1. Membrane Transporter/Ion Channel
  2. ATP Synthase
  3. BTB06584

BTB06584 

Cat. No.: HY-15877 Purity: 96.75%
Handling Instructions

BTB06584 is a selective and IF1-dependent mitochondrial F1Fo-ATPase inhibitor without compromising ATP synthesis. BTB06584 can delays ischaemic cell death.

For research use only. We do not sell to patients.

BTB06584 Chemical Structure

BTB06584 Chemical Structure

CAS No. : 219793-45-0

Size Price Stock Quantity
Solution
10 mM * 1 mL in DMSO USD 66 In-stock
Estimated Time of Arrival: December 31
Solid + Solvent
10 mM * 1 mL
ready for reconstitution
USD 66 In-stock
Estimated Time of Arrival: December 31
Solid
5 mg USD 60 In-stock
Estimated Time of Arrival: December 31
10 mg USD 90 In-stock
Estimated Time of Arrival: December 31
50 mg USD 165 In-stock
Estimated Time of Arrival: December 31
100 mg USD 280 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

* Please select Quantity before adding items.

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Based on 1 publication(s) in Google Scholar

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Description

BTB06584 is a selective and IF1-dependent mitochondrial F1Fo-ATPase inhibitor without compromising ATP synthesis. BTB06584 can delays ischaemic cell death[1].

IC50 & Target

Mitochondrial F1Fo-ATPase[1]

In Vitro

In HL-1 cells, BTB06584 (100 μM) inhibits F1Fo-ATPase activity with no effect on the mitochondrial membrane potential (ΔΨm ) or O2 consumption. BTB06584 (100 μM) pretreatmet protects against ischaemic cell death in HL-1 cells prior to a period of ischaemia. ATP consumption is decreased following inhibition of respiration, and ischaemic cell death is reduced[1].
BTB06584 efficiency is increased by IF1 overexpression and reduced by silencing the protein[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

BTB06584 (1 μM; 24 hours) treatment rescued defective haemoglobin synthesis in zebrafish pinotage (pnt) mutants in which expression of the Atpif1a gene is lost. The concentrations of BTB06584 that restore haemoglobin biosynthesis also alter mitochondrial bioenergetics in living fish[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

417.82

Formula

C₁₉H₁₂ClNO₆S

CAS No.
SMILES

ClC1=CC=C(C(OC2=C([N+]([O-])=O)C=CC(S(C3=CC=CC=C3)(=O)=O)=C2)=O)C=C1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 47 mg/mL (112.49 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.3934 mL 11.9669 mL 23.9338 mL
5 mM 0.4787 mL 2.3934 mL 4.7867 mL
10 mM 0.2393 mL 1.1967 mL 2.3934 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (5.98 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Keywords:

BTB06584BTB 06584BTB-06584ATP SynthasemitochondrialATPsynthaseIF1cardioprotectiveischaemicInhibitorinhibitorinhibit

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Product Name:
BTB06584
Cat. No.:
HY-15877
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