2902671-74-1
Chemical Structure
CCT368772
- CAS No.: 2902671-74-1
- Formula:C25H32N6O5S
- Molecular Weight:528.63
IUPAC Name: propyl (S)-4-methyl-2-(3-(3-(5-methyl-1,2,4-oxadiazol-3-yl)benzamido)-6-(methylamino)hexanamido)thiazole-5-carboxylate
InChIKey: IPKOTWUYIAGZGD-IBGZPJMESA-N
SMILES: C(N[C@H](CC(NC=1SC(C(OCCC)=O)=C(C)N1)=O)CCCNC)(=O)C=2C=C(C=CC2)C=3N=C(C)ON3
Biological Activity: CCT368772 (compound 35) is a selective kinesin HSET inhibitor (HSET ADP-Glo IC50 = 0.019 μM). CCT368772 exhibits selectivity over Eg5 (Eg5 ADP-Glo IC50 >200 μM)[1]. CCT368772 (compound 152) can be used for the study of hyperproliferative diseases and disorders such as cancer[2].
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CCT368772 | CCT368772 (compound 35) is a selective kinesin HSET inhibitor (HSET ADP-Glo IC50 = 0.019 μM). CCT368772 exhibits selectivity over Eg5 (Eg5 ADP-Glo IC50 >200 μM). CCT368772 (compound 152) can be used for the study of hyperproliferative diseases and disorders such as cancer. | |||||||||||||||||||||
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- [1]. Saint-Dizier F, et al. Discovery of 2-(3-Benzamidopropanamido)thiazole-5-carboxylate Inhibitors of the Kinesin HSET (KIFC1) and the Development of Cellular Target Engagement Probes. J Med Chem. 2023 Feb 23;66(4):2622-2645. [Content Brief]
- [2]. Hans-Peter Buchstaller, et al. Substituted heterocycles as hset inhibitors. WO2023131690A1. 2023-07-13.
Keywords
