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Fluconazole (UK-49858) is a triazole antifungal agent with excellent activities against a broad range of fungi, especially against Candidaalbicans. Fluconazole inhibits C. albicans and Candida kefyr with IC99s range from 0.20 μg/mL to 0.39 μg/mL .
Lipase,Candida antarctica (Immobilized) is an immobilized lipase isolated from Candida antarctica fraction B. Lipase,Candida antarctica (Immobilized) features high stability and selectivity. Lipase,Candida antarctica (Immobilized) is widely used in fields such as chemical synthesis, food oil modification, and biodiesel production .
Ibrexafungerp citrate (MK 3118 citrate) is an orally active β-1,3-glucan synthesis inhibitor, with potential antifungal activity. Ibrexafungerp citrate is an investigational agent for the treatment of Candida and Aspergillus infections .
Ibrexafungerp (MK 3118) is an orally active β-1,3-glucan synthesis inhibitor, with potential antifungal activity. Ibrexafungerp can be used for research of Candida and Aspergillus infections .
Lipase,Candida antarctica (Immobilized on hydrophilic carrier) (Candida antarctica lipase B) is a lipase derived from Candida antarctica and immobilized on a hydrophilic carrier. Lipase,Candida antarctica (Immobilized on hydrophilic carrier) is a green catalyst that can be used to catalyze polymer synthesis .
Cyclo(Arg-Pro) (Cyclo(Pro-Arg)) is an inhibitor for chitinase. Cyclo(Arg-Pro) inhibits cell separation of Saccharomyces cerevisiae, without affecting its growth. Cyclo(Arg-Pro) inhibits the morphological change of Candidaalbicans from yeast form to filamentous form .
Lipase, Candida cylindracea (Immobilized) is an immobilized hydrolase and biocatalyst with relaxed positional and substrate specificity. Lipase, Candida cylindracea (Immobilized) can target primary and secondary ester bonds to completely hydrolyze triglycerides into fatty acids and glycerol, producing only trace amounts of monoglycerides. Lipase, Candida cylindracea (Immobilized) exhibits chain specificity, with a relatively fast hydrolysis rate for oleic acid and lauric acid chains, and the slowest hydrolysis rate for stearic acid chains. Lipase, Candida cylindracea (Immobilized) shows high catalytic activity toward long-chain triglycerides under the conditions of pH 8.0 and 37°C .
Tetraethylenepentamine pentahydrochloride is an orally active copper chelator and copper mobilizer. Tetraethylenepentamine pentahydrochloride exhibits growth inhibitory and hypolipidemic properties. Tetraethylenepentamine pentahydrochloride significantly increases urinary copper excretion and reduces renal copper accumulation in copper overload models, but does not significantly alter hepatic copper levels. Tetraethylenepentamine pentahydrochloride exerts growth inhibitory effects on Candidaalbicans and Fluconazole (HY-B0101)-resistant strains, and can be widely used in studies related to Wilson's disease and Candida infections .
Uricase, candida utilis (Uox, candida utilis) is a uricase (urate oxidase) derived from Candida utilis. Uricase, candida utilis converts uric acid into allantoin. The absence of Uricase in mammals causes kidney diseases resulting from uric acid accumulation. Uricase, candida utilis can be used for research on chronic refractory gout and hyperuricemia .
Trimetozine is an Antifungal agent and sedative. Trimetozine exhibits antibacterial activity against Candidaalbicans, Candida glabrata, and Miconazole (HY-B0454)-resistant Candida glabrata cultures. Trimetozine exerts a sedative effect. Trimetozine can be used in research related to candidiasis and anxiety disorders .
High-efficiency lipase,Candida antarctica (Immobilized on hydrophilic carrier) is a biocatalyst and a key enzyme in new biocatalyst technology. Enzyme engineering focuses on enhancing enzyme reaction kinetics, substrate selectivity, and activity under harsh conditions such as low or high pH. By introducing stimulus responsiveness to these enzyme modifications, dynamic control of activity is also possible .
Fluconazole (Standard) is the analytical standard of Fluconazole. This product is intended for research and analytical applications. Fluconazole (UK-49858) is a triazole antifungal agent with excellent activities against a broad range of fungi, especially against Candidaalbicans. Fluconazole inhibits C. albicans and Candida kefyr with IC99s range from 0.20 μg/mL to 0.39 μg/mL .
2,6-Dichlorodiphenylamine is an analogue of Diclofenac Sodium (HY-15037) and has anti-Candidaalbicans activity. Diclofenac Sodium is a potent and nonselective anti-inflammatory agent, acts as a COX inhibitor, with IC50s of 4 and 1.3 nM for human COX-1 and COX-2 in CHO cells.
Cyclo (Arg-Pro) TFA is a chitinase inhibitor. Cyclo (Arg-Pro) TFA disrupts cell separation and morphological transition of yeast by inhibiting chitinase activity. Cyclo (Arg-Pro) TFA prevents cell separation of Saccharomyces cerevisiae, leading to the formation of grape-like cell clusters, without inhibiting cell growth. Cyclo (Arg-Pro) TFA blocks the morphological transition of Candidaalbicans from yeast form to hyphal form, without inhibiting cell growth .
NP-BTA is an allosteric inhibitor for glutaminyl-tRNA synthetase (GlnRS). NP-BTA exhibits antifungal efficacy against Candidaalbicans, with MIC50 of 6.25 μM .
Antifungal agent 136 is a CYP51 inhibitor and antifungal agent. Antifungal agent 136 downregulates the expression of interleukin-6 to alleviate inflammatory responses. Antifungal agent 136 exhibits activity against both drug-sensitive and drug-resistant Candidaalbicans strains. Antifungal agent 136 can be used in the research of fungal infections and inflammatory diseases .
Invertase from Candida sp. is responsible for catalyzing the hydrolysis of sucrose into glucose and fructose and is widely used in the field of carbohydrate processing. Invertase from Candida sp. can be used for enzymatic determination of sucrose concentration as well as for structural analysis of carbohydrates containing β-D-fructofuranosyl residues .
Cholesterol esterase, Candida cylindracea is an enzyme located in the intestines that hydrolyzes cholesterol esters into cholesterol and free fatty acids. Also known as bile salt-stimulated lipase or carboxylester lipase, this enzyme facilitates cholesterol metabolism and absorption in the body. It can also be used as a biochemical reagent, and is employed in conjunction with cholesterol oxidase (HY-P2848) to measure cholesterol levels .
D-Cateslytin is an antimicrobial peptide that exhibits potent inhibition activity against Candidaalbicans (MIC = 2.9 μM). D-Cateslytin can rapidly enter C. albicans, and shows no cytotoxicity to human gingival fibroblasts, and is stable in saliva. D-Cateslytin can be used for research on Candidaalbicans related diseases, such as oral candidosis .
Piroctone is a potent hydroxypyridone antimicrobial agent that shows remarkable activity against fungi including Candida species. Piroctone inhibits hyphal induction of Candidaalbicans. Piroctone can efficiently chelate intracellular iron to induce relevant cytotoxicity in neuroblastoma cells. Piroctone can be used for antimicrobial and neuroblastoma research .
SP1 is an α-peptide encoded by the mating pheromone MFα1 gene in Candidaalbicans, which can induce cell growth arrest at the mating type locus MTLa in Candidaalbicans. SP1 can be used in the study of the prevention and treatment of Candidaalbicans infection .
Chitin synthase inhibitor 3 (compound 2d) is a potent chitin synthase inhibitor with an IC50 value of 0.16 mM, and MIC of 1 µg/mL against candidaalbicans. Antifungal activity .
Kanosamine (3-Amino-3-deoxyglucose) is an antibiotic against Saccharomyces cerevisiae and human pathogenic fungi Candidaalbicans. Kanosamine exhibits antifungal activity through inhibition of cell wall synthesis and inhibition of GlcN-6-P synthase with phosphorylated kanosamine-6-phosphate in cytoplasma .
Prolylrapamycin (21-Norrapamycin) is the derivative of Rapamycin (HY-10219). Prolylrapamycin exhibits antifungal activity, that inhibits Candidaalbicans, Saccharomyces cerevisiae, and Fusarium oxysporum with MIC of 0.125-2 μg/mL .
(-)-Dicentrine is an aporphine alkaloid that can be isolated from the stem bark of Talauma arcabucoana. (-)-Dicentrine shows moderate growth inhibition against Staphylococcus aureus and
Candidaalbicans .
Filiformin ((-)-Filiformin) is a sesquiterpene compound that can be isolated from Laurencia filiformis forma heteroclada. Filiformin exhibits certain cytotoxicity against P388 and BSC-1 cells. Filiformin has antimicrobial activity against Bacillus subtilis, Trichophyton mentagrophytes and Candidaalbicans. In addition, Filiformin can inhibit oxygen uptake in isolated rat liver mitochondria at a concentration of 150 μM .
Antifungal agent 51 (Compound 5c) has potent antifungal activity, especially against Candidaalbicans FDC 151 , Candida parapsilosis ATCC 22019 and Candida tropicalis FDC 138, with the MIC value is less than 0.063 μg/mL, and it has low toxicity to cells and no carcinogenicity .
β-Nor-lapachone is a Candida glabrata antibiofilm agent. β-Nor-lapachone can stimulate ROS production, inhibits efflux activity, adhesion, biofilm formation and the metabolism of mature biofilms of Candida glabrata. β-Nor-lapachone has antifungal activity .
Candicidin D (CndD) is an antibiotic, which exhibits antifungal activity through interaction with steroids in cell membranes. Candicidin D inhibits S. cerevisiae, Candidaalbicans and other Candida spp. with MIC of 0.25-1 μg/mL in RPMI-1640 medium.
Sporminarin B is an antibacterial and antifungal agent. Sporminarin B exhibits inhibitory activity against microorganisms such as Candidaalbicans and Staphylococcus aureus .
Antifungal agent 32 (compound 1a) is a potent antifungal agent. Antifungal agent 32 inhibits Candidaalbicans filamentation and biofilm formation. Antifungal agent 32 inhibits the morphological switching of Candidaalbicans and its adherence to epithelial cells. Antifungal agent 32 can be used for Candidaalbicans infections research .
Antifungal agent 67 (compound 9) is an imidazole antifungal agent that is effective against Candida. Antifungal agent 67 has a CC50 value of 33.6 μM on healthy neonatal rat cardiomyoblasts .
Cleroindicin F ((-)-Rengyolone), a cleroindicin, is an antimicrobial agent. Cleroindicin F shows relatively high anticandidal activity against Candida strains with a MIC value down to 12.5 µg/mL .
Clavariopsin A is a cyclic depsipeptide antibiotic. Clavariopsin A shows antifungal activity for Candidaalbicans IFO 0583, Candidaalbicans ATCC 10231, Aspergillus niger AJ117374, Aspergillus fumigatus AJ117190, Aspergillus fumigatus JCM1739 with MIC values of 8, 8, 16, 2, 4 μg/mL, respectively .
Amorolfine (Ro 14-4767) is an antifungal agent. Amorolfine ameliorates the onychomycosis through inhibition of ergosterol biosynthesis. Amorolfine inhibits Candidaalbicans with a MIC of 0.404 µg/mL .
Clavariopsin B is a cyclic depsipeptide antibiotic. Clavariopsin B shows antifungal activity for Candidaalbicans IFO 0583, Candidaalbicans ATCC 10231, Aspergillus niger AJ117374, Aspergillus fumigatus AJ117190, Aspergillus fumigatus JCM1739 with MIC values of 8, 8, 16, 4, 4 μg/mL, respectively .
Ibrexafungerp phosphate is an orally active β-1,3-glucan synthesis inhibitor, with potential antifungal activity. Ibrexafungerp phosphate can be used for research of Candida and Aspergillus infections .
Nikkomycin Lx is an antibiotic that can be extracted from Streptomyces tendae TU901. Nikkomycin Lx exhibits anti-CandidaAlbicans activity and can be utilized in relevant research .
Haloprogin (Standard) is the analytical standard of Haloprogin. This product is intended for research and analytical applications. Haloprogin is a potent antifungal agent. Haloprogin has activity against dermatophytes, Candida spp and a limited number of Gram-positive bacteria .
Antifungal agent 68 (compound 10) is an antifungal agent against Candida and Cryptococcus gattii. Antifungal agent 68 inhibits fungal ergosterol biosynthesis, possibly by targeting lanosterol 14α-demethylase (CYP51). There is an interaction between the imidazole ring of antifungal agent 68 and the heme group of CYP51 .
Nikkomycin Lz is a nucleoside peptide antifungal compound isolated from genetically engineered Streptomyces tendae TU901. Nikkomycin Lz has antifungal activity against Candidaalbicans .
Antifungal agent 28 (compound 18) is a potent and selective antifungal agent. Antifungal agent 28 inhibits pathogenic strains of C. albicans and non-albicans species including fluconazole-resistant strains. Antifungal agent 28 inhibits Cryptococcus and Aspergillus strains. Antifungal agent 28 disrupts mature Candida biofilm .
Filipin II is an antibiotic, which exhibits antifungal efficacy. Filipin II interacts with membrane sterols, leads to changes in membrane structure, inhibits Candida utilis and Saccharomyces cerevisiae with the MIC of 0.03 mg/L and 0.2 μg/L .
Antifungal agent 112 (Compound 1e) exhibits antifungal activity against Candidaalbicans, Aspergillus niger and Aspergillus fumigatus with MIC of 0.0024, 0.0022 and 0.0028 M, respectively .
CYP51-IN-2 (compound 1n), a Fluconazole (HY-B0101) analog, is a potent antifungal agent. CYP51-IN-2 shows MIC80 of 1 μg/mL for Microsporum gypseum and Candidaalbicans .
CYP51-IN-2 (compound 1i), a Fluconazole (HY-B0101) analog, is a potent antifungal agent. CYP51-IN-2 shows MIC80 of 62.5 for Microsporum gypseum and Candidaalbicans .
CYP51-IN-2 (compound 1l), a Fluconazole (HY-B0101) analog, is a potent antifungal agent. CYP51-IN-2 shows MIC80 of 15.6 ng/mL for Microsporum gypseum and Candidaalbicans .
CYP51-IN-2 (compound 1d), a Fluconazole (HY-B0101) analog, is a potent antifungal agent. CYP51-IN-2 shows MIC80 of 15.6 ng/mL for Microsporum gypseum and Candidaalbicans .
C. rugosa Lipase is a biocatalyst that has recently attracted much attention because of its regio-selectivity in various types of reactions, such as trans-esterification, hydrolysis, and esterification .
CaMdr1p-IN-1 (Compound A) is an inhibitor for the major facilitator superfamily transporter CaMdr1p. CaMdr1p-IN-1 exhibits chemosensitizing efficacy. CaMdr1p-IN-1 synergizes with Fluconazole (HY-B0101), that inhibits CaMdr1p overexpressing Candidaalbicans with MIC of 10 μM .
CYP51-IN-2 (compound 1m), a Fluconazole (HY-B0101) analog, is a potent antifungal agent. CYP51-IN-2 shows MIC80s of 62.5 and 250 ng/mL for Microsporum gypseum and Candidaalbicans, respectively .
CYP51-IN-2 (compound 1h), a Fluconazole (HY-B0101) analog, is a potent antifungal agent. CYP51-IN-2 shows MIC80s of 15.6 and 62.5 ng/mL for Microsporum gypseum and Candidaalbicans, respectively .
Antibacterial agent 215 (Compound 3b) is an inhibitor for carbonic anhydrase (CA), with Ki of 17.61, 5.14 and 43.74 nM, for hCA I, hCA II and AChE, respectively. Antibacterial agent 215 exhibits anti-tuberculosis, with MIC of 62.5 µg/ml against M. tuberculosis. Antibacterial agent 215 exhibits antifungal activities against Candida spp. strains ATCC 14053, ATCC 1369, and ATCC 15126, with MICs of 125 µg/ml .
17-Hydroxyventuricidin A (YP-02259L-C) is an antimicrobial compound.17-Hydroxyventuricidin A inhibits the growth of the two tested filamentous fungi (Verticillium dahlia and Fusarium sp.) and of Candida tropicalis R2 CIP203 .
Neodidymelliosides A (compound 1)It is a secondary metabolite of fungi and has a significant inhibitory effect on Staphylococcus aureus and Candidaalbicans biofilms. Neodidymelliosides AIt also has anti-cancer activity and can inhibit KB3.1 (cervix),PC-3 (prostate),MCF-7(breast),SKOV-3 (ovary),A431 (skin )and A549 (lung )Cell viability of cell lines .
Antibacterial agent 100 (Compound 7c) is an antibacterial and antifungal agent. Antibacterial agent 100 shows promising activity with MIC values of 4, 4 and 8 μg/mL against Staphylococcus aureus, Candidaalbicans and Cryptococcus neoformans, respectively .
Antifungal agent 41 (compound B01) is an antifungal agent. Antifungal agent 41 shows inhibitory effect on Candidaalbicans in virto and vivo. Antifungal agent 41 can be used for the research of invasive fungal infections .
Antifungal agent 114 (Compound 19g) is an inhibitor for Cytochrome P450, that inhibits CYP1A2, CYP2C9, CYP2C19 CYP2D6 and CYP3A4 at 10 μM. Antifungal agent 114 exhibits antifungal activity against Cryptococcus neoformans, Candida and Aspergillus, with MIC <0.0625 μg/mL. Antifungal agent 114 exhibits good metabolic stability in human liver microsomes with a half-time of 107 minutes .
GVLSNVIGYLKKLGTGALNAVLKQ is an antimicrobial peptide with 24-amino acid. GVLSNVIGYLKKLGTGALNAVLKQ can potentially form α-helix. GVLSNVIGYLKKLGTGALNAVLKQ (PGQ) has activity against Gram-negative, Gram-positive bacteria and the yeast Candidaalbicans .
Balteatide is an antimicrobial peptide, which can be found in skin secretion of Phyllomedusa baltea. Balteatide inhibits the gram-positive Staphylococcus aureus (MIC=435 μM), the gram-negative Escherichia coli (MIC=109 μM), and Candidaalbicans (MIC=27 μM). Balteatide lacks hemolytic activity (at 512 mg/L) and myotropic activity .
8-Acetylverrucarin L (Verrucarin L acetate) is a mycotoxin, which exhibits antitumor and antimicrobial activities. 8-Acetylverrucarin L exhibits cytotoxicity to cancer cells HCT116 and A2780S, with IC100 of 9.77 and 9.77 ng/mL. 8-Acetylverrucarin L exhibits antifungal activity against Saccharomyces cerevisiae, Candidaalbicans and Geotrichum candidum .
Uricase, Candida sp. (Uox, Candida sp.) is a uricase (urate oxidase) derived from Candida sp.. Uricase, Candida sp. converts uric acid into allantoin. The absence of Uricase in mammals causes kidney diseases resulting from uric acid accumulation. Uricase, Candida sp. can be used for research on chronic refractory gout and hyperuricemia .
Anti-Candida auris β-1,3-glucans Antibody (2G8) is an antibody targeting Candida auris β-1,3-glucans, and also acts as an inhibitor of AChE and TGF-β receptor 2. Anti-Candida auris β-1,3-glucans Antibody (2G8) also targets fungal cell wall components, effectively inhibits fungal growth and interferes with capsule formation, thereby significantly reducing the fungal load in mouse tissues. Anti-Candida auris β-1,3-glucans Antibody (2G8) not only blocks TGF-β receptor binding to inhibit the Smad signaling pathway, reduces fibroblast activation and collagen deposition, but also induces epithelial differentiation of tumor cells and reduces pancreatic tumor metastasis. Anti-Candida auris β-1,3-glucans Antibody (2G8) specifically binds to the conserved N-linked glycoepitope on AChE to inhibit its activity without interfering with BChE, and can be used in studies of cryptococcosis and related tumor mechanisms .The isotype control is Human IgG1 kappa, Isotype Control (HY-P99001).
Cholesterol esterase, Candida Rugosa (EC 3.1.1.13), catalyzes the synthesis of sterols and fatty acids from sterol esters. In the presence of bile acids, it aggregates to form a hexamer, which may be the active form of this enzyme.
CYP51-IN-5 is a cytochrome P450 14α-demethylase (CYP51) inhibitor and an antifungal (fungal) agent belonging to the triazole derivative class. CYP51-IN-5 is applicable to the research of Candidaalbicans, Cryptococcus neoformans, Candida parapsilosis, Candida tropicalis, Trichophyton rubrum, Candida krusei and Microsporum gypseum .
Anticandidal agent-2 is an anti-Candidaalbicans agent with a MIC of 1.6 μg/mL. Anticandidal agent-2 disrupts Candidaalbicans biofilms and inhibits Candidaalbicans. Anticandidal agent-2 can be used in the research of Candidaalbicansinfections .
FTR1335 is an Antifungal agent as well as a selective, substrate peptide-competitive, and myristoyl-CoA non-competitive inhibitor of N-myristoyltransferase CaNmt, with an IC50 of 0.49 nM against CandidaalbicansCaNmt. FTR1335 exhibits fungicidal activity against Candidaalbicans and inhibits the growth of Candida tropicalis. FTR1335 can be used in research related to Candidaalbicans infections .
Penoxsulam is an acetolactate synthase (ALS) inhibitor herbicide. Penoxsulam inhibits Candida auris acetohydroxyacid synthase (AHAS) with a Ki value of <32 nM. Penoxsulam can be used for postemergence control of annual grasses, sedges, and broadleaf weeds in rice culture. Penoxsulam can be used for the study of Candida auris infections .
Ducloudine C is an alkaloid present in the roots of Aconitum duclouxii with antifungal activity. Ducloudine C has an MIC of 128 μg/mL against Candidaalbicans .
Antifungal agent-161 (Compound 7) is an Antifungal agent. Antifungal agent-161 potently inhibits Candidaalbicans ATCC 36082 (with a MIC of 1.32 μM) and Candida glabrata ATCC 2001 (with a MIC of 1.66 μM). Antifungal agent-161 reduces fungal loads in infected mice and eliminates Candidaalbicans and Candida glabrata infections. Antifungal agent-161 can be used for the research of candidiasis .
Antifungal agent-164 is an exo-β-(1,3)-glucanase inhibitor that binds to the enzyme’s binding site. Antifungal agent-164 inhibits the growth of fungal. Antifungal agent-164 can be used for the research of candida infection .
CYP51-IN-32 is an antifungal agent with an IC50 of 0.331 μM against CYP51 of Candidaalbicans. CYP51-IN-32 releases hydrogen sulfide (H2S) and inhibits hyphal formation and biofilm development of Candidaalbicans. CYP51-IN-32 can be formulated into PEG-based nanovesicles. CYP51-IN-32 is applicable to the research of Candidaalbicans infection .
Cyclo(Pro-dArg) acetate is a chitinase inhibitor. Cyclo(Pro-dArg) acetate inhibits the cell separation of Saccharomyces cerevisiae but does not affect its growth. Cyclo(Pro-dArg) acetate inhibits the transition of Candidaalbicans from yeast to filamentous morphology .
Antifungal agent-162 (Compound 1c) is an Antifungal agent. Antifungal agent-162 exhibits potent in vitro antifungal activity against Candidaalbicans, Cryptococcus neoformans, Candida parapsilosis, Candida tropicalis, Candida krusei, and Microsporum gypseum (with MIC80 values ranging from 0.0156 to 0.25 μg/mL), while shows no activity against Aspergillus fumigatus .
Antifungal agent 145 (Compound 14') is a highly effective fungicide. Antifungal agent 145 exhibits MICs against Candidaalbicans, Candida tropicalis, and Cryptococcus neoformans of 4, 8, and 8 μg/mL respectively. Antifungal agent 145 exerts a potent and rapid bactericidal effect by disrupting the fungal cell membrane, and can effectively inhibit and destroy biofilms. Antifungal agent 145 has improved safety and can be used in antifungal research .
L-705589 is a semi-synthetic penicillin-type antifungal agent. L-705589 exerts its antifungal effect by inhibiting the 1,3-β-D-glucan synthase in the fungal cell wall. L-705589 exhibits potent bactericidal activity against various Candida species (such as Candidaalbicans, Candida glabrata, Candida krusei, etc.) (MFC: 0.06 - 8 μg/mL), but has relatively weak activity against Cryptococcus neoformans (MFC: 32 - 64 μg/mL). L-705589 remains active against drug-resistant Candida strains and is not prone to inducing drug resistance. L-705589 significantly improves survival rates in the model of minor invasive aspergillosis .
(E)-2-(4-Cinnamoylphenoxy)acetic acid is an antimicrobial agent with a minimum inhibitory concentration of 125 μg/mL against Mycobacterium smegmatis, Staphylococcus aureus, and Candidaalbicans .
Ibrexafungerp citrate (Standard) (MK 3118 citrate (Standard)) is the analytical standard of Ibrexafungerp (citrate) (HY-107126A). This product is intended for research and analytical applications. Ibrexafungerp citrate (MK 3118 citrate) is an orally active β-1,3-glucan synthesis inhibitor, with potential antifungal activity. Ibrexafungerp citrate is an investigational agent for the treatment of Candida and Aspergillus infections .
CYP51-IN-2 (compound 1g), a Fluconazole (HY-B0101) analog, is a potent antifungal agent. CYP51-IN-2 shows MIC80s of 62.5 and 250 ng/mL for Microsporum gypseum and Candidaalbicans, respectively .
CYP51-IN-2 (compound 1f), a Fluconazole (HY-B0101) analog, is a potent antifungal agent. CYP51-IN-2 shows MIC80s of 62.5 and 15.6 ng/mL for Microsporum gypseum and Candidaalbicans, respectively .
CYP51-IN-2 (compound 1b), a Fluconazole (HY-B0101) analog, is a potent antifungal agent. CYP51-IN-2 shows 64 and 128 times higher activity than that of Fluconazole against Microsporum gypseum and Candidaalbicans, respectively .
5,6,7,8-Tetramethoxyflavone is a flavonoid with antifungal and antibacterial activities, capable of inhibiting the growth of *Staphylococcus aureus* and *Candidaalbicans*. 5,6,7,8-Tetramethoxyflavone can be utilized in research related to infections [1].
Tunicamycin X (Tunicamycin 17:1) is a nucleoside Antibiotic. Tunicamycin X is isolated from Streptomyces xinghaiensis SCSIO S15077. Tunicamycin X acts as a growth inhibitor against bacteria and fungi. Tunicamycin X inhibits the growth of Bacillus thuringiensis strains. Tunicamycin X inhibits the growth of Candidaalbicans strains .
CHNQD-02204 is a potent and selective antifungal agent with in vitro activity against Candidaalbicans, with a MIC of 0.025 μg/mL. CHNQD-02204 inhibits ergosterol biosynthesis, disrupts the membrane integrity and biofilm formation of Candidaalbicans, and suppresses the morphological transition of Candidaalbicans from yeast to hyphal form. CHNQD-02204 can be used in studies related to candidal infections .
Vincadifformine N (4)-oxide is a monoterpenoid indole alkaloid. Vincadifformine N (4)-oxide can be isolated from Rhazya stricta. Vincadifformine N (4)-oxide shows a MIC > 50 μg/mL against tested Candida strains and exhibits no antifungal activity .
P-gp-IN-34 (compound 4a) is an Mdr1p (Mdr1 pump) inhibitor. P-gp-IN-34 inhibits yeast to hyphal shift in Candidaalbicans. P-gp-IN-34 can be used for the research of candidiasis .
Tunicamycin B is a Tunicamycin (HY-A0098) derivative with antimicrobial activity. Tunicamycin B shows antibacterial activity against Bacillus thuringiensis BT01 and B. thuringiensis W102 (MICs of 0.125 and 0.063 μg/mL, respectively) and antifungal activity against Candidaalbicans ATCC 96901 and C. albicans CMCC (F) 98001 (MICs of 8.0 and 4.0 μg/mL, respectively). Tunicamycin B can be used for antimicrobial research .
Antifungal agent 141, a Phenoxazine (HY-34463) derivative, is an antifungal agent. Antifungal agent shows potent antifungal activity in Cryptococcus neoformans and Candidaalbicans with MIC values of 2 and 4 µg/mL. Antifungal agent 141 can be used for the research of cryptococcal meningitis .
Citronellyl butyrate is a terpenoid ester with antibacterial, antifungal and other biological activities. Citronellyl butyrate has inhibitory effects on both Staphylococcus aureus and Escherichia coli. Citronellyl butyrate has inhibitory and bactericidal effects on various strains of Candidaalbicans (MIC: 156-1250 μg/mL). Citronellyl butyrate can be used in the research of infectious conditions .
T-2307, an arylamidine, has antifungal activities in vitro and in vivo. T-2307 exhibits broad-spectrum activity against clinically significant pathogens, including Candida species (MIC range, 0.00025 to 0.0078 μg/ml), Cryptococcus neoformans (MIC range, 0.0039 to 0.0625 μg/ml), and Aspergillus species (MIC range, 0.0156 to 4 μg/mL) .
Eleutherol is a naphthalene isolated from E. americana with antifungal activities . Eleutherol is against yeasts Candidaalbicans, C. tropicalis, Saccharomyces cerevisiae and Cryptococcus neoformans with MIC values between 7.8 µg/mL and 250 µg/mL . Eleutherol inhibits α-glucosidase function with an IC50>1.00 mM .
HDM-IN-1 (Compound A4) is an inhibitor for fungal histone demethylase (HDM), that inhibits the H3K27me3 in Cryptococcus neoformans and in Candida auris with IC50s of 134 and 12 nM. HDM-IN-1 exhibits inhibitory efficacy against C. neoformans and C. auris with MIC80 of 0.5-2 μg/mL, through inhibition of the biofilm and capsule formation. HDM-IN-1 exhibits antifungal activity in ICR mouse model .
Embeconazole (CS-758; R-120758) is an antifungal agent against Candidaalbicans, Cryptococcus neoformans, Aspergillus fumigatus and Aspergillus flavus, with MICs of 8, 16, 63 and 250 μM, respectively .
CYP51-IN-31 (compound T24) is a selective CYP51 inhibitor with potent and broad-spectrum antifungal activity, including efficacy against drug-resistant fungal strains. CYP51-IN-31 exhibits fungicidal activity against Candida parapsilosis, anti-biofilm activity, and the ability to inhibit fungal morphological transitions. CYP51-IN-31 can be used for infection research .
Terbinafine hydrochloride (TDT 067 hydrochloride) is an orally active and potent antifungal agent. Terbinafine hydrochloride is a potent non-competitive inhibitor of squalene epoxidase from Candida, with a Ki of 30 nM. Terbinafine hydrochloride also shows antibacterial activity against certain Gram-positive and Gram-negative bacteria . Terbinafine hydrochloride is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
Terbinafine (TDT 067) is an orally active and potent antifungal agent. Terbinafine is a potent non-competitive inhibitor of squalene epoxidase from Candida, with a Ki of 30 nM. Terbinafine also shows antibacterial activity against certain Gram-positive and Gram-negative bacteria . Terbinafine is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
Pulvinamide is a tetronic acid pigment, a pulvinic acid derivative, an Antibacterial agent and Antifungal agent. Pulvinamide can be isolated from lichens. Pulvinamide weakly inhibits the growth of Bacillus subtilis (ATCC 6633) with an MIC of 50 μg/mL. Pulvinamide weakly inhibits the growth of Candidaalbicans (ATCC 10231) and Saccharomyces cerevisiae (ATCC 9763), with MIC values of 200 μg/mL and 100 μg/mL, respectively .
