Sordarin sodium

Cat. No.: HY-126396: FAQs
Data Sheet Handling Instructions

Sordarin is a potent diphthamide-dependent eEF2 inhibitor with antifungal properties. Sordarin targets eEF2 so as to inhibit protein translation by blocking eEF2-mediated translocation of tRNAs. Sordarin inhibits translation specifically in certain fungi (e.g. C. albicans, C. glabrata, and C. neoformans) while unable to do so in some other fungal species (e.g. Candida parapsilosis and Candida lusitaniae).

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Sordarin sodium Chemical Structure

CAS No. : 463356-00-5

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Description	Sordarin is a potent diphthamide-dependent eEF2 inhibitor with antifungal properties. Sordarin targets eEF2 so as to inhibit protein translation by blocking eEF2-mediated translocation of tRNAs. Sordarin inhibits translation specifically in certain fungi (e.g. C. albicans, C. glabrata, and C. neoformans) while unable to do so in some other fungal species (e.g. Candida parapsilosis and Candida lusitaniae)^[1]^[2].
IC₅₀ & Target	IC50: eEF2; fungal^[1]
Molecular Weight	514.58
Formula	C₂₇H₃₉NaO₈
CAS No.	463356-00-5
SMILES	O=C([[email protected]]([[email protected]]12C=O)(C(C(C)C)=C[[email protected]]3C1)[[email protected]@]3(C[[email protected]@]4([H])[[email protected]@]2([H])CC[[email protected]]4C)CO[[email protected]](O[[email protected]@H]5C)[[email protected]]([[email protected]@H]([[email protected]@H]5OC)O)O)O[Na]
Shipping	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation	Data Sheet (275 KB) Handling Instructions (2659 KB)
References	[1]. Wael Abdel-Fattah, et al. Insights into diphthamide, key diphtheria toxin effector. Toxins (Basel). 2013 May 3;5(5):958-68. [Content Brief] [2]. Biprashekhar Chakraborty, et al. Structure-based designing of sordarin derivative as potential fungicide with pan-fungal activity. J Mol Graph Model. 2016 May;66:133-42. [Content Brief]

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Keywords:

Sordarin463356-00-5CaMKFungalAntibioticCalmodulin-dependent protein kinasesCalmodulin-dependent kinasesC.?albicansC.?glabrataC.?neoformansCandida parapsilosisCandida lusitaniaeeEF2antifungalInhibitorinhibitorinhibit

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Sordarin sodium

View All Antibiotic Isoform Specific Products:

Biological Activity

Purity & Documentation

References

Customer Review

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