myeloma cells, as a potent inhibitor of ER stress-induced XBP1 mRNA splicing. Blood Cancer J. 2012 Jul;2(7):e79. [Content Brief]

[2]. Belosludtseva NV, et al. ANT-Mediated Inhibition of the Permeability Transition Pore Alleviates Palmitate-Induced Mitochondrial Dysfunction and Lipotoxicity. Biomolecules. 2024 Sep 15;14(9):1159. [Content Brief]

[3]. García N, et al. Cyclosporin A is unable to inhibit carboxyatractyloside-induced permeability transition in aged mitochondria. Comp Biochem Physiol C Toxicol Pharmacol. 2009 Apr;149(3):374-81. [Content Brief]

[4]. Luciani S, et al. Effects of carboxyatractyloside a structural analogue of atractyloside on mitochondrial oxidative phosphorylation. Life Sci II. 1971 Sep 8;10(17):961-8. [Content Brief]

[5]. Hatch RC, et al. Toxicologic study of carboxyatractyloside (active principle in cocklebur--Xanthium strumarium) in rats treated with enzyme inducers and inhibitors and glutathione precursor and depletor. Am J Vet Res. 1982 Jan;43(1):111-6. [Content Brief]

[6]. Pebay-Peyroula E, et al. Structure of mitochondrial ADP/ATP carrier in complex with carboxyatractyloside. Nature. 2003 Nov 6;426(6962):39-44.

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
H₂O	1 mM	1.1298 mL	5.6491 mL	11.2983 mL	28.2457 mL
	5 mM	0.2260 mL	1.1298 mL	2.2597 mL	5.6491 mL
	10 mM	0.1130 mL	0.5649 mL	1.1298 mL	2.8246 mL
	15 mM	0.0753 mL	0.3766 mL	0.7532 mL	1.8830 mL
	20 mM	0.0565 mL	0.2825 mL	0.5649 mL	1.4123 mL
	25 mM	0.0452 mL	0.2260 mL	0.4519 mL	1.1298 mL
	30 mM	0.0377 mL	0.1883 mL	0.3766 mL	0.9415 mL
	40 mM	0.0282 mL	0.1412 mL	0.2825 mL	0.7061 mL
	50 mM	0.0226 mL	0.1130 mL	0.2260 mL	0.5649 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Keywords

Carboxyatractyloside tripotassium

2 Cited Publications

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Carboxyatractyloside tripotassium

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Publications Citing Use of MedChemExpress (MCE) Carboxyatractyloside tripotassium

All Calcium Channel Isoforms

Biological Activity

Chemical Information

Publications (2)

Solvent & Solubility

Purity & Documentation

References

Help & FAQs

Complete Stock Solution Preparation Table

Carboxyatractyloside tripotassium Related Classifications

HY-N1502 Related Classifications