Callophycin A, a red seaweed derived metabolite, possessing potent activity against Candidaalbicans with MIC of 62.5~250 mg/L. Callophycin A significantly reduces fungal burden of vaginal candidiasis induced mice, also decreases inflammatory response and immune molecules .
PK-10 is a synergistic antibacterial agent of Fluconazole (HY-B0101) and has strong antifungal activity against a variety of Fluconazole-resistant Candidaalbicans strains. PK-10 combined with Fluconazole can inhibit hyphae formation and induce the accumulation of reactive oxygen species. It further causes damage to mitochondrial membrane potential, reduces intracellular ATP content, and leads to mitochondrial dysfunction .
Rilopirox (HOE 351) is a hydroxy-pyridone compound with antimycotic properties. Rilopirox, a chelating agent, can inhibit catalase. Rilopirox inhibits the respiratory chain. Rilopirox inhibits growth of yeast isolates with a MIC50 of 4 μg/mL. Rilopirox has the potential for vaginal candidosis and oropharyngeal Candida infections research .
Terbinafine lactate (TDT 067 lactate) is an orally active and potent antifungal agent. Terbinafine lactate is a potent non-competitive inhibitor of squalene epoxidase from Candida, with a Ki of 30 nM. Terbinafine lactate also shows antibacterial activity against certain Gram-positive and Gram-negative bacteria . Terbinafine (lactate) is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
Inz-1 is a potent and selective mitochondrial cytochrome bc1 inhibitor for yeast (IC50=8.092 μM) over humans (IC50=45.320 μM). Inz-1 reverses Fluconazole (HY-B0101) or other triazole antifungals’ resistance in the pathogenic fungus Candidaalbicans .
α-Guaiene is a natural sesquiterpene and fungicidal agent found in Pogostemon cablin (patchouli) essential oil. α-Guaiene suppresses the growth of Aspergillus niger, Candidaalbicans, Microsporum gypseum, and Trichophyton mentagrophytes. α-Guaiene can be used for the study of fungal infection .
Dimethyloctadecyl[3-(trimethoxysilyl) propyl]ammonium chloride is a quaternary ammonium silane monomer-based disinfectant/antimicrobial agent. Dimethyloctadecylammonium chloride exhibits bactericidal activity against Gram-positive and Gram-negative bacteria, as well as fungicidal activity against Candidaalbicans in solution; it can form a hydrophobic glass coating that displays bactericidal activity against Gram-positive and Gram-negative bacteria but has limited fungicidal activity against Candidaalbicans .
Terbinafine hydrochloride (Standard) is the analytical standard of Terbinafine hydrochloride. This product is intended for research and analytical applications. Terbinafine hydrochloride (TDT 067 hydrochloride) is an orally active and potent antifungal agent. Terbinafine hydrochloride is a potent non-competitive inhibitor of squalene epoxidase from Candida, with a Ki of 30 nM. Terbinafine hydrochloride also shows antibacterial activity against certain Gram-positive and Gram-negative bacteria . Terbinafine hydrochloride is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
Terbinafine (Standard) is the analytical standard of Terbinafine. This product is intended for research and analytical applications. Terbinafine (TDT 067) is an orally active and potent antifungal agent. Terbinafine is a potent non-competitive inhibitor of squalene epoxidase from Candida, with a Ki of 30 nM. Terbinafine also shows antibacterial activity against certain Gram-positive and Gram-negative bacteria . Terbinafine is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
trans-β-Bergamotene is a sesquiterpene hydrocarbon and antifungal agent found in the essential oil of Bixa orellana L. leaves. trans-β-Bergamotene possesses antiungal and anti-inflammatory properties. trans-β-Bergamotene can be used for the research of Candidaalbicans infection .
Antifungal agent 143 is potent antifungal agent which also exihibits antibacterial activity. Antifungal agent 143 inhibits growth of Candidaalbicans and Aspergillus niger, Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus, and Streptococcus pyogenes. Antifungal agent 143 can be used for antimicrobial research.
Naphthalene-2,3-dicarboxaldehyde (NDA) is an effective inhibitor of Candidaalbicansaspartate semialdehyde dehydrogenase (ASADH), with a Ki value of 45 μM. Naphthalene-2,3-dicarboxaldehyde targets ASADH in the aspartate biosynthetic pathway of Candidaalbicans. Naphthalene-2,3-dicarboxaldehyde reacts with primary amines to generate highly fluorescent and stable derivatives. Naphthalene-2,3-dicarboxaldehyde serves as a fungistatic agent and a fluorogenic derivatization reagent. Naphthalene-2,3-Dicarboxaldehyde can be used for the research of candidiasis .
Pantinin-2 is a cysteine-free toxic peptide found in the emperor scorpion (paninus imperator). Pantinin-2 has high activity against Gram-positive bacteria but weak activity against Gram-negative bacteria. Pantinin-2 also exhibits activity against Candida tropicalis and has relatively mild hemolytic activity against human erythrocytes. Pantinin-2 can be used in the development of antimicrobial drugs for drug-resistant pathogens .
Antifungal agent 30 (compound A18) is a potent antifungal agent. Antifungal agent 30 shows excellent antifungal activity against Candidaalbicans (CPCC400616) and Aspergillus fumigatus, with MIC of 0.03 and 0.5 μg/mL, respectively. Antifungal agent 30 also shows excellent antifungal activity against fluconazole-resistant strains. The potent antifungal activity of Antifungal agent 30 mainly causes by hydrogen and coordination bond interaction with the CYP51 .
Burnettramic acid A is an antibiotic, which can be isolated from Aspergillus burnettii. Burnettramic acid A exhibits antibacterial and antifungal activities, with IC50 of 0.2, 0.5, 2.3 and 5.9 μg/mL, for Saccharomyces cerevisiae, Candidaalbicans, Bacillus subtilis and Staphylococcus aureus, respectively. Burnettramic acid A exhibits cytotoxicity in cancer cell NS-1 with IC50 of 13.8 μg/mL .
AR-23 is a melittin-related antimicrobial peptide that can be isolated from Rana tagoi. AR-23 exhibits broad-spectrum growth inhibitory activity against aerobic bacteria, the opportunistic yeast pathogen Candidaalbicans and clinical isolates of Methicillin (HY-121544)-resistant Staphylococcus aureus (MRSA). AR-23 can be used for antimicrobial research .
Cyclo(L-Trp-L-Trp) is an antibiotic, and shows antimicrobial activity. Cyclo(L-Trp-L-Trp) can inhibit A. baumannii, as well as Candidaalbicans, Bacillus subtilis, Micrococcus luteus, Saccharomyces cerevisiae, Aspergillus niger, Staphylococcus aureus. Cyclo(L-Trp-L-Trp) can be used in microbial infection research .
Antifungal agent 31 (compound 12) is a potent and orally active triazole antifungal agents with a pyrrolotriazinone scaffold. Antifungal agent 31 shows antifungal activity against Candida spp. and filamentous fungi. Antifungal agent 31 significantly reduced mortality rates and kidney fungal burden in two murine models of lethal systemic infections .
(+)-Medioresinol is a furofuran-type lignan with antifungal and antibacterial properties. (+)-Medioresinol synergizes with antibiotics to exert antimicrobial and antibiofilm effects. (+)-Medioresinol induces intracellular ROS accumulation and mitochondrial-mediated apoptosis in Candidaalbicans. (+)-Medioresinol inhibits LPS (HY-D1056)-stimulated IL-12p40 production. (+)-Medioresinol is a PGC-1α activator that protects against endothelial cell pyroptosis in ischemic stroke via the PPARα-GOT1 axis. (+)-Medioresinol can be used in research on fungal and bacterial infection, inflammation, and ischemic stroke .
Penicolinate B is a picolinic acid derivative that can be isolated from Penicillium sp. Penicolinate B exhibits antimalarial activity (IC50: 1.40 μg/mL), antitubercular activity (MIC: 25.0 μg/mL), activity against Bacillus cereus (IC50: 25.0 μg/mL), and activity against Candidaalbicans (IC50: 1.45 μg/mL). Penicolinate B also has certain cytotoxicity against cancer cells such as MCF-7, KB, and NCI-H187. Penicolinate B can be used in research on malaria, tuberculosis, bacterial/fungal infections and tumors .
N-Phthaloylglycine (Phthaloyl glycine) is a Type II fragmentary hapten (FX-type) with antimicrobial activity.N-Phthaloylglycine acts against Candidaalbicans, Escherichia coli, and Staphylococcus epidermidis.N-Phthaloylglycine can be used for the research of fungal and bacterial infection .
Pradimicin A is a potent antifungal agent with a minimum inhibitory concentration (MIC) of 4 μg/mL against Candida rugosa. Pradimicin A exhibits antiviral activity against SARS-CoV, human immunodeficiency virus (HIV) and other enveloped viruses. Pradimicin A exerts its fungicidal activity through a Ca 2+-dependent mechanism, which induces fungal lysis. Pradimicin A can be used in research related to fungal infections, HIV infections and COVID-19 .
Ac-CoA-IN-1 is an acyl-AMP phosphate analog and weak inhibitor of Candidaalbicans acetyl-CoA synthetase 2, with no activity against Cryptococcus neoformans acetyl-CoA synthetase 1. Ac-CoA-IN-1 crystallizes with Cryptococcus neoformans ACS1 enzyme to yield structural insight for inhibitor design. Ac-CoA-IN-1 can be used for the research of fungal infections .
Dihydroavicine is a benzophenanthridine alkaloid antibacterial agent isolated from the stem bark of Zanthoxylum rhoifolium. Dihydroavicine inhibits the growth of Gram-positive bacteria, Gram-negative bacteria, and Candidaalbicans. Dihydroavicine shows no activity against Saccharomyces cerevisiae and Cryptococcus neoformans. Dihydroavicine can be used for the research of bacterial infections and candidal infections .
Suloctidil is an orally active calcium channel blocker and antifungal agent. Suloctidil antagonizes vasoconstriction induced by norepinephrine, angiotensin and serotonin. Suloctidil inhibits platelet function and exhibits neuroprotective effects. Suloctidil exerts inhibitory effects on Candidaalbicans biofilm and virulence. Suloctidil can be used in research on vasospasm relief, antithrombosis and superficial candidiasis .
Candicidin (≥50%) (Levorin (≥50%)) is an Antifungal antibiotic. Candicidin (≥50%) exhibits potent antifungal activity against yeasts and yeast-like fungi, such as Candidaalbicans and Saccharomyces cerevisiae. Low concentrations of Candicidin (≥50%) do not adversely affect pea seed germination .
Antibacterial agent 303 (compound 3) is an antibacterial agent exhibiting potent antibacterial activity against MDR strains, with MICs of 10 and 100 µg/mL against Pseudomonas aeruginosa MDR1 and Staphylococcus aureus MDR strains, respectively. Antibacterial agent 303 displays strong binding affinities to E. coli DNA gyrase and Candidaalbicans lanosterol 14α-demethylase. Antibacterial agent 303 can be used for drug-resistant infections research .
Verrucarin J (Muconomycin B) is a metabolite of the Myrothecium fungus family. Verrucarin J generates reactive oxygen species (ROS) and induces apoptosis of cancer cell lines, such as A549, HCT 116 and SW-620 cells. Verrucarin J shows activities against Candidaalbicans and Mucor miehei. Verrucarin J inhibits arenavirus Junin (JUNV) yield with an IC50 of 1.2 ng/mL .
Quinalizarin is a protein kinase CK2 inhibitor with a Ki of 0.052 μM. Quinalizarin exhibits antifungal and anticancer activities. Quinalizarin induces ROS production, apoptotic signaling, mitochondrial pathway activation, cell cycle arrest, and cytotoxicity in cancer cells. Quinalizarin inhibits hyphal growth, biofilm formation, and mature biofilm integrity of Candidaalbicans. Quinalizarin can be used in research related to cancer and fungal infections .
Chitin, from crab carapace (powder),biomedical research grade is a long-chain polymer of N-acetylglucosamine with β-(1-4) linkages. Chitin, from crab carapace (powder),biomedical research grade is found in the exoskeleton of crabs. Chitin, from crab carapace (powder),biomedical research grade inhibits the activation of NF-κB p65, alters the translocation of NF-κB p65 to the nucleus, and interacts with the cell wall of Candida species. Chitin, from crab carapace (powder),biomedical research grade exerts antifungal and anti-inflammatory effects. Chitin, from crab carapace (powder),biomedical research grade can be used in the research of gastric ulcer and candidiasis .
Prothioconazole is an orally active broad-spectrum fungicide. Prothioconazole weakly inhibits CaCYP51 activity in Candidaalbicans, with an apparent IC50 of approximately 120 μM. Prothioconazole disrupts Microtubule stability by reducing the acetylation level of α-tubulin. Prothioconazole induces Mitochondrial dysfunction, oxidative stress, DNA damage, and Apoptosis. Prothioconazole accumulates 14-methylated sterols and depletes ergosterol in cells, culture media, plants, and animals. Prothioconazole interferes with pyruvate metabolism and glycolysis/gluconeogenesis processes in mouse liver, downregulates Fasn mRNA expression, and induces hepatotoxicity and renal metabolic disorders. Prothioconazole reduces the fertility of female mice. Prothioconazole inhibits body weight gain and increases liver/kidney indices in mice. Prothioconazole can be used in studies related to candidiasis .
Diorcinol D is a natural product with antifungal activity. Diorcinol D inhibits CYP51 expression, reduces Cdr1 expression, blocks efflux pump activity, and impedes ergosterol biosynthesis. It inhibits planktonic and biofilm growth of Candidaalbicans. Diorcinol D is applicable to research related to fungal infections .
Glidobactin A is an acyl peptide antibiotic. Glidobactin A has activity against Candida, Aspergillus fumigatus and Trichophyton, but it is not effective against Candidaalbicans M-9 infection in mice .
1-Hydroxyphenazine (Hemipyocyanine; 1-Phenazinol; Hemi-pyocyanin) is an inhibitor for α-Amylase with an IC50 of 3.1 μg/mL . 1-Hydroxyphenazine exhibits anticancer and anti-inflammatory activity against cells A549, 1321N1 and RAW264.7, antifungal and antibacterial activity against strains Candidaalbicans, Aspergillus fumigatus, Escherichia coli and Xanthomonas campestris .
(E,Z)-Platanoside is a flavonoid glycoside. (E,Z)-Platanoside is a potent and highly selective MRSA inhibitor; it exhibits low activity against other tested strains, including Gram-negative bacteria, intracellular Mycobacterium intracellulare, Candidaalbicans, Cryptococcus neoformans, and Aspergillus fumigatus. (E,Z)-Platanoside can be used in research on MRSA infections .
Anti-inflammatory agent 84 (Compound 4D) is a derivative of Coumarin (HY-N0709) with antimicrobial and anti-inflammatory activities. Anti-inflammatory agent 84 inhibits E. coli, Candidaalbicans, Staphylococcus aureus and methicillin-resistant S. aureus (MRSA), with MIC of 312, 156, 19 and 316 μg/mL, respectively. Anti-inflammatory agent 84 inhibits biofilm formation of S. aureus, E. coli and MRSA, with IC50 of 185, 321 and 99 μM, respectively. Anti-inflammatory agent 84 inhibits nitric oxide production in Lipopolysaccharide (HY-D1056)-stimulated RAW264.7 macrophage cell .
Antibiofilm agent-12 (Compound C13) is an antifungal agent that belongs to the class of carbazate derivatives. Antibiofilm agent-12 exhibits significant antifungal activity against Candida auris, with a MIC90 of 237.9 μM. By inhibiting the drug efflux pump activity of Candida auris and promoting ergosterol depletion, Antibiofilm agent-12 hinders biofilm formation and reduces the metabolic flexibility of Candida auris. Additionally, Antibiofilm agent-12 demonstrates antifungal activity in a Candida auris-infected C. elegans model .
(E,E)-Farnesol (trans,trans-Farnesol) is a quorum-sensing molecule of Candida species. (E,E)-Farnesol can inhibit the growth, metabolism and biofilm formation of various Candida species, and affect their morphology and invasiveness .
Butoconazole, an imidazole antifungal agent, is active against Candida spp. and effective against vaginal infections due to Candidaalbicans. Butoconazole is presumed to function as other imidazole derivatives via inhibition of steroid synthesis .
3MB-PP1, a bulky purine analog, is a Polo-like kinase 1 (Plk1) inhibitor. 3MB-PP1 blocks mitotic progression and cell division arise through target Plk1 in in cells expressing analog-sensitive Plk1 alleles. 3MB-PP1 specifically inhibits the activity of analog-sensitive Ssn3 (Cdk8). 3MB-PP1 inhibits Leu93 Mutant Zipper-interacting protein kinase (Leu93-ZIPK; IC50=2 μM). 3MB-PP1 can be used for the research of hypha formation of Candidaalbicans and cell division .
Antifungal agent 130 (Compound A7) is an orally active antifungal agent. Antifungal agent 130 has good antifungal activity against Candidaalbicans (MIC = 0.12 ng/mL) and Cryptococcus neoformans (MIC = 0.12 ng/mL) and has excellent antivirulence effect. Antifungal agent 130 exerts its antifungal effect by disrupting the iron homeostasis of fungal cells and inducing oxidative stress damage. Antifungal agent 130 can inhibit the formation of fungal virulence factors (such as biofilm, capsule, urease and melanin). Antifungal agent 130 has good antifungal effect and can be used in the study of drug-resistant fungal infections .
Halofantrine (SKF-102886 hydrochloride; WR-171669 hydrochloride) is a blocker that delays the delayed rectifier potassium current by inhibiting human ERG channels, and it is a potent antimalarial agent with oral activity. Halofantrine inhibits the Cap1-dependent oxidative stress response of Candidaalbicans, suppresses ROS responses, and enhances the antifungal (Fungal) activity of oxidative damage agents. Halofantrine exhibits antifungal activity in the Galleria mellonella model, and shows antimalarial activity against Plasmodium strains both in vitro and in animal models. Halofantrine can be used in studies related to invasive candidiasis, falciparum malaria, and vivax malaria .
Halofantrine hydrochloride (SKF-102886 hydrochloride; WR-171669 hydrochloride) is a blocker that delays the delayed rectifier potassium current by inhibiting human ERG channels, and it is a potent antimalarial agent with oral activity. Halofantrine hydrochloride inhibits the Cap1-dependent oxidative stress response of Candidaalbicans, suppresses ROS responses, and enhances the antifungal (Fungal) activity of oxidative damage agents. Halofantrine hydrochloride exhibits antifungal activity in the Galleria mellonella model, and shows antimalarial activity against Plasmodium strains both in vitro and in animal models. Halofantrine hydrochloride can be used in studies related to invasive candidiasis, falciparum malaria, and vivax malaria .
Hsp90-IN-47 (Compound C15) is a Hsp90 inhibitor and antifungal agent, with an IC50 of 0.014 μM against Hsp90α. When combined with Fluconazole (HY-B0101), Hsp90-IN-47 exerts significant synergistic antifungal effects against fluconazole-resistant Candidaalbicans 0304103. Hsp90-IN-47 exhibits antitumor activity against acute myeloid leukemia and non-small cell lung cancer .
Antifungal agent 25 is a potent broad-spectrum antifungal agent. Antifungal agent 25 shows antifungal effect against Candidaalbicans and fluconazole-resistant strain of Candidaalbicans. Antifungal agent 25 stable metabolic property in vivo .
Butoconazole nitrate (RS 35887), an imidazole antifungal agent, is active against Candida spp. and effective against vaginal infections due to Candidaalbicans. Butoconazole nitrate is presumed to function as other imidazole derivatives via inhibition of steroid synthesis .
Candidalysin is a cytolytic peptide toxin secreted by the fungus Candidaalbicans. Candidalysin drives epithelial immune responses by activating the EGFR-MAPK signaling pathway, inducing MMP expression and calcium influx, and regulating the c-Fos transcription factor and MKP1 via p38 MAPK and ERK1/2 respectively. Candidalysin is essential for mucosal and systemic infections, activating NLRP3 to promote inflammatory responses, neutrophil recruitment, and Th17 immunity. Candidalysin activates LDH causing membrane damage and exhibiting cytotoxicity
3MB-PP1 (Standard) is the analytical standard of 3MB-PP1 (HY-102069). This product is intended for research and analytical applications. 3MB-PP1, a bulky purine analog, is a Polo-like kinase 1 (Plk1) inhibitor. 3MB-PP1 blocks mitotic progression and cell division arise through target Plk1 in in cells expressing analog-sensitive Plk1 alleles. 3MB-PP1 specifically inhibits the activity of analog-sensitive Ssn3 (Cdk8). 3MB-PP1 inhibits Leu93 Mutant Zipper-interacting protein kinase (Leu93-ZIPK; IC50=2 μM). 3MB-PP1 can be used for the research of hypha formation of Candidaalbicans and cell division .
Puupehenone is a cytotoxic and antifungal agent present in various marine sponge species. Puupehenone exerts cytotoxic activity against leukemia, lung cancer, colon cancer and breast cancer cells, and inhibits the growth of Candidaalbicans. Puupehenone can be used in research related to cancers such as leukemia, lung cancer, colon cancer and breast cancer .
Glyceryl 1-monooctanoate is a glycerol monolaurate derivative. Glyceryl 1-monooctanoate is a broad-spectrum antimicrobial, suppresses the growth of pathogenic yeast (Candidaalbicans and Candida parapsilosis), as well as Gram-positive (Staphylococcus aureus) and Gram-negative (Escherichia coli, Klebsiella pneumoniae) bacteria .
(-)-γ-Cuparenol is a sesquiterpene compound with an IC50 of 23.6 μg/mL against porcine Na +/K +-ATPase. (-)-γ-Cuparenol reduces phytohemagglutinin (PHA)-induced activation of NF-AT and NF-κB in Jurkat cells. (-)-γ-Cuparenol inhibits the growth of Gram-positive bacteria and some Gram-negative bacteria. (-)-γ-Cuparenol exhibits weak inhibitory activity against Candidaalbicans. (-)-γ-Cuparenol is applicable for research related to immunoregulation, cardiovascular diseases and bacterial infections .
GW461484A is a small-molecule inhibitor targeting CandidaalbicansYck2, with an IC50 of 0.11 µM. It exhibits antifungal activity against C. albicans with a MIC80 of 12.5 µM. GW461484A holds potential for research on fungal diseases, such as drug-resistant Candida infections .
Arborcandin A is a 1,3-β-glucan synthase inhibitor that serves as an antifungal antibiotic. Arborcandin A exhibits IC50 values of 0.25 μg/mL and 0.05 μg/mL against Candidaalbicans and Aspergillus fumigatus, respectively. Additionally, Arborcandin A has an MIC of 4-8 μg/mL against the genus Candida .
Arborcandin F is a 1,3-β-glucan synthase inhibitor that serves as an antifungal antibiotic. Arborcandin F exhibits IC50 values of 0.012 μg/mL against both Candidaalbicans and Aspergillus fumigatus. Additionally, Arborcandin F has an MIC of 2-4 μg/mL against the genus Candida .
2-Deethoxy-2-hydroxyphantomolin, Germacranolide, is an Antifungal and Antibacterial agent. 2-Deethoxy-2-hydroxyphantomolin can be isolated from Elephantopus tomentosus Linn and E. mollis. 2-Deethoxy-2-hydroxyphantomolin is moderately active againstCandidaalbicans (14 mm clearing zone) and slightly active against Escherichia coli (12 mm), Pseudomonas aeruginosa (12 mm), Bacillus subtilis (14 mm), and Trichophyton mentagrophytes (13 mm) .
Flucytosine (5-Fluorocytosine) is an antifungal compound with oral activity. Flucytosine is a widely used cytotoxic drug that, after further metabolism, produces fluorinated ribonucleotides and deoxyribonucleotides, inhibits DNA and protein synthesis, and has multiple effects such as inhibiting candida and candida neoplasm infection and producies cytotoxicity to cancer cells .
Arborcandin D is a 1,3-β-glucan synthase inhibitor that serves as an antifungal antibiotic. Arborcandin D exhibits IC50 values of 3 μg/mL and 0.35 μg/mL against Candidaalbicans and Aspergillus fumigatus, respectively. Additionally, Arborcandin D has an MIC of 4 μg/mL against the genus Candida .
Dihydroaeruginoic acid ((Rac)-CGP 52547), an antifungal antibiotic, is a thiazoline iron chelator. Dihydroaeruginoic acid is the condensation product of salicylate and one cysteine residue. Dihydroaeruginoic acid chelates Fe(III), inhibits DNA replication via ribonucleotide reductase, induces G1/S cell cycle block, reduces leukemia cell clonogenic viability. Dihydroaeruginoic acid inhibits phytopathogenic fungi and bacteria, suppresses Candidaalbicans development, and inhibits Agrobacterium tumefaciens biofilm formation via extracellular iron sequestration. Dihydroaeruginoic acid can be used for the research of phytopathogenic fungal and bacterial infections, and leukemia .
Antifungal agent 34 (compound 6i) is a potent antifungal agent. Antifungal agent 34 shows a potent antifungal activity against Candidaalbicans, with a MIC of 4 µg/mL. Antifungal agent 34 shows significant inhibition on Candidaalbicans hyphae and biofilm development. Antifungal agent 34 exhibits no cytotoxicity to mammalian cells .
Arborcandin C is a 1,3-β-glucan synthase inhibitor that serves as an antifungal antibiotic. Arborcandin C exhibits IC50 values of 0.15 μg/mL and 0.015 μg/mL against Candidaalbicans and Aspergillus fumigatus, respectively. Additionally, Arborcandin C has an MIC of 1-2 μg/mL against the genus Candida .
Sphinganine-C17 (Heptadecasphinganine) is a synthetic bioactive sphingolipid and an isomer of sphinganine. Sphinganine-C17 inhibits the growth of Candida glabrata and Candidaalbicans with a minimum bactericidal concentration (MBC) of 0.5 μg/mL for both. Sphinganine-C17 can be used as an internal standard for the chromatographic analysis of sphingosine compounds .
Arborcandin B is a 1,3-β-glucan synthase inhibitor that serves as an antifungal antibiotic. Arborcandin B exhibits IC50 values of 0.30 μg/mL and 0.025 μg/mL against Candidaalbicans and Aspergillus fumigatus, respectively. Additionally, Arborcandin B has an MIC of 2-4 μg/mL against the genus Candida .
PA36-2 is an Mdr1 inhibitor and azole resistance reversal agent, with a IC50 of 1.0 μg/mL and a Kd of 4.209 μM against Candidaalbicans Mdr1. By effectively inhibiting the activity of the Mdr1 efflux pump, PA36-2 prevents the pumping of substrates out of cells, enhances the intracellular accumulation of azole antibiotics, and exerts a synergistic effect with antifungal agents such as Fluconazole (FLC) (HY-B0101). PA36-2 can be used in the research of azole-resistant candidiasis .
Butoconazole (nitrate) (Standard) is the analytical standard of Butoconazole (nitrate). This product is intended for research and analytical applications. Butoconazole nitrate (RS 35887), an imidazole antifungal agent, is active against Candida spp. and effective against vaginal infections due to Candidaalbicans. Butoconazole nitrate is presumed to function as other imidazole derivatives via inhibition of steroid synthesis .
Fluconazole-d4 is the deuterium labeled Fluconazole. Fluconazole (UK-49858) is a triazole antifungal agent with excellent activities against a broad range of fungi, especially against Candidaalbicans. Fluconazole inhibits C. albicans and Candida kefyr with IC99s range from 0.20 μg/mL to 0.39 μg/mL .
Arborcandin E is a 1,3-β-glucan synthase inhibitor that serves as an antifungal antibiotic. Arborcandin E exhibits IC50 values of 0.1 μg/mL and 0.012 μg/mL against Candidaalbicans and Aspergillus fumigatus, respectively. Additionally, Arborcandin E has an MIC of 0.5-2 μg/mL against the genus Candida .
Filastatin is a long-lasting inhibitor of Candidaalbicans filamentation. Filastatin inhibits adhesion by multiple pathogenic Candida species with an IC50 of ~3 μM in the GFP-based adhesion assay. Filastatin inhibits fungal adhesion to polystyrene and human cells, the yeast-to-hyphal morphological transition, induction of the hyphal-specific HWP1 promoter. Filastatin has potent antifungal effect .
Nikkomycin Z is a nucleoside peptide and an orally active antifungal agent. Nikkomycin Z inhibits chitin synthesis by acting as a competitive analogue of the chitin synthase substrate UDP-N-acetylglucosamine. Nikkomycin Z has antifungal activity .
(E,E)-Farnesol (Standard) (trans,trans-Farnesol (Standard)) is the analytical standard of (E,E)-Farnesol (HY-Y0248). This product is intended for research and analytical applications. (E,E)-Farnesol (trans,trans-Farnesol) is a quorum-sensing molecule of Candida species. (E,E)-Farnesol can inhibit the growth, metabolism and biofilm formation of various Candida species, and affect their morphology and invasiveness .
Flucytosine (Standard) is the analytical standard of Flucytosine. This product is intended for research and analytical applications. Flucytosine (5-Fluorocytosine) is an antifungal compound with oral activity. Flucytosine is a widely used cytotoxic drug that, after further metabolism, produces fluorinated ribonucleotides and deoxyribonucleotides, inhibits DNA and protein synthesis, and has multiple effects such as inhibiting candida and candida neoplasm infection and producies cytotoxicity to cancer cells .
(E,E)-Farnesol-d6 (trans,trans-Farnesol-d6) is deuterium labeled (E,E)-Farnesol (HY-Y0248). (E,E)-Farnesol (trans,trans-Farnesol) is a quorum-sensing molecule of Candida species. (E,E)-Farnesol can inhibit the growth, metabolism and biofilm formation of various Candida species, and affect their morphology and invasiveness .
Isoconazole is an antifungal agent against Candidaalbicans. Isoconazole is a broad-spectrum antimicrobial azole that can be studied in research on dermatomycoses .
Tetramethylkaempferol is an antifungal agent. Tetramethylkaempferol shows antifungal activity against Candida albicansCandida albicans with an IC50 value of 17.63 µg/mL .
Crotocin has the fungal activity of anti-cryptococcus neoforme, candidaalbicans, Tinea trichoderma of brewer's yeast, and can be inactivated by blood .
Dactylfungin B (MK 2266 B) is an antifungal antibiotic that is active against Candida pseudotropicalis and other fungi, with an MIC value at <10 μg/mL .
1-Monomyristin acts as an insecticide, enzyme inhibitor, antibacterial and antifungal agent, with an IC50 of 18 μM against rat FAAH and an IC50 of 32 μM against rat MAGL. 1-Monomyristin inhibits 2-oleoylglycerol hydrolysis via MAGL. 1-Monomyristin suppresses the growth of Staphylococcus aureus, Aggregatibacter actinomycetemcomitans and Candidaalbicans. 1-Monomyristin is lethal to brine shrimp . 1-Monomyristin exhibits marginal cytotoxicity against prostate cancer cells. 1-Monomyristin is applicable to research related to bacterial infections, fungal infections, renal cancer, prostate adenocarcinoma and pancreatic cancer .
Glyceryl 1-monooctanoate-d15 is the deuterium labeled Glyceryl 1-monooctanoate (HY-W012444). Glyceryl 1-monooctanoate is a glycerol monolaurate derivative. Glyceryl 1-monooctanoate is a broad-spectrum antimicrobial, suppresses the growth of pathogenic yeast (Candidaalbicans and Candida parapsilosis), as well as Gram-positive (Staphylococcus aureus) and Gram-negative (Escherichia coli, Klebsiella pneumoniae) bacteria .
