2. Cell Cycle/DNA Damage Epigenetics
  3. PARP
  4. MC2050

MC2050 is a selective PARP-1 inhibitor with an IC50 of 119 nM. MC2050 functionally inhibits PARP-1 activity, including hyperactivation induced by oxidative stress, and reduces the poly (ADP-ribosyl) ation level of histone H1. MC2050 protects neuroblastoma cells from oxidative stress-mediated cell death induced by hydrogen peroxide. MC2050 is applicable to research related to neuroblastoma and Burkitt lymphoma.

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MC2050

MC2050 Chemical Structure

CAS No. : 1301757-19-6

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MC2050 Related Antibodies

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PARP PARP1 PARP2 PARP3 PARP4 TNKS1/PARP5A TNKS2/PARP5B PARP7 PARP10 PARP14 PARP15 PARP12 PARP16

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Description

MC2050 is a selective PARP-1 inhibitor with an IC50 of 119 nM. MC2050 functionally inhibits PARP-1 activity, including hyperactivation induced by oxidative stress, and reduces the poly (ADP-ribosyl) ation level of histone H1. MC2050 protects neuroblastoma cells from oxidative stress-mediated cell death induced by hydrogen peroxide. MC2050 is applicable to research related to neuroblastoma and Burkitt lymphoma[1].

IC50 & Target[1]

PARP-1

119 nM (IC50)

PARP-2

1.8 μM (IC50)

In Vitro

MC2050 (25-100 μM; 0-72 h) does not reduce the viability of human SH-SY5Y neuroblastoma cells in adherent culture models, nor does it induce cell apoptosis[1].
MC2050 (0-100 μM; 0-72 h) does not reduce the viability of EBV-latently infected human Raji Burkitt's lymphoma cells in suspension culture models[1].
MC2050 (50 μM; 2-24 h) inhibits intracellular PARP-1 activity by 55%-60% in human SH-SY5Y neuroblastoma cells, and the inhibitory effect lasts up to 24 h[1].
MC2050 (50 μM; 24-48 h) inhibits intracellular PARP-1 activity by up to 60% in EBV latently infected and EBV-induced lytic human Raji Burkitt's lymphoma cells[1].
MC2050 (50 μM; 2 h) inhibits H2O2-induced overactivation of PARP-1 in human SH-SY5Y neuroblastoma cells[1].
MC2050 (50 μM) inhibits H2O2-induced poly (ADP-ribosyl) ation modification of histone H1 in human SH-SY5Y neuroblastoma cells[1].
MC2050 (1-100 μM; 30 min) concentration-dependently attenuates H2O2-induced cell death in human SH-SY5Y neuroblastoma cells[1].
MC2050 (50 μM; 24-72 h) increases the protein level of EBNA1 by up to 2.5-fold in EBV lytic phase-induced human Raji Burkitt's lymphoma cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

MC2050 Related Antibodies

Cell Viability Assay[1]

Cell Line: Human SH-SY5Y neuroblastoma cells (adherent culture)
Concentration: 25 μM; 50 μM; 100 μM
Incubation Time: up to 72 h
Result: Did not reduce cell viability compared to untreated controls at concentrations up to 100 μM for up to 72 h.

Western Blot Analysis[1]

Cell Line: EBV-lytic induced human Raji Burkitt lymphoma cells
Concentration: 50 μM
Incubation Time: 24 h, 48 h, 72 h
Result: Increased EBNA1 protein levels in a time-dependent manner, reaching an approximate 2.5-fold increase relative to untreated induced cells after 72 h.
Molecular Weight

440.39

Formula

C19H23Cl2N5OS
CAS No.
SMILES

O=C1N=C(NC2=C1C=CC=C2)SCCN3CCN(CC3)C4=NC=CC=C4.Cl.Cl
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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MC2050 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

MC20501301757-19-6MC 2050MC-2050PARPpoly ADP ribose polymeraseEBNA1SH-SY5Y neuroblastoma cellshydrogen peroxideRaji Burkitt lymphoma cellspoly(ADP-ribosylation)PARP-2PARP-1EBV-positive Burkitt's lymphoma cellsneuroblastoma cellsH1 histoneInhibitorinhibitorinhibit

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