1. Membrane Transporter/Ion Channel
  2. ATP Synthase
  3. BTB06584

BTB06584 

Cat. No.: HY-15877 Purity: 96.75%
Handling Instructions

BTB06584 is an IF1-dependent selective inhibitor of the mitochondrial F1Fo-ATPase.

For research use only. We do not sell to patients.

BTB06584 Chemical Structure

BTB06584 Chemical Structure

CAS No. : 219793-45-0

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 66 In-stock
Estimated Time of Arrival: December 31
5 mg USD 60 In-stock
Estimated Time of Arrival: December 31
10 mg USD 90 In-stock
Estimated Time of Arrival: December 31
50 mg USD 165 In-stock
Estimated Time of Arrival: December 31
100 mg USD 280 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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Description

BTB06584 is an IF1-dependent selective inhibitor of the mitochondrial F1Fo-ATPase. Target: ATPase in vitro: BTB06584 inhibits F1Fo-ATPase activity with no effect on ΔΨm or O2 consumption. ATP consumption was decreased following inhibition of respiration, and ischaemic cell death was reduced. BTB06584 efficiency was increased by IF1 overexpression and reduced by silencing the protein. BTB06584 may represent a valuable tool to selectively inhibit mitochondrial F1Fo-ATPase activity without compromising ATP synthesis and to limit ischaemia-induced injury caused by reversal of the mitochondrial F1Fo-ATPsynthase. in vivo: BTB06584 rescues defective haemoglobin synthesis in zebrafish pinotage (pnt) mutants in which expression of the Atpif1a gene is lost.

Molecular Weight

417.82

Formula

C₁₉H₁₂ClNO₆S

CAS No.

219793-45-0

SMILES

ClC1=CC=C(C(OC2=C([N+]([O-])=O)C=CC(S(C3=CC=CC=C3)(=O)=O)=C2)=O)C=C1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 47 mg/mL (112.49 mM)

H2O : < 0.1 mg/mL (insoluble)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.3934 mL 11.9669 mL 23.9338 mL
5 mM 0.4787 mL 2.3934 mL 4.7867 mL
10 mM 0.2393 mL 1.1967 mL 2.3934 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (5.98 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Keywords:

BTB06584BTB 06584BTB-06584ATP SynthaseInhibitorinhibitorinhibit

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Product Name:
BTB06584
Cat. No.:
HY-15877
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