Glyceryl 1-monooctanoate-d5 is the deuterium labeled Glyceryl 1-monooctanoate (HY-W012444). Glyceryl 1-monooctanoate is a glycerol monolaurate derivative. Glyceryl 1-monooctanoate is a broad-spectrum antimicrobial, suppresses the growth of pathogenic yeast (Candidaalbicans and Candida parapsilosis), as well as Gram-positive (Staphylococcus aureus) and Gram-negative (Escherichia coli, Klebsiella pneumoniae) bacteria .
Azure A eosinate is a dye for hematological and histological applications. Azure A eosinate can be used as new photosensitizer prototypes to determine growth inhibition of Candidaalbicans .
Ochracenomicin A has a strong effect against Gram-positive bacteria (including MRSA strain), and also against Gram-negative bacteria and candidaalbicans .
Goniothalamin (GTN) is a styryl lactone. Goniothalamin exhibits insecticidal, anti-tumor and antibacterial activities. Goniothalamin induces cell cycle arrest and apoptosis in tumor cells. Goniothalamin acts as a larvicide against Culex quinquefasciatus larvae and as a cytotoxin against brine shrimp larvae. Goniothalamin functions as an antibacterial agent against Gram-positive and Gram-negative bacteria, and also acts as an antifungal agent against pathogens including Candidaalbicans, Trichophyton rubrum and Trichophyton mentagrophytes. Goniothalamin is applicable to research related to breast cancer, lymphatic filariasis, bacterial infections and fungal infections .
Roseoside is an inhibitor of DNA gyrase and HAV 3C protease, and also inhibits HCV NS5A/B replicase in human systems with an IC50 of 20 μM. Roseoside binds to the active site of enzymes and stabilizes the interaction by forming hydrogen bonds with key amino acid residues. Roseoside inhibits the growth of Gram-positive bacteria, Gram-negative bacteria, and Candidaalbicans, and interferes with HCV RNA replicationin vitro by inhibiting HCV NS5A/B replicase (IC50=20 μM). Roseoside shows no cytotoxicity and serves as a research tool for studies related to bacterial infections, candidiasis, HAV and HCV .
Flucytosine- 15N2 (5-Fluorocytosine- 15N2) hydrochloride is the 15N-labeled Flucytosine hydrochloride (HY-B0139). Flucytosine (5-Fluorocytosine) is an antifungal compound with oral activity. Flucytosine is a widely used cytotoxic drug that, after further metabolism, produces fluorinated ribonucleotides and deoxyribonucleotides, inhibits DNA and protein synthesis, and has multiple effects such as inhibiting candida and candida neoplasm infection and producies cytotoxicity to cancer cells.
SP-B peptide is an antimicrobial peptide. SP-B peptide has antifungal activity against strains of Cryptococcus neoformans, Candidaalbicans and Aspergillus fumigatus
Bagremycin A is found in the strain of Streptomyce sp. Tu 4128. Bagremycin A has weak activity against Gram-positive bacteria, Saccharomyces cerevisiae and Candidaalbicans .
Antifungal agent 2 is a broad-spectrum fungal inhibitor which inhibits growth of pertinent species of Candida, Cryptococcus, and Aspergillus at a concentration as low as 0.5 μg/mL.
RO-09-4609 exhibits antimicrobial activity, that inhibits Candidaalbicans, Trypanosoma brucei and Plasmodium vivax through inhibition of N-myristoyl transferase .
Glucoallosamidin A is a glycoside antibiotic that can inhibit Chitinase activity. Glucoallosamidin A can inhibit Candidaalbicans ATCC 10231 chitinase with an IC50 of 3.4 μg/mL .
BE-31405 is an antifungal antibiotic. BE-31405 can be isolated from the culture broth of the fungal strains such as Penicillium minioluteum F31405, Talaromyces siamensis FKA-61, and Phomopsis sp. FKA-62. BE-31405 exhibits potent growth inhibitory activity against pathogenic fungal strains including Candidaalbicans, Candida glabrata, and Cryptococcus neoformans. BE-31405 shows no cytotoxicity against mammalian cells .
Myxinidin is an antimicrobial peptide. Myxinidin exhibits the ability to inhibit and eradicate biofilms formed by Pseudomonas aeruginosa and various Candida species. Myxinidin can be used for the study of infection .
2-Hydroxyhexacosanoic acid is a hydroxylated fatty acid. 2-Hydroxyhexacosanoic acid can be obtained from C26 acids by the 2-hydroxylase of Candida utilis .
Methylxanthoxylin is a ketone that can be isolated from the leaves and bark of Acradenia Jianklinii . Methylxanthoxylin exhibited moderate antifungal activity against Candidaalbicans and Penicillium expansum .
Epelmycin A has anti-Gram positive, negative bacteria and candidaalbicans activity, and has anti-leukemic L1210 activity, which is stronger than Aclacinomycin .
Deacylketoconazole (N-Deacetylketoconazole; R-39519) is an orally active metabolite of Ketoconazole (HY-B0105). Deacylketoconazole exhibits antifungal and antibacterial activity. Deacylketoconazole is cytotoxic in rats hepatocyte .
Epelmycin C has anti-Gram positive, negative bacteria and candidaalbicans activity, and has anti-leukemic L1210 activity, which is stronger than Aclacinomycin .
Epelmycin D has anti-Gram positive, negative bacteria and candidaalbicans activity, and has anti-leukemic L1210 activity, which is stronger than Aclacinomycin .
13-Hydroxydocosanoate 13-β-glucosyltransferase (EC 2.4.1.158) can act as acceptor, leading to the formation by Candida bogoriensis of the extracellular glycolipid, hydroxydocosanoate sophoroside diacetate.
Geraniol (Standard) is the analytical standard of Geraniol. This product is intended for research and analytical applications. Geraniol, an olefinic terpene, was found to inhibit growth of Candidaalbicans and Saccharomyces cerevisiae strains .
Chondramide A has anti-candida, Henson yeast, lipids yeast, ball-like yeast and other fungal activities, but has no anti-Gram positive and negative bacteria activities .
Bagremycin B is found in the strain of Streptomyce sp. Tu 4128. Bagremycin B has weak activity against Gram-positive bacteria, Saccharomyces cerevisiae and Candidaalbicans .
Teflubenzuron (Standard) is the analytical standard of Teflubenzuron. This product is intended for research and analytical applications. Teflubenzuron is a chitin synthesis inhibitor used as a biocide. Teflubenzuron is toxic for F. candida .
Naftifine hydrochloride is an antibiotic. Naftifine hydrochloride has antifungal activity against dermatophytes, aspergilli, Sporothrix schenckii, and yeasts of the genus Candida. Naftifine hydrochloride can be used for the research of superficial dermatomycoses inhibition .
Epelmycin E has anti-Gram positive, negative bacteria and candidaalbicans activity, and has anti-leukemic L1210 activity, which is stronger than Aclacinomycin .
SS-750 is an orally active Triazole derivative and antifungal agent. SS-750 binds to fungal cytochrome P450. SS-750 shows antifungal activities against Candida species and C. neoformans strains tested. SS750 shows MIC90 values of 0.25, 1, and 2 μg/mL against Candida parapsilosis, C. krusei, and C. glabrata, respectively. SS-750 improves systemic and pulmonary candidiasis caused by C. albicans .
Rezafungin (Biafungin) is a next-generation, broad-spectrum, and long-lasting echinocandin. Rezafungin shows potent antifungal activity against Candida spp., Aspergillus spp., and Pneumocystis spp. .
Chondramide D has anti-candida, Henson yeast, lipids yeast, ball-like yeast and other fungal activities, but has no anti-Gram positive and negative bacteria activities .
Chondramide C has anti-candida, Henson yeast, lipids yeast, ball-like yeast and other fungal activities, but has no anti-Gram positive and negative bacteria activities .
Farnesol (Standard) is the analytical standard of Farnesol. This product is intended for research and analytical applications. Farnesol is a sesquiterpene alcohol that modulates cell-to-cell communication in Candidaalbicans, and has the activity in inhibiting bacteria.
Chondramide B has anti-candida, Henson yeast, lipids yeast, ball-like yeast and other fungal activities, but has no anti-Gram positive and negative bacteria activities .
27-O-Demethylrapamycin, a Rapamycin (HY-10219) derivative, is an antifungal agent. 27-O-Demethylrapamycin inhibits Candidaalbicans, Saccharomyces cerevisiae, and Fusarium oxysporum .
Bisdionin F is a compound with the ability to restore the antibacterial function of macrophages, which can block the arginase activity induced by Candidaalbicans and restore the nitric oxide production and antibacterial function of macrophages.
Casuarinin is an orally active antiproliferative, anti-inflammatory, antifungal, virucidal and gastroprotective agent. Casuarinin upregulates the expression of p21/WAF1, Fas/APO‑1, mFasL, sFasL and HSP‑70, arrests cell cycle, induces apoptosis and inhibits cancer cell proliferation. Casuarinin inhibits TNF‑α-induced phosphorylation of MAPK and activation of NF‑κB, downregulates the expression of iNOS, NF‑κB, COX‑2 and ICAM‑1, and reduces the production of proinflammatory mediators. Casuarinin attenuates ethanol-induced activation of caspase‑3 and elevation of TNF‑α, inhibits the growth of Candidaalbicans, and inhibits HSV‑2. Casuarinin can be used in research related to mammary adenocarcinoma, inflammatory skin diseases, gastric ulcers, candidiasis and herpes simplex virus infections .
Peptaibolin has anti-Gram-positive bacteria and yeast activity, but the antibacterial activity is weak. Peptaibolin inhibits Subtilis ATCC 6633 and candidaalbicans with MICs (μg/mL) of 100, 100, respectively .
Icofungipen is an orally active antifungal agent. Icofungipen is the representative of beta amino acids, is toxic against Candida species. Icofungipen protects infected mice survival from C. albicans infection .
Clavamycin A has strong anti-candida activity, and its action can be antagonized by dipeptide or tripeptide, but amino acid can not cancel its action. No antibacterial activity and no inhibition of β-lactamase .
Fluconazole-13C2,15N (UK-49858-13C2,15N) is the 13C and 15N labeled isotope of Fluconazole (HY-B0101). Fluconazole (UK-49858) is a triazole antifungal agent with excellent activities against a broad range of fungi, especially against Candidaalbicans. Fluconazole inhibits C. albicans and Candida kefyr with IC99s range from 0.20 μg/mL to 0.39 μg/mL .
Clavamycin D has strong anti-candida activity, and its action can be antagonized by dipeptide or tripeptide, but amino acid can not cancel its action. No antibacterial activity and no inhibition of β-lactamase .
Clavamycin C has strong anti-candida activity, and its action can be antagonized by dipeptide or tripeptide, but amino acid can not cancel its action. No antibacterial activity and no inhibition of β-lactamase .
Chloramultilide B is a lindenane dimer that can be isolated from Chloranthus serratus. Chloramultilide B has inhibitory activities against Candidaalbicans and C.parapsilosis with a MIC value of 0.068 μM .
Clavamycin B has strong anti-candida activity, and its action can be antagonized by dipeptide or tripeptide, but amino acid can not cancel its action. No antibacterial activity and no inhibition of β-lactamase .
Antifungal agent 69 (compound 13) is a eugenol-imidazole against Candidaalbicans (MIC: 4.6 μM) with no relevant cytotoxicity. Antifungal agent 69 alters the fungal ergosterol biosynthesis and shows antifungal activity .
Sargentodoside D is a phenolic glycoside. Sargentodoside D occurs in the stems of Sargentodoxa cuneata. Sargentodoside D is applicable to research on infections caused by Acinetobacter baumannii, Candidaalbicans and Staphylococcus aureus, as well as research on cervical cancer .
Antifungal agent 27 (compound 7) is a antifungal agent. Antifungal agent 27 shows moderate antibacterial and weak antifungal activities against MRSA and C. albicans SS5314, with MIC values of 8 and 32 μg/mL, respectively .
Cyclo(Pro-dArg) is an inhibitor of chitinase. Cyclo(Pro-dArg) inhibits the cell separation of Saccharomyces cerevisiae but does not affect its growth. Cyclo(Pro-dArg) inhibits the transition of Candidaalbicans from yeast to filamentous morphology.
Bombinin H-BO1 is an antimicrobial peptide derived from toad Bombina orientalis skin secretions. Bombinin H-BO1 is active against Candidaalbicans, and the MIC value is 256 mg/L .
Purpuride is a sesquiterpene ester found in aciduric fungi. Purpuride shows moderate antibacterial activities against Candidaalbicans, Enterobacter aerogenes and Pseudomonas aeruginosa with MIC values ranging from 1.2 to 3.3 μM .
Antifungal agent 53 (A03) is a potent inhibitor of Candidaalbicans CYP51 with antifungal activity. Antifungal agent 53 prevents the formation of fungi biofilms. Antifungal agent 53 also exhibits good safety .
Omiganan is a cationic antimicrobial peptide. Omiganan as an analogue of indolicidin shows activity against gram-positive and gram-negative bacteria but also Candida spp. isolates. Omiganan can be used for the research of alcohol nose and acne .
Group II intron-IN-1 (Compound 1) is an inhibitor of fungal Group II introns, with an IC50 of 3 μM. Group II intron-IN-1 can be used for research on infections caused by fungi such as Candida .
Endo-1,3-β-glucanase (Lyticase) is an endoenzyme that can specifically cleave β-1,3-glycosidic bonds. Endo-1,3-β-glucanase recognizes and binds to β-1,3-glucan chains, catalyzing the cleavage of glycosidic bonds and hydrolyzing polysaccharides into oligosaccharides. Endo-1,3-β-glucanase eliminates vaginal Candida. Endo-1,3-β-glucanase can be used in the study of recurrent Candida vaginitis .
Antitubercular agent-23 (Compound 3a) is a potent anticandidiasis and antitubercular agent with MIC values of 1.1 µg/ml and 1 µg/ml against Candidaalbicans MTCC 3017 and M. tuberculosis (H37Rv), respectively .
Naftifine-d3 is the deuterium labeled Naftifine. Naftifine hydrochloride is an antibiotic. Naftifine hydrochloride has antifungal activity against dermatophytes, aspergilli, Sporothrix schenckii, and yeasts of the genus Candida. Naftifine hydrochloride can be used for the research of superficial dermatomycoses inhibition .
Ys-II (Compound 1) is a spirostanol glycoside that can be isolated from the stem of Yucca elephantipe. Ys-II has antifungal activity against the growth of Candidaalbicans and Cryptococcus neoformans (IC50: 5 and 6 μg/mL respectively) .
Naftifine-d3 (hydrochloride) is the deuterium labeled Naftifine hydrochloride. Naftifine hydrochloride is an antibiotic. Naftifine hydrochloride has antifungal activity against dermatophytes, aspergilli, Sporothrix schenckii, and yeasts of the genus Candida. Naftifine hydrochloride can be used for the research of superficial dermatomycoses inhibition .
Antitubercular agent-22 (Compound 2) is a potent anticandidiasis and antitubercular agent with MIC values of 2.34 µg/ml and 2 µg/ml against Candidaalbicans MTCC 3017 and M. tuberculosis (H37Rv), respectively .
Cyclopent-4-ene-1,3-dione is a potent antifungal inhibitor of chitin synthesis. Cyclopent-4-ene-1,3-dione is potently antifungal against human pathogenic Candida species (IC50 = 1-2 μM). Cyclopent-4-ene-1,3-dione is detected in feijoa cultivars with high antifungal bioactivity. Cyclopent-4-ene-1,3-dione can be used for the research of fungal infections .
Antifungal agent 59 is an antifungal agent, with MIC values of 0.01-1 μg/mL. Antifungal agent 59 prevents the formation of fungi biofilms, but also has safety .
Micafungin metabolite M1 is an active metabolite of Micafungin (HY-17579), which is metabolized by arylsulfatase and exhibits antifungal activity. Micafungin metabolite M1 can be used for research on deep fungal infections caused by Candida and Aspergillus species .
Mutanocyclin is a potent antifungal agent. Mutanocyclin inhibits Candidaalbicans (C. albicans) filamentation. Mutanocyclin decreases the mRNA expression of HWP1, ECE1, FLO8, TEC1. Mutanocyclin inhibits yeast-form in ex vivo mouse .
Epicorazine A has activity against Gram-positive bacteria, including methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin resistant enterococcus (VRE), MICs of 12.5-25 μg/mL. Epicorazine A also has effect on Candidaalbicans with a MIC of 25 μg/mL .
Naftifine (hydrochloride) (Standard) is the analytical standard of Naftifine (hydrochloride). This product is intended for research and analytical applications. Naftifine hydrochloride is an antibiotic. Naftifine hydrochloride has antifungal activity against dermatophytes, aspergilli, Sporothrix schenckii, and yeasts of the genus Candida. Naftifine hydrochloride can be used for the research of superficial dermatomycoses inhibition .
Pneumocandin A1 is a lipopeptide antibiotic. Pneumocandin A1 has a strong anti-Candida effect. Pneumocandin A1 has the effect of inhibiting the synthesis of 1,3 early-glucan in vitro, with an IC50 of 0.07-0.5 μg/mL .
Pneumocandin A3 is a lipopeptide antibiotic. Pneumocandin A3 has a strong anti-Candida effect. Pneumocandin A3 has the effect of inhibiting the synthesis of 1,3 early-glucan in vitro, with an IC50 of 0.07-0.5 μg/mL .
Pyrazine-2-amidoxime is a structural analogue of pyrazine-2-carboxamide with antimicrobial activity. Pyrazine-2-amidoxime shows killing and inhibiting properties against Candidaalbicans, fungal pathogen and Gram-positive bacteria .
Pneumocandin A4 is a lipopeptide antibiotic. Pneumocandin A4 has a strong anti-Candida effect. Pneumocandin A4 has the effect of inhibiting the synthesis of 1,3 early-glucan in vitro, with an IC50 of 0.07-0.5 μg/mL .
Pneumocandin B2 is a lipopeptide antibiotic. Pneumocandin B2 has a strong anti-Candida effect. Pneumocandin B2 has the effect of inhibiting the synthesis of 1,3 early-glucan in vitro, with an IC50 of 0.07-0.5 μg/mL .
Pneumocandin A2 is a lipopeptide antibiotic. Pneumocandin A2 has a strong anti-Candida effect. Pneumocandin A2 has the effect of inhibiting the synthesis of 1,3 early-glucan in vitro, with an IC50 of 0.07-0.5 μg/mL .
Zingibroside R1 is an orally active triterpene saponin with multiple biological activities including antioxidant, anti-inflammatory, antiviral, and metabolic regulatory properties. Zingibroside R1 reduces the expression of PIN family members, inhibits the expression of PLT1/PLT2, WOX5, SHR, and SCR, disrupts auxin transport and distribution, triggers plant ROS responses, and inhibits root growth. Zingibroside R1 extends the lifespan of Caenorhabditis elegans, enhances its heat stress resistance, and improves its motor ability. Hydrogel derivatives of Zingibroside R1 inhibit the proliferation of Candidaalbicans by binding to its β-1,3-glucan and exhibit antifungal activity. Zingibroside R1 inhibits GLUT1-mediated uptake and alleviates liver injury. Zingibroside R1 can be used in research related to neurodegenerative diseases, vulvovaginal candidiasis, acute liver injury, Ehrlich ascites tumor and HIV-1 infection .
Myristamidopropyl dimethylamine (MAPD) is an antimicrobial agent (including against bacteria and fungi) and an insecticide, exhibiting inhibitory activity against Pseudomonas aeruginosa, Staphylococcus aureus, Candidaalbicans, Fusarium solani, and Acanthamoeba polyphaga. Myristamidopropyl dimethylamine can be used in research on microbial-induced keratitis .
Naftoxate is an ester compound containing aminomethylsulfate, and its ammonium salt analog can inhibit free thiols to chemically weaken the reactive oxygen species (ROS)-sensitive anaerobic bacterium Trichomonas vaginalis and inhibit common pathogens causing vaginal infections: Candidaalbicans and Staphylococcus aureus .
Lateritin is a potent inhibitor of acyl-CoA:cholesterol acyltransferase (ACAT), isolated from the mycelial cake of Gibberella lateritium IFO 7188 . Lateritin also inhibits the growth of a mini-panel of human cancer cell lines, gram-positive bacteria, and Candidaalbicans .
Sordarin sodium is an eEF2 inhibitor and antibiotic. Sordarin sodium's function is dependent on the diphthamide modification on eEF2. Sordarin sodium inhibits protein synthesis by preventing the binding of eEF2 to the ribosome complex. Sordarin sodium has antifungal activity .
Bullatenone is a volatile bioactive compound that can be found in Lophomyrtus bullata. It has insect - repellent, anti - ulcer, anti - UV, and antifungal activities. Bullatenone can inhibit the growth of fungi such as Candidaalbicans and Cladosporium resinae. Bullatenone can be used in the research of diseases such as inflammation and infections .
Epicorazine B has activity against Gram-positive bacteria, including methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin resistant enterococcus (VRE), MICs of 12.5-25 μg/mL. Epicorazine B also has effect on Candidaalbicans with a MIC of 25 μg/mL .
Naftifine- 13C,d3 is the 13C- and deuterium labeled Naftifine. Naftifine hydrochloride is an antibiotic. Naftifine hydrochloride has antifungal activity against dermatophytes, aspergilli, Sporothrix schenckii, and yeasts of the genus Candida. Naftifine hydrochloride can be used for the research of superficial dermatomycoses inhibition .
Fenchyl alcohol is a monoterpene alcohol that can be used as a fragrance. Fenchyl alcohol has antifungal activity and can inhibit the formation of biofilms and hyphae of Candidaalbicans. Fenchyl alcohol also has a strong inhibitory effect on the rumen microbial activity of sheep and deer .
Fenchyl alcohol is a monoterpene alcohol that can be used as a fragrance. Fenchyl alcohol has antifungal activity and can inhibit the formation of biofilms and hyphae of Candidaalbicans. Fenchyl alcohol also has a strong inhibitory effect on the rumen microbial activity of sheep and deer .
Linearmycin B is an antibacterial and antifungal agent. Linearmycin B shows activity against Bacillus subtilis (Bs), Staphylococcus aureus (Sa). Candidaalbicans (Ca), and Saccharomyces cerevisiae (Sc), with MIC values of 0.097, 1.5, 0.0008, and 0.0002 μg/mL, respectively .
9-Hydroxyoudemansin A is an antibiotic. 9-Hydroxyoudemansin A has antifungal activity, has an MIC of 12.5 μg/mL against ochre-like yeast, and is resistant to fungi such as Candidaalbicans, Crimson Yeast, Penicillium and Streptomyces with MICs are all> 50 μg/mL. No anti-bacterial effect .
Heptaibin is a peptaibol antifungal antibiotic. Heptaibin has the activity against Gram-positive bacteria (MIC is 8 μg/mL) such as Staphylococcus aureus and fungi (MIC is 13-32 μg/mL) such as Aspergillus, Candidaalbicans and cryptococcus neofordii, and it has moderate anti-Rhabditella pseudoelongata activity (MIC is 50 μg/mL) .
CYP51-IN-29 (Compound B3) is a CYP51 inhibitor and antifungal agent. CYP51-IN-29 effectively suppresses the yeast-to-hyphal transition. CYP51-IN-29 exhibits potent antifungal activity against Candidaalbicans .
Almurtide (nor-MDP), a muramyl dipeptide derivative with anti-inflammatory and anti-tumor activity. Almurtide also shows protective effects against intraperitoneal Pseudomonas aeruginosa infection or intravenously Candidaalbicans infection in mice. Almurtide also inhibits the carcinogenic Friend leukemia virus .
Isofusidienol A (Compound 26) is a chromone compound. Isofusidienol A can be isolated from Artemisia vulgaris. Isofusidienol A has significant antibacterial activity against Bacillus subtilis. Isofusidienol A also has potent antifungal activity against Candidaalbicans. Isofusidienol A can be used for bacterial and fungal infections research .
FBA-IN-1 (compound 2a11) is a first-in-class, covalent and allosteric inhibitor of fructose-1,6-bisphosphate aldolase from Candidaalbicans (CaFBA). FBA-IN-1 inhibits the growth of Azole-resistant strains 103 with the MIC80 of 1 μg/mL .
Naphthalene-2,3-dicarboxaldehyde (Standard) is the analytical standard for Naphthalene-2,3-dicarboxaldehyde (HY-W016288). This product is for research and analytical applications. Naphthalene-2,3-dicarboxaldehyde (NDA) is an effective inhibitor of Candidaalbicansaspartate semialdehyde dehydrogenase (ASADH), with a Ki value of 45 μM. Naphthalene-2,3-dicarboxaldehyde targets ASADH in the aspartate biosynthetic pathway of Candidaalbicans. Naphthalene-2,3-dicarboxaldehyde reacts with primary amines to generate highly fluorescent and stable derivatives. Naphthalene-2,3-dicarboxaldehyde serves as a fungistatic agent and a fluorogenic derivatization reagent. Naphthalene-2,3-Dicarboxaldehyde can be used for the research of candidiasis .
Leucinostatin A (Antibiotic P168) is a nonapeptide exerting a remarkable activity especially against Candidaalbicans and Cryptococcus neoformans. Leucinostatin A is a hydrophobic nonapeptide antibiotic. Leucinostatin A inhibits prostate cancer growth through reduction of insulin-like growth factor-I expression in prostate stromal cells. Antiprotozoal activies .
Poacic Acid is a plant-derived stilbenoid with an antifungal activity. Poacic Acid localizes to the yeast cell wall and disrupts the production and assembly of β-1,3-glucan in the fungal cell walls. Poacic Acid exhibits fungicidal activity to Saccharomyces cerevisiae and plasma membrane-compromised Candida albicans mutants .
DHFR-IN-25 (Compound N2) is a type of inhibitor of dihydrofolate reductase (DHFR). DHFR-IN-25 is a broad-spectrum and highly effective antibacterial agent, particularly showing significant effects on Candidaalbicans and Staphylococcus aureus. DHFR-IN-25 can be used for the study of local anti-infection .
(Rac)-CPI-098 shows antibacterial activity. (Rac)-CPI-098 exhibits superior anti-fungal activity against Monascus ruber, better activity against Aspergillus fumigates, good activity against Aspergillus niger and Aspergillus parasites and moderate activity against Candidaalbicans .
Oteseconazole (VT-1161) is a potent and orally active anti-fungal agent. Oteseconazole potently binds to and inhibits Candidaalbicans cytochrome P45051 (CYP51) activity (Kd ≤39 nM), shows no obvious effect on human CYP51. Oteseconazole also can be used for the research of dermatophytes .
Apoptosis inducer 33 (Compound H2) is a hydrazone derivative. Apoptosis inducer 33 has antioxidant and antibacterial activity that inhibits the growth of Staphylococcus aureus, Escherichia coli and Candidaalbicans. Apoptosis inducer 33 inhibits tumor cells proliferation and induces apoptosis, which can be used in the study of cancer .
Antibiotic AB023b is part of macrocyclic pentaene antibiotic complex, forming the main components with Antibiotic AB023a (HY-137084). Antibiotic AB023b exhibits antifungal activity against Candidaalbicans, and plant pathogenic fungi, Botrytis cinerea, Fusarium moniliforme and Pythium ultimum .
Terbinafine-d3 hydrochloride is the deuterium labeled Terbinafine hydrochloride. Terbinafine hydrochloride (TDT 067 hydrochloride) is an antifungal medication used to treat fungal infections. It is a potent non-competitive inhibitor of squalene epoxidase from Candida with a Ki of 30 nM . Terbinafine hydrochloride also antibacterial activity against certain Gram-positive and Gram-negative bacteria .
Terbinafine-d7 is the deuterium labeled Terbinafine. Terbinafine (TDT 067) is an antifungal medication used to treat fungal infections. It is a potent non-competitive inhibitor of squalene epoxidase from Candida with a Ki of 30 nM . Terbinafine also antibacterial activity against certain Gram-positive and Gram-negative bacteria .
Antibiotic AB023a is part of macrocyclic pentaene antibiotic complex, forming the main components with Antibiotic AB023b (HY-137085). Antibiotic AB023a exhibits antifungal activity against Candidaalbicans, and plant pathogenic fungi, Botrytis cinerea (MIC= 5 μg/mL), Fusarium moniliforme and Pythium ultimum .
Antifungal agent 123 (Compound 4b) exhibits good affinity to the oxidoreductase of Staphylococcus aureus or the membrane protein of Candidaalbicans, exhibits antibacterial and antifungal activities. Antifungal agent 123 scavenges free radical, exhibits antioxidant efficacy. Antifungal agent 123 inhibits the TLR signaling pathway, and exhibits anti-inflammatory efficacy .
Glidobactin C (GlbC) is an anti-tumor antibiotic. Glidobactin C (GlbC) has the activity against pathogenic fungi and yeast. Glidobactin C has anti-Candidaalbicans and Aspergillus fumigatus activity with a MIC of 0.8 μg/mL. Glidobactin C also extends the survival of mice inoculated with leukemia P388 cells .
Efinaconazole (KP-103) is a triazole antifungal agent and againsts T. mentagrophytes SM-110 and C. albicans ATCC 10231 with MICs of 0.0039 μg/mL and 0.00098 μg/mL, respectively . Efinaconazole has a potent in vitro activity against fungal pathogens including dermatophytes, Candida and Malassezia species .
Sporminarin A (Compound 1), a polyketide, is a microbial secondary metabolite. Sporminarin A can be isolated from the Sporormiella minimoides. Sporminarin A has significant antifungal activity against Aspergillus flavus with an MIC50 of 25 μg/mL. Sporminarin A also has antibacterial activity against Staphylococcus aureus (ATCC 29213) and Candidaalbicans (ATCC 14053) .
Nidulin (Methylustin) is a depsidone isolated from a marine fungus Aspergillus unguis. Nidulin shows antifungal and antibacterial against pathogenetic strains, Pseudomonas aeruginosa, Methicillin-resistant Staphylococcus aureus and Candidaalbicans with inhibition zones of 9.5 mm, 9.0 mm and 9.0 mm, respectively. Nidulin exhibits potent larvicidality against brine shrimp .
AB-22, a vinyl sulfate compound, is an orally active antifungal agent. AB-22 inhibits hyphal growth and biofilm initiation by inhibiting the gene expression of ALS3, HWP1, and ECE1 in Candidaalbicans SC5314 cells. AB-22 can be used for the research of infrction, such as systemic candidiasis .
Antifungal agent 75 (compound 6r) is a potent antifungal agent against Candidaalbicans. Antifungal agent 75 significantly inhibits the formation of C. albicans biofilm, increases the permeability of the cell membrane, reduces the ergosterol level of the cell membrane, damages the membrane structure, and destroys the integrity of the cell structure to exert excellent antifungal activity .
Tebuconazole-d9 is the deuterium labeled Tebuconazole. Tebuconazole is an agricultural azole fungicide which can also inhibit CYP51 with IC50s of 0.9 and 1.3 μM for Candidaalbicans CYP51 (CaCYP51) and truncated Homo sapiens CYP51 (Δ60HsCYP51), respectively.
Tylophorinicine is an anti-leukemic and anti-fungal agent. Tylophorinicine exhibits minimum inhibitory concentrations (MIC) in the range of 2-4 mg/mL for TdnH and 0.6-2.5 mg/mL for TnnH against Candida species. Tylophorinicine is a phenanthroindolizidine alkaloid from tylophora asthamatica and pergulatia pallid. Tylophorinicine inhibits thymidylate synthase by pergularinine .
