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Cat. No.: HY-155865

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CCT368772

CCT368772 (compound 35) is a selective kinesin HSET inhibitor (HSET ADP-Glo IC₅₀ = 0.019 μM). CCT368772 exhibits selectivity over Eg5 (Eg5 ADP-Glo IC₅₀ >200 μM). CCT368772 (compound 152) can be used for the study of hyperproliferative diseases and disorders such as cancer.

For research use only. We do not sell to patients.

CAS No.: 2902671-74-1
Formula: C₂₅H₃₂N₆O₅S
Molecular Weight:528.63

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (269 KB)

CCT368772 Chemical Structure

CAS No.: 2902671-74-1

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

CCT368772 (compound 35) is a selective kinesin HSET inhibitor (HSET ADP-Glo IC₅₀ = 0.019 μM). CCT368772 exhibits selectivity over Eg5 (Eg5 ADP-Glo IC₅₀ >200 μM)^[1]. CCT368772 (compound 152) can be used for the study of hyperproliferative diseases and disorders such as cancer^[2].

IC₅₀ & Target^[1]

Eg5

>200 μM (IC₅₀)

HSET/KIFC1

0.019 μM (IC₅₀)

All Kinesin Isoforms :

Chemical Information

CAS No. 2902671-74-1
Molecular Weight 528.63
Formula C₂₅H₃₂N₆O₅S
SMILES

C(N[C@H](CC(NC=1SC(C(OCCC)=O)=C(C)N1)=O)CCCNC)(=O)C=2C=C(C=CC2)C=3N=C(C)ON3
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (269 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Saint-Dizier F, et al. Discovery of 2-(3-Benzamidopropanamido)thiazole-5-carboxylate Inhibitors of the Kinesin HSET (KIFC1) and the Development of Cellular Target Engagement Probes. J Med Chem. 2023 Feb 23;66(4):2622-2645. [Content Brief]

[2]. Hans-Peter Buchstaller, et al. Substituted heterocycles as hset inhibitors. WO2023131690A1. 2023-07-13.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Biological Activity
- Description
- IC₅₀ & Target
Chemical Information
Purity & Documentation
References

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CCT368772

All Kinesin Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

CCT368772 Related Classifications

HY-155865 Related Classifications