1301757-19-6
Chemical Structure
MC2050
- CAS No.: 1301757-19-6
- Formula:C19H23Cl2N5OS
- Molecular Weight:440.39
InChIKey: LGUFWJGLDSDLAW-UHFFFAOYSA-N
SMILES: O=C1N=C(NC2=C1C=CC=C2)SCCN3CCN(CC3)C4=NC=CC=C4.Cl.Cl
Biological Activity: MC2050 is a selective PARP-1 inhibitor with an IC50 of 119 nM. MC2050 functionally inhibits PARP-1 activity, including hyperactivation induced by oxidative stress, and reduces the poly (ADP-ribosyl) ation level of histone H1. MC2050 protects neuroblastoma cells from oxidative stress-mediated cell death induced by hydrogen peroxide. MC2050 is applicable to research related to neuroblastoma and Burkitt lymphoma[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
|
MC2050 | MC2050 is a selective PARP-1 inhibitor with an IC50 of 119 nM. MC2050 functionally inhibits PARP-1 activity, including hyperactivation induced by oxidative stress, and reduces the poly (ADP-ribosyl) ation level of histone H1. MC2050 protects neuroblastoma cells from oxidative stress-mediated cell death induced by hydrogen peroxide. MC2050 is applicable to research related to neuroblastoma and Burkitt lymphoma. | |||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
Keywords