Suloctidil hydrochloride is an orally active calcium channel blocker and antifungal agent. Suloctidil hydrochloride antagonizes vasoconstriction induced by norepinephrine, angiotensin and serotonin. Suloctidil hydrochloride inhibits platelet function and exhibits neuroprotective effects. Suloctidil hydrochloride exerts inhibitory effects on Candidaalbicans biofilm and virulence. Suloctidil hydrochloride can be used in research on vasospasm relief, antithrombosis and superficial candidiasis .
Antifungal agent 55 (compound A07) is a potent antifungal agent, against Fluconazole (HY-B0101)-resistant strains. Antifungal agent 55 is more effective than Miconazole (HY-B0454). Antifungal agent 55 inhibits Candidaalbicans strains with MIC values of 0.25-1 μg/mL .
Antifungal agent 57 (compound A19) is a potent antifungal agent, against Fluconazole (HY-B0101)-resistant strains. Antifungal agent 57 is more effective than Miconazole (HY-B0454). Antifungal agent 57 inhibits Candidaalbicans strains with MIC values of 0.5-2 μg/mL .
Antifungal agent 58 (compound A21) is a potent antifungal agent, against Fluconazole (HY-B0101)-resistant strains. Antifungal agent 58 is more effective than Miconazole (HY-B0454). Antifungal agent 58 inhibits Candidaalbicans strains with MIC values of 0.06-8 μg/mL .
Antifungal agent 54 (compound A05) is a potent antifungal agent, against Fluconazole (HY-B0101)-resistant strains. Antifungal agent 54 is more effective than Miconazole (HY-B0454). Antifungal agent 54 inhibits Candidaalbicans strains with MIC values of 0.25-1 μg/mL .
VT-1598 is an orally active and selective fungal inhibitor targeting CYP51. VT-1598 shows anti-fungal activity against Candida auris . VT-1598 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
Antifungal agent 56 (compound A09) is a potent antifungal agent, against Fluconazole (HY-B0101)-resistant strains. Antifungal agent 56 is more effective than Miconazole (HY-B0454). Antifungal agent 56 inhibits Candidaalbicans strains with MIC values of 0.03-0.25 μg/mL .
Temporin A is a short alpha-helical antimicrobial peptide isolated from the skin of the frog Rana temporaria. Temporin A is effective against a broad spectrum of Gram-positive bacteria. Temporin A interacts directly with the cell membrane of the microorganism and it is non-toxic to erythrocytes at concentrations that are antimicrobial. Temporin A also has antifungal activities (against yeast-like Candidaalbicans) .
Antifungal agent 146 (Compound 19l) is a broad-spectrum antifungal agent. Antifungal agent 146 has inhibitory effects on the main dermatophytes that cause onychomycosis (Trichophyton rubrum, Trichophyton mentagrophytes) and other fungi (Candidaalbicans,Cryptococcus neoformans and Aspergillus fumigatus) with MIC values of 16, 16, 64, 32, and 32 μg/mL. Antifungal agent 146 can be used for the research of infection .
Bromoflavone (CJ-19784) is a flavone that can be isolated from Aspergillus candidus. Bromoflavone shows anti-Mtb activity with an MIC90 value of 1.2 μM. Bromoflavone is also an antifungal agent. Bromoflavone inhibits the growth of pathogenic fungi, Candidaalbicans, Cryptococcus neoformans and Aspergillus fumigatus with IC50 values of 0.11, 20 and 0.54 μg/mL, respectively. .
Efinaconazole-d4 is the deuterium labeled Efinaconazole. Efinaconazole (KP-103) is a triazole antifungal agent and againsts T. mentagrophytes SM-110 and C. albicans ATCC 10231 with MICs of 0.0039 μg/mL and 0.00098 μg/mL, respectively . Efinaconazole has a potent in vitro activity against fungal pathogens including dermatophytes, Candida and Malassezia species .
Maximin H2 is an antimicrobial peptide derived from the skin secretions of Chinese red belly toad Bombina maxima. Maximin H2 has activity against Escherichia coli ATCC25922, Staphylococcus aureus ATCC2592, Bacillus pyocyaneus CMCCB1010 and Candidaalbicans ATCC2002, the MIC values are 20, 2, 4, 2 μg/ml, respectively .
Amphotericin X1 is an 13-O-methyl derivative of Amphotericin B with good antifungal activity. Amphotericin X1 inhibits Candidaalbicans 33/079, C.parapsilosis 937A, Cryptococcus neoformans 451, Aspergillus niger 57A and A.fumigatus with MIC values of 1 μg/mL, 8 μg/mL, 1 μg/mL, 2 μg/mL and 2 μg/mL, respectively .
Deferasirox methyl ester (compound 6a), a derivative of Deferasirox (HY-17359), is an antimicrobial agent. Deferasirox methyl ester exhibits activities against Staphylococcus aureus, Staphylococcus epidermidis, Escherichia coli, Candidaalbicans and Aspergillus niger with MICs of 0.5, 4.0, 1.0, 4.0, and 2.0 μg/mL, respectively. Deferasirox methyl ester can be used for antimicrobial research .
Maximin H4 is an antimicrobial peptide derived from the skin secretions of Chinese red belly toad Bombina maxima. Maximin H4 has activity against Escherichia coli ATCC25922, Staphylococcus aureus ATCC2592, Bacillus pyocyaneus CMCCB1010 and Candidaalbicans ATCC2002, the MIC values are 12, 6, 12, 6 μg/ml, respectively .
Ombuoside has antioxidant properties, inhibiting ROS production and apoptosis. Ombuoside exerts neuroprotective effects through the ERK-JNK-caspase-3 system. Ombuoside promotes Dopamine biosynthesis through TH and CREB activation. Ombuoside exhibits antimicrobial activity against several Gram-positive and Gram-negative bacteria, as well as Candidaalbicans
Oteseconazole (Standard) is the analytical standard of Oteseconazole. This product is intended for research and analytical applications. Oteseconazole (VT-1161) is a potent and orally active anti-fungal agent. Oteseconazole potently binds to and inhibits Candidaalbicans cytochrome P45051 (CYP51) activity (Kd ≤39 nM), shows no obvious effect on human CYP51. Oteseconazole also can be used for the research of dermatophytes .
1-Monomyristin, extracted from Serenoa repens, inhibits the hydrolysis of 2-oleoylglycerol (IC50=32 μM) and fatty acid amide hydrolase (FAAH) activity (IC50=18 μM). 1-Monomyristin shows antibacterial activity against Staphylococcus aureus and Aggregatibacter actinomycetemcomitans and also antifungal activity against Candidaalbicans .
Maximin H3 is an antimicrobial peptide derived from the skin secretions of Chinese red belly toad Bombina maxima. Maximin H3 has activity against Escherichia coli ATCC25922, Staphylococcus aureus ATCC2592, Bacillus pyocyaneus CMCCB1010 and Candidaalbicans ATCC2002, the MIC values are 20, 10, 20, 5 μg/ml, respectively .
Graveoline (Rutamine) is an orally active alkaloid with various activities such as antifungal, antiparasitic, anti-inflammatory, and antitumor effects. Graveoline can induce tumor cell apoptosis and autophagy through a reactive oxygen species-mediated pathway. Graveoline has an MIC of 500 μg/mL for Candidaalbicans. Graveoline can be used in the research of various diseases such as tumors and liver injury .
Antiproliferative agent-18 (Compound 5k) is an anti-proliferative agent. Antiproliferative agent-18 also displays moderate anti-bacterial and anti-fungi activity .
Maximin H1 is an antimicrobial peptide derived from the skin secretions of Chinese red belly toad Bombina maxima. Maximin H1 has activity against Escherichia coli ATCC25922, Staphylococcus aureus ATCC2592, Bacillus pyocyaneus CMCCB1010 and Candidaalbicans ATCC2002, the MIC values are 9, 4.5, 9, 4.5 μg/ml, respectively .
1,3-β-Glucanase is one of the primary components in C. albicans biofilm extrapolymeric substance (EPS). 1,3-β-Glucanase can degrade β-1,3-glucan so as to disrupt the Candida biofilm matrix and increase the effect of the antimicrobial agent. 1,3-β-Glucanase can be used as an antibiofilm agent .
CYP51-IN-10 is cytochrome P450 14a-demethylase (CYP51) inhibitor with antifungal activity. CYP51-IN-10 can be used for the research of fungal infection .
Milbemycin A4 oxime (5-Ketomilbemycin A4 oxime; 5-Oxomilbemycin A4 5-oxime) is a derivative of Milbemycin A4 (HY-126906) and a component of Milbemycin oxime (HY-B0778), both of which have insecticidal and nematicidal activities. Milbemycin A4 oxime (0.05 mg/kg) reduces the number of microfilariae in naturally infected dogs with D. immitis and inhibits the growth of clinical isolates of Candida glabrata (MIC80=16-32 μg/mL). Milbemycin A4 oxime (2.5 μg/mL) blocks the efflux of Fluconazole (HY-B0101) from clinical isolates of Candida glabrata. Milbemycin A4 oxime enhances doxorubicin-induced cell growth inhibition and increases the intracellular accumulation of doxorubicin and P-glycoprotein substrate Rhodamine 123 (HY-D0816) in doxorubicin-resistant but not sensitive MCF-7 breast cancer cells in a concentration-dependent manner.
Cystothiazole A has antifungal activity. Cystothiazole A can inhibit candidaalbicans, saccharomyces cerevisiae and aspergillus smoke with MIC values of 0.4 μg/mL, 0.1 μg/mL and 1.6 μg/mL, respectively. Cystothiazole A also inhibits human tumor cell, such as HPT-116 and K562 cells with MIC values of 130 ng/mL and 110 ng/mL, respectively. Cystothiazole A has no anti-bacterial effect .
Guanine-7-oxide (Guanine 7-N-oxide) is an antitumor antibiotic with anti-tumor, anti-Candidaalbicans activity, and can inhibit viral replication effect of herpes virus, infectious blood virus (IHNV), infectious pancreatic necrosis virus (IPNV) and so on. Guanine-7-oxide has good activity against mouse L1210 leukemia cells .
Chevalone B was isolated from the ethyl acetate extract of the marine sponge-associated fungus Aspergillus similanensis. The structure of Chevalone B was confirmed by 1D and 2D NMR spectroscopy. Chevalone B showed antimicrobial activity against Gram-positive and Gram-negative bacteria, Candidaalbicans, and multidrug-resistant strains from the environment. Studies on Chevalone B have shown its potential value in antimicrobial applications.
(Z)-Methyl tetradec-9-enoate (Myristoleic acid methyl ester; Methyl myristoleate) is a cytotoxic component extracted from S. repens fruit extract. It induces apoptosis and necrosis in human prostate cancer LNCaP cells. In addition, (Z)-Methyl tetradec-9-enoate found in cheese-making byproducts inhibits Candidaalbicans germination with a minimum inhibitory concentration (MIC) of 9 μM in vivo.
Theasaponin E1 is an orally effective tea saponin. Theasaponin E1 inhibits the proliferation of cancer cells by activating apoptosis. Theasaponin E1 inhibits angiogenesis in ovarian cancer cells and HUVECs by reducing the expression of VEGF. Theasaponin E1 upregulates the phosphorylation level of ATM protein and the expression level of PTEN protein in cancer cells, decreases the phosphorylation levels of Akt, mTOR, p70S6K and 4E-BP1 proteins, downregulates the expression of HIF-1α and NF-κB, and reduces the protein expression of Notch ligands Dll4 and Jagged1. Theasaponin E1 exerts neuroprotective effects by inhibiting the activity of acetylcholinesterase, activating α-secretase and neprilysin, reducing the concentration of Aβ, and inhibiting the activities of β-secretase and γ-secretase. Theasaponin E1 exhibits toxic effects on cancer cells and quinone reductase-inducing activity, and inhibits tumor growth in vivo. Theasaponin E1 induces ferroptosis in Pomacea canaliculata by synergistically disrupting cholesterol homeostasis and sphingolipid metabolism. Theasaponin E1 possesses anti-biofilm activity against Candidaalbicans. Theasaponin E1 can be used in the research of ovarian cancer, obesity, Alzheimer's disease and fungal infections .
Mazethramycin B (Compound II) is an antitumor antibiotic. Mazethramycin B can be isolated from the Streptomyces thioluteusM ME561-L4. Mazethramycin B has a broad-spectrum antimicrobial activity (such as MICs of 1.56 and 6.25 μg/mL for the bacteria Bacillus subtilis PCI 219 and the fungus Candida pseudotropicalis, resepectively). Mazethramycin B significantly increases survival in L1210 leukemia mice model .
Human β-defensin-2 (HβD-2) is a small cysteine-rich cationic skin-antimicrobial peptide (SAP) produced by a number of epithelial cells.Human β-defensin-2 has antimicrobial activity against gram-negative bacteria and Candida, but not gram-positive Staphylococcus aureus . Human β-defensin-2 can be used for the study of colitis .
2-Phenylethanol-d9 is the deuterium labeled 2-Phenylethanol . 2-Phenylethanol (Phenethyl alcohol), extracted from rose, carnation, hyacinth, Aleppo pine, orange blossom and other organisms, is a colourless liquid. It has a pleasant floral odor and also an autoantibiotic produced by the fungus Candidaalbicans . It is used as an additive in cigarettes and also used as a preservative in soaps due to its stability in basic conditions.
2-Phenylethanol-d5 is the deuterium labeled 2-Phenylethanol . 2-Phenylethanol (Phenethyl alcohol), extracted from rose, carnation, hyacinth, Aleppo pine, orange blossom and other organisms, is a colourless liquid. It has a pleasant floral odor and also an autoantibiotic produced by the fungus Candidaalbicans . It is used as an additive in cigarettes and also used as a preservative in soaps due to its stability in basic conditions.
2-Phenylethanol-d4 is the deuterium labeled 2-Phenylethanol . 2-Phenylethanol (Phenethyl alcohol), extracted from rose, carnation, hyacinth, Aleppo pine, orange blossom and other organisms, is a colourless liquid. It has a pleasant floral odor and also an autoantibiotic produced by the fungus Candidaalbicans . It is used as an additive in cigarettes and also used as a preservative in soaps due to its stability in basic conditions.
10-Isobutyryloxy-8,9-epoxythymol isobutyrate is a major constituent of Inula helenium and Inula royleana root cultures. 10-Isobutyryloxy-8,9-epoxythymol isobutyrate shows moderate antimicrobial activity against Staphylococcus aureus FDA 209 P, Staphylococcus aureus, Enterococcus faecalis, Candidaalbicans and Pseudomonas aeruginosa with MICs of 50, 250, 250, 250, and 1000 μg/mL, respectively .
Sertaconazole (nitrate) (Standard) is the analytical standard of Sertaconazole (nitrate). This product is intended for research and analytical applications. Sertaconazole nitrate (FI7056) is a broad-spectrum topical antifungal agent, exhibits anti-inflammatory activity via activation of a p38-COX-2-PGE2 pathway. Sertaconazole nitrate is also a microtubule inhibitor, shows antiproliferative effect, induces apoptosis and autophagy, and can also inhibit the migration of cells .
Sertaconazole (FI7056 free base) is a broad-spectrum topical antifungal agent, exhibits anti-inflammatory activity via activation of a p38-COX-2-PGE2 pathway. Sertaconazole is also a microtubule inhibitor, shows antiproliferative effect, induces apoptosis and autophagy, and can also inhibit the migration of cells .
Sertaconazole nitrate (FI7056) is a broad-spectrum topical antifungal agent, exhibits anti-inflammatory activity via activation of a p38-COX-2-PGE2 pathway. Sertaconazole nitrate is also a microtubule inhibitor, shows antiproliferative effect, induces apoptosis and autophagy, and can also inhibit the migration of cells .
Monascorubrin is a compound that can be isolated from Monascus mycelia. Monascorubrin has activities such as anti-inflammatory, anti-tumor, antibacterial, and immunomodulatory. Monascorubrin also has certain embryotoxicity, with an ED50 of 4.3 μg for chicken embryos. Monascorubrin can be used for the research of tumors and inflammatory diseases .
Micafungin-d11 ammonium (FK463-d11 ammonium) is the deuterium labeled Micafungin ammonium. Micafungin (FK463) is an antifungal agent and can inhibit β-1,3-glucan synthase.Micafungin inhibits 1,3-β-glucan biosynthesis in fungal cell walls.Micafungin can be used for the research of fungal infection, such as candida infections and aspergillosis .
Antifungal agent 60 (compound 16) is an inhibitor of ergosterol biosynthesis with broad-spectrum antifungal activity. Antifungal agent 60 inhibits 7 human pathogenic fungal species, 2 fluconazole-resistant C. albicans isolates and 2 multi-drug resistant Candida auris isolates. Antifungal agent 60 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
NK-2 (Antibiotic NK 2), a shortened linear amphipathic NK-Lysin analog (comprising residues 39 to 65 of NK-lysin), is an antimicrobial peptide that exhibits potent activities against trypanosoma cruzi, Candidaalbicans, gram-positive and gram-negative bacteria. NK-2 can kill trypanosomes residing inside the human glioblastoma cell line 86HG39, left the host cells apparently unharmed .
Abafungin (BAY-W-6341) is a broad-spectrum fungicidal arylguanidine compound and a selective inhibitor of sterol-C-24-methyltransferase. Abafungin blocks the transmethylation reaction at the C-24 position of the sterol side chain during the ergosterol biosynthesis pathway. Abafungin directly disrupts fungal cell membrane integrity, and diminishes fungal viability independent of the fungal growth state. Abafungin can be applied to the research of fungal infections, particularly dermatomycoses .
β-Phenylethyl β-D-glucoside (Phenylethyl β-D-glucopyranoside) (Compound 7), a phenolic compounds, is an antifungal agent. β-Phenylethyl β-D-glucoside can be isolated from the leaves of Piper crocatum. β-Phenylethyl β-D-glucoside has antifungal activity against Candidaalbicans. β-Phenylethyl β-D-glucoside can be used for fungal infections research .
14-epi-Berkeleylactone F (Compound 8) is a C-14 epimer of Berkeleylactone F (HY-N8386). 14-epi-Berkeleylactone F can be isolated from Penicillium turbatum NRRL 5630. 14-epi-Berkeleylactone F has no significant biological activity against bacterium (Staphylococcus aureus, Bacillus subtilis and E. coli), fungi Candidaalbicans, the parasite Giardia duodenalis and NS-1 murine myeloma cells .
Mansonone E (Compound 5) is a pesticide. Mansonone E can be isolated from heartwood of Mansonia gagei. Mansonone E has significant antifungal activity against Cladosporium cucumerinum, Candidaalbicans and Phytophthora parasitica. Mansonone E has potent antibacterial activity with MIC50s of both 7.8 μg/mL for Xanthomonas oryzae pv. oryzae and X. oryzae pv. Oryzicola. Mansonone E also has antifeedant and herbicidal activities .
Graveoline (Standard) is the analytical standard of Graveoline (HY-12538). This product is intended for research and analytical applications. Graveoline (Rutamine) is an orally active alkaloid with various activities such as antifungal, antiparasitic, anti-inflammatory, and antitumor effects. Graveoline can induce tumor cell apoptosis and autophagy through a reactive oxygen species-mediated pathway. Graveoline has an MIC of 500 μg/mL for Candidaalbicans. Graveoline can be used in the research of various diseases such as tumors and liver injury .
Sordarin (Compound 1) is an antifungal agent targeting Elongation factor 2 (EF2) with a tetracyclic diterpene core including a norbornene system. Sordarin can be isolated from the fungus Sordaria araneosa. Sordarin has potent antifungal activity against Saccharomyces cerevisiae and Candidaalbicans. Sordarin prevents the translocation of the ribosome along mRNA during elongation of the emerging polypeptide chain, inhibiting protein synthesis in fungi by stabilizing the ribosome/EF2 complex .
Corticostatin, human (Human Neutrophil Peptide-4) TFA is an antimicrobial peptide with demonstrated antiviral activity. Corticostatin, human TFA can kill Escherichia coli, Streptococcus faecalis, and Candidaalbicans. Corticostatin, human (HNP-4) TFA is more bactericidal against Gram-negative bacteria than any of HNP-1-3. Corticostatin, human TFA can be isolated from the azurophil granule fraction of discontinuous Percoll gradients .
Damnacanthal is an anthraquinone isolated from the root of Morinda citrifolia. Damnacanthal is a highly potent, selective inhibitor of p56 lck tyrosine kinase activity. Natural Damnacanthal inhibits p56 lck autophosphorylation and phosphorylation of exogenous substrates with IC50s of 46 nM and 220 nM, respectively. Damnacanthal is a potent inducer of apoptosis with anticancer activity. Damnacanthal also has antinociceptive, anti-inflammatory effects in mice and anti-fungal activity against Candidaalbicans .
Aldox-d6 (Lexamine M-13-d6; MAPD-d6) is the deuterium labeled Myristamidopropyl dimethylamine (HY-W099582). Myristamidopropyl dimethylamine (MAPD) is an antimicrobial agent (including against bacteria and fungi) and an insecticide, exhibiting inhibitory activity against Pseudomonas aeruginosa, Staphylococcus aureus, Candidaalbicans, Fusarium solani, and Acanthamoeba polyphaga. Myristamidopropyl dimethylamine can be used in research on microbial-induced keratitis .
CYP51/Hsp90-IN-1 (Compound MM4) is a dual CYP51/Hsp90 inhibitor. CYP51/Hsp90-IN-1 shows antifungal activity against Candidaalbicans and effectively inhibits important fungal virulence factors. CYP51/Hsp90-IN-1 is promising for research of invasive candidiasis .
Deacetylsclerotiorin is a secondary metabolite of chloramphenicol isolated from the fungus Bartalinia robillardoides strain LF550. Deacetylsclerotiorin has significant inhibitory effects on Candidaalbicans (IC50=24 μM), Trichophyton rubrum (IC50=2.83 μM) and Septoria tritici (IC50=7..45 μM). In addition, Deacetylsclerotiorin also exhibits inhibitory effects on the enzyme phosphodiesterase 4 (PDE4) (IC50=2.8 μM) .
Oxiconazole (Ro 13-8996) is a broad spectrum anti-fungal agent which can inhibit the growth of Candida, Aspergillus and Trichophyton. Oxiconazole is also a highly efficacious activator of CYP3A4 transactivation, which could be antagonized by Rifampicin (HY-B0272) in a competitive manner. Oxiconazole exhibits inhibitory effect against colorectal cancer (CRC) via peroxiredoxin-2 (PRDX2)-mediated autophagy arrest .
Antimicrobial agent-42 (Compound 6j) is an antimicrobial agent. Antimicrobial agent-42 interacts with key amino acids such as Lys59 and Ser170 within the ALS3 protein, crucial for the binding of host peptides. Antimicrobial agent-42 significantly inhibits Candidaalbicans biofilm formation and reduces planktonic cells aggregation and hyphal formation. Antimicrobial agent-42 has an antifungal activity, promising for fungal infections reseach .
Gibberellin A7 (GA7) is a terpenoid that serve as an important plant hormone. Gibberellin A7 acts as a growth and response modulator against injuries and parasitism. Gibberellin A7 presents antibiofilm properties at 940 mM concentration. Gibberellin A7 can inhibit flower bud formation in some plants. Gibberellin A7 shows antioxidant activity against peroxyl radicals. Gibberellin A7 exhibits anti-Candida activity against Candia albicans .
2,6-Dichlorodiphenylamine (Standard) is the analytical standard of 2,6-Dichlorodiphenylamine. This product is intended for research and analytical applications. 2,6-Dichlorodiphenylamine is an analogue of Diclofenac Sodium (HY-15037) and has anti-Candidaalbicans activity. Diclofenac Sodium is a potent and nonselective anti-inflammatory agent, acts as a COX inhibitor, with IC50s of 4 and 1.3 nM for human COX-1 and COX-2 in CHO cells.
(E)-Ferulic acid acyl-β-D-glucoside ((E)-Ferulic acid glucoside) (compoun 4C) is an acyl-β-D-glucoside that can be isolated from Riesling Wine. (E)-Ferulic acid acyl-β-D-glucoside exhibits antioxidant activity .
Oxiconazole (Ro 13-8996) nitrate is a broad spectrum anti-fungal agent which can inhibit the growth of Candida, Aspergillus and Trichophyton. Oxiconazole nitrate is also a highly efficacious activator of CYP3A4 transactivation, which could be antagonized by Rifampicin (HY-B0272) in a competitive manner. Oxiconazole nitrate exhibits inhibitory effect against colorectal cancer (CRC) via peroxiredoxin-2 (PRDX2)-mediated autophagy arrest .
Myristinin A (YM 26567-1) is a trans-isomer flavan compound found in Horsfieldia amygdaline and Myristica cinnamomea. Myristinin A can selectively inhibit COX-2 activity with an IC50 of 16.9 μg/mL. Myristinin A can reduce the production of prostaglandin E2 (PGE2) and inhibit phospholipase A2 (PLA2), thereby blocking the release of inflammatory mediators. Myristinin A can inhibit Candidaalbicans with an IC50 of 8.8 μg/mL. Myristinin A can be used for the research of inflammation and infection, such as rheumatoid arthritis .
Nifuratel (NF 113) is an orally active broad-spectrum antibiotic with antiprotozoal, antibacterial, anticancer and anti-inflammatory activities, and has good inhibitory effects on Candida and Trichomonas. Nifuratel is also a STAT3 inhibitor, which significantly inhibits the growth and proliferation of human gastric cancer cells and induces apoptosis. In addition, Nifuratel also inhibits mast cell-mediated antigen hypersensitivity reactions and can be used in the study of IgE-mediated allergic diseases .
Aspergillus niger-IN-1 (Compound 17), a derivative of thiazolidine-2,4-dione, acts as an antimicrobial agent. Aspergillus niger-IN-1 exhibited antimicrobial activity against various bacterial and fungal strains, including Bacillus subtilis, Staphylococcus aureus, Klebsiella pneumonia, Escherichia coli, Salmonella typhi, Candidaalbicans and Aspergillus niger, with MIC values of 11.3, 5.65, 11.3, 5.65, 5.65, 5.65, and 5.65 μM/mL, respectively .
3-O-α-L-Arabinopyranosyl hederagenin 28-O-α-L-rhamnopyranosyl ester is an anti-fungal triterpene saponin. 3-O-α-L-Arabinopyranosyl hederagenin 28-O-α-L-rhamnopyranosyl ester can be isolated from the aerial parts of Clematis tangutica. 3-O-α-L-Arabinopyranosyl hederagenin 28-O-α-L-rhamnopyranosyl ester exhibits antifungal activity against fungal strains (P. avellaneum, C. glabrata, S. cerevisiae, T. beigelii), with the strongest activity against S. cerevisiae .
N-Acetyl-D-Glucosamine (N-Acetyl-2-amino-2-deoxy-D-glucose), the D isomer of N-acetylglucosamine, is an orally active monosaccharide derivative of glucose with anti-tumor and anti-inflammation properties. N-Acetyl-D-Glucosamine is also a bacterial metabolite, which is found in Escherichia coli. N-Acetyl-D-Glucosamine can induce yeast-mycelial conversion in Candidaalbicans. N-Acetyl-D-Glucosamine also enhances healing of cartilaginous injuries in rabbits .
Terbinafine-d3 (TDT 067-d3) is deuterium labeled Terbinafine. Terbinafine (TDT 067) is an orally active and potent antifungal agent. Terbinafine is a potent non-competitive inhibitor of squalene epoxidase from Candida, with a Ki of 30 nM. Terbinafine also shows antibacterial activity against certain Gram-positive and Gram-negative bacteria . Terbinafine is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
CYP51-IN-20 (compound 5b) is an inhibitor of CYP51 and has antifungal activity. CYP51-IN-20 has a significant inhibitory effect on Candidaalbicans ATCC 10231, downregulates ERG11 (Cyp51) gene expression, and significantly reduces the yeast-to-hyphae morphological transition. CYP51-IN-20 can synergize with Voriconazole (HY-76200) to occupy the entire CYP51 binding site and exert a synergistic inhibitory effect in the Glechoma moth model .
Lombazole is an antimicrobial compound with activity that inhibits cell membrane synthesis. Lombazole had little effect on K+ permeability in S. aureus. Lombazole inhibited only de novo synthesis of cell enclosure in S. aureus, and this effect occurred before growth was affected. The main effect of lombazole was through inhibition of lipid synthesis. Lombazole may have an effect on key steps in lipid biosynthesis, as inferred from the lack of changes in lipid patterns after treatment. Lombazole also inhibited the sterol C-14 demethylation step in Candidaalbicans .
Yck2-IN-1 (Compound 2a) is an inhibitor of the fungal CandidaalbicansYck2 kinase. It exhibits an IC50 of approximately 80 nM against Yck2 and a MIC80 of 12.5 µM against C. albicans, with good metabolic stability (66% remaining in mouse liver microsomes). In a mouse model of drug-resistant candidiasis, Yck2-IN-1 significantly reduced fungal burden in the kidneys. Yck2-IN-1 holds promise for research in the field of antifungal infection .
(-)-Deacetylsclerotiorin (Compound 30) is the enantiomer of Deacetylsclerotiorin (HY-126167). Deacetylsclerotiorin is the metabolite of chloramphenicol isolated from the fungus Bartalinia robillardoides strain LF550. Deacetylsclerotiorin has significant inhibitory effects on Candidaalbicans (IC50=24 μM), Trichophyton rubrum (IC50=2.83 μM) and Septoria tritici (IC50=7.45 μM). In addition, Deacetylsclerotiorin also exhibits inhibitory effects on the enzyme phosphodiesterase 4 (PDE4) (IC50=2.8 μM) .
Chitin, from crab carapace is a long-chain polymer of N-acetylglucosamine with β-(1-4) linkages. Chitin, from crab carapace is found in the exoskeleton of crabs. Chitin, from crab carapace inhibits the activation of NF-κB p65, alters the translocation of NF-κB p65 to the nucleus, and interacts with the cell wall of Candida species. Chitin, from crab carapace exerts antifungal and anti-inflammatory effects. Chitin, from crab carapace can be used in the research of gastric ulcer and candidiasis .
3-Acetyl-28-N–(3–guanidinobutoxy)-oleanolic acid (compound J1) is a potent antimicrobial agent. 3-Acetyl-28-N–(3–guanidinobutoxy)-oleanolic acid shows anti-gram-positive bacteria and fungi activity. 3-Acetyl-28-N–(3–guanidinobutoxy)-oleanolic acid can be used as antibiotic adjuvants. 3-Acetyl-28-N–(3–guanidinobutoxy)-oleanolic disrupts the bacterial cell membrane, inserts into the DNA, and binds to DNA gyrase. 3-Acetyl-28-N–(3–guanidinobutoxy)-oleanolic reduces microbial count in a mouse MRSA skin infection model and accelerates wound healing .
1-Prenyl-2-methoxy-6-formyl-8-hydroxy-9H-carbazole (Compound 19) is a carbazole alkaloid that can be isolated from Murraya koenigii. 1-Prenyl-2-methoxy-6-formyl-8-hydroxy-9H-carbazole exhibits anti-inflammatory and antimicrobial activities. 1-Prenyl-2-methoxy-6-formyl-8-hydroxy-9H-carbazole can inhibit the production of pro-inflammatory cytokines TNF-α and IL-6 . 1-Prenyl-2-methoxy-6-formyl-8-hydroxy-9H-carbazole has IC50 values of 10.9 μM and 95 μM for Bacillus cereus and Staphylococcus aureus, respectively. 1-Prenyl-2-methoxy-6-formyl-8-hydroxy-9H-carbazole can be used in the research of inflammatory and infectious diseases .
