1301757-19-6
1301757-19-6
Chemical Structure
MC2050
- CAS No.: 1301757-19-6
- Formula:C19H23Cl2N5OS
- Molecular Weight:440.39
InChIKey: LGUFWJGLDSDLAW-UHFFFAOYSA-N
SMILES: O=C1N=C(NC2=C1C=CC=C2)SCCN3CCN(CC3)C4=NC=CC=C4.Cl.Cl
Biological Activity: MC2050 is a selective PARP-1 inhibitor with an IC50 of 119 nM. MC2050 functionally inhibits PARP-1 activity, including hyperactivation induced by oxidative stress, and reduces the poly (ADP-ribosyl) ation level of histone H1. MC2050 protects neuroblastoma cells from oxidative stress-mediated cell death induced by hydrogen peroxide. MC2050 is applicable to research related to neuroblastoma and Burkitt lymphoma[1].
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MC2050 | MC2050 is a selective PARP-1 inhibitor with an IC50 of 119 nM. MC2050 functionally inhibits PARP-1 activity, including hyperactivation induced by oxidative stress, and reduces the poly (ADP-ribosyl) ation level of histone H1. MC2050 protects neuroblastoma cells from oxidative stress-mediated cell death induced by hydrogen peroxide. MC2050 is applicable to research related to neuroblastoma and Burkitt lymphoma. | |||||||||||||||||||||
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