Amphotericin A is a tetraenic polyene antifungal agent, produced in the fermentation broth of Amphotericin B (HY-B0221).Amphotericin A has a structure identical to Amphotericin B except for a single bond between carbons 28 and 29 instead of a double bond. Amphotericin A can be used for research on fungal infection .
Tebuconazole is an orally active agricultural azole fungicide which can also inhibit CYP51 with IC50s of 0.9 and 1.3 μM for Candidaalbicans CYP51 (CaCYP51) and truncated Homo sapiens CYP51 (Δ60HsCYP51), respectively. Tebuconazole induces lipid accumulation and oxidative stress in HepG2 Cells. Tebuconazole decreases MAC-T cells viability and proliferation, induces ER-stress-mediated apoptosis and increases oxidative stress levels in MAC-T cells .
N,N'-Bis(2,3-Dihydroxybenzoyl)-O-L-seryl-L-serine is a enterochelin hydrolyzed product. N,N'-Bis(2,3-Dihydroxybenzoyl)-O-L-seryl-L-serine can inhibit the invasion of murine colon cancer cells 26-L5 with an IC50 of 2.7 μM, and has anti-tumor effect. In addition, N,N'-Bis(2,3-Dihydroxybenzoyl)-O-L-seryl-L-serine has no appreciable antimicrobial activities against Micrococcus luteus, Escherichia coli and Candidaalbicans .
2,6-Dichlorodiphenylamine- 13C6 (2,6-Dichloro-N-phenylaniline- 13C6) is the 13C-labeled 2,6-Dichlorodiphenylamine (HY-W012126). 2,6-Dichlorodiphenylamine is an analogue of Diclofenac Sodium (HY-15037) and has anti-Candidaalbicans activity. Diclofenac Sodium is a potent and nonselective anti-inflammatory agent, acts as a?COX?inhibitor, with?IC50s of 4 and 1.3 nM for human COX-1 and COX-2 in CHO cells.
Chitin, from shrimp shells (powder) is a long-chain polymer of N-acetylglucosamine with β-(1-4) linkages. Chitin, from shrimp shells (powder) is found in the exoskeleton of crabs. Chitin, from shrimp shells (powder) inhibits the activation of NF-κB p65, alters the translocation of NF-κB p65 to the nucleus, and interacts with the cell wall of Candida species. Chitin, from shrimp shells (powder) exerts antifungal and anti-inflammatory effects. Chitin, from shrimp shells (powder) can be used in the research of gastric ulcer and candidiasis .
Sabinene hydrate is a volatile organic compound of a bicyclic monoterpene alcohol. Sabinene hydrate, as a plant secondary metabolite, is naturally present in various plants and their essential oils. Sabinene hydrate exhibits broad-spectrum but varying-intensity antibacterial activity, with the greatest sensitivity to Gram-positive bacteria, especially Bacillus subtilis (MIC = 0.0312 mg/mL) and Staphylococcus aureus (MIC = 0.0625 mg/mL). Sabinene hydrate also shows certain sensitivity to Escherichia coli and Candidaalbicans, with MIC values of 0.125 mg/mL for both. Sabinene hydrate can be used in the research of the ecological functions of plant defense substances .
Bamethan (hemisulfate) (Standard) is the analytical standard of Bamethan (hemisulfate). This product is intended for research and analytical applications. Bamethan (DL-Bamethane) hemisulfate is a vasodilator that exhibits significant activity in enhancing blood flow and reducing vascular resistance. Bamethan hemisulfate plays a crucial role in the treatment of cardiovascular conditions by improving oxygen delivery to tissues. Bamethan hemisulfate also aids in the management of hypertension through its relaxing effects on blood vessels.
Azazerine (CI-337) is a competitive inhibitor of glutamine amidotransferase. Azaserine is an antibiotic, it shows antibacterial activities. Azazerine shows anti-tumor activities and it may also act as a tumor inducer. Azazerine can be used for the research of cancer and infection .
Allyl α-D-galactopyranoside is an α-galactoside and acceptor/donor substrate for transgalactosylation reactions. Allyl α-D-galactopyranoside acts as an acceptor substrate in α-galactosidase-catalyzed transgalactosylation, and serves as a donor substrate to form longer α-galactosyl-containing oligosaccharides. Allyl α-D-galactopyranoside serves as a model compound for investigating the catalytic mechanism and substrate specificity of glycoside hydrolases and glycosyltransferases .
Oxiconazole nitrate (Standard) is the analytical standard of Oxiconazole nitrate. This product is intended for research and analytical applications. Oxiconazole (Ro 13-8996) nitrate is a broad spectrum anti-fungal agent which can inhibit the growth of Candida, Aspergillus and Trichophyton. Oxiconazole nitrate is also a highly efficacious activator of CYP3A4 transactivation, which could be antagonized by Rifampicin (HY-B0272) in a competitive manner. Oxiconazole nitrate exhibits inhibitory effect against colorectal cancer (CRC) via peroxiredoxin-2 (PRDX2)-mediated autophagy arrest .
Mollicellin K is a depsidone that can be isolated from the fungus Chaetomium brasiliense. Mollicellin K exhibits antimicrobial activity against Myobacterium tuberculosis, antimalarial activity (IC50 = 1.2 μM) against Plasmodium falciparum as well as antifungal property (IC50 = 1.2 μM) against Candidaalbicans. Mollicellin K is cytotoxic against KB (IC50 = 1.9 μM), BC1 (IC50 = 6.8 μM), NCI-H187 (IC50 = 0.35 μM), and five cholangiocarcinoma cell lines. Mollicellin K also has an MIC of 12.5 μM for tuberculosis .
Myristinin B/C is a mixture of Myristinin B and Myristinin C. Myristinin B/C is a flavan compound found in Horsfieldia amygdaline and Myristica cinnamomea. Myristinin B/C can selectively inhibit COX-2 activity with an IC50 of 2.1 μg/mL. Myristinin B/C can reduce the production of prostaglandin E2 (PGE2) and inhibit phospholipase A2 (PLA2), thereby blocking the release of inflammatory mediators. Myristinin B/C can inhibit Candidaalbicans with an IC50 of 6 μg/mL. Myristinin B/C can be used for the research of inflammation and infection, such as rheumatoid arthritis .
Poly diallyldimethylammonium chloride is a cationic polymer with quaternary ammonium side groups, which exhibits excellent flocculation performance and thermal stability. Poly diallyldimethylammonium chloride also possesses microbicidal activity. Poly diallyldimethylammonium chloride can be used in studies on bacterial and fungal infections, as well as in research related to water treatment, textile printing and dyeing, papermaking chemical industry and other fields, with a wide range of applications .
o-Cymen-5-ol is a broad-spectrum antimicrobial agent with direct antimicrobial activity. o-Cymen-5-ol showed effective minimum inhibitory concentrations (MICs) against a variety of bacteria and fungi, such as Streptococcus mutans and Candidaalbicans. The combination of o-Cymen-5-ol and zinc showed synergistic effects, enhancing the inhibitory effect against oral pathogens. o-Cymen-5-ol was able to inhibit the glycolysis process and co-enhanced this effect with zinc. o-Cymen-5-ol showed a stronger antibacterial effect in toothpaste than placebo .
Periplanetasin-4 is an antimicrobial peptide that can be derived from the American cockroach (Periplaneta americana). Periplanetasin-4 reduces cell rounding and apoptosis. Periplanetasin-4 blocks Clostridium difficile toxin A-induced ROS production and the activation of downstream p38 MAPK and p21. Periplanetasin-4 significantly increases mitochondrial calcium level, reduces DPH fluorescence intensity and vacuolar dysfunction in Candidaalbicans ATCC 90028 cells. Periplanetasin-4 significantly ameliorates toxin A-induced mucosal damage in the mouse gut. Periplanetasin-4 can be used for the study of colitis .
Halofantrine hydrochloride (Standard) is the analytical standard of Halofantrine hydrochloride. This product is intended for research and analytical applications. Halofantrine hydrochloride (SKF-102886 hydrochloride; WR-171669 hydrochloride) is a blocker that delays the delayed rectifier potassium current by inhibiting human ERG channels, and it is a potent antimalarial agent. Halofantrine hydrochloride inhibits the Cap1-dependent oxidative stress response of Candidaalbicans, suppresses ROS responses, and enhances the antifungal (Fungal) activity of oxidative damage agents. Halofantrine hydrochloride exhibits antifungal activity in the Galleria mellonella model, and shows antimalarial activity against Plasmodium strains both in vitro and in animal models. Halofantrine hydrochloride can be used in studies related to invasive candidiasis, falciparum malaria, and vivax malaria.
IKE16 is a fungi-selective eukaryotic topoisomerase II inhibitor, with an IC50 value of 13.68 μM. IKE16 suppresses both the DNA relaxation activity and the decatenation activity of yTOPOII selectively. IKE16 shows moderate activity against standard fungal strains (Candidaalbicans ATCC 10231, Saccharomyces cerevisiae ATCC 89763) with a minimum inhibitory concentration (MIC) of 2 μg/mL against S. cerevisiae ATCC 89763. IKE16 exhibits high cytotoxicity against human cells, with an EC50 of 0.07 μM in HepG2 and 0.045 μM in HEK-293. IKE16 can be used for the study of antifungal infection .
Tebuconazole-d4 is the deuterium labeled Tebuconazole (HY-B0852). Tebuconazole is an orally active agricultural azole fungicide which can also inhibit CYP51 with IC50s of 0.9 and 1.3 μM for Candidaalbicans CYP51 (CaCYP51) and truncated Homo sapiens CYP51 (Δ60HsCYP51), respectively. Tebuconazole induces lipid accumulation and oxidative stress in HepG2 Cells. Tebuconazole decreases MAC-T cells viability and proliferation, induces ER-stress-mediated apoptosis and increases oxidative stress levels in MAC-T cells .
Tebuconazole-d6 is a deuterium labeled Tebuconazole (HY-B0852). Tebuconazole is an orally active agricultural azole fungicide which can also inhibit CYP51 with IC50s of 0.9 and 1.3 μM for Candidaalbicans CYP51 (CaCYP51) and truncated Homo sapiens CYP51 (Δ60HsCYP51), respectively. Tebuconazole induces lipid accumulation and oxidative stress in HepG2 Cells. Tebuconazole decreases MAC-T cells viability and proliferation, induces ER-stress-mediated apoptosis and increases oxidative stress levels in MAC-T cells .
Isostrictiniin (ITN) is a polyphenolic compound isolated from Nymphaea candida. It upregulates the expression of Nrf2 and HO-1, while downregulating the expression of Keap1. Isostrictiniin reduces the phosphorylation levels of JNK, ERK1/2, p38, IκBα, and NF-κB p65. Isostrictiniin decreases the levels of pro-inflammatory mediators (IL-1β, IL-6, TNF-α, PGE2). Isostrictiniin alleviates LPS-induced acute lung injury and exerts protective effects against acute alcoholic liver injury. Additionally, isostrictiniin exhibits anti-inflammatory, antioxidant, and anti-fibrotic activities.
Tebuconazole (Standard) is the analytical standard of Tebuconazole. This product is intended for research and analytical applications. Tebuconazole is an orally active agricultural azole fungicide which can also inhibit CYP51 with IC50s of 0.9 and 1.3 μM for Candidaalbicans CYP51 (CaCYP51) and truncated Homo sapiens CYP51 (Δ60HsCYP51), respectively. Tebuconazole induces lipid accumulation and oxidative stress in HepG2 Cells. Tebuconazole decreases MAC-T cells viability and proliferation, induces ER-stress-mediated apoptosis and increases oxidative stress levels in MAC-T cells .
Caerulomycin A is an orally active immunomodulator and antimicrobial agent. Caerulomycin A targets Smad3, STAT1 and GATA-3. Caerulomycin A downregulates GATA-3 expression, inhibits Th2 cell differentiation and Th2 cytokine production, reduces IgE levels, and alleviates pulmonary inflammatory responses and eosinophil infiltration. Caerulomycin A ameliorates collagen-induced arthritis symptoms, reduces joint inflammation and synovitis, and decreases the levels of proinflammatory cytokines in joints. Caerulomycin A inhibits the growth of some filamentous fungi, yeasts and specific bacteria. Caerulomycin A can be used in research related to arthritis and asthma .
1-Methyl-4-nitroimidazole is an antibacterial agent. 1-Methyl-4-nitroimidazole is reduced by bacterial nitroreductases to form toxic derivatives, which cause DNA damage, inhibit bacterial nucleic acid synthesis, generate toxic superoxides through futile cycling of reduced radical anions, and induce bacterial cell death. 1-Methyl-4-nitroimidazole exhibits moderate in vitro activity against bacteria and fungal. 1-Methyl-4-nitroimidazole can be used in the research of skin infections, purulent infections and urinary tract infections .
Antimicrobial agent-40 (Compound 5a) has antimicrobial activity against fungi, Gram-negative and Gram-positive bacteria. Antimicrobial agent-40 has good cytotoxicity against MCF-7 cells (IC50: 33.52 μM) and exhibits anticancer activity .
Alexidine, a bis-biguanide, exhibits antifungal and antibiofilm activity against a diverse range of fungal pathogens. Alexidine is an anticancer agent that targets a mitochondrial tyrosine phosphatase, PTPMT1, in mammalian cells and causes mitochondrial apoptosis .
Chitin, from shrimp shells (chitinase substrate) serves as a substrate for chitinase. Chitin, from shrimp shells (chitinase substrate) is a long-chain polymer of N-acetylglucosamine with β-(1-4) linkages. Chitin, from shrimp shells (chitinase substrate) is found in the exoskeleton of crabs. Chitin, from shrimp shells (chitinase substrate) inhibits the activation of NF-κB p65, alters the translocation of NF-κB p65 to the nucleus, and interacts with the cell wall of Candida species. Chitin, from shrimp shells (chitinase substrate) exerts antifungal and anti-inflammatory effects. Chitin, from shrimp shells (chitinase substrate) can be used in the research of gastric ulcer and candidiasis .
N-Acetyl-D-glucosamine-d3 (N-Acetyl-2-amino-2-deoxy-D-glucose-d3) is deuterium labeled N-Acetyl-D-glucosamine. N-Acetyl-D-Glucosamine (N-Acetyl-2-amino-2-deoxy-D-glucose), the D isomer of N-acetylglucosamine, is an orally active monosaccharide derivative of glucose with anti-tumor and anti-inflammation properties. N-Acetyl-D-Glucosamine is also a bacterial metabolite, which is found in Escherichia coli. N-Acetyl-D-Glucosamine can induce yeast-mycelial conversion in Candidaalbicans. N-Acetyl-D-Glucosamine also enhances healing of cartilaginous injuries in rabbits .
Xylitol can be classified as a polyol and sugar alcohol, exhibiting inhibitory activity on cancer cell proliferation. It induces autophagy (Autophagy) and cell death in A549 cells by activating the autophagy signaling pathway, as evidenced by the increased expression of LC3-II and Atg5-Atg12 upon Xylitol treatment. Additionally, Xylitol inhibits acetaldehyde production by Candida species, thereby reducing their carcinogenic potential. In vivo, Xylitol induces alterations in the gut microbiota of mice, which may enhance cholesterol accumulation and upregulate hepatic ChREBP, while also slowing tumor growth in the B16F10 melanoma C57BL/6 mouse model .
Pyrithioxin (Pyritinol) is an orally active neurodynamic compound. Pyrithioxin can promote the metabolism of glucose and amino acids, increase carotid blood flow and improve cerebral blood flow. Pyrithioxin exhibits anti-inflammation, anti-tumor and neuroprotective effect. Pyrithioxin can be used for the researches of cancer, inflammation, immunology, metabolic and neurological disease such as cerebral infarct, epilepsy, fibrosarcomas and rheumatoid polyarthritis .
Pyrithioxin (Pyritinol) dihydrochloride (Standard) is the analytical standard of Pyrithioxin dihydrochloride (HY-B0910A). Pyrithioxin (Pyritinol) is an orally active neurodynamic compound. Pyrithioxin can promote the metabolism of glucose and amino acids, increase carotid blood flow and improve cerebral blood flow. Pyrithioxin exhibits anti-inflammation, anti-tumor and neuroprotective effect. Pyrithioxin can be used for the researches of cancer, inflammation, immunology, metabolic and neurological disease such as cerebral infarct, epilepsy, fibrosarcomas and rheumatoid polyarthritis .
Pyrithioxin (Pyritinol) dihydrochloride is the dihydrochloride salt of Pyrithioxin (HY-B0910). Pyrithioxin (Pyritinol) is an orally active neurodynamic compound. Pyrithioxin can promote the metabolism of glucose and amino acids, increase carotid blood flow and improve cerebral blood flow. Pyrithioxin exhibits anti-inflammation, anti-tumor and neuroprotective effect. Pyrithioxin can be used for the researches of cancer, inflammation, immunology, metabolic and neurological disease such as cerebral infarct, epilepsy, fibrosarcomas and rheumatoid polyarthritis .
Hazelnutin F is an indoleacetic acid glycoside found in the kernels of Corylus avellana L.. Hazelnutin F lacks significant antioxidant activity against ABTS and DPPH radicals .
Anandamide is an endocannabinoid. Anandamide modulates both neuronal and immune functions through two protein-coupled cannabinoid receptors (CB1 and CB2). Anandamide can activate numerous other receptors like PPARS, TRPV1, and GPR18/GPR55. Anandamide also has potential anti-fungal and anti-inflammatory activities. Anandamide can be used for the research of Alzheimer’s disease (AD) and ulcerative colitis .
Nyasol ((-)-Nyasol) is an active compound that has antifungal, antibacterial, antileishmanial, hyaluronidase inhibition activities. Nyasol inhibits LTB4 binding to human neutrophils. Nyasol suppresses neuroinflammatory response through the inhibition of I-κB degradation in LPS (HY-D1056)-stimulated BV-2 microglial cells .
Haplopine is a substance with anti-inflammatory, antioxidant and photoactivated antibacterial activities. It also acts as an inhibitor of UGT1A7 and a photoactivated restriction endonuclease inhibitor. Haplopine inhibits the mRNA/protein expression of IL-6, TSLP, GM-CSF, G-CSF, IL-4, IL-13 and COX-2, while upregulating the mRNA/protein expression of SOD, CAT and HO-1. Haplopine inhibits the glucuronidation reaction catalyzed by UGT1A7 through competitive hydrophobic binding. Haplopine exerts photoactivated restriction endonuclease inhibitory effects by binding to DNA. Haplopine exhibits photoactivated activity against methicillin-resistant Staphylococcus aureus. Haplopine alleviates symptoms of atopic dermatitis. Haplopine can be used in research related to atopic dermatitis and methicillin-resistant Staphylococcus aureus infections .
L-Isoleucine (Standard) is the analytical standard of L-Isoleucine. This product is intended for research and analytical applications. L-Isoleucine is an orally active branched chain amino acid, which is the L-enantiomer of isoleucine. L-Isoleucine has a role as a Saccharomyces cerevisiae metabolite, an Escherichia coli metabolite, a plant metabolite, a human metabolite, an algal metabolite and a mouse metabolite. L-Isoleucine regulates the inflammatory response to protect against pathogens in vivo and in vitro .
Aspergillusidone F is a Depsidone and antibacterial agent. Aspergillusidone F can be isolated from a marine fungus Aspergillus unguis. Aspergillusidone F potently inhibits Aromatase with an IC50 of 0.5 μM. Aspergillusidone F exhibits antibacterial activity against Pseudomonas aeruginosa and Methicillin (HY-121544)-resistant Staphylococcus aureus. Aspergillusidone F exhibits potent larvicidal activity against Artemia salina larvae, with an LC50 value of 12.8 μM. Aspergillusidone F exhibits anticancer activity against intrahepatic cholangiocarcinoma, non-small cell lung cancer, and acute lymphoblastic leukemia .
Petalostemumol G is a flavonol derivative present in Petalostemum purpureum. Petalostemum G has no antibacterial activity. Petalostemumol G is formed by air oxidation of petalostemumol .
Benzo-17R-RvD2 (Benzo-17R-Resolvin D2) is a benzo-containing analog of RvD2 (HY-121636). Benzo-17R-RvD2 enhances human macrophage efferocytosis, limits neutrophil infiltration, reduces TNF-α, and increases IL-1 receptor antagonist in peritonitis. Benzo-17R-RvD2 promotes E. coli killing by human leukocytes and reduces neutrophil swarm area without compromising anti-Candida activity. Benzo-17R-RvD2 activates the human-RvD2 receptor with an EC50 ∼1.5 nM. Benzo-17R-RvD2 can be used in research on inflammation-associated diseases such as cardiovascular disease, cancer, neuroinflammation, pain, and muscle regeneration .
Xylitol- 13C5 (Xylite- 13C5) is the 13C-labeled Xylitol (HY-N0538). Xylitol can be classified as a polyol and sugar alcohol, exhibiting inhibitory activity on cancer cell proliferation. It induces autophagy (Autophagy) and cell death in A549 cells by activating the autophagy signaling pathway, as evidenced by the increased expression of LC3-II and Atg5-Atg12 upon Xylitol treatment. Additionally, Xylitol inhibits acetaldehyde production by Candida species, thereby reducing their carcinogenic potential. In vivo, Xylitol induces alterations in the gut microbiota of mice, which may enhance cholesterol accumulation and upregulate hepatic ChREBP, while also slowing tumor growth in the B16F10 melanoma C57BL/6 mouse model .
Temporin-Sha is an antibacterial peptide with extensive biological activity. Temporin-Sha exhibits broad-spectrum antibacterial activity (e.g., against L. ivanovii, MIC = 6.25 μM), and is effective against Gram-negative bacteria (such as Escherichia coli, MIC = 10 μM), including drug-resistant strains (such as Methicillin (HY-121544)-resistant Staphylococcus aureus). Temporin-Sha also has inhibitory effects on Candidaalbicans (MIC = 25 μM), Saccharomyces cerevisiae (MIC = 12 μM), the pre-flagellated and non-flagellated forms of Leishmania infantum (IC50 = 5-20 μM), and Trypanosoma cruzi (IC50 = 17 μM). Temporin-Sha exhibits antiviral activity against HSV-1 and has anti-cancer effects (cytotoxicity against breast cancer cells MCF-7 and lung cancer cells H460, etc.) .
Glochidioboside, a neolignan glucoside found in Sambucus williamsii, is an antifungal agent. Glochidioboside induces membrane depolarization, membrane permeabilization, and pore formation on fungal membranes. Glochidioboside exerts an antifungal activity through a membrane-disruptive mechanism .
(S)-4-(3-Thienyl) phenyl-α-methylacetic acid is the S-enantiomer of the racemate corresponding to 4-(3-Thienyl) phenyl-α-methylacetic acid. As a key synthetic precursor, 4-(3-Thienyl) phenyl-α-methylacetic acid is used to prepare the cyclooxygenase inhibitor S-Atliprofen .
α-MSH (11-13) (ACTH-(11-13)) is a C-terminal tripeptide of α-MSH that can cross the blood-brain barrier. α-MSH (11-13) exhibits antipyretic, anti-inflammatory, and antibacterial activities. α-MSH (11-13) also exerts neuroprotective effects after traumatic brain injury by inhibiting excessive activation of microglia and reducing neuronal apoptosis. α-MSH (11-13) can be used in research related to traumatic brain injury, fever, and bacterial infections .
5-Bromo-5-nitro-1,3-dioxane is a broad-spectrum antimicrobial agent active against Gram-positive bacteria, Gram-negative bacteria and fungi. 5-Bromo-5-nitro-1,3-dioxane oxidizes free thiol groups to their corresponding disulfides. 5-Bromo-5-nitro-1,3-dioxane induces intracellular substance leakage in Escherichia coli and Staphylococcus aureus. 5-Bromo-5-nitro-1,3-dioxane modulates the oxygen consumption of Escherichia coli and Staphylococcus aureus .
6-Methoxydihydrosanguinarine is an alkaloid with activity across multiple cancer cell types. 6-Methoxydihydrosanguinarine activates IRE1/JNK signaling, blocks Akt/mTOR and PI3K/AKT/mTOR pathways, reduces expression of Cdc25C, CyclinB1, Cdc2, YAP/TAZ, Survivin, GPX4, and EGFR, upregulates IRE1 and DR5, and activates JNK and caspases. 6-Methoxydihydrosanguinarine induces apoptosis, G2/M phase arrest, DNA damage, ROS generation, lipid peroxidation, ferroptosis, autophagy, and suppresses cancer cell growth. 6-Methoxydihydrosanguinarine disruptes the biofilm formation of Candidaalbicans (C. albicans). 6-Methoxydihydrosanguinarine can be used for the research of non-small cell lung cancer, hepatocellular carcinoma, melanoma, colon carcinoma, ovarian cancer and breast cancer .
6-Methoxydihydrosanguinarine hydrochloride is an alkaloid with activity across multiple cancer cell types. 6-Methoxydihydrosanguinarine hydrochloride activates IRE1/JNK signaling, blocks Akt/mTOR and PI3K/AKT/mTOR pathways, reduces expression of Cdc25C, CyclinB1, Cdc2, YAP/TAZ, Survivin, GPX4, and EGFR, upregulates IRE1 and DR5, and activates JNK and caspases. 6-Methoxydihydrosanguinarine hydrochloride induces apoptosis, G2/M phase arrest, DNA damage, ROS generation, lipid peroxidation, ferroptosis, autophagy, and suppresses cancer cell growth. 6-Methoxydihydrosanguinarine hydrochloride disruptes the biofilm formation of Candidaalbicans (C. albicans). 6-Methoxydihydrosanguinarine hydrochloride can be used for the research of non-small cell lung cancer, hepatocellular carcinoma, melanoma, colon carcinoma, ovarian cancer and breast cancer .
N,N,N',N'-Tetrakis(2-hydroxyethyl)ethylenediamine (THEED; THEEN) is a tetrapodal pentadentate chelating ligand that functions as a chelator to form stable complexes with metal ions. N,N,N',N'-Tetrakis(2-hydroxyethyl)ethylenediamine serves as a versatile building block for organic synthesis, a reagent for metal extraction, and an auxiliary for catalytic reactions. N,N,N',N'-Tetrakis(2-hydroxyethyl)ethylenediamine-derived metal complexes exhibit antibacterial, antifungal, and anticancer activities. N,N,N',N'-Tetrakis(2-hydroxyethyl)ethylenediamine and its metal complexes can be used for research related to breast cancer, leukemia, various bacterial and fungal infections .
1,1,3-Tris (3-indolyl) butane is an indole alkaloid. It is isolated from North Sea bacteria closely related to Vibrio parahaemolyticus. 1,1,3-Tris (3-indolyl) butane shows no activity against a variety of bacteria and fungi .
Koninginin D is a potent antifungal agent that can be isolated from fungi including Trichoderma applanatum. Koninginin D inhibits growth of various fungal species including Gaeumannomyces graminis var. tritici, Bipolaris sorokiniana and so on. Koninginin D can be used for the research of fungal infection .
Nonoxynol-9 is a nonionic detergent. Nonoxynol-9 inhibits SOD activity. Nonoxynol-9 exhibits activity against diverse microbes and pathogens. Nonoxynol-9 can be used for the research of HIV infection .
Podocarpusflavone A is a biflavonoid present in the leaves of Podocarpus henkelii, with anti-tumor, topoisomerase I inhibitory, antibacterial and antifungal activities. Podocarpusflavone A exhibits antibacterial activity against Enterococcus faecalis and Pseudomonas aeruginosa. Podocarpusflavone A shows weak activity against fungal pathogens. Podocarpusflavone A targets topoisomerase I and induces cell cycle arrest and apoptosis in MCF-7 cells. Podocarpusflavone A can be used for studies on cancer, bacterial and fungal infections .
Geranyl isobutyrate is a synthetic α,β‑unsaturated branched‑chain aliphatic ester and a geraniol derivative. Geranyl isobutyrate acts as a food and feed flavouring agent and a biologically active antimicrobial compound. Geranyl isobutyrate shows antimicrobial activity against Gram‑positive and most Gram‑negative bacteria .
2-Cyanothioacetamide is an antimicrobial agent with activity against Gram-positive bacteria, Gram-negative bacteria, and fungi. 2-Cyanothioacetamide inhibits essential microbial enzymes and disrupts microbial cell membrane integrity.2-Cyanothioacetamide can be used for the research of bacterial infections and fungal infections .
HDAC/HSP90-IN-3 (compound J5) is a potent and selective fungal Hsp90 and HDAC dual inhibitor, with IC50 values of 0.83 and 0.91 μM, respectively. HDAC/HSP90-IN-3 shows antifungal activity against azole resistant C. albicans. HDAC/HSP90-IN-3 can suppress important virulence factors and down-regulate drug-resistant genes ERG11 and CDR1 .
Drimenal is a pimarane-type natural sesquiterpene with antifungal activity. Drimenal inhibits the growth of yeasts and dermatophytes. Drimenal can be used for the development of pesticide candidates and in research related to fungal infections .
KS 619-1 is a Ca 2+/calmodulin-dependent cyclic nucleotide phosphodiesterase inhibitor. KS 619-1 exhibits strong inhibitory activity against this enzyme derived from bovine brain and heart, but shows weak inhibitory effects on calmodulin-independent phosphodiesterase and protein kinase C. KS 619-1 displays weak antibacterial activity against Staphylococcus aureus .
Ac-CoA Synthase-IN-2 is an Ac-CoA Synthase (ACS) inhibitor and antifungal agent. Ac-CoA Synthase-IN-2 binds in the ATP/acetyl-AMP pocket of fungal and human ACS enzymes to exert competitive inhibition with ATP, and inhibits Cryptococcus neoformans CnKbc1-mediated acetoacetate-to-aceto-acetyl CoA conversion. Ac-CoA Synthase-IN-2 can be used for the research of fungal infections .
Cm-CATH2 is an antimicrobial peptide discovered from Chelonia mydas. Cm-CATH2 has a potent, broad-spectrum and rapid bactericidal ability by rapidly destroying the integrity of bacterial cell membranes. It shows strong activity against Gram-positive bacteria (such as VREF, Staphylococcus aureus), Gram-negative bacteria (such as Escherichia coli, Klebsiella pneumoniae), and fungi (such as Candidaalbicans) with MICs ranges from 1.17 to 18.75 μg/mL. Cm-CATH2 is also effective against various aquatic pathogenic bacteria. Cm-CATH2 not only inhibits biofilm formation but can also remove the formed biofilms. Cm-CATH2 has immunomodulatory functions and chemotactic effects on immune cells, and can inhibit the production of pro-inflammatory cytokines by macrophages stimulated by LPS (HY-D1056). Cm-CATH2 prevents the activation of NF-κB by inhibiting the degradation of IκBα, and also inhibits the phosphorylation of MAPK signaling pathways (p38, JNK, ERK). Cm-CATH2 demonstrates strong anti-infective ability in mouse peritonitis models and pneumonia models .
Demethoxyhexahydrocurcumin is a Curcumin (HY-N0005) biotransformation metabolite and diarylheptanoid with antioxidant and antimicrobial activities.Demethoxyhexahydrocurcumin scavenges free radicals, inhibits cancer cell viability, and suppresses microbial growth. Demethoxyhexahydrocurcumin can be used for the research of colorectal cancer .
Ternidazole hydrochloride is a nitroimidazole Antibiotic with anti-pathogenic microbial activity. Ternidazole hydrochloride kills and inhibits the visible growth of Clostridium perfringens type A in vitro. Ternidazole hydrochloride helps improve the therapeutic efficacy against bacterial vaginosis, candidal vaginitis and mixed vaginitis. Ternidazole hydrochloride effectively alleviates chronic alcoholism. Ternidazole hydrochloride can be used in research related to vaginitis, pathogenic microbial infections and chronic alcoholism .
α-MSH (11-13) (ACTH-(11-13)) acetate is a C-terminal tripeptide of α-MSH that can cross the blood-brain barrier. α-MSH (11-13) acetate exhibits antipyretic, anti-inflammatory, and antibacterial activities. α-MSH (11-13) acetate also exerts neuroprotective effects after traumatic brain injury by inhibiting excessive activation of microglia and reducing neuronal apoptosis. α-MSH (11-13) acetate can be used in research related to traumatic brain injury, fever, and bacterial infections .
Propyl dodecanoate (Propyl laurate) is a synthetic dodecanoic acid ester, exhibiting biting deterrent activity against Aedes aegypti mosquitoes. Propyl dodecanoate can be used for the research of mosquito-borne disease vectors (Aedes aegypti) .
5-(Pyridin-4-yl)-1,3,4-oxadiazole-2-thiol (Compound 3n) is an antimicrobial and antioxidant agent, that inhibits Escherichia coli and Staphylococcus epidermidis, with MIC of 8 and 4 μg/mL. 5-(Pyridin-4-yl)-1,3,4-oxadiazole-2-thiol exhibits antioxidant activity with IC50 of 17.47 μM using DPPH free radical-scavenging method .
Kipukasin B is an antibacterial agent. Kipukasin B exhibits activity against the Gram-positive strain Bacillus subtilis. Kipukasin B is isolated from Aspergillus versicolor obtained from Hawaii. Kipukasin B can be used in the research of Gram-positive bacterial infections .
Ambigol C is an ambigol, Antibacterial agent and Antimalarial agent. Ambigol C is isolated from Fischerella ambigua 108b. Ambigol C exhibits selective antibacterial activity against Gram-positive Staphylococcus aureus strains (including MRSA) with MIC values of 0.98-3.91 μg/mL. Ambigol C also shows potent antibacterial activity against B. megaterium, and possesses weak antimalarial and trypanocidal effects. Ambigol C can be used in the research of bacterial infections, plasmodial infections and trypanosomal infections .
ML267 free base is a blood-brain barrier permeable Antibacterial agent and bacterial phosphopantetheinyl transferase (PPTase) inhibitor, with an IC50 of 0.29 μM against Bacillus subtilis Sfp-PPTase and an IC50 of 8.1 μM against bacterial AcpS-PPTase. ML267 free base attenuates bacterial secondary metabolism, activity, and the production of Sfp-PPTase-dependent metabolites. ML267 free base inhibits the growth of Gram-positive bacteria, including Methicillin (HY-121544)-resistant Staphylococcus aureus. ML267 free base is applicable to research related to bacterial infections, including methicillin-resistant Staphylococcus aureus infections .
Vidarabine phosphate (ara-AMP; ara-A 5'-monophosphate) is a purine nucleoside antiviral agent and a prodrug of Vidarabine (HY-B0277). Vidarabine phosphate is rapidly converted into the antiviral active Vidarabine in vivo, which selectively inhibits viral DNA polymerase and cellular ribonucleotide reductase, thereby blocking viral replication. Vidarabine phosphate also exhibits antifungal activity, induces late-stage cellular apoptosis, and causes cell cycle arrest. Vidarabine phosphate can be used in research related to severe chronic active Epstein-Barr virus (EBV) infection, herpes infection, and candidiasis .
3-Hydroxyglabrol is an Antibacterial agent. 3-Hydroxyglabrol can be isolated from Glycyrrhiza glabra L. var. typica. 3-Hydroxyglabrol inhibits the growth of Staphylococcus aureus (ATCC 13709) and Mycobacterium smegmatis (ATCC 607), with a MIC of 6.25 mcg/mL. 3-Hydroxyglabrol can be used for the research of Staphylococcus aureus infection, Mycobacterium smegmatis infection .
Fosmanogepix TFA (APX001 TFA) is an orally active APX001A (HY-18233) prodrug and antifungal agent. Fosmanogepix TFA is effective against Cryptococcus neoformans, Fluconazole (HY-B0101)-resistant C. auris. Fosmanogepix TFA is effective in the treatment of invasive pulmonary aspergillosis and pulmonary murine mucormycosis .
RWJ-49815 is a histidine kinase inhibitor. RWJ-49815 inhibits the autokinase activity of purified GST-Sln1 and the autophosphorylation of KinA in vitro. RWJ-49815 acts as a fungal growth inhibitor . RWJ-49815 serves as a bactericide against Gram-positive pathogenic bacteria. RWJ-49815 is applicable to research related to fungal infections and Gram-positive bacterial infections .
TP-S1-68 (Compound 10) is a TIE-2 inhibitor with an IC50 of 3.65 μM. TP-S1-68 exhibits antibacterial activity against a variety of fungal and bacteria. TP-S1-68 serves as a starting compound for the further development of TIE-2 inhibitors. TP-S1-68 can be used in research related to solid tumors, bacterial infections and fungal infections .
Allitol (Allodulcitol) is an orally active rare sugar alcohol found in Itea virginica L, Tylopilus plumbeoviolaceus.Allitol has anti-obesity and hypoglycaemic activities. Allitol reduces carcass and total body fat mass, increases cecal weight, surface area, and short-chain fatty acid production, and upregulates cecal microbial enzymes linked to butyrate metabolism. Allitol can be used for the researches of obesity and diabetes .
Glucomoringin, a structurally unusual glucosinolate found in seeds of Moringa oleifera Lam., is an antimicrobial agent. Glucomoringin permits to maximize it's power when bioactivated with myrosinase. Glucomoringin can be used for the research of bacterial infections .
APX2039 is a brain-penetrant and orally active Gwt1 protein inhibitor. APX2039 inhibits an early step in fungal glycosylphosphatidylinositol anchor biosynthesis. APX2039 can be used for the research of cryptococcal meningitis and invasive mycosis caused by Talaromyces marneffei .
Glenthmycin E is an antibacterial agent found in Australian sheep pasture-derived Streptomyces sp. CMB-PB041. Glenthmycin E inhibits growth of multiple bacterial and exhibits no detectable cytotoxicity to eukaryotic cells including fungal and human carcinoma cells. Glenthmycin E can be used for the research of bacterial infections .
Neryl acetate is an essential oil component. Neryl acetate upregulates genes associated with epidermal differentiation, skin barrier formation and ceramide synthesis; it also increases filaggrin expression, total lipid and ceramide contents. Neryl acetate acts as the core driver mediating the skin barrier-forming and antibacterial effects of Helichrysum italicum essential oil .
Pithecolobine is a saponin-like alkaloid found in the bark, seeds, and leaves of Samanea saman. Pithecolobine can inhibit the growth of Gram-positive bacteria, Gram-negative bacteria, and pathogenic yeasts. Pithecolobine scavenges DPPH radicals. Pithecolobine can be used for the research of infections caused by pathogenic bacteria and yeasts .
1,2-Hexanediol (Hexane-1,2-diol) is a broad-spectrum antibacterial agent. 1,2-Hexanediol exhibits bactericidal activity against Gram-positive and Gram-negative bacteria, as well as antifungal activity against fungal organisms. 1,2-Hexanediol disrupts the cytoplasmic membrane potential of bacteria. 1,2-Hexanediol can be used in research on bacterial and fungal infections, as well as cosmetic preservation .
(-)-Codonopsine is an alkaloid with antibacterial activity. (-)-Codonopsine can be used in research related to Staphylococcus aureus and Escherichia coli infections .
Azure A eosinate is a dye for hematological and histological applications. Azure A eosinate can be used as new photosensitizer prototypes to determine growth inhibition of Candidaalbicans .
Chitin, from crab carapace (powder),biomedical research grade is a long-chain polymer of N-acetylglucosamine with β-(1-4) linkages. Chitin, from crab carapace (powder),biomedical research grade is found in the exoskeleton of crabs. Chitin, from crab carapace (powder),biomedical research grade inhibits the activation of NF-κB p65, alters the translocation of NF-κB p65 to the nucleus, and interacts with the cell wall of Candida species. Chitin, from crab carapace (powder),biomedical research grade exerts antifungal and anti-inflammatory effects. Chitin, from crab carapace (powder),biomedical research grade can be used in the research of gastric ulcer and candidiasis .
Chitin, from shrimp shells (chitinase substrate) serves as a substrate for chitinase. Chitin, from shrimp shells (chitinase substrate) is a long-chain polymer of N-acetylglucosamine with β-(1-4) linkages. Chitin, from shrimp shells (chitinase substrate) is found in the exoskeleton of crabs. Chitin, from shrimp shells (chitinase substrate) inhibits the activation of NF-κB p65, alters the translocation of NF-κB p65 to the nucleus, and interacts with the cell wall of Candida species. Chitin, from shrimp shells (chitinase substrate) exerts antifungal and anti-inflammatory effects. Chitin, from shrimp shells (chitinase substrate) can be used in the research of gastric ulcer and candidiasis .
(E,E)-Farnesol (trans,trans-Farnesol) is a quorum-sensing molecule of Candida species. (E,E)-Farnesol can inhibit the growth, metabolism and biofilm formation of various Candida species, and affect their morphology and invasiveness .
Chitin, from crab carapace is a long-chain polymer of N-acetylglucosamine with β-(1-4) linkages. Chitin, from crab carapace is found in the exoskeleton of crabs. Chitin, from crab carapace inhibits the activation of NF-κB p65, alters the translocation of NF-κB p65 to the nucleus, and interacts with the cell wall of Candida species. Chitin, from crab carapace exerts antifungal and anti-inflammatory effects. Chitin, from crab carapace can be used in the research of gastric ulcer and candidiasis .
Allyl α-D-galactopyranoside is an α-galactoside and acceptor/donor substrate for transgalactosylation reactions. Allyl α-D-galactopyranoside acts as an acceptor substrate in α-galactosidase-catalyzed transgalactosylation, and serves as a donor substrate to form longer α-galactosyl-containing oligosaccharides. Allyl α-D-galactopyranoside serves as a model compound for investigating the catalytic mechanism and substrate specificity of glycoside hydrolases and glycosyltransferases .
Chitin, from shrimp shells (powder) is a long-chain polymer of N-acetylglucosamine with β-(1-4) linkages. Chitin, from shrimp shells (powder) is found in the exoskeleton of crabs. Chitin, from shrimp shells (powder) inhibits the activation of NF-κB p65, alters the translocation of NF-κB p65 to the nucleus, and interacts with the cell wall of Candida species. Chitin, from shrimp shells (powder) exerts antifungal and anti-inflammatory effects. Chitin, from shrimp shells (powder) can be used in the research of gastric ulcer and candidiasis .
(E,E)-Farnesol (Standard) (trans,trans-Farnesol (Standard)) is the analytical standard of (E,E)-Farnesol (HY-Y0248). This product is intended for research and analytical applications. (E,E)-Farnesol (trans,trans-Farnesol) is a quorum-sensing molecule of Candida species. (E,E)-Farnesol can inhibit the growth, metabolism and biofilm formation of various Candida species, and affect their morphology and invasiveness .
Candidalysin is a cytolytic peptide toxin secreted by the fungus Candidaalbicans. Candidalysin drives epithelial immune responses by activating the EGFR-MAPK signaling pathway, inducing MMP expression and calcium influx, and regulating the c-Fos transcription factor and MKP1 via p38 MAPK and ERK1/2 respectively. Candidalysin is essential for mucosal and systemic infections, activating NLRP3 to promote inflammatory responses, neutrophil recruitment, and Th17 immunity. Candidalysin activates LDH causing membrane damage and exhibiting cytotoxicity
Cyclo(Arg-Pro) (Cyclo(Pro-Arg)) is an inhibitor for chitinase. Cyclo(Arg-Pro) inhibits cell separation of Saccharomyces cerevisiae, without affecting its growth. Cyclo(Arg-Pro) inhibits the morphological change of Candidaalbicans from yeast form to filamentous form .
Omiganan is a cationic antimicrobial peptide. Omiganan as an analogue of indolicidin shows activity against gram-positive and gram-negative bacteria but also Candida spp. isolates. Omiganan can be used for the research of alcohol nose and acne .
α-MSH (11-13) (ACTH-(11-13)) acetate is a C-terminal tripeptide of α-MSH that can cross the blood-brain barrier. α-MSH (11-13) acetate exhibits antipyretic, anti-inflammatory, and antibacterial activities. α-MSH (11-13) acetate also exerts neuroprotective effects after traumatic brain injury by inhibiting excessive activation of microglia and reducing neuronal apoptosis. α-MSH (11-13) acetate can be used in research related to traumatic brain injury, fever, and bacterial infections .
Cyclo(L-Trp-L-Trp) is an antibiotic, and shows antimicrobial activity. Cyclo(L-Trp-L-Trp) can inhibit A. baumannii, as well as Candidaalbicans, Bacillus subtilis, Micrococcus luteus, Saccharomyces cerevisiae, Aspergillus niger, Staphylococcus aureus. Cyclo(L-Trp-L-Trp) can be used in microbial infection research .
Temporin A is a short alpha-helical antimicrobial peptide isolated from the skin of the frog Rana temporaria. Temporin A is effective against a broad spectrum of Gram-positive bacteria. Temporin A interacts directly with the cell membrane of the microorganism and it is non-toxic to erythrocytes at concentrations that are antimicrobial. Temporin A also has antifungal activities (against yeast-like Candidaalbicans) .
Cyclo (Arg-Pro) TFA is a chitinase inhibitor. Cyclo (Arg-Pro) TFA disrupts cell separation and morphological transition of yeast by inhibiting chitinase activity. Cyclo (Arg-Pro) TFA prevents cell separation of Saccharomyces cerevisiae, leading to the formation of grape-like cell clusters, without inhibiting cell growth. Cyclo (Arg-Pro) TFA blocks the morphological transition of Candidaalbicans from yeast form to hyphal form, without inhibiting cell growth .
α-MSH (11-13) (ACTH-(11-13)) is a C-terminal tripeptide of α-MSH that can cross the blood-brain barrier. α-MSH (11-13) exhibits antipyretic, anti-inflammatory, and antibacterial activities. α-MSH (11-13) also exerts neuroprotective effects after traumatic brain injury by inhibiting excessive activation of microglia and reducing neuronal apoptosis. α-MSH (11-13) can be used in research related to traumatic brain injury, fever, and bacterial infections .
Cyclo(Pro-dArg) is an inhibitor of chitinase. Cyclo(Pro-dArg) inhibits the cell separation of Saccharomyces cerevisiae but does not affect its growth. Cyclo(Pro-dArg) inhibits the transition of Candidaalbicans from yeast to filamentous morphology.
D-Cateslytin is an antimicrobial peptide that exhibits potent inhibition activity against Candidaalbicans (MIC = 2.9 μM). D-Cateslytin can rapidly enter C. albicans, and shows no cytotoxicity to human gingival fibroblasts, and is stable in saliva. D-Cateslytin can be used for research on Candidaalbicans related diseases, such as oral candidosis .
Human β-defensin-2 (HβD-2) is a small cysteine-rich cationic skin-antimicrobial peptide (SAP) produced by a number of epithelial cells.Human β-defensin-2 has antimicrobial activity against gram-negative bacteria and Candida, but not gram-positive Staphylococcus aureus . Human β-defensin-2 can be used for the study of colitis .
Periplanetasin-4 is an antimicrobial peptide that can be derived from the American cockroach (Periplaneta americana). Periplanetasin-4 reduces cell rounding and apoptosis. Periplanetasin-4 blocks Clostridium difficile toxin A-induced ROS production and the activation of downstream p38 MAPK and p21. Periplanetasin-4 significantly increases mitochondrial calcium level, reduces DPH fluorescence intensity and vacuolar dysfunction in Candidaalbicans ATCC 90028 cells. Periplanetasin-4 significantly ameliorates toxin A-induced mucosal damage in the mouse gut. Periplanetasin-4 can be used for the study of colitis .
SP1 is an α-peptide encoded by the mating pheromone MFα1 gene in Candidaalbicans, which can induce cell growth arrest at the mating type locus MTLa in Candidaalbicans. SP1 can be used in the study of the prevention and treatment of Candidaalbicans infection .
AR-23 is a melittin-related antimicrobial peptide that can be isolated from Rana tagoi. AR-23 exhibits broad-spectrum growth inhibitory activity against aerobic bacteria, the opportunistic yeast pathogen Candidaalbicans and clinical isolates of Methicillin (HY-121544)-resistant Staphylococcus aureus (MRSA). AR-23 can be used for antimicrobial research .
Corticostatin, human (Human Neutrophil Peptide-4) TFA is an antimicrobial peptide with demonstrated antiviral activity. Corticostatin, human TFA can kill Escherichia coli, Streptococcus faecalis, and Candidaalbicans. Corticostatin, human (HNP-4) TFA is more bactericidal against Gram-negative bacteria than any of HNP-1-3. Corticostatin, human TFA can be isolated from the azurophil granule fraction of discontinuous Percoll gradients .
Temporin-Sha is an antibacterial peptide with extensive biological activity. Temporin-Sha exhibits broad-spectrum antibacterial activity (e.g., against L. ivanovii, MIC = 6.25 μM), and is effective against Gram-negative bacteria (such as Escherichia coli, MIC = 10 μM), including drug-resistant strains (such as Methicillin (HY-121544)-resistant Staphylococcus aureus). Temporin-Sha also has inhibitory effects on Candidaalbicans (MIC = 25 μM), Saccharomyces cerevisiae (MIC = 12 μM), the pre-flagellated and non-flagellated forms of Leishmania infantum (IC50 = 5-20 μM), and Trypanosoma cruzi (IC50 = 17 μM). Temporin-Sha exhibits antiviral activity against HSV-1 and has anti-cancer effects (cytotoxicity against breast cancer cells MCF-7 and lung cancer cells H460, etc.) .
Cysteine proteinase inhibitor peptide is a peptide that can be isolated form the culture media of Candidaalbicans with a molecular weight of 15 kDa and a PI of 4.9. Cysteine proteinase inhibitor peptide exhibits stability under both high temperature and a broad pH range .
GVLSNVIGYLKKLGTGALNAVLKQ is an antimicrobial peptide with 24-amino acid. GVLSNVIGYLKKLGTGALNAVLKQ can potentially form α-helix. GVLSNVIGYLKKLGTGALNAVLKQ (PGQ) has activity against Gram-negative, Gram-positive bacteria and the yeast Candidaalbicans .
Balteatide is an antimicrobial peptide, which can be found in skin secretion of Phyllomedusa baltea. Balteatide inhibits the gram-positive Staphylococcus aureus (MIC=435 μM), the gram-negative Escherichia coli (MIC=109 μM), and Candidaalbicans (MIC=27 μM). Balteatide lacks hemolytic activity (at 512 mg/L) and myotropic activity .
Pantinin-2 is a cysteine-free toxic peptide found in the emperor scorpion (paninus imperator). Pantinin-2 has high activity against Gram-positive bacteria but weak activity against Gram-negative bacteria. Pantinin-2 also exhibits activity against Candida tropicalis and has relatively mild hemolytic activity against human erythrocytes. Pantinin-2 can be used in the development of antimicrobial drugs for drug-resistant pathogens .
SP-B peptide is an antimicrobial peptide. SP-B peptide has antifungal activity against strains of Cryptococcus neoformans, Candidaalbicans and Aspergillus fumigatus
Bombinin H-BO1 is an antimicrobial peptide derived from toad Bombina orientalis skin secretions. Bombinin H-BO1 is active against Candidaalbicans, and the MIC value is 256 mg/L .
Micafungin metabolite M1 is an active metabolite of Micafungin (HY-17579), which is metabolized by arylsulfatase and exhibits antifungal activity. Micafungin metabolite M1 can be used for research on deep fungal infections caused by Candida and Aspergillus species .
Bombinin-BO1 is an antimicrobial peptide derived from toad Bombina orientalis skin secretions. Bombinin-BO1 is active against E. coli, S. aureus and Candidaalbicans, the MIC values are 64, 64, 128 mg/L, respectively .
Maximin H2 is an antimicrobial peptide derived from the skin secretions of Chinese red belly toad Bombina maxima. Maximin H2 has activity against Escherichia coli ATCC25922, Staphylococcus aureus ATCC2592, Bacillus pyocyaneus CMCCB1010 and Candidaalbicans ATCC2002, the MIC values are 20, 2, 4, 2 μg/ml, respectively .
Maximin H4 is an antimicrobial peptide derived from the skin secretions of Chinese red belly toad Bombina maxima. Maximin H4 has activity against Escherichia coli ATCC25922, Staphylococcus aureus ATCC2592, Bacillus pyocyaneus CMCCB1010 and Candidaalbicans ATCC2002, the MIC values are 12, 6, 12, 6 μg/ml, respectively .
Maximin H3 is an antimicrobial peptide derived from the skin secretions of Chinese red belly toad Bombina maxima. Maximin H3 has activity against Escherichia coli ATCC25922, Staphylococcus aureus ATCC2592, Bacillus pyocyaneus CMCCB1010 and Candidaalbicans ATCC2002, the MIC values are 20, 10, 20, 5 μg/ml, respectively .
Maximin H1 is an antimicrobial peptide derived from the skin secretions of Chinese red belly toad Bombina maxima. Maximin H1 has activity against Escherichia coli ATCC25922, Staphylococcus aureus ATCC2592, Bacillus pyocyaneus CMCCB1010 and Candidaalbicans ATCC2002, the MIC values are 9, 4.5, 9, 4.5 μg/ml, respectively .
NK-2 (Antibiotic NK 2), a shortened linear amphipathic NK-Lysin analog (comprising residues 39 to 65 of NK-lysin), is an antimicrobial peptide that exhibits potent activities against trypanosoma cruzi, Candidaalbicans, gram-positive and gram-negative bacteria. NK-2 can kill trypanosomes residing inside the human glioblastoma cell line 86HG39, left the host cells apparently unharmed .
L-Isoleucine (Standard) is the analytical standard of L-Isoleucine. This product is intended for research and analytical applications. L-Isoleucine is an orally active branched chain amino acid, which is the L-enantiomer of isoleucine. L-Isoleucine has a role as a Saccharomyces cerevisiae metabolite, an Escherichia coli metabolite, a plant metabolite, a human metabolite, an algal metabolite and a mouse metabolite. L-Isoleucine regulates the inflammatory response to protect against pathogens in vivo and in vitro .
Cm-CATH2 is an antimicrobial peptide discovered from Chelonia mydas. Cm-CATH2 has a potent, broad-spectrum and rapid bactericidal ability by rapidly destroying the integrity of bacterial cell membranes. It shows strong activity against Gram-positive bacteria (such as VREF, Staphylococcus aureus), Gram-negative bacteria (such as Escherichia coli, Klebsiella pneumoniae), and fungi (such as Candidaalbicans) with MICs ranges from 1.17 to 18.75 μg/mL. Cm-CATH2 is also effective against various aquatic pathogenic bacteria. Cm-CATH2 not only inhibits biofilm formation but can also remove the formed biofilms. Cm-CATH2 has immunomodulatory functions and chemotactic effects on immune cells, and can inhibit the production of pro-inflammatory cytokines by macrophages stimulated by LPS (HY-D1056). Cm-CATH2 prevents the activation of NF-κB by inhibiting the degradation of IκBα, and also inhibits the phosphorylation of MAPK signaling pathways (p38, JNK, ERK). Cm-CATH2 demonstrates strong anti-infective ability in mouse peritonitis models and pneumonia models .
Cyclo(Pro-dArg) acetate is a chitinase inhibitor. Cyclo(Pro-dArg) acetate inhibits the cell separation of Saccharomyces cerevisiae but does not affect its growth. Cyclo(Pro-dArg) acetate inhibits the transition of Candidaalbicans from yeast to filamentous morphology .
Myxinidin is an antimicrobial peptide. Myxinidin exhibits the ability to inhibit and eradicate biofilms formed by Pseudomonas aeruginosa and various Candida species. Myxinidin can be used for the study of infection .
Anti-Candida auris β-1,3-glucans Antibody (2G8) is an antibody targeting Candida auris β-1,3-glucans, and also acts as an inhibitor of AChE and TGF-β receptor 2. Anti-Candida auris β-1,3-glucans Antibody (2G8) also targets fungal cell wall components, effectively inhibits fungal growth and interferes with capsule formation, thereby significantly reducing the fungal load in mouse tissues. Anti-Candida auris β-1,3-glucans Antibody (2G8) not only blocks TGF-β receptor binding to inhibit the Smad signaling pathway, reduces fibroblast activation and collagen deposition, but also induces epithelial differentiation of tumor cells and reduces pancreatic tumor metastasis. Anti-Candida auris β-1,3-glucans Antibody (2G8) specifically binds to the conserved N-linked glycoepitope on AChE to inhibit its activity without interfering with BChE, and can be used in studies of cryptococcosis and related tumor mechanisms .The isotype control is Human IgG1 kappa, Isotype Control (HY-P99001).
(+)-Medioresinol is a furofuran-type lignan with antifungal and antibacterial properties. (+)-Medioresinol synergizes with antibiotics to exert antimicrobial and antibiofilm effects. (+)-Medioresinol induces intracellular ROS accumulation and mitochondrial-mediated apoptosis in Candidaalbicans. (+)-Medioresinol inhibits LPS (HY-D1056)-stimulated IL-12p40 production. (+)-Medioresinol is a PGC-1α activator that protects against endothelial cell pyroptosis in ischemic stroke via the PPARα-GOT1 axis. (+)-Medioresinol can be used in research on fungal and bacterial infection, inflammation, and ischemic stroke .
1-Monomyristin acts as an insecticide, enzyme inhibitor, antibacterial and antifungal agent, with an IC50 of 18 μM against rat FAAH and an IC50 of 32 μM against rat MAGL. 1-Monomyristin inhibits 2-oleoylglycerol hydrolysis via MAGL. 1-Monomyristin suppresses the growth of Staphylococcus aureus, Aggregatibacter actinomycetemcomitans and Candidaalbicans. 1-Monomyristin is lethal to brine shrimp . 1-Monomyristin exhibits marginal cytotoxicity against prostate cancer cells. 1-Monomyristin is applicable to research related to bacterial infections, fungal infections, renal cancer, prostate adenocarcinoma and pancreatic cancer .
Eleutherol is a naphthalene isolated from E. americana with antifungal activities . Eleutherol is against yeasts Candidaalbicans, C. tropicalis, Saccharomyces cerevisiae and Cryptococcus neoformans with MIC values between 7.8 µg/mL and 250 µg/mL . Eleutherol inhibits α-glucosidase function with an IC50>1.00 mM .
Casuarinin is an orally active antiproliferative, anti-inflammatory, antifungal, virucidal and gastroprotective agent. Casuarinin upregulates the expression of p21/WAF1, Fas/APO‑1, mFasL, sFasL and HSP‑70, arrests cell cycle, induces apoptosis and inhibits cancer cell proliferation. Casuarinin inhibits TNF‑α-induced phosphorylation of MAPK and activation of NF‑κB, downregulates the expression of iNOS, NF‑κB, COX‑2 and ICAM‑1, and reduces the production of proinflammatory mediators. Casuarinin attenuates ethanol-induced activation of caspase‑3 and elevation of TNF‑α, inhibits the growth of Candidaalbicans, and inhibits HSV‑2. Casuarinin can be used in research related to mammary adenocarcinoma, inflammatory skin diseases, gastric ulcers, candidiasis and herpes simplex virus infections .
Zingibroside R1 is an orally active triterpene saponin with multiple biological activities including antioxidant, anti-inflammatory, antiviral, and metabolic regulatory properties. Zingibroside R1 reduces the expression of PIN family members, inhibits the expression of PLT1/PLT2, WOX5, SHR, and SCR, disrupts auxin transport and distribution, triggers plant ROS responses, and inhibits root growth. Zingibroside R1 extends the lifespan of Caenorhabditis elegans, enhances its heat stress resistance, and improves its motor ability. Hydrogel derivatives of Zingibroside R1 inhibit the proliferation of Candidaalbicans by binding to its β-1,3-glucan and exhibit antifungal activity. Zingibroside R1 inhibits GLUT1-mediated uptake and alleviates liver injury. Zingibroside R1 can be used in research related to neurodegenerative diseases, vulvovaginal candidiasis, acute liver injury, Ehrlich ascites tumor and HIV-1 infection .
Fluconazole (Standard) is the analytical standard of Fluconazole. This product is intended for research and analytical applications. Fluconazole (UK-49858) is a triazole antifungal agent with excellent activities against a broad range of fungi, especially against Candidaalbicans. Fluconazole inhibits C. albicans and Candida kefyr with IC99s range from 0.20 μg/mL to 0.39 μg/mL .
Goniothalamin (GTN) is a styryl lactone. Goniothalamin exhibits insecticidal, anti-tumor and antibacterial activities. Goniothalamin induces cell cycle arrest and apoptosis in tumor cells. Goniothalamin acts as a larvicide against Culex quinquefasciatus larvae and as a cytotoxin against brine shrimp larvae. Goniothalamin functions as an antibacterial agent against Gram-positive and Gram-negative bacteria, and also acts as an antifungal agent against pathogens including Candidaalbicans, Trichophyton rubrum and Trichophyton mentagrophytes. Goniothalamin is applicable to research related to breast cancer, lymphatic filariasis, bacterial infections and fungal infections .
Geraniol (Standard) is the analytical standard of Geraniol. This product is intended for research and analytical applications. Geraniol, an olefinic terpene, was found to inhibit growth of Candidaalbicans and Saccharomyces cerevisiae strains .
Fenchyl alcohol is a monoterpene alcohol that can be used as a fragrance. Fenchyl alcohol has antifungal activity and can inhibit the formation of biofilms and hyphae of Candidaalbicans. Fenchyl alcohol also has a strong inhibitory effect on the rumen microbial activity of sheep and deer .
Verrucarin J (Muconomycin B) is a metabolite of the Myrothecium fungus family. Verrucarin J generates reactive oxygen species (ROS) and induces apoptosis of cancer cell lines, such as A549, HCT 116 and SW-620 cells. Verrucarin J shows activities against Candidaalbicans and Mucor miehei. Verrucarin J inhibits arenavirus Junin (JUNV) yield with an IC50 of 1.2 ng/mL .
Farnesol (Standard) is the analytical standard of Farnesol. This product is intended for research and analytical applications. Farnesol is a sesquiterpene alcohol that modulates cell-to-cell communication in Candidaalbicans, and has the activity in inhibiting bacteria.
Kanosamine (3-Amino-3-deoxyglucose) is an antibiotic against Saccharomyces cerevisiae and human pathogenic fungi Candidaalbicans. Kanosamine exhibits antifungal activity through inhibition of cell wall synthesis and inhibition of GlcN-6-P synthase with phosphorylated kanosamine-6-phosphate in cytoplasma .
Prolylrapamycin (21-Norrapamycin) is the derivative of Rapamycin (HY-10219). Prolylrapamycin exhibits antifungal activity, that inhibits Candidaalbicans, Saccharomyces cerevisiae, and Fusarium oxysporum with MIC of 0.125-2 μg/mL .
(-)-Dicentrine is an aporphine alkaloid that can be isolated from the stem bark of Talauma arcabucoana. (-)-Dicentrine shows moderate growth inhibition against Staphylococcus aureus and
Candidaalbicans .
Filiformin ((-)-Filiformin) is a sesquiterpene compound that can be isolated from Laurencia filiformis forma heteroclada. Filiformin exhibits certain cytotoxicity against P388 and BSC-1 cells. Filiformin has antimicrobial activity against Bacillus subtilis, Trichophyton mentagrophytes and Candidaalbicans. In addition, Filiformin can inhibit oxygen uptake in isolated rat liver mitochondria at a concentration of 150 μM .
27-O-Demethylrapamycin, a Rapamycin (HY-10219) derivative, is an antifungal agent. 27-O-Demethylrapamycin inhibits Candidaalbicans, Saccharomyces cerevisiae, and Fusarium oxysporum .
Chloramultilide B is a lindenane dimer that can be isolated from Chloranthus serratus. Chloramultilide B has inhibitory activities against Candidaalbicans and C.parapsilosis with a MIC value of 0.068 μM .
Mutanocyclin is a potent antifungal agent. Mutanocyclin inhibits Candidaalbicans (C. albicans) filamentation. Mutanocyclin decreases the mRNA expression of HWP1, ECE1, FLO8, TEC1. Mutanocyclin inhibits yeast-form in ex vivo mouse .
Leucinostatin A (Antibiotic P168) is a nonapeptide exerting a remarkable activity especially against Candidaalbicans and Cryptococcus neoformans. Leucinostatin A is a hydrophobic nonapeptide antibiotic. Leucinostatin A inhibits prostate cancer growth through reduction of insulin-like growth factor-I expression in prostate stromal cells. Antiprotozoal activies .
Nidulin (Methylustin) is a depsidone isolated from a marine fungus Aspergillus unguis. Nidulin shows antifungal and antibacterial against pathogenetic strains, Pseudomonas aeruginosa, Methicillin-resistant Staphylococcus aureus and Candidaalbicans with inhibition zones of 9.5 mm, 9.0 mm and 9.0 mm, respectively. Nidulin exhibits potent larvicidality against brine shrimp .
Sporminarin B is an antibacterial and antifungal agent. Sporminarin B exhibits inhibitory activity against microorganisms such as Candidaalbicans and Staphylococcus aureus .
Cleroindicin F ((-)-Rengyolone), a cleroindicin, is an antimicrobial agent. Cleroindicin F shows relatively high anticandidal activity against Candida strains with a MIC value down to 12.5 µg/mL .
Clavariopsin A is a cyclic depsipeptide antibiotic. Clavariopsin A shows antifungal activity for Candidaalbicans IFO 0583, Candidaalbicans ATCC 10231, Aspergillus niger AJ117374, Aspergillus fumigatus AJ117190, Aspergillus fumigatus JCM1739 with MIC values of 8, 8, 16, 2, 4 μg/mL, respectively .
Clavariopsin B is a cyclic depsipeptide antibiotic. Clavariopsin B shows antifungal activity for Candidaalbicans IFO 0583, Candidaalbicans ATCC 10231, Aspergillus niger AJ117374, Aspergillus fumigatus AJ117190, Aspergillus fumigatus JCM1739 with MIC values of 8, 8, 16, 4, 4 μg/mL, respectively .
Nikkomycin Lx is an antibiotic that can be extracted from Streptomyces tendae TU901. Nikkomycin Lx exhibits anti-CandidaAlbicans activity and can be utilized in relevant research .
Nikkomycin Lz is a nucleoside peptide antifungal compound isolated from genetically engineered Streptomyces tendae TU901. Nikkomycin Lz has antifungal activity against Candidaalbicans .
Filipin II is an antibiotic, which exhibits antifungal efficacy. Filipin II interacts with membrane sterols, leads to changes in membrane structure, inhibits Candida utilis and Saccharomyces cerevisiae with the MIC of 0.03 mg/L and 0.2 μg/L .
17-Hydroxyventuricidin A (YP-02259L-C) is an antimicrobial compound.17-Hydroxyventuricidin A inhibits the growth of the two tested filamentous fungi (Verticillium dahlia and Fusarium sp.) and of Candida tropicalis R2 CIP203 .
Neodidymelliosides A (compound 1)It is a secondary metabolite of fungi and has a significant inhibitory effect on Staphylococcus aureus and Candidaalbicans biofilms. Neodidymelliosides AIt also has anti-cancer activity and can inhibit KB3.1 (cervix),PC-3 (prostate),MCF-7(breast),SKOV-3 (ovary),A431 (skin )and A549 (lung )Cell viability of cell lines .
8-Acetylverrucarin L (Verrucarin L acetate) is a mycotoxin, which exhibits antitumor and antimicrobial activities. 8-Acetylverrucarin L exhibits cytotoxicity to cancer cells HCT116 and A2780S, with IC100 of 9.77 and 9.77 ng/mL. 8-Acetylverrucarin L exhibits antifungal activity against Saccharomyces cerevisiae, Candidaalbicans and Geotrichum candidum .
Burnettramic acid A is an antibiotic, which can be isolated from Aspergillus burnettii. Burnettramic acid A exhibits antibacterial and antifungal activities, with IC50 of 0.2, 0.5, 2.3 and 5.9 μg/mL, for Saccharomyces cerevisiae, Candidaalbicans, Bacillus subtilis and Staphylococcus aureus, respectively. Burnettramic acid A exhibits cytotoxicity in cancer cell NS-1 with IC50 of 13.8 μg/mL .
Penicolinate B is a picolinic acid derivative that can be isolated from Penicillium sp. Penicolinate B exhibits antimalarial activity (IC50: 1.40 μg/mL), antitubercular activity (MIC: 25.0 μg/mL), activity against Bacillus cereus (IC50: 25.0 μg/mL), and activity against Candidaalbicans (IC50: 1.45 μg/mL). Penicolinate B also has certain cytotoxicity against cancer cells such as MCF-7, KB, and NCI-H187. Penicolinate B can be used in research on malaria, tuberculosis, bacterial/fungal infections and tumors .
Glidobactin A is an acyl peptide antibiotic. Glidobactin A has activity against Candida, Aspergillus fumigatus and Trichophyton, but it is not effective against Candidaalbicans M-9 infection in mice .
Arborcandin A is a 1,3-β-glucan synthase inhibitor that serves as an antifungal antibiotic. Arborcandin A exhibits IC50 values of 0.25 μg/mL and 0.05 μg/mL against Candidaalbicans and Aspergillus fumigatus, respectively. Additionally, Arborcandin A has an MIC of 4-8 μg/mL against the genus Candida .
Arborcandin F is a 1,3-β-glucan synthase inhibitor that serves as an antifungal antibiotic. Arborcandin F exhibits IC50 values of 0.012 μg/mL against both Candidaalbicans and Aspergillus fumigatus. Additionally, Arborcandin F has an MIC of 2-4 μg/mL against the genus Candida .
Arborcandin D is a 1,3-β-glucan synthase inhibitor that serves as an antifungal antibiotic. Arborcandin D exhibits IC50 values of 3 μg/mL and 0.35 μg/mL against Candidaalbicans and Aspergillus fumigatus, respectively. Additionally, Arborcandin D has an MIC of 4 μg/mL against the genus Candida .
Arborcandin C is a 1,3-β-glucan synthase inhibitor that serves as an antifungal antibiotic. Arborcandin C exhibits IC50 values of 0.15 μg/mL and 0.015 μg/mL against Candidaalbicans and Aspergillus fumigatus, respectively. Additionally, Arborcandin C has an MIC of 1-2 μg/mL against the genus Candida .
Arborcandin B is a 1,3-β-glucan synthase inhibitor that serves as an antifungal antibiotic. Arborcandin B exhibits IC50 values of 0.30 μg/mL and 0.025 μg/mL against Candidaalbicans and Aspergillus fumigatus, respectively. Additionally, Arborcandin B has an MIC of 2-4 μg/mL against the genus Candida .
Arborcandin E is a 1,3-β-glucan synthase inhibitor that serves as an antifungal antibiotic. Arborcandin E exhibits IC50 values of 0.1 μg/mL and 0.012 μg/mL against Candidaalbicans and Aspergillus fumigatus, respectively. Additionally, Arborcandin E has an MIC of 0.5-2 μg/mL against the genus Candida .
Tetramethylkaempferol is an antifungal agent. Tetramethylkaempferol shows antifungal activity against Candida albicansCandida albicans with an IC50 value of 17.63 µg/mL .
Dactylfungin B (MK 2266 B) is an antifungal antibiotic that is active against Candida pseudotropicalis and other fungi, with an MIC value at <10 μg/mL .
Ochracenomicin A has a strong effect against Gram-positive bacteria (including MRSA strain), and also against Gram-negative bacteria and candidaalbicans .
Bagremycin A is found in the strain of Streptomyce sp. Tu 4128. Bagremycin A has weak activity against Gram-positive bacteria, Saccharomyces cerevisiae and Candidaalbicans .
Glucoallosamidin A is a glycoside antibiotic that can inhibit Chitinase activity. Glucoallosamidin A can inhibit Candidaalbicans ATCC 10231 chitinase with an IC50 of 3.4 μg/mL .
Methylxanthoxylin is a ketone that can be isolated from the leaves and bark of Acradenia Jianklinii . Methylxanthoxylin exhibited moderate antifungal activity against Candidaalbicans and Penicillium expansum .
Epelmycin A has anti-Gram positive, negative bacteria and candidaalbicans activity, and has anti-leukemic L1210 activity, which is stronger than Aclacinomycin .
Epelmycin C has anti-Gram positive, negative bacteria and candidaalbicans activity, and has anti-leukemic L1210 activity, which is stronger than Aclacinomycin .
Epelmycin D has anti-Gram positive, negative bacteria and candidaalbicans activity, and has anti-leukemic L1210 activity, which is stronger than Aclacinomycin .
Chondramide A has anti-candida, Henson yeast, lipids yeast, ball-like yeast and other fungal activities, but has no anti-Gram positive and negative bacteria activities .
Bagremycin B is found in the strain of Streptomyce sp. Tu 4128. Bagremycin B has weak activity against Gram-positive bacteria, Saccharomyces cerevisiae and Candidaalbicans .
Epelmycin E has anti-Gram positive, negative bacteria and candidaalbicans activity, and has anti-leukemic L1210 activity, which is stronger than Aclacinomycin .
Chondramide C has anti-candida, Henson yeast, lipids yeast, ball-like yeast and other fungal activities, but has no anti-Gram positive and negative bacteria activities .
Chondramide B has anti-candida, Henson yeast, lipids yeast, ball-like yeast and other fungal activities, but has no anti-Gram positive and negative bacteria activities .
Peptaibolin has anti-Gram-positive bacteria and yeast activity, but the antibacterial activity is weak. Peptaibolin inhibits Subtilis ATCC 6633 and candidaalbicans with MICs (μg/mL) of 100, 100, respectively .
Clavamycin A has strong anti-candida activity, and its action can be antagonized by dipeptide or tripeptide, but amino acid can not cancel its action. No antibacterial activity and no inhibition of β-lactamase .
Clavamycin D has strong anti-candida activity, and its action can be antagonized by dipeptide or tripeptide, but amino acid can not cancel its action. No antibacterial activity and no inhibition of β-lactamase .
Clavamycin C has strong anti-candida activity, and its action can be antagonized by dipeptide or tripeptide, but amino acid can not cancel its action. No antibacterial activity and no inhibition of β-lactamase .
Purpuride is a sesquiterpene ester found in aciduric fungi. Purpuride shows moderate antibacterial activities against Candidaalbicans, Enterobacter aerogenes and Pseudomonas aeruginosa with MIC values ranging from 1.2 to 3.3 μM .
Ys-II (Compound 1) is a spirostanol glycoside that can be isolated from the stem of Yucca elephantipe. Ys-II has antifungal activity against the growth of Candidaalbicans and Cryptococcus neoformans (IC50: 5 and 6 μg/mL respectively) .
Epicorazine A has activity against Gram-positive bacteria, including methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin resistant enterococcus (VRE), MICs of 12.5-25 μg/mL. Epicorazine A also has effect on Candidaalbicans with a MIC of 25 μg/mL .
Pneumocandin A1 is a lipopeptide antibiotic. Pneumocandin A1 has a strong anti-Candida effect. Pneumocandin A1 has the effect of inhibiting the synthesis of 1,3 early-glucan in vitro, with an IC50 of 0.07-0.5 μg/mL .
Pneumocandin A3 is a lipopeptide antibiotic. Pneumocandin A3 has a strong anti-Candida effect. Pneumocandin A3 has the effect of inhibiting the synthesis of 1,3 early-glucan in vitro, with an IC50 of 0.07-0.5 μg/mL .
Pneumocandin A4 is a lipopeptide antibiotic. Pneumocandin A4 has a strong anti-Candida effect. Pneumocandin A4 has the effect of inhibiting the synthesis of 1,3 early-glucan in vitro, with an IC50 of 0.07-0.5 μg/mL .
Pneumocandin B2 is a lipopeptide antibiotic. Pneumocandin B2 has a strong anti-Candida effect. Pneumocandin B2 has the effect of inhibiting the synthesis of 1,3 early-glucan in vitro, with an IC50 of 0.07-0.5 μg/mL .
Pneumocandin A2 is a lipopeptide antibiotic. Pneumocandin A2 has a strong anti-Candida effect. Pneumocandin A2 has the effect of inhibiting the synthesis of 1,3 early-glucan in vitro, with an IC50 of 0.07-0.5 μg/mL .
Bullatenone is a volatile bioactive compound that can be found in Lophomyrtus bullata. It has insect - repellent, anti - ulcer, anti - UV, and antifungal activities. Bullatenone can inhibit the growth of fungi such as Candidaalbicans and Cladosporium resinae. Bullatenone can be used in the research of diseases such as inflammation and infections .
Fenchyl alcohol is a monoterpene alcohol that can be used as a fragrance. Fenchyl alcohol has antifungal activity and can inhibit the formation of biofilms and hyphae of Candidaalbicans. Fenchyl alcohol also has a strong inhibitory effect on the rumen microbial activity of sheep and deer .
Linearmycin B is an antibacterial and antifungal agent. Linearmycin B shows activity against Bacillus subtilis (Bs), Staphylococcus aureus (Sa). Candidaalbicans (Ca), and Saccharomyces cerevisiae (Sc), with MIC values of 0.097, 1.5, 0.0008, and 0.0002 μg/mL, respectively .
Heptaibin is a peptaibol antifungal antibiotic. Heptaibin has the activity against Gram-positive bacteria (MIC is 8 μg/mL) such as Staphylococcus aureus and fungi (MIC is 13-32 μg/mL) such as Aspergillus, Candidaalbicans and cryptococcus neofordii, and it has moderate anti-Rhabditella pseudoelongata activity (MIC is 50 μg/mL) .
Glidobactin C (GlbC) is an anti-tumor antibiotic. Glidobactin C (GlbC) has the activity against pathogenic fungi and yeast. Glidobactin C has anti-Candidaalbicans and Aspergillus fumigatus activity with a MIC of 0.8 μg/mL. Glidobactin C also extends the survival of mice inoculated with leukemia P388 cells .
Ducloudine C is an alkaloid present in the roots of Aconitum duclouxii with antifungal activity. Ducloudine C has an MIC of 128 μg/mL against Candidaalbicans .
5,6,7,8-Tetramethoxyflavone is a flavonoid with antifungal and antibacterial activities, capable of inhibiting the growth of *Staphylococcus aureus* and *Candidaalbicans*. 5,6,7,8-Tetramethoxyflavone can be utilized in research related to infections [1].
Tunicamycin X (Tunicamycin 17:1) is a nucleoside Antibiotic. Tunicamycin X is isolated from Streptomyces xinghaiensis SCSIO S15077. Tunicamycin X acts as a growth inhibitor against bacteria and fungi. Tunicamycin X inhibits the growth of Bacillus thuringiensis strains. Tunicamycin X inhibits the growth of Candidaalbicans strains .
Vincadifformine N (4)-oxide is a monoterpenoid indole alkaloid. Vincadifformine N (4)-oxide can be isolated from Rhazya stricta. Vincadifformine N (4)-oxide shows a MIC > 50 μg/mL against tested Candida strains and exhibits no antifungal activity .
Tunicamycin B is a Tunicamycin (HY-A0098) derivative with antimicrobial activity. Tunicamycin B shows antibacterial activity against Bacillus thuringiensis BT01 and B. thuringiensis W102 (MICs of 0.125 and 0.063 μg/mL, respectively) and antifungal activity against Candidaalbicans ATCC 96901 and C. albicans CMCC (F) 98001 (MICs of 8.0 and 4.0 μg/mL, respectively). Tunicamycin B can be used for antimicrobial research .
Citronellyl butyrate is a terpenoid ester with antibacterial, antifungal and other biological activities. Citronellyl butyrate has inhibitory effects on both Staphylococcus aureus and Escherichia coli. Citronellyl butyrate has inhibitory and bactericidal effects on various strains of Candidaalbicans (MIC: 156-1250 μg/mL). Citronellyl butyrate can be used in the research of infectious conditions .
trans-β-Bergamotene is a sesquiterpene hydrocarbon and antifungal agent found in the essential oil of Bixa orellana L. leaves. trans-β-Bergamotene possesses antiungal and anti-inflammatory properties. trans-β-Bergamotene can be used for the research of Candidaalbicans infection .
Dihydroavicine is a benzophenanthridine alkaloid antibacterial agent isolated from the stem bark of Zanthoxylum rhoifolium. Dihydroavicine inhibits the growth of Gram-positive bacteria, Gram-negative bacteria, and Candidaalbicans. Dihydroavicine shows no activity against Saccharomyces cerevisiae and Cryptococcus neoformans. Dihydroavicine can be used for the research of bacterial infections and candidal infections .
Diorcinol D is a natural product with antifungal activity. Diorcinol D inhibits CYP51 expression, reduces Cdr1 expression, blocks efflux pump activity, and impedes ergosterol biosynthesis. It inhibits planktonic and biofilm growth of Candidaalbicans. Diorcinol D is applicable to research related to fungal infections .
(E,Z)-Platanoside is a flavonoid glycoside. (E,Z)-Platanoside is a potent and highly selective MRSA inhibitor; it exhibits low activity against other tested strains, including Gram-negative bacteria, intracellular Mycobacterium intracellulare, Candidaalbicans, Cryptococcus neoformans, and Aspergillus fumigatus. (E,Z)-Platanoside can be used in research on MRSA infections .
Puupehenone is a cytotoxic and antifungal agent present in various marine sponge species. Puupehenone exerts cytotoxic activity against leukemia, lung cancer, colon cancer and breast cancer cells, and inhibits the growth of Candidaalbicans. Puupehenone can be used in research related to cancers such as leukemia, lung cancer, colon cancer and breast cancer .
(-)-γ-Cuparenol is a sesquiterpene compound with an IC50 of 23.6 μg/mL against porcine Na +/K +-ATPase. (-)-γ-Cuparenol reduces phytohemagglutinin (PHA)-induced activation of NF-AT and NF-κB in Jurkat cells. (-)-γ-Cuparenol inhibits the growth of Gram-positive bacteria and some Gram-negative bacteria. (-)-γ-Cuparenol exhibits weak inhibitory activity against Candidaalbicans. (-)-γ-Cuparenol is applicable for research related to immunoregulation, cardiovascular diseases and bacterial infections .
2-Deethoxy-2-hydroxyphantomolin, Germacranolide, is an Antifungal and Antibacterial agent. 2-Deethoxy-2-hydroxyphantomolin can be isolated from Elephantopus tomentosus Linn and E. mollis. 2-Deethoxy-2-hydroxyphantomolin is moderately active againstCandidaalbicans (14 mm clearing zone) and slightly active against Escherichia coli (12 mm), Pseudomonas aeruginosa (12 mm), Bacillus subtilis (14 mm), and Trichophyton mentagrophytes (13 mm) .
Crotocin has the fungal activity of anti-cryptococcus neoforme, candidaalbicans, Tinea trichoderma of brewer's yeast, and can be inactivated by blood .
2-Hydroxyhexacosanoic acid is a hydroxylated fatty acid. 2-Hydroxyhexacosanoic acid can be obtained from C26 acids by the 2-hydroxylase of Candida utilis .
Chondramide D has anti-candida, Henson yeast, lipids yeast, ball-like yeast and other fungal activities, but has no anti-Gram positive and negative bacteria activities .
Clavamycin B has strong anti-candida activity, and its action can be antagonized by dipeptide or tripeptide, but amino acid can not cancel its action. No antibacterial activity and no inhibition of β-lactamase .
Sargentodoside D is a phenolic glycoside. Sargentodoside D occurs in the stems of Sargentodoxa cuneata. Sargentodoside D is applicable to research on infections caused by Acinetobacter baumannii, Candidaalbicans and Staphylococcus aureus, as well as research on cervical cancer .
Cyclopent-4-ene-1,3-dione is a potent antifungal inhibitor of chitin synthesis. Cyclopent-4-ene-1,3-dione is potently antifungal against human pathogenic Candida species (IC50 = 1-2 μM). Cyclopent-4-ene-1,3-dione is detected in feijoa cultivars with high antifungal bioactivity. Cyclopent-4-ene-1,3-dione can be used for the research of fungal infections .
Epicorazine B has activity against Gram-positive bacteria, including methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin resistant enterococcus (VRE), MICs of 12.5-25 μg/mL. Epicorazine B also has effect on Candidaalbicans with a MIC of 25 μg/mL .
9-Hydroxyoudemansin A is an antibiotic. 9-Hydroxyoudemansin A has antifungal activity, has an MIC of 12.5 μg/mL against ochre-like yeast, and is resistant to fungi such as Candidaalbicans, Crimson Yeast, Penicillium and Streptomyces with MICs are all> 50 μg/mL. No anti-bacterial effect .
Sporminarin A (Compound 1), a polyketide, is a microbial secondary metabolite. Sporminarin A can be isolated from the Sporormiella minimoides. Sporminarin A has significant antifungal activity against Aspergillus flavus with an MIC50 of 25 μg/mL. Sporminarin A also has antibacterial activity against Staphylococcus aureus (ATCC 29213) and Candidaalbicans (ATCC 14053) .
Tylophorinicine is an anti-leukemic and anti-fungal agent. Tylophorinicine exhibits minimum inhibitory concentrations (MIC) in the range of 2-4 mg/mL for TdnH and 0.6-2.5 mg/mL for TnnH against Candida species. Tylophorinicine is a phenanthroindolizidine alkaloid from tylophora asthamatica and pergulatia pallid. Tylophorinicine inhibits thymidylate synthase by pergularinine .
Bromoflavone (CJ-19784) is a flavone that can be isolated from Aspergillus candidus. Bromoflavone shows anti-Mtb activity with an MIC90 value of 1.2 μM. Bromoflavone is also an antifungal agent. Bromoflavone inhibits the growth of pathogenic fungi, Candidaalbicans, Cryptococcus neoformans and Aspergillus fumigatus with IC50 values of 0.11, 20 and 0.54 μg/mL, respectively. .
Ombuoside has antioxidant properties, inhibiting ROS production and apoptosis. Ombuoside exerts neuroprotective effects through the ERK-JNK-caspase-3 system. Ombuoside promotes Dopamine biosynthesis through TH and CREB activation. Ombuoside exhibits antimicrobial activity against several Gram-positive and Gram-negative bacteria, as well as Candidaalbicans
1-Monomyristin, extracted from Serenoa repens, inhibits the hydrolysis of 2-oleoylglycerol (IC50=32 μM) and fatty acid amide hydrolase (FAAH) activity (IC50=18 μM). 1-Monomyristin shows antibacterial activity against Staphylococcus aureus and Aggregatibacter actinomycetemcomitans and also antifungal activity against Candidaalbicans .
Graveoline (Rutamine) is an orally active alkaloid with various activities such as antifungal, antiparasitic, anti-inflammatory, and antitumor effects. Graveoline can induce tumor cell apoptosis and autophagy through a reactive oxygen species-mediated pathway. Graveoline has an MIC of 500 μg/mL for Candidaalbicans. Graveoline can be used in the research of various diseases such as tumors and liver injury .
Cystothiazole A has antifungal activity. Cystothiazole A can inhibit candidaalbicans, saccharomyces cerevisiae and aspergillus smoke with MIC values of 0.4 μg/mL, 0.1 μg/mL and 1.6 μg/mL, respectively. Cystothiazole A also inhibits human tumor cell, such as HPT-116 and K562 cells with MIC values of 130 ng/mL and 110 ng/mL, respectively. Cystothiazole A has no anti-bacterial effect .
Guanine-7-oxide (Guanine 7-N-oxide) is an antitumor antibiotic with anti-tumor, anti-Candidaalbicans activity, and can inhibit viral replication effect of herpes virus, infectious blood virus (IHNV), infectious pancreatic necrosis virus (IPNV) and so on. Guanine-7-oxide has good activity against mouse L1210 leukemia cells .
Chevalone B was isolated from the ethyl acetate extract of the marine sponge-associated fungus Aspergillus similanensis. The structure of Chevalone B was confirmed by 1D and 2D NMR spectroscopy. Chevalone B showed antimicrobial activity against Gram-positive and Gram-negative bacteria, Candidaalbicans, and multidrug-resistant strains from the environment. Studies on Chevalone B have shown its potential value in antimicrobial applications.
Theasaponin E1 is an orally effective tea saponin. Theasaponin E1 inhibits the proliferation of cancer cells by activating apoptosis. Theasaponin E1 inhibits angiogenesis in ovarian cancer cells and HUVECs by reducing the expression of VEGF. Theasaponin E1 upregulates the phosphorylation level of ATM protein and the expression level of PTEN protein in cancer cells, decreases the phosphorylation levels of Akt, mTOR, p70S6K and 4E-BP1 proteins, downregulates the expression of HIF-1α and NF-κB, and reduces the protein expression of Notch ligands Dll4 and Jagged1. Theasaponin E1 exerts neuroprotective effects by inhibiting the activity of acetylcholinesterase, activating α-secretase and neprilysin, reducing the concentration of Aβ, and inhibiting the activities of β-secretase and γ-secretase. Theasaponin E1 exhibits toxic effects on cancer cells and quinone reductase-inducing activity, and inhibits tumor growth in vivo. Theasaponin E1 induces ferroptosis in Pomacea canaliculata by synergistically disrupting cholesterol homeostasis and sphingolipid metabolism. Theasaponin E1 possesses anti-biofilm activity against Candidaalbicans. Theasaponin E1 can be used in the research of ovarian cancer, obesity, Alzheimer's disease and fungal infections .
Mazethramycin B (Compound II) is an antitumor antibiotic. Mazethramycin B can be isolated from the Streptomyces thioluteusM ME561-L4. Mazethramycin B has a broad-spectrum antimicrobial activity (such as MICs of 1.56 and 6.25 μg/mL for the bacteria Bacillus subtilis PCI 219 and the fungus Candida pseudotropicalis, resepectively). Mazethramycin B significantly increases survival in L1210 leukemia mice model .
10-Isobutyryloxy-8,9-epoxythymol isobutyrate is a major constituent of Inula helenium and Inula royleana root cultures. 10-Isobutyryloxy-8,9-epoxythymol isobutyrate shows moderate antimicrobial activity against Staphylococcus aureus FDA 209 P, Staphylococcus aureus, Enterococcus faecalis, Candidaalbicans and Pseudomonas aeruginosa with MICs of 50, 250, 250, 250, and 1000 μg/mL, respectively .
Monascorubrin is a compound that can be isolated from Monascus mycelia. Monascorubrin has activities such as anti-inflammatory, anti-tumor, antibacterial, and immunomodulatory. Monascorubrin also has certain embryotoxicity, with an ED50 of 4.3 μg for chicken embryos. Monascorubrin can be used for the research of tumors and inflammatory diseases .
β-Phenylethyl β-D-glucoside (Phenylethyl β-D-glucopyranoside) (Compound 7), a phenolic compounds, is an antifungal agent. β-Phenylethyl β-D-glucoside can be isolated from the leaves of Piper crocatum. β-Phenylethyl β-D-glucoside has antifungal activity against Candidaalbicans. β-Phenylethyl β-D-glucoside can be used for fungal infections research .
14-epi-Berkeleylactone F (Compound 8) is a C-14 epimer of Berkeleylactone F (HY-N8386). 14-epi-Berkeleylactone F can be isolated from Penicillium turbatum NRRL 5630. 14-epi-Berkeleylactone F has no significant biological activity against bacterium (Staphylococcus aureus, Bacillus subtilis and E. coli), fungi Candidaalbicans, the parasite Giardia duodenalis and NS-1 murine myeloma cells .
Mansonone E (Compound 5) is a pesticide. Mansonone E can be isolated from heartwood of Mansonia gagei. Mansonone E has significant antifungal activity against Cladosporium cucumerinum, Candidaalbicans and Phytophthora parasitica. Mansonone E has potent antibacterial activity with MIC50s of both 7.8 μg/mL for Xanthomonas oryzae pv. oryzae and X. oryzae pv. Oryzicola. Mansonone E also has antifeedant and herbicidal activities .
Graveoline (Standard) is the analytical standard of Graveoline (HY-12538). This product is intended for research and analytical applications. Graveoline (Rutamine) is an orally active alkaloid with various activities such as antifungal, antiparasitic, anti-inflammatory, and antitumor effects. Graveoline can induce tumor cell apoptosis and autophagy through a reactive oxygen species-mediated pathway. Graveoline has an MIC of 500 μg/mL for Candidaalbicans. Graveoline can be used in the research of various diseases such as tumors and liver injury .
Sordarin (Compound 1) is an antifungal agent targeting Elongation factor 2 (EF2) with a tetracyclic diterpene core including a norbornene system. Sordarin can be isolated from the fungus Sordaria araneosa. Sordarin has potent antifungal activity against Saccharomyces cerevisiae and Candidaalbicans. Sordarin prevents the translocation of the ribosome along mRNA during elongation of the emerging polypeptide chain, inhibiting protein synthesis in fungi by stabilizing the ribosome/EF2 complex .
Damnacanthal is an anthraquinone isolated from the root of Morinda citrifolia. Damnacanthal is a highly potent, selective inhibitor of p56 lck tyrosine kinase activity. Natural Damnacanthal inhibits p56 lck autophosphorylation and phosphorylation of exogenous substrates with IC50s of 46 nM and 220 nM, respectively. Damnacanthal is a potent inducer of apoptosis with anticancer activity. Damnacanthal also has antinociceptive, anti-inflammatory effects in mice and anti-fungal activity against Candidaalbicans .
Gibberellin A7 (GA7) is a terpenoid that serve as an important plant hormone. Gibberellin A7 acts as a growth and response modulator against injuries and parasitism. Gibberellin A7 presents antibiofilm properties at 940 mM concentration. Gibberellin A7 can inhibit flower bud formation in some plants. Gibberellin A7 shows antioxidant activity against peroxyl radicals. Gibberellin A7 exhibits anti-Candida activity against Candia albicans .
(E)-Ferulic acid acyl-β-D-glucoside ((E)-Ferulic acid glucoside) (compoun 4C) is an acyl-β-D-glucoside that can be isolated from Riesling Wine. (E)-Ferulic acid acyl-β-D-glucoside exhibits antioxidant activity .
Myristinin A (YM 26567-1) is a trans-isomer flavan compound found in Horsfieldia amygdaline and Myristica cinnamomea. Myristinin A can selectively inhibit COX-2 activity with an IC50 of 16.9 μg/mL. Myristinin A can reduce the production of prostaglandin E2 (PGE2) and inhibit phospholipase A2 (PLA2), thereby blocking the release of inflammatory mediators. Myristinin A can inhibit Candidaalbicans with an IC50 of 8.8 μg/mL. Myristinin A can be used for the research of inflammation and infection, such as rheumatoid arthritis .
3-O-α-L-Arabinopyranosyl hederagenin 28-O-α-L-rhamnopyranosyl ester is an anti-fungal triterpene saponin. 3-O-α-L-Arabinopyranosyl hederagenin 28-O-α-L-rhamnopyranosyl ester can be isolated from the aerial parts of Clematis tangutica. 3-O-α-L-Arabinopyranosyl hederagenin 28-O-α-L-rhamnopyranosyl ester exhibits antifungal activity against fungal strains (P. avellaneum, C. glabrata, S. cerevisiae, T. beigelii), with the strongest activity against S. cerevisiae .
N-Acetyl-D-Glucosamine (N-Acetyl-2-amino-2-deoxy-D-glucose), the D isomer of N-acetylglucosamine, is an orally active monosaccharide derivative of glucose with anti-tumor and anti-inflammation properties. N-Acetyl-D-Glucosamine is also a bacterial metabolite, which is found in Escherichia coli. N-Acetyl-D-Glucosamine can induce yeast-mycelial conversion in Candidaalbicans. N-Acetyl-D-Glucosamine also enhances healing of cartilaginous injuries in rabbits .
1-Prenyl-2-methoxy-6-formyl-8-hydroxy-9H-carbazole (Compound 19) is a carbazole alkaloid that can be isolated from Murraya koenigii. 1-Prenyl-2-methoxy-6-formyl-8-hydroxy-9H-carbazole exhibits anti-inflammatory and antimicrobial activities. 1-Prenyl-2-methoxy-6-formyl-8-hydroxy-9H-carbazole can inhibit the production of pro-inflammatory cytokines TNF-α and IL-6 . 1-Prenyl-2-methoxy-6-formyl-8-hydroxy-9H-carbazole has IC50 values of 10.9 μM and 95 μM for Bacillus cereus and Staphylococcus aureus, respectively. 1-Prenyl-2-methoxy-6-formyl-8-hydroxy-9H-carbazole can be used in the research of inflammatory and infectious diseases .
Sabinene hydrate is a volatile organic compound of a bicyclic monoterpene alcohol. Sabinene hydrate, as a plant secondary metabolite, is naturally present in various plants and their essential oils. Sabinene hydrate exhibits broad-spectrum but varying-intensity antibacterial activity, with the greatest sensitivity to Gram-positive bacteria, especially Bacillus subtilis (MIC = 0.0312 mg/mL) and Staphylococcus aureus (MIC = 0.0625 mg/mL). Sabinene hydrate also shows certain sensitivity to Escherichia coli and Candidaalbicans, with MIC values of 0.125 mg/mL for both. Sabinene hydrate can be used in the research of the ecological functions of plant defense substances .
Myristinin B/C is a mixture of Myristinin B and Myristinin C. Myristinin B/C is a flavan compound found in Horsfieldia amygdaline and Myristica cinnamomea. Myristinin B/C can selectively inhibit COX-2 activity with an IC50 of 2.1 μg/mL. Myristinin B/C can reduce the production of prostaglandin E2 (PGE2) and inhibit phospholipase A2 (PLA2), thereby blocking the release of inflammatory mediators. Myristinin B/C can inhibit Candidaalbicans with an IC50 of 6 μg/mL. Myristinin B/C can be used for the research of inflammation and infection, such as rheumatoid arthritis .
Isostrictiniin (ITN) is a polyphenolic compound isolated from Nymphaea candida. It upregulates the expression of Nrf2 and HO-1, while downregulating the expression of Keap1. Isostrictiniin reduces the phosphorylation levels of JNK, ERK1/2, p38, IκBα, and NF-κB p65. Isostrictiniin decreases the levels of pro-inflammatory mediators (IL-1β, IL-6, TNF-α, PGE2). Isostrictiniin alleviates LPS-induced acute lung injury and exerts protective effects against acute alcoholic liver injury. Additionally, isostrictiniin exhibits anti-inflammatory, antioxidant, and anti-fibrotic activities.
Caerulomycin A is an orally active immunomodulator and antimicrobial agent. Caerulomycin A targets Smad3, STAT1 and GATA-3. Caerulomycin A downregulates GATA-3 expression, inhibits Th2 cell differentiation and Th2 cytokine production, reduces IgE levels, and alleviates pulmonary inflammatory responses and eosinophil infiltration. Caerulomycin A ameliorates collagen-induced arthritis symptoms, reduces joint inflammation and synovitis, and decreases the levels of proinflammatory cytokines in joints. Caerulomycin A inhibits the growth of some filamentous fungi, yeasts and specific bacteria. Caerulomycin A can be used in research related to arthritis and asthma .
Xylitol can be classified as a polyol and sugar alcohol, exhibiting inhibitory activity on cancer cell proliferation. It induces autophagy (Autophagy) and cell death in A549 cells by activating the autophagy signaling pathway, as evidenced by the increased expression of LC3-II and Atg5-Atg12 upon Xylitol treatment. Additionally, Xylitol inhibits acetaldehyde production by Candida species, thereby reducing their carcinogenic potential. In vivo, Xylitol induces alterations in the gut microbiota of mice, which may enhance cholesterol accumulation and upregulate hepatic ChREBP, while also slowing tumor growth in the B16F10 melanoma C57BL/6 mouse model .
Pyrithioxin (Pyritinol) is an orally active neurodynamic compound. Pyrithioxin can promote the metabolism of glucose and amino acids, increase carotid blood flow and improve cerebral blood flow. Pyrithioxin exhibits anti-inflammation, anti-tumor and neuroprotective effect. Pyrithioxin can be used for the researches of cancer, inflammation, immunology, metabolic and neurological disease such as cerebral infarct, epilepsy, fibrosarcomas and rheumatoid polyarthritis .
Pyrithioxin (Pyritinol) dihydrochloride (Standard) is the analytical standard of Pyrithioxin dihydrochloride (HY-B0910A). Pyrithioxin (Pyritinol) is an orally active neurodynamic compound. Pyrithioxin can promote the metabolism of glucose and amino acids, increase carotid blood flow and improve cerebral blood flow. Pyrithioxin exhibits anti-inflammation, anti-tumor and neuroprotective effect. Pyrithioxin can be used for the researches of cancer, inflammation, immunology, metabolic and neurological disease such as cerebral infarct, epilepsy, fibrosarcomas and rheumatoid polyarthritis .
Pyrithioxin (Pyritinol) dihydrochloride is the dihydrochloride salt of Pyrithioxin (HY-B0910). Pyrithioxin (Pyritinol) is an orally active neurodynamic compound. Pyrithioxin can promote the metabolism of glucose and amino acids, increase carotid blood flow and improve cerebral blood flow. Pyrithioxin exhibits anti-inflammation, anti-tumor and neuroprotective effect. Pyrithioxin can be used for the researches of cancer, inflammation, immunology, metabolic and neurological disease such as cerebral infarct, epilepsy, fibrosarcomas and rheumatoid polyarthritis .
Hazelnutin F is an indoleacetic acid glycoside found in the kernels of Corylus avellana L.. Hazelnutin F lacks significant antioxidant activity against ABTS and DPPH radicals .
Anandamide is an endocannabinoid. Anandamide modulates both neuronal and immune functions through two protein-coupled cannabinoid receptors (CB1 and CB2). Anandamide can activate numerous other receptors like PPARS, TRPV1, and GPR18/GPR55. Anandamide also has potential anti-fungal and anti-inflammatory activities. Anandamide can be used for the research of Alzheimer’s disease (AD) and ulcerative colitis .
Nyasol ((-)-Nyasol) is an active compound that has antifungal, antibacterial, antileishmanial, hyaluronidase inhibition activities. Nyasol inhibits LTB4 binding to human neutrophils. Nyasol suppresses neuroinflammatory response through the inhibition of I-κB degradation in LPS (HY-D1056)-stimulated BV-2 microglial cells .
Haplopine is a substance with anti-inflammatory, antioxidant and photoactivated antibacterial activities. It also acts as an inhibitor of UGT1A7 and a photoactivated restriction endonuclease inhibitor. Haplopine inhibits the mRNA/protein expression of IL-6, TSLP, GM-CSF, G-CSF, IL-4, IL-13 and COX-2, while upregulating the mRNA/protein expression of SOD, CAT and HO-1. Haplopine inhibits the glucuronidation reaction catalyzed by UGT1A7 through competitive hydrophobic binding. Haplopine exerts photoactivated restriction endonuclease inhibitory effects by binding to DNA. Haplopine exhibits photoactivated activity against methicillin-resistant Staphylococcus aureus. Haplopine alleviates symptoms of atopic dermatitis. Haplopine can be used in research related to atopic dermatitis and methicillin-resistant Staphylococcus aureus infections .
Aspergillusidone F is a Depsidone and antibacterial agent. Aspergillusidone F can be isolated from a marine fungus Aspergillus unguis. Aspergillusidone F potently inhibits Aromatase with an IC50 of 0.5 μM. Aspergillusidone F exhibits antibacterial activity against Pseudomonas aeruginosa and Methicillin (HY-121544)-resistant Staphylococcus aureus. Aspergillusidone F exhibits potent larvicidal activity against Artemia salina larvae, with an LC50 value of 12.8 μM. Aspergillusidone F exhibits anticancer activity against intrahepatic cholangiocarcinoma, non-small cell lung cancer, and acute lymphoblastic leukemia .
Petalostemumol G is a flavonol derivative present in Petalostemum purpureum. Petalostemum G has no antibacterial activity. Petalostemumol G is formed by air oxidation of petalostemumol .
Glochidioboside, a neolignan glucoside found in Sambucus williamsii, is an antifungal agent. Glochidioboside induces membrane depolarization, membrane permeabilization, and pore formation on fungal membranes. Glochidioboside exerts an antifungal activity through a membrane-disruptive mechanism .
6-Methoxydihydrosanguinarine is an alkaloid with activity across multiple cancer cell types. 6-Methoxydihydrosanguinarine activates IRE1/JNK signaling, blocks Akt/mTOR and PI3K/AKT/mTOR pathways, reduces expression of Cdc25C, CyclinB1, Cdc2, YAP/TAZ, Survivin, GPX4, and EGFR, upregulates IRE1 and DR5, and activates JNK and caspases. 6-Methoxydihydrosanguinarine induces apoptosis, G2/M phase arrest, DNA damage, ROS generation, lipid peroxidation, ferroptosis, autophagy, and suppresses cancer cell growth. 6-Methoxydihydrosanguinarine disruptes the biofilm formation of Candidaalbicans (C. albicans). 6-Methoxydihydrosanguinarine can be used for the research of non-small cell lung cancer, hepatocellular carcinoma, melanoma, colon carcinoma, ovarian cancer and breast cancer .
6-Methoxydihydrosanguinarine hydrochloride is an alkaloid with activity across multiple cancer cell types. 6-Methoxydihydrosanguinarine hydrochloride activates IRE1/JNK signaling, blocks Akt/mTOR and PI3K/AKT/mTOR pathways, reduces expression of Cdc25C, CyclinB1, Cdc2, YAP/TAZ, Survivin, GPX4, and EGFR, upregulates IRE1 and DR5, and activates JNK and caspases. 6-Methoxydihydrosanguinarine hydrochloride induces apoptosis, G2/M phase arrest, DNA damage, ROS generation, lipid peroxidation, ferroptosis, autophagy, and suppresses cancer cell growth. 6-Methoxydihydrosanguinarine hydrochloride disruptes the biofilm formation of Candidaalbicans (C. albicans). 6-Methoxydihydrosanguinarine hydrochloride can be used for the research of non-small cell lung cancer, hepatocellular carcinoma, melanoma, colon carcinoma, ovarian cancer and breast cancer .
1,1,3-Tris (3-indolyl) butane is an indole alkaloid. It is isolated from North Sea bacteria closely related to Vibrio parahaemolyticus. 1,1,3-Tris (3-indolyl) butane shows no activity against a variety of bacteria and fungi .
Koninginin D is a potent antifungal agent that can be isolated from fungi including Trichoderma applanatum. Koninginin D inhibits growth of various fungal species including Gaeumannomyces graminis var. tritici, Bipolaris sorokiniana and so on. Koninginin D can be used for the research of fungal infection .
Podocarpusflavone A is a biflavonoid present in the leaves of Podocarpus henkelii, with anti-tumor, topoisomerase I inhibitory, antibacterial and antifungal activities. Podocarpusflavone A exhibits antibacterial activity against Enterococcus faecalis and Pseudomonas aeruginosa. Podocarpusflavone A shows weak activity against fungal pathogens. Podocarpusflavone A targets topoisomerase I and induces cell cycle arrest and apoptosis in MCF-7 cells. Podocarpusflavone A can be used for studies on cancer, bacterial and fungal infections .
Geranyl isobutyrate is a synthetic α,β‑unsaturated branched‑chain aliphatic ester and a geraniol derivative. Geranyl isobutyrate acts as a food and feed flavouring agent and a biologically active antimicrobial compound. Geranyl isobutyrate shows antimicrobial activity against Gram‑positive and most Gram‑negative bacteria .
Drimenal is a pimarane-type natural sesquiterpene with antifungal activity. Drimenal inhibits the growth of yeasts and dermatophytes. Drimenal can be used for the development of pesticide candidates and in research related to fungal infections .
KS 619-1 is a Ca 2+/calmodulin-dependent cyclic nucleotide phosphodiesterase inhibitor. KS 619-1 exhibits strong inhibitory activity against this enzyme derived from bovine brain and heart, but shows weak inhibitory effects on calmodulin-independent phosphodiesterase and protein kinase C. KS 619-1 displays weak antibacterial activity against Staphylococcus aureus .
Demethoxyhexahydrocurcumin is a Curcumin (HY-N0005) biotransformation metabolite and diarylheptanoid with antioxidant and antimicrobial activities.Demethoxyhexahydrocurcumin scavenges free radicals, inhibits cancer cell viability, and suppresses microbial growth. Demethoxyhexahydrocurcumin can be used for the research of colorectal cancer .
Ternidazole hydrochloride is a nitroimidazole Antibiotic with anti-pathogenic microbial activity. Ternidazole hydrochloride kills and inhibits the visible growth of Clostridium perfringens type A in vitro. Ternidazole hydrochloride helps improve the therapeutic efficacy against bacterial vaginosis, candidal vaginitis and mixed vaginitis. Ternidazole hydrochloride effectively alleviates chronic alcoholism. Ternidazole hydrochloride can be used in research related to vaginitis, pathogenic microbial infections and chronic alcoholism .
Kipukasin B is an antibacterial agent. Kipukasin B exhibits activity against the Gram-positive strain Bacillus subtilis. Kipukasin B is isolated from Aspergillus versicolor obtained from Hawaii. Kipukasin B can be used in the research of Gram-positive bacterial infections .
Ambigol C is an ambigol, Antibacterial agent and Antimalarial agent. Ambigol C is isolated from Fischerella ambigua 108b. Ambigol C exhibits selective antibacterial activity against Gram-positive Staphylococcus aureus strains (including MRSA) with MIC values of 0.98-3.91 μg/mL. Ambigol C also shows potent antibacterial activity against B. megaterium, and possesses weak antimalarial and trypanocidal effects. Ambigol C can be used in the research of bacterial infections, plasmodial infections and trypanosomal infections .
3-Hydroxyglabrol is an Antibacterial agent. 3-Hydroxyglabrol can be isolated from Glycyrrhiza glabra L. var. typica. 3-Hydroxyglabrol inhibits the growth of Staphylococcus aureus (ATCC 13709) and Mycobacterium smegmatis (ATCC 607), with a MIC of 6.25 mcg/mL. 3-Hydroxyglabrol can be used for the research of Staphylococcus aureus infection, Mycobacterium smegmatis infection .
Allitol (Allodulcitol) is an orally active rare sugar alcohol found in Itea virginica L, Tylopilus plumbeoviolaceus.Allitol has anti-obesity and hypoglycaemic activities. Allitol reduces carcass and total body fat mass, increases cecal weight, surface area, and short-chain fatty acid production, and upregulates cecal microbial enzymes linked to butyrate metabolism. Allitol can be used for the researches of obesity and diabetes .
Glucomoringin, a structurally unusual glucosinolate found in seeds of Moringa oleifera Lam., is an antimicrobial agent. Glucomoringin permits to maximize it's power when bioactivated with myrosinase. Glucomoringin can be used for the research of bacterial infections .
Glenthmycin E is an antibacterial agent found in Australian sheep pasture-derived Streptomyces sp. CMB-PB041. Glenthmycin E inhibits growth of multiple bacterial and exhibits no detectable cytotoxicity to eukaryotic cells including fungal and human carcinoma cells. Glenthmycin E can be used for the research of bacterial infections .
Neryl acetate is an essential oil component. Neryl acetate upregulates genes associated with epidermal differentiation, skin barrier formation and ceramide synthesis; it also increases filaggrin expression, total lipid and ceramide contents. Neryl acetate acts as the core driver mediating the skin barrier-forming and antibacterial effects of Helichrysum italicum essential oil .
Pithecolobine is a saponin-like alkaloid found in the bark, seeds, and leaves of Samanea saman. Pithecolobine can inhibit the growth of Gram-positive bacteria, Gram-negative bacteria, and pathogenic yeasts. Pithecolobine scavenges DPPH radicals. Pithecolobine can be used for the research of infections caused by pathogenic bacteria and yeasts .
(-)-Codonopsine is an alkaloid with antibacterial activity. (-)-Codonopsine can be used in research related to Staphylococcus aureus and Escherichia coli infections .
FDH1 protein serves as a catalyst in the NAD(+)-dependent oxidation of formate to carbon dioxide. This enzymatic activity represents the conclusive step in the methanol oxidation pathway within methylotrophic microorganisms. Beyond its involvement in methylotrophic organisms, FDH1 also plays a crucial role in non-methylotrophic organisms, where it contributes to the detoxification of exogenous formate. FDH1 Protein, Candida boidinii (C23S, C262A, His, Strep) is the recombinant Candida boidinii-derived FDH1, expressed by E. coli, with Strep, His labeled tag.
FDH1 protein serves as a catalyst in the NAD(+)-dependent oxidation of formate to carbon dioxide. This enzymatic activity represents the conclusive step in the methanol oxidation pathway within methylotrophic microorganisms. Beyond its involvement in methylotrophic organisms, FDH1 also plays a crucial role in non-methylotrophic organisms, where it contributes to the detoxification of exogenous formate. FDH1 Protein, Candida boidinii is the recombinant FDH1 protein, expressed by E. coli , with tag free.
FDH1 protein serves as a catalyst in the NAD(+)-dependent oxidation of formate to carbon dioxide. This enzymatic activity represents the conclusive step in the methanol oxidation pathway within methylotrophic microorganisms. Beyond its involvement in methylotrophic organisms, FDH1 also plays a crucial role in non-methylotrophic organisms, where it contributes to the detoxification of exogenous formate. FDH1 Protein, Candida boidinii (His) is the recombinant FDH1 protein, expressed by E. coli , with N-6*His labeled tag.
Fluconazole-d4 is the deuterium labeled Fluconazole. Fluconazole (UK-49858) is a triazole antifungal agent with excellent activities against a broad range of fungi, especially against Candidaalbicans. Fluconazole inhibits C. albicans and Candida kefyr with IC99s range from 0.20 μg/mL to 0.39 μg/mL .
(E,E)-Farnesol-d6 (trans,trans-Farnesol-d6) is deuterium labeled (E,E)-Farnesol (HY-Y0248). (E,E)-Farnesol (trans,trans-Farnesol) is a quorum-sensing molecule of Candida species. (E,E)-Farnesol can inhibit the growth, metabolism and biofilm formation of various Candida species, and affect their morphology and invasiveness .
Terbinafine-d3 hydrochloride is the deuterium labeled Terbinafine hydrochloride. Terbinafine hydrochloride (TDT 067 hydrochloride) is an antifungal medication used to treat fungal infections. It is a potent non-competitive inhibitor of squalene epoxidase from Candida with a Ki of 30 nM . Terbinafine hydrochloride also antibacterial activity against certain Gram-positive and Gram-negative bacteria .
Efinaconazole-d4 is the deuterium labeled Efinaconazole. Efinaconazole (KP-103) is a triazole antifungal agent and againsts T. mentagrophytes SM-110 and C. albicans ATCC 10231 with MICs of 0.0039 μg/mL and 0.00098 μg/mL, respectively . Efinaconazole has a potent in vitro activity against fungal pathogens including dermatophytes, Candida and Malassezia species .
Terbinafine-d7 is the deuterium labeled Terbinafine. Terbinafine (TDT 067) is an antifungal medication used to treat fungal infections. It is a potent non-competitive inhibitor of squalene epoxidase from Candida with a Ki of 30 nM . Terbinafine also antibacterial activity against certain Gram-positive and Gram-negative bacteria .
2-Phenylethanol-d5 is the deuterium labeled 2-Phenylethanol . 2-Phenylethanol (Phenethyl alcohol), extracted from rose, carnation, hyacinth, Aleppo pine, orange blossom and other organisms, is a colourless liquid. It has a pleasant floral odor and also an autoantibiotic produced by the fungus Candidaalbicans . It is used as an additive in cigarettes and also used as a preservative in soaps due to its stability in basic conditions.
Fluconazole-13C2,15N (UK-49858-13C2,15N) is the 13C and 15N labeled isotope of Fluconazole (HY-B0101). Fluconazole (UK-49858) is a triazole antifungal agent with excellent activities against a broad range of fungi, especially against Candidaalbicans. Fluconazole inhibits C. albicans and Candida kefyr with IC99s range from 0.20 μg/mL to 0.39 μg/mL .
Tebuconazole-d9 is the deuterium labeled Tebuconazole. Tebuconazole is an agricultural azole fungicide which can also inhibit CYP51 with IC50s of 0.9 and 1.3 μM for Candidaalbicans CYP51 (CaCYP51) and truncated Homo sapiens CYP51 (Δ60HsCYP51), respectively.
2-Phenylethanol-d9 is the deuterium labeled 2-Phenylethanol . 2-Phenylethanol (Phenethyl alcohol), extracted from rose, carnation, hyacinth, Aleppo pine, orange blossom and other organisms, is a colourless liquid. It has a pleasant floral odor and also an autoantibiotic produced by the fungus Candidaalbicans . It is used as an additive in cigarettes and also used as a preservative in soaps due to its stability in basic conditions.
2-Phenylethanol-d4 is the deuterium labeled 2-Phenylethanol . 2-Phenylethanol (Phenethyl alcohol), extracted from rose, carnation, hyacinth, Aleppo pine, orange blossom and other organisms, is a colourless liquid. It has a pleasant floral odor and also an autoantibiotic produced by the fungus Candidaalbicans . It is used as an additive in cigarettes and also used as a preservative in soaps due to its stability in basic conditions.
Naftifine-d3 (hydrochloride) is the deuterium labeled Naftifine hydrochloride. Naftifine hydrochloride is an antibiotic. Naftifine hydrochloride has antifungal activity against dermatophytes, aspergilli, Sporothrix schenckii, and yeasts of the genus Candida. Naftifine hydrochloride can be used for the research of superficial dermatomycoses inhibition .
Aldox-d6 (Lexamine M-13-d6; MAPD-d6) is the deuterium labeled Myristamidopropyl dimethylamine (HY-W099582). Myristamidopropyl dimethylamine (MAPD) is an antimicrobial agent (including against bacteria and fungi) and an insecticide, exhibiting inhibitory activity against Pseudomonas aeruginosa, Staphylococcus aureus, Candidaalbicans, Fusarium solani, and Acanthamoeba polyphaga. Myristamidopropyl dimethylamine can be used in research on microbial-induced keratitis .
Terbinafine-d3 (TDT 067-d3) is deuterium labeled Terbinafine. Terbinafine (TDT 067) is an orally active and potent antifungal agent. Terbinafine is a potent non-competitive inhibitor of squalene epoxidase from Candida, with a Ki of 30 nM. Terbinafine also shows antibacterial activity against certain Gram-positive and Gram-negative bacteria . Terbinafine is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
2,6-Dichlorodiphenylamine- 13C6 (2,6-Dichloro-N-phenylaniline- 13C6) is the 13C-labeled 2,6-Dichlorodiphenylamine (HY-W012126). 2,6-Dichlorodiphenylamine is an analogue of Diclofenac Sodium (HY-15037) and has anti-Candidaalbicans activity. Diclofenac Sodium is a potent and nonselective anti-inflammatory agent, acts as a?COX?inhibitor, with?IC50s of 4 and 1.3 nM for human COX-1 and COX-2 in CHO cells.
Tebuconazole-d6 is a deuterium labeled Tebuconazole (HY-B0852). Tebuconazole is an orally active agricultural azole fungicide which can also inhibit CYP51 with IC50s of 0.9 and 1.3 μM for Candidaalbicans CYP51 (CaCYP51) and truncated Homo sapiens CYP51 (Δ60HsCYP51), respectively. Tebuconazole induces lipid accumulation and oxidative stress in HepG2 Cells. Tebuconazole decreases MAC-T cells viability and proliferation, induces ER-stress-mediated apoptosis and increases oxidative stress levels in MAC-T cells .
N-Acetyl-D-glucosamine-d3 (N-Acetyl-2-amino-2-deoxy-D-glucose-d3) is deuterium labeled N-Acetyl-D-glucosamine. N-Acetyl-D-Glucosamine (N-Acetyl-2-amino-2-deoxy-D-glucose), the D isomer of N-acetylglucosamine, is an orally active monosaccharide derivative of glucose with anti-tumor and anti-inflammation properties. N-Acetyl-D-Glucosamine is also a bacterial metabolite, which is found in Escherichia coli. N-Acetyl-D-Glucosamine can induce yeast-mycelial conversion in Candidaalbicans. N-Acetyl-D-Glucosamine also enhances healing of cartilaginous injuries in rabbits .
Xylitol- 13C5 (Xylite- 13C5) is the 13C-labeled Xylitol (HY-N0538). Xylitol can be classified as a polyol and sugar alcohol, exhibiting inhibitory activity on cancer cell proliferation. It induces autophagy (Autophagy) and cell death in A549 cells by activating the autophagy signaling pathway, as evidenced by the increased expression of LC3-II and Atg5-Atg12 upon Xylitol treatment. Additionally, Xylitol inhibits acetaldehyde production by Candida species, thereby reducing their carcinogenic potential. In vivo, Xylitol induces alterations in the gut microbiota of mice, which may enhance cholesterol accumulation and upregulate hepatic ChREBP, while also slowing tumor growth in the B16F10 melanoma C57BL/6 mouse model .
Glyceryl 1-monooctanoate-d15 is the deuterium labeled Glyceryl 1-monooctanoate (HY-W012444). Glyceryl 1-monooctanoate is a glycerol monolaurate derivative. Glyceryl 1-monooctanoate is a broad-spectrum antimicrobial, suppresses the growth of pathogenic yeast (Candidaalbicans and Candida parapsilosis), as well as Gram-positive (Staphylococcus aureus) and Gram-negative (Escherichia coli, Klebsiella pneumoniae) bacteria .
Glyceryl 1-monooctanoate-d5 is the deuterium labeled Glyceryl 1-monooctanoate (HY-W012444). Glyceryl 1-monooctanoate is a glycerol monolaurate derivative. Glyceryl 1-monooctanoate is a broad-spectrum antimicrobial, suppresses the growth of pathogenic yeast (Candidaalbicans and Candida parapsilosis), as well as Gram-positive (Staphylococcus aureus) and Gram-negative (Escherichia coli, Klebsiella pneumoniae) bacteria .
Flucytosine- 15N2 (5-Fluorocytosine- 15N2) hydrochloride is the 15N-labeled Flucytosine hydrochloride (HY-B0139). Flucytosine (5-Fluorocytosine) is an antifungal compound with oral activity. Flucytosine is a widely used cytotoxic drug that, after further metabolism, produces fluorinated ribonucleotides and deoxyribonucleotides, inhibits DNA and protein synthesis, and has multiple effects such as inhibiting candida and candida neoplasm infection and producies cytotoxicity to cancer cells.
Naftifine-d3 is the deuterium labeled Naftifine. Naftifine hydrochloride is an antibiotic. Naftifine hydrochloride has antifungal activity against dermatophytes, aspergilli, Sporothrix schenckii, and yeasts of the genus Candida. Naftifine hydrochloride can be used for the research of superficial dermatomycoses inhibition .
Naftifine- 13C,d3 is the 13C- and deuterium labeled Naftifine. Naftifine hydrochloride is an antibiotic. Naftifine hydrochloride has antifungal activity against dermatophytes, aspergilli, Sporothrix schenckii, and yeasts of the genus Candida. Naftifine hydrochloride can be used for the research of superficial dermatomycoses inhibition .
Micafungin-d11 ammonium (FK463-d11 ammonium) is the deuterium labeled Micafungin ammonium. Micafungin (FK463) is an antifungal agent and can inhibit β-1,3-glucan synthase.Micafungin inhibits 1,3-β-glucan biosynthesis in fungal cell walls.Micafungin can be used for the research of fungal infection, such as candida infections and aspergillosis .
Tebuconazole-d4 is the deuterium labeled Tebuconazole (HY-B0852). Tebuconazole is an orally active agricultural azole fungicide which can also inhibit CYP51 with IC50s of 0.9 and 1.3 μM for Candidaalbicans CYP51 (CaCYP51) and truncated Homo sapiens CYP51 (Δ60HsCYP51), respectively. Tebuconazole induces lipid accumulation and oxidative stress in HepG2 Cells. Tebuconazole decreases MAC-T cells viability and proliferation, induces ER-stress-mediated apoptosis and increases oxidative stress levels in MAC-T cells .
Xylitol can be classified as a polyol and sugar alcohol, exhibiting inhibitory activity on cancer cell proliferation. It induces autophagy (Autophagy) and cell death in A549 cells by activating the autophagy signaling pathway, as evidenced by the increased expression of LC3-II and Atg5-Atg12 upon Xylitol treatment. Additionally, Xylitol inhibits acetaldehyde production by Candida species, thereby reducing their carcinogenic potential. In vivo, Xylitol induces alterations in the gut microbiota of mice, which may enhance cholesterol accumulation and upregulate hepatic ChREBP, while also slowing tumor growth in the B16F10 melanoma C57BL/6 mouse model .
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Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred
to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was
used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.
Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred
to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was
used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.
Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred
to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was
used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.
Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred
to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was
MedchemExpress Validation 03
Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred
MedchemExpress Validation 04
Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred
to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was
used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.
MedchemExpress Validation
Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred
to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was
used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.
Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred
to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was
used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.
MedchemExpress Validation
Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred
to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was
used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.
MedchemExpress Validation
Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred
to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was
used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.
MedchemExpress Validation
Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred
to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was
used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.
MedchemExpress Validation
Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred
to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was
used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.
MedchemExpress Validation
Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred
to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was
used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.
MedchemExpress Validation
Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred
to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was
used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